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11. 发明申请

US20070225281A1 6-Amino-1,4-dihydro-benzo[d][1,3]oxazin-2-ones and analogs useful as progesterone receptor modulators 失效
标题翻译： 6-氨基-1,4-二氢 - 苯并[d] [1,3]恶嗪-2-酮和可用作孕酮受体调节剂的类似物
公开(公告)号：US20070225281A1
公开(公告)日：2007-09-27
申请号：US11804831
申请日：2007-05-21
申请人： Puwen Zhang , Jeffrey Kern
发明人： Puwen Zhang , Jeffrey Kern
IPC分类号： A61K31/535 , C07D265/18
CPC分类号： A61K31/538 , A61K31/517 , C07D265/18
摘要： Compounds having the structure of formula I are provided. In formula I, R1 is H, OH, substituted or unsubstituted C1 to C3 alkyl, C1 to C3 perfluoroalkyl, or COR6; R6 is H, substituted or unsubstituted C1 to C4 alkyl, aryl, substituted or unsubstituted C1 to C4 alkoxy, substituted or unsubstituted C1 to C3 aminoalkyl; R2 and R3 are H, substituted or unsubstituted C1 to C6 alkyl, C1 to C6 perfluoroalkyl, substituted or unsubstituted C2 to C6 alkenyl, substituted or unsubstituted C2 to C6 alkynyl, substituted or unsubstituted C3 to C6 cycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heterocyclic; or R2 and R3 are fused to form spirocyclic rings; R4 is NHR7, OR7, NHSO2R7, or OSO2R7; Q is O, S, NR8, or CR9R10; or a pharmaceutically acceptable salt, ester, or prodrug thereof. Such compounds are useful as progesterone receptor modulators and for treating progesterone receptor related conditions.
摘要翻译：提供具有式I结构的化合物。在式I中，R 1是H，OH，取代或未取代的C 1至C 3烷基，C 1或N 2 C 3至C 3全氟烷基或COR 6; R 6是H，取代或未取代的C 1至C 4烷基，芳基，取代或未取代的C 1〜至C 4烷氧基，取代或未取代的C 1至C 3氨基烷基; R 2和R 3均为H，取代或未取代的C 1至C 6烷基，C 1至C 6烷基， C 6至C 6全氟烷基，取代或未取代的C 2至C 6链烯基，取代或未取代的C 2，取代或未取代的C 3至C 6环烷基，取代或未取代的芳基或取代或未取代的杂环基; 或R 2和R 3 3稠合形成螺环; R 4是NHR 7，OR 7，NHSO 2 R 7，或 OSO 2 R 7; Q是O，S，NR 8或CR 9 R 10; 或其药学上可接受的盐，酯或前药。这些化合物可用作孕酮受体调节剂和用于治疗孕酮受体相关病症。

12. 发明申请

US20050215539A1 7-aryl 1,5-dihydro-4, 1-benzoxazepin-2(3H)-one derivatives and their use as progesterone receptor modulators 失效
标题翻译： 7-芳基1,5-二氢-4,1-苯并氧氮杂-2（3H） - 酮衍生物及其作为孕酮受体调节剂的用途
公开(公告)号：US20050215539A1
公开(公告)日：2005-09-29
申请号：US11087051
申请日：2005-03-22
申请人： Puwen Zhang , Jay Wrobel , Eugene Terefenko , Jeffrey Kern
发明人： Puwen Zhang , Jay Wrobel , Eugene Terefenko , Jeffrey Kern
IPC分类号： C07D267/14 , C07D413/04 , C07D413/14 , C07D417/14 , A61K31/553 , C07D413/02
CPC分类号： C07D267/14 , C07D413/04 , C07D413/14 , C07D417/14
摘要： This invention provides progesterone receptor modulators having the structure: wherein R1 to R7, X, and Q are as defined in the specification; or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供具有以下结构的孕酮受体调节剂：其中R 1至R 7，X和Q如说明书中所定义; 或其药学上可接受的盐。

13. 发明授权

US07354915B2 6-amino-1,4-dihydro-benzo[d][1,3]oxazin-2-ones and analogs useful as progesterone receptor modulators 失效
标题翻译： 6-氨基-1,4-二氢 - 苯并[d] [1,3]恶嗪-2-酮和可用作孕酮受体调节剂的类似物
公开(公告)号：US07354915B2
公开(公告)日：2008-04-08
申请号：US11804831
申请日：2007-05-21
申请人： Puwen Zhang , Jeffrey Kern
发明人： Puwen Zhang , Jeffrey Kern
IPC分类号： C07D279/08 , A61K31/5415
CPC分类号： A61K31/538 , A61K31/517 , C07D265/18
摘要： Compounds having the structure of formula I are provided. In formula I, R1 is H, OH, substituted or unsubstituted C1 to C3 alkyl, C1 to C3 perfluoroalkyl, or COR6; R6 is H, substituted or unsubstituted C1 to C4 alkyl, aryl, substituted or unsubstituted C1 to C4 alkoxy, substituted or unsubstituted C1 to C3 aminoalkyl; R2 and R3 are H, substituted or unsubstituted C1 to C6 alkyl, C1 to C6 perfluoroalkyl, substituted or unsubstituted C2 to C6 alkenyl, substituted or unsubstituted C2 to C6 alkynyl, substituted or unsubstituted C3 to C6 cycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heterocyclic; or R2 and R3 are fused to form spirocyclic rings; R4 is NHR7, OR7, NHSO2R7, or OSO2R7; Q is O, S, NR8, or CR9R10; or a pharmaceutically acceptable salt, ester, or prodrug thereof. Such compounds are useful as progesterone receptor modulators and for treating progesterone receptor related conditions
摘要翻译：提供了具有式I结构的化合物。在式I中，R 1是H，OH，取代或未取代的C 1至C 3烷基，C 1或N 2 C 3至C 3全氟烷基或COR 6; R 6是H，取代或未取代的C 1至C 4烷基，芳基，取代或未取代的C 1〜至C 4烷氧基，取代或未取代的C 1至C 3氨基烷基; R 2和R 3均为H，取代或未取代的C 1至C 6烷基，C 1至C 6烷基， C 6至C 6全氟烷基，取代或未取代的C 2至C 6链烯基，取代或未取代的C 2，取代或未取代的C 3至C 6环烷基，取代或未取代的芳基或取代或未取代的杂环基; 或R 2和R 3 3稠合形成螺环; R 4是NHR 7，OR 7，NHSO 2 R 7，或 OSO 2 R 7; Q是O，S，NR 8或CR 9 R 10; 或其药学上可接受的盐，酯或前药。这些化合物可用作孕酮受体调节剂和用于治疗孕酮受体相关病症

14. 发明申请

US20070208584A1 Method and system for managing fundraising campaigns 审中-公开
标题翻译：管理筹款活动的方法和制度
公开(公告)号：US20070208584A1
公开(公告)日：2007-09-06
申请号：US11368111
申请日：2006-03-06
申请人： Jeffrey Kern , Aviv Aviad
发明人： Jeffrey Kern , Aviv Aviad
IPC分类号： G06Q10/00 , G06Q30/00
CPC分类号： G06Q10/00 , G06Q30/00 , G06Q30/0279 , G06Q30/0601
摘要： A method of providing greeting cards, the method comprises: providing, over a communication network, a list of potential recipients of a greeting card to multiple potential senders; receiving, from multiple potential senders, selection indication representative of one or more selected recipients and greeting information associated with the selection; generating, for each selected recipient, a greeting card that comprises the greeting information associated with the selected recipient. A system, comprising: an interface, adapted to: (i) provide to a communication network, a list of potential recipients of a greeting card to be sent over the communication network to multiple potential senders; (ii) receive, from multiple potential senders, selection indication representative of one or more selected recipients and greeting information associated with the selection; and a processor, coupled to the interface, adapted to generate, for each selected recipient, a greeting card that comprises the greeting information associated with the selected recipient.
摘要翻译：一种提供贺卡的方法，所述方法包括：在通信网络上向多个潜在发送者提供贺卡的潜在接收者的列表; 从多个潜在发送者接收表示一个或多个所选择的接收者的选择指示和与所述选择相关联的问候信息; 为每个所选收件人生成包含与所选择的接收者相关联的问候信息的贺卡。一种系统，包括：接口，适于：（i）向通信网络提供要通过所述通信网络发送到多个潜在发送者的贺卡的潜在接收者的列表; （ii）从多个潜在发送者接收代表一个或多个所选择的接收者的选择指示和与所述选择相关联的问候信息; 以及耦合到所述接口的处理器，适于为每个所选接收者生成包含与所选接收者相关联的问候信息的贺卡。

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