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11. 发明授权

US06379320B1 Ultrasound applicator for heating an ultrasound absorbent medium 有权
标题翻译：用于加热超声波吸收介质的超声波施加器
公开(公告)号：US06379320B1
公开(公告)日：2002-04-30
申请号：US09424878
申请日：2000-03-02
申请人： Cyril Lafon , Jean-Yves Chapelon , Dominique Cathignol , Frederic Prat
发明人： Cyril Lafon , Jean-Yves Chapelon , Dominique Cathignol , Frederic Prat
IPC分类号： A61H100
CPC分类号： A61B8/546 , A61N7/02 , A61N2007/025
摘要： An ultrasound applicator for heating, via an internal path, an ultrasound absorbent medium, includes an application head having a longitudinal axis and including at least one ultrasonic transducer having a planar emission face and an opposite face, a leakproof membrane which overlays and is spaced from the emission face, and which is transparent to ultrasound, and means for preventing propagation of ultrasound from the opposite face; means for remotely connecting the transducer to an electricity generator; and means for providing ultrasound coupling with the membrane. The planar emission face emits ultrasound waves through the membrane and in a direction that is substantially perpendicular to the emission face, such that the waves emitted are substantially planar and do not diverge in the vicinity of the transducer and the application head.
摘要翻译：用于经由内部路径加热超声波吸收介质的超声波施加器包括具有纵向轴线并包括至少一个具有平面发射面和相对面的超声换能器的施加头，覆盖并与之隔开的防漏膜发射面，并且其对于超声波是透明的，以及用于防止超声从相对面传播的装置; 用于将传感器远程连接到发电机的装置; 以及用于提供与膜的超声耦合的装置。平面发射面通过膜发射超声波并且在基本上垂直于发射面的方向上发射超声波，使得所发射的波基本上是平面的，并且不会在换能器和应用头附近发散。

12. 发明授权

US5720287A Therapy and imaging probe and therapeutic treatment apparatus utilizing it 失效
标题翻译：治疗和成像探针和治疗仪器利用它
公开(公告)号：US5720287A
公开(公告)日：1998-02-24
申请号：US659581
申请日：1996-06-06
申请人： Jean-Yves Chapelon , Emmanuel Blanc , Francois Lacoste
发明人： Jean-Yves Chapelon , Emmanuel Blanc , Francois Lacoste
IPC分类号： A61B1/00 , A61B8/12 , A61B17/00 , A61B18/00 , A61N7/02 , G10K11/35
CPC分类号： A61B8/4461 , A61B18/00 , A61B8/12 , A61B8/4209 , A61B8/445 , A61N7/022 , G10K11/35 , G10K11/355 , A61B2017/00106
摘要： The therapy and imaging probe of the invention comprises a probe body (20') of an elongate shape defining a general axis (X--X), one imaging transducer (40') for transmitting imaging waves, and one therapy transducer (30') for transmitting therapy waves. The imaging transducer is mounted on first support means providing translational movement of the imaging transducer within the probe, parallel to the general axis (X--X) of the probe, between a withdrawn position and an extended position. The therapy transducer is mounted on second support means providing rotation of the therapy transducer within the probe, about an axis of rotation (X1--X1) parallel to the general axis (X--X) of the probe but offset with respect to the imaging transducer, to allow rotation of the therapy transducer between a withdrawn position and a treatment position. In the withdrawn or non-active position of the therapy transducer, the imaging transducer may be brought by translational movement to its extended position to occupy the place occupied by the therapy transducer in its treatment position. Thus, the imaging transducer may form an image of a region for treatment by the therapy transducer. In the treatment position of the therapy transducer, the imaging transducer is at its withdrawn position. The therapy transducer, during the transmission of therapy waves, directly transmits the therapy waves in a direction substantially identical to the direction in which the imaging transducer transmits the imaging waves when imaging waves are being transmitted.
摘要翻译：本发明的治疗和成像探针包括限定总轴线（XX）的细长形状的探针体（20'），用于传输成像波的一个成像传感器（40'）和用于传输成像波的一个治疗传感器（30'）治疗波。成像传感器安装在第一支撑装置上，其提供平行于探针的总轴（X-X）的探针内的成像传感器在撤回位置和延伸位置之间的平移运动。所述治疗传感器安装在第二支撑装置上，所述第二支撑装置提供所述探针内的所述治疗换能器的旋转，所述第二支撑装置绕所述探针的平行于所述探针的所述总轴线（XX）的旋转轴线（X1-X1）相对于所述成像换能器偏移，允许治疗换能器在撤回位置和治疗位置之间旋转。在治疗换能器的撤回或非活动位置，成像换能器可以通过平移运动而被带到其延伸位置，以占据治疗换能器处于其治疗位置所占据的位置。因此，成像换能器可以形成用于由治疗换能器进行治疗的区域的图像。在治疗传感器的治疗位置，成像换能器处于其撤回位置。治疗传感器在治疗波的传送期间，在成像波被传送时，以与成像传感器发射成像波的方向基本相同的方向直接传递治疗波。

13. 发明授权

US4320765A Doppler pseudorandom noise velocimeters 失效
标题翻译：多普勒伪随机噪声速度计
公开(公告)号：US4320765A
公开(公告)日：1982-03-23
申请号：US112528
申请日：1980-01-16
申请人： Dominique Cathignol , Claude Fourcade , Jean-Yves Chapelon
发明人： Dominique Cathignol , Claude Fourcade , Jean-Yves Chapelon
IPC分类号： A61B8/06 , G01F1/66 , G01P5/24 , G01S15/34 , G01S15/58 , A61B10/00
CPC分类号： G01P5/244 , A61B8/06 , G01F1/663 , G01S15/34 , G01S15/586
摘要： This invention is directed to improved pseudorandom noise velocimeters and methods therefor, using the Doppler effect, to enable the external measurement of the speed of a moving target within a fixed conveying medium. In accordance with a preferred embodiment of the present invention a continuous pseudorandom ultrasonic noise signal formed by a repetitive code C having n different elementary segments S is radiated. Correlation between a received echo and the delayed radiated signal is accomplished by proceeding successively for each elementary segment, using a different measuring band, for a period corresponding to the period of each segment. The correlation values thus obtained are then stored and thereafter a Doppler low frequency curve is reconstituted by regrouping the correlation values corresponding to the different elementary segments of the repetitive code.
摘要翻译：本发明涉及使用多普勒效应的改进的伪随机噪声速度计及其方法，以便能够外部测量固定传送介质内的移动目标的速度。根据本发明的优选实施例，辐射由具有n个不同基本段S的重复码C形成的连续伪随机超声波噪声信号。接收到的回波和延迟的辐射信号之间的相关性是通过使用不同的测量带在每个段的周期相应的时段内针对每个基本段连续进行的。然后存储如此获得的相关值，然后通过重新分组对应于重复码的不同基本段的相关值来重构多普勒低频曲线。

14. 发明授权

US09403039B2 High intensity focused ultrasound device and method for ocular pathology treatment 有权
标题翻译：高强度聚焦超声装置及眼病理治疗方法
公开(公告)号：US09403039B2
公开(公告)日：2016-08-02
申请号：US12867977
申请日：2009-02-18
申请人： Fabrizio Romano , Cyril Lafon , Jean-Yves Chapelon , Francoise Chavrier , Alain Birer
发明人： Fabrizio Romano , Cyril Lafon , Jean-Yves Chapelon , Francoise Chavrier , Alain Birer
IPC分类号： A61N7/00 , A61N7/02 , A61F9/007
CPC分类号： A61F9/00745 , A61F9/00781 , A61N7/00 , A61N7/02 , A61N2007/0056 , A61N2007/006 , A61N2007/0065 , A61N2007/0078 , A61N2007/027
摘要： A method of treating an ocular pathology by generating high intensity focused ultrasound onto at least one eye's area, the method comprises at least the following steps of: positioning onto the eye a device capable of directing high intensity focused ultrasound onto at least one annular segment, and generating high intensity focused ultrasound energy onto the segment to treat at least one annular segment in the eye. Another embodiment of the invention concerns a device for treatment of an ocular pathology comprising at least one eye ring wherein the proximal end of the eye ring is suitable to be applied onto the globe and a high intensity focused ultrasound beam generator to generate ultrasound beam fixed on the distal end of the eye ring capable of treating the whole circumference of the eye in one step.
摘要翻译：一种通过在至少一个眼睛区域上产生高强度聚焦超声来治疗眼部病理的方法，所述方法至少包括以下步骤：将能够将高强度聚焦超声引导到至少一个环形部分上的装置，以及将高强度聚焦超声能量产生到所述片段上以处理眼睛中的至少一个环形片段。本发明的另一个实施例涉及一种用于治疗眼病理的装置，其包括至少一个眼环，其中眼环的近端适合于施加到球体上，以及高强度聚焦超声波束发生器，以产生固定在眼环的远端能够一步处理眼睛的整个周长。

15. 发明授权

US08652073B2 Parameters for an ultrasound device comprising means to generate high intensity ultrasound beam 有权
标题翻译：用于超声装置的参数包括产生高强度超声波束的装置
公开(公告)号：US08652073B2
公开(公告)日：2014-02-18
申请号：US13389044
申请日：2009-08-18
申请人： Fabrizio Romano , Cyril Lafon , Jean-Yves Chapelon , Françoise Chavrier , Alain Birer , Laurent Farcy , Philippe Chapuis
发明人： Fabrizio Romano , Cyril Lafon , Jean-Yves Chapelon , Françoise Chavrier , Alain Birer , Laurent Farcy , Philippe Chapuis
IPC分类号： A61H1/00
CPC分类号： A61F9/007 , A61F9/00781 , A61N7/02
摘要： The present invention relates to a device for treatment of an ocular pathology, the device comprising at least one eye ring wherein the proximal end of said eye ring is suitable to be applied onto the globe and means to generate ultrasound beam fixed on the distal end of the eye ring, said means to generate ultrasound beam presenting a concave segment shape conformed along a single curvature corresponding to a single direction wherein the concavity is designed to be tuned towards the eyeglobe.
摘要翻译：本发明涉及一种用于治疗眼部病理的装置，该装置包括至少一个眼环，其中所述眼环的近端适于施加到球体上，并且产生固定在远端上的超声波束的装置所述眼环，所述产生超声波束的装置，其呈现出沿着单个曲率对应的凹形段形状，所述单个曲率对应于单个方向，其中所述凹部被设计成朝向眼球调整。

16. 发明授权

US07713203B2 Ultrasound treatment device and method 有权
标题翻译：超声治疗装置及方法
公开(公告)号：US07713203B2
公开(公告)日：2010-05-11
申请号：US11572465
申请日：2005-07-19
申请人： François Lacoste , Jean-Yves Chapelon , Olivier Pichot , René Milleret , Samuel Pichardo
发明人： François Lacoste , Jean-Yves Chapelon , Olivier Pichot , René Milleret , Samuel Pichardo
IPC分类号： A61B8/14 , A61B5/00 , G01N29/00
CPC分类号： A61N7/02 , A61B17/00008 , A61B2017/22097 , A61B2090/378 , A61N2007/0065 , A61N2007/0078 , A61N2007/027
摘要： The inventive ultrasound treating device comprises a first processing transducer set (11) for transmitting a beam of high-intensity ultrasound waves to a treatable area (3), wherein said beam comprises an aspheric wavefront and forms a focal spot (6) on the treatable area elongated and inclined with respect to the direction of the ultrasound wave propagation and the focal spot (6) length is less than the length of the transducer (11). The inventive device is particularly suitable for treating an elongated area such as vein portions enveloping a pathological valve.
摘要翻译：本发明的超声治疗装置包括用于将高强度超声波束发射到可治疗区域（3）的第一处理换能器组（11），其中所述束包括非球面波前，并在可治疗区域上形成焦斑（6）区域相对于超声波传播的方向伸长并倾斜，并且焦点（6）的长度小于换能器（11）的长度。本发明的装置特别适用于处理细长区域，例如包围病理瓣膜的静脉部分。

17. 发明申请

US20080194955A1 Ultrasound Treatment Device And Method 有权
标题翻译：超声治疗装置及方法
公开(公告)号：US20080194955A1
公开(公告)日：2008-08-14
申请号：US11572465
申请日：2005-07-19
申请人： Francois Lacoste , Jean-Yves Chapelon , Olivier Pichot , Rene Milleret , Samuel Pichardo
发明人： Francois Lacoste , Jean-Yves Chapelon , Olivier Pichot , Rene Milleret , Samuel Pichardo
IPC分类号： A61N7/00
CPC分类号： A61N7/02 , A61B17/00008 , A61B2017/22097 , A61B2090/378 , A61N2007/0065 , A61N2007/0078 , A61N2007/027
摘要： The inventive ultrasound treating device comprises a first processing transducer set (11) for transmitting a beam of high-intensity ultrasound waves to a treatable area (3), wherein said beam comprises an aspheric wavefront and forms a focal spot (6) on the treatable area elongated and inclined with respect to the direction of the ultrasound wave propagation and the focal spot (6) length is less than the length of the transducer (11). The inventive device is particularly suitable for treating an elongated area such as vein portions enveloping a pathological valve.
摘要翻译：本发明的超声治疗装置包括用于将高强度超声波束发射到可治疗区域（3）的第一处理换能器组（11），其中所述束包括非球面波前，并在可治疗区域上形成焦斑（6）区域相对于超声波传播的方向伸长并倾斜，并且焦点（6）的长度小于换能器（11）的长度。本发明的装置特别适用于处理细长区域，例如包围病理瓣膜的静脉部分。

18. 发明申请

US20080097202A1 Method for Performing Elastography 审中-公开
标题翻译：执行弹性成像的方法
公开(公告)号：US20080097202A1
公开(公告)日：2008-04-24
申请号：US11571650
申请日：2005-07-05
申请人： Jean-Yves Chapelon , Remi Souchon
发明人： Jean-Yves Chapelon , Remi Souchon
IPC分类号： A61B8/00
CPC分类号： A61B8/0833 , A61B8/485 , G01S7/52042 , G01S15/8959 , G01S15/8977
摘要： A method for performing elastography is provided, comprising the following steps. First, emitting a first coded signal towards tissue and recording an echoed signal in response. Next, applying a strain on the tissue, such as a compression or an expansion. Then, emitting a second coded signal towards the tissue under strain, said second signal being a compressed (or stretched) version of the first emitted signal in the time domain, and recording an echoed signal in response. Then processing the second echoed signal by stretching (or compressing) it in the time domain by a factor matched to the compression (or stretching) factor that was applied to the second emitted signal. Finally, cross-correlating the first echoed signal and the processed second echoed signal to provide an elastographic image of said tissue. The method of the invention uses different emitted signals before and during strain applied to the tissue. The image quality in elastography can therefore be considerably improved.
摘要翻译：提供了一种用于进行弹性成像的方法，包括以下步骤。首先，向组织发射第一编码信号并且响应于记录回波信号。接下来，在组织上施加应变，例如压缩或膨胀。然后，在应变下向组织发射第二编码信号，所述第二信号是在时域中的第一发射信号的压缩（或拉伸）版本，并响应于记录回波信号。然后通过在时域中拉伸（或压缩）与施加到第二发射信号的压缩（或拉伸）因子相匹配的因子来处理第二回波信号。最后，将第一回波信号和经处理的第二回波信号互相关，以提供所述组织的弹性图像。本发明的方法在应用于组织的应变之前和期间使用不同的发射信号。因此，弹性成像的图像质量可以大大提高。

19. 发明授权

US08977361B2 Apparatus for the treatment of brain affections and method implementing thereof 有权
标题翻译：用于治疗脑部感觉的装置及其实施方法
公开(公告)号：US08977361B2
公开(公告)日：2015-03-10
申请号：US13577938
申请日：2011-02-22
申请人： Alexandre Carpentier , Cyril Lafon , Jean-Yves Chapelon , Michael Sean Canney , Kévin Beccaria
发明人： Alexandre Carpentier , Cyril Lafon , Jean-Yves Chapelon , Michael Sean Canney , Kévin Beccaria
IPC分类号： A61N1/00 , A61N1/36 , A61N5/06 , A61N7/02 , A61B8/08 , A61N7/00
CPC分类号： A61N1/3606 , A61B8/0816 , A61B8/56 , A61N5/0601 , A61N7/02 , A61N2005/0651 , A61N2007/0021 , A61N2007/0052 , A61N2007/0078 , A61N2007/025
摘要： The present invention relates to an apparatus for the treatment of a brain affection, which comprises at least one implantable generator (4) made of non-ferromagnetic material comprising a casing (7), an ultrasound generating treating device (11) positioned into said casing to induce brain affection treatment by emission of ultrasound waves, and means for fastening the implantable casing into the skull. The apparatus further comprises a power controller (PwC) to supply electricity to the treating device of the implantable generator and to set and control its working parameters, and connecting means (6) to connect the power controller and the treating device of the implantable generator. A method for treating a brain affection with such an apparatus is also disclosed.
摘要翻译：本发明涉及一种用于治疗脑部感受的装置，其包括由非铁磁材料制成的至少一个植入式发生器（4），该植入式发生器由非壳型材料制成，其包括壳体（7），超声波产生处理装置（11）以通过发射超声波来诱导大脑感受治疗，以及用于将可植入的外壳固定到颅骨中的装置。该装置还包括电力控制器（PwC），用于向可植入发电机的处理装置供电并设置和控制其工作参数，以及连接装置（6）以连接可植入发电机的功率控制器和处理装置。还公开了用这种装置治疗脑感染的方法。

20. 发明申请

US20140257262A1 INTERSTITIAL ULTRASONIC DISPOSABLE APPLICATOR AND METHOD FOR TISSUE THERMAL CONFORMAL VOLUME ABLATION AND MONITORING THE SAME 审中-公开
标题翻译：互联超声波处理应用者和组织热合力体积检测与监测方法
公开(公告)号：US20140257262A1
公开(公告)日：2014-09-11
申请号：US13794347
申请日：2013-03-11
申请人： Alexandre CARPENTIER , An NGUYEN-DINH , Jean-Yves CHAPELON , Rémi DUFAIT , Christophe NOTARD , Françoise CHAVRIER , Cyril LAFON , Michael CANNEY , William Apoutou N'DJIN
发明人： Alexandre CARPENTIER , An NGUYEN-DINH , Jean-Yves CHAPELON , Rémi DUFAIT , Christophe NOTARD , Françoise CHAVRIER , Cyril LAFON , Michael CANNEY , William Apoutou N'DJIN
IPC分类号： A61N7/02
CPC分类号： A61N7/02 , A61N7/022 , A61N2007/0043 , A61N2007/0047 , A61N2007/0078 , A61N2007/025
摘要： An interstitial ultrasound thermal ablation applicator for conformal treatment of inhomogeneous tumor lesions includes: a body having a longitudinal axis, the body defining a hollow central channel along the longitudinal axis; and a plurality of CMUT array transducers mounted on the body, arranged side by side to form a cylindrical shape, having azimuth plans parallel to a longitudinal axis of the body, each of the plurality of CMUT array transducers having elevation dimensions predetermined to steer emitted ultrasonic waves to obtain a conformal volume treatment of the tumor lesions. An electronic driving method for driving an applicator having multiple independent transducer elements arranged in rows and columns includes: controlling focal parameters of each row and column of transducer elements; and controlling a contribution of each row and column of transducer elements in a manner to provide a conformal ablated volume.
摘要翻译：用于对不均匀肿瘤病变进行保形治疗的间质超声热消融施加器包括：具有纵向轴线的主体，所述主体沿着纵向轴线限定中空的中心通道; 以及安装在所述主体上的多个CMUT阵列换能器，并排布置以形成具有平行于所述主体的纵向轴线的方位平面图的圆柱形形状，所述多个CMUT阵列换能器中的每一者具有预定的尺寸，以调节发射的超声波波浪获得肿瘤病变的保形体积治疗。一种用于驱动具有排列成行和列的多个独立换能器元件的施加器的电子驱动方法包括：控制换能器元件的每行和列的焦点参数; 以及以提供适形消融体积的方式控制每行和每列换能器元件的贡献。

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