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11. 发明申请

US20060110436A1 Phospholipid derivative 有权
标题翻译：磷脂衍生物
公开(公告)号：US20060110436A1
公开(公告)日：2006-05-25
申请号：US10529692
申请日：2003-09-30
申请人： Syunsuke Ohhashi , Kazuhiro Kubo , Chika Itoh , Tohru Yasukohchi , Hiroshi Kikuchi , Norio Suzuki , Miho Kurosawa , Hitoshi Yamauchi
发明人： Syunsuke Ohhashi , Kazuhiro Kubo , Chika Itoh , Tohru Yasukohchi , Hiroshi Kikuchi , Norio Suzuki , Miho Kurosawa , Hitoshi Yamauchi
IPC分类号： A61K31/795 , C08F291/00 , A61K9/127
CPC分类号： C08F8/40 , A61K8/14 , A61K8/8164 , A61K9/127 , A61K9/1271 , A61K9/1278 , A61K31/795 , A61Q19/00 , C08F220/28 , C08F222/06 , C08L53/00 , C08F222/04 , C08L2666/02
摘要： A phospholipid derivative, utilizable for modification of liposomes and the like, which is a copolymer containing, as essential component units, a component unit A represented by the formula (1), a component unit B represented by the formula (2A) and/or the formula (2B), and a component unit C represented by the formula (3) [R1 and R2 represent hydrogen atom or methyl group, provided that R1 and R2 do not simultaneously represent methyl group; R3 represents a divalent hydrocarbon group having 1 to 3 carbon atoms; AO represents an oxyalkylene group having 2 to 4 carbon atoms; m represents an average molar number of the added oxyalkylene groups and is a number in the range represented as 4≦m≦100; R4 represents hydrogen atom, a hydrocarbon group or acyl group having 1 to 20 carbon atoms; R5CO and R6CO represent an acyl group having 8 to 24 carbon atoms; R7 represents a divalent hydrocarbon group having 2 to 4 carbon atoms; and X and Y represent hydrogen atom, an alkali metal atom, ammonium or an organic ammonium] wherein a molar ratio of the component unit A relative to a total of the component unit B and the component unit C is from 7/3 to 3/7, and the component unit C is contained at a ratio of from 1 to 4 moles per 1 mole of the copolymer.
摘要翻译：可用于脂质体改性的磷脂衍生物等，其是以式（1）表示的成分单元A，式（2A）表示的成分单元B和/或式式（2B）和式（3）表示的成分单元C [R 1和R 2]表示氢原子或甲基，条件是R 0 > 1 和R 2不同时表示甲基; R 3表示具有1至3个碳原子的二价烃基; AO表示碳原子数2〜4的氧化烯基， m表示加成的氧化烯基的平均摩尔数，是在4≤M≤100的范围内的数字; R 4表示氢原子，碳原子数为1〜20的烃基或酰基， R 5 CO和R 6 CO表示具有8至24个碳原子的酰基; R 7表示具有2至4个碳原子的二价烃基; 并且X和Y表示氢原子，碱金属原子，铵或有机铵]，其中组分单元A相对于组分单元B和组分单元C的总量的摩尔比为7/3至3 / 7，组分单元C的含量相对于1摩尔共聚物为1〜4摩尔。

12. 发明授权

US5141751A Lipid membrane structures 失效
标题翻译：脂质膜结构
公开(公告)号：US5141751A
公开(公告)日：1992-08-25
申请号：US663775
申请日：1991-03-04
申请人： Munehiro Tomikawa , Sadao Hirota , Hitoshi Yamauchi , Hiroshi Kikuchi , Yasuyoshi Kawato
发明人： Munehiro Tomikawa , Sadao Hirota , Hitoshi Yamauchi , Hiroshi Kikuchi , Yasuyoshi Kawato
IPC分类号： A61K9/107 , A61K9/127
CPC分类号： A61K9/1075 , A61K9/1272 , Y10S436/829 , Y10T428/2984
摘要： Lipid membrane structures containing, in the lipid membrane thereof, a compound represented by formula (I): ##STR1## wherein R.sub.1 represents a hydrogen atom or a fatty acid residue; R.sub.2 represents a hydrogen atom or an acyclic hydrocarbon residue; R.sub.3 represents an amino group, a guanidino group or an amidino group; and n represents an integer of from 1 to 6; provided that R.sub.1 and R.sub.2 do not represent hydrogen atoms at the same time, or a salt thereof. The lipid membrane structures exhibit excellent specific affinity for tumor cells and can be delivered preferentially to tumor cells.
摘要翻译：脂质膜结构在其脂质膜中含有式（I）表示的化合物：其中R1表示氢原子或脂肪酸残基; R2表示氢原子或无环烃残基; R3表示氨基，胍基或脒基; n表示1〜6的整数，条件是R1和R2不同时表示氢原子或其盐。脂质膜结构对肿瘤细胞表现出优异的特异性亲和力，并可优先递送至肿瘤细胞。

13. 发明授权

US5096891A Cyclic amp derivative ointments 失效
标题翻译：循环AMP衍生品
公开(公告)号：US5096891A
公开(公告)日：1992-03-17
申请号：US330580
申请日：1989-03-30
申请人： Sadao Hirota , Hitoshi Yamauchi
发明人： Sadao Hirota , Hitoshi Yamauchi
IPC分类号： A61K9/00 , A61K47/02 , A61K47/10 , A61K47/36 , A61K47/40
CPC分类号： A61K31/70 , A61K47/02 , A61K47/10 , A61K47/36 , A61K47/40 , A61K9/0014 , Y10S514/925 , Y10S514/928 , Y10S514/969 , Y10S514/97
摘要： An ointment comprising an adenosine 3',5'-cyclic phosphate derivative as an active ingrediment, an ointment base having water-absorbing and drying properties, a saccharide and/or inorganic high polymer is disclosed. The ointment exhibits improved stability of the adenosine 3',5'-cyclic phosphate derivative.

14. 发明授权

US08677001B2 Streaming transmission method system, data processing apparatus and computer readable storage medium for making unwanted and malicious data unexecutable from voice or animation data streams 有权
标题翻译：流传输方法系统，数据处理装置和计算机可读存储介质，用于使不需要的恶意数据不能从语音或动画数据流中执行
公开(公告)号：US08677001B2
公开(公告)日：2014-03-18
申请号：US10740538
申请日：2003-12-22
申请人： Ai Yano , Masahide Noda , Yasuhide Matsumoto , Kenichi Horio , Masanobu Morinaga , Hitoshi Yamauchi , Hideaki Miyazaki , Noriyuki Fukuyama
发明人： Ai Yano , Masahide Noda , Yasuhide Matsumoto , Kenichi Horio , Masanobu Morinaga , Hitoshi Yamauchi , Hideaki Miyazaki , Noriyuki Fukuyama
IPC分类号： G06F15/16
CPC分类号： H04L65/605 , H04L29/06 , H04L29/06027 , H04L65/607
摘要： A data processing apparatus edits an actual data portion excluding a header from data transmitted by streaming transmission from a first information processing apparatus after start of streaming transmission. The data processing apparatus transmits edited actual data portion and header to a second information processing apparatus by streaming transmission. The second information processing apparatus reproduces the voice data or the animation data transmitted by streaming transmission. The actual data portion is edited so that the voice data or the animation data to be transmitted may be reproducible in the second information processing apparatus, and so that a program may become unexecutable even if it would be transmitted to the second information processing apparatus. Even if the voice data or the animation data transmitted from the first information processing apparatus by streaming transmission would be deteriorated, an executable virus program does not transmitted to the second information processing apparatus, thereby that makes it possible to realize the streaming transmission method which can realize simple and high security.
摘要翻译：数据处理装置在开始流传输之后，从第一信息处理装置，通过流传输发送的数据，不包括报头的实际数据部分。数据处理装置通过流传输将编辑的实际数据部分和报头发送到第二信息处理装置。第二信息处理装置再现通过流传输发送的语音数据或动画数据。对实际数据部分进行编辑，使得要发送的语音数据或动画数据可以在第二信息处理装置中可再现，并且即使将程序发送到第二信息处理装置，程序也可能变得不可执行。即使通过流式传输从第一信息处理装置发送的语音数据或动画数据将恶化，可执行的病毒程序也不会发送到第二信息处理装置，从而可以实现可以实现简单高安全性。

15. 发明授权

US08229087B2 Relay apparatus, relay method, relay program, and communication system 有权
标题翻译：中继装置，中继方式，中继程序和通信系统
公开(公告)号：US08229087B2
公开(公告)日：2012-07-24
申请号：US11525053
申请日：2006-09-22
申请人： Motoshi Sumioka , Ryuichi Matsukura , Hitoshi Yamauchi
发明人： Motoshi Sumioka , Ryuichi Matsukura , Hitoshi Yamauchi
IPC分类号： H04M11/00
CPC分类号： H04L29/06027 , H04L47/10 , H04L47/14 , H04L47/2416 , H04L47/2433 , H04L65/1083 , H04L65/4076 , H04L65/4084 , H04L65/80
摘要： A relay apparatus for relaying communication between a plurality of wireless terminals and a wired network includes a priority data recording part for recording communication identification data and required bandwidth data, a priority control part for relaying, by priority, the communication recorded in the priority data recording part, a request receiving part for receiving communication identification data and multimedia type data, a selecting part for selecting a multimedia type to be relayed by priority, an updating part for additionally recording data that represents a bandwidth required for relaying a stream of the selected multimedia type and the communication identification data, and a responding part for transmitting a response. The selecting part selects the multimedia type so that a sum of bandwidths represented by the required bandwidth data does not exceed a predetermined upper limit value. With the above configuration, the relay apparatus can perform bandwidth control of communication to be relayed, considering the multimedia type included in the communication by a wireless terminal.
摘要翻译：用于中继多个无线终端和有线网络之间的通信的中继装置包括用于记录通信识别数据和所需带宽数据的优先级数据记录部分，优先级优先控制记录在优先级数据记录中的通信的优先级控制部分部分，用于接收通信识别数据和多媒体类型数据的请求接收部分，用于选择要优先中继的多媒体类型的选择部分，用于附加地记录表示所选择的多媒体流的中继所需的带宽的数据的更新部分类型和通信识别数据，以及用于发送响应的响应部分。选择部分选择多媒体类型，使得由所需带宽数据表示的带宽之和不超过预定的上限值。利用上述配置，考虑到由无线终端进行的通信中包含的多媒体类型，中继装置可以进行要中继的通信的带宽控制。

16. 发明申请

US20110150974A1 Agent For Oral Mucosal Administration 审中-公开
标题翻译：口服粘膜管理代理
公开(公告)号：US20110150974A1
公开(公告)日：2011-06-23
申请号：US11573209
申请日：2005-08-04
申请人： Noriko Nakajima , Norihiro Shinkai , Hitoshi Yamauchi , Masahiko Kikuchi
发明人： Noriko Nakajima , Norihiro Shinkai , Hitoshi Yamauchi , Masahiko Kikuchi
IPC分类号： A61K31/4747 , A61K9/24 , A61L15/16
CPC分类号： A61K9/006 , A61K9/0056 , A61K9/06 , A61K9/08 , A61K9/12 , A61K9/7007 , A61K31/439 , C07D497/20
摘要： A medicament used for prophylactic and/or therapeutic treatment of xerostomia, which is in the form for oral mucosal administration comprising a spirooxathiolane quinuclidine derivative represented by the following general formula (I) or an acid addition salt thereof:[Formula 1] (wherein R1 and R2 may be the same or different, and independently represent a hydrogen atom, an alkyl group, a cyclopentyl group, a cyclohexyl group, a monoaryl- or diaryl-substituted methylol group, or an aryl-substituted alkyl group) as an active ingredient.
摘要翻译：一种用于预防和/或治疗口腔干燥症的药物，其为口腔粘膜施用形式，其包含由以下通式（I）表示的螺恶噻唑烷奎宁环衍生物或其酸加成盐：[式1]（其中R1 和R2可以相同或不同，并且独立地表示氢原子，烷基，环戊基，环己基，单芳基或二芳基取代的羟甲基或芳基取代的烷基）作为活性成分。

17. 发明授权

US07702804B2 Communication relay method, communication relay device, communication relay program and computer-readable recording medium storing communication relay program 有权
标题翻译：通信中继方法，通信中继装置，通信中继程序和存储通信中继程序的计算机可读记录介质
公开(公告)号：US07702804B2
公开(公告)日：2010-04-20
申请号：US10737803
申请日：2003-12-18
申请人： Masanobu Morinaga , Hideaki Miyazaki , Hitoshi Yamauchi , Noriyuki Fukuyama
发明人： Masanobu Morinaga , Hideaki Miyazaki , Hitoshi Yamauchi , Noriyuki Fukuyama
IPC分类号： G06F15/16 , G06F15/173 , G06F17/00
CPC分类号： H04L67/20 , G06Q30/02
摘要： A communication relay device adds information to communication data without depending on a communication application of a communication terminal. The relay device (1) includes a relay control portion (13), a control information database (14), an adder portion (15) and a database for addition (16). The relay control portion (13) controls the adder portion (15) in accordance with information accumulated in the control information DB 14. The adder portion (15) adds the additional data accumulated in the database for addition (16) to decoded first contents in accordance with a control instruction by the relay control portion (13).
摘要翻译：通信中继装置将信息添加到通信数据，而不依赖于通信终端的通信应用。中继装置（1）包括中继控制部分（13），控制信息数据库（14），加法器部分（15）和加法数据库（16）。继电器控制部分（13）根据控制信息DB14中累积的信息控制加法器部分（15）。加法器部分（15）将累加在数据库中的附加数据（16）添加到解码的第一内容根据继电器控制部分（13）的控制指令。

18. 发明授权

US07399877B2 Phospholipid derivative 有权
标题翻译：磷脂衍生物
公开(公告)号：US07399877B2
公开(公告)日：2008-07-15
申请号：US10549630
申请日：2004-03-19
申请人： Chika Itoh , Syunsuke Ohhashi , Kazuhiro Kubo , Tohru Yasukohchi , Hiroshi Kikuchi , Norio Suzuki , Miho Takahashi , Hitoshi Yamauchi
发明人： Chika Itoh , Syunsuke Ohhashi , Kazuhiro Kubo , Tohru Yasukohchi , Hiroshi Kikuchi , Norio Suzuki , Miho Takahashi , Hitoshi Yamauchi
IPC分类号： C07F9/02
CPC分类号： A61K9/127 , C07F9/10 , C11D1/345
摘要： A phospholipid derivative represented by the following formula (I) wherein R1CO and R2CO independently represent an acyl group; R3 represents hydrogen atom, or a hydrocarbon group; symbol “a” represents an integer of 0 to 4; symbol “b” represents 0 or 1, provided that when a is 0, b is 0; X represents hydrogen atom, an alkali metal atom, an ammonium, or an organic ammonium; A1O and A3O represent an oxyalkylene group containing oxyethylene group, wherein the ratio of the oxyethylene group to the oxyalkylene group in A1O and A3O is 0.5 or larger in terms of a weight ratio; A2O represents an oxyalkylene group; symbols “m” and “q” represent an average molar number of added oxyalkylene groups; and symbol “n” represent an average molar number of added oxyalkylene groups; provided that m, n and q satisfy the following conditions: 5≦m≦600, 1≦n≦45, 0≦q≦200, 10≦m+n+q≦600, 0.04≦n/(m+n+q), and q/(m+n+q)≦0.8, which can thicken the water shell of liposome surface by suppressing the spreading of the polyalkylene oxide structure on the surface and thus increase stability of the liposome
摘要翻译：由下式（I）表示的磷脂衍生物，其中R 1 CO和R 2 CO独立地表示酰基; R 3表示氢原子或烃基; 符号“a”表示0〜4的整数，符号“b”表示0或1，条件是当a为0时，b为0; X表示氢原子，碱金属原子，铵或有机铵; A 1 O和A 3 O表示含氧化乙烯基的氧化烯基，其中A 1 O 3中的氧乙烯基与氧化烯基的比例 O和A 3 O以重量比计为0.5以上; O 2表示氧化烯基; 符号“m”和“q”表示加成的氧化烯基团的平均摩尔数; 符号“n”表示加成的氧化烯基的平均摩尔数; 条件是m，n和q满足以下条件：5 <= m <= 600,1 <= n <= 45,0 <= q <= 200,10 <= m + n + q <= 600,0.04 < = n /（m + n + q）和q /（m + n + q）<= 0.8，这可以通过抑制聚环氧烷结构在表面上的扩散而增加脂质体表面的水壳，从而增加稳定性的脂质体

19. 发明授权

US5626751A Filter unit and high-pressure sizing apparatus 失效
标题翻译：过滤单元和高压定型设备
公开(公告)号：US5626751A
公开(公告)日：1997-05-06
申请号：US91714
申请日：1993-07-15
申请人： Hiroshi Kikuchi , Hitoshi Yamauchi , Kiyoto Yachi , Hiroshi Honda , Norio Suzuki , Akinori Hoshio , Takazo Hirose
发明人： Hiroshi Kikuchi , Hitoshi Yamauchi , Kiyoto Yachi , Hiroshi Honda , Norio Suzuki , Akinori Hoshio , Takazo Hirose
IPC分类号： A61K9/127 , B01D29/05 , B01D61/14 , B01D63/08 , B01D63/00 , B01D35/30
CPC分类号： B01D61/147 , A61K9/127 , B01D29/05 , B01D63/08 , B01D63/081 , Y10T156/1057
摘要： A filter unit comprises a metallic supporting plate possessed of stepped through holes opening with a larger diameter in one main surface and with a smaller diameter in the other main surface (wherein the diameter ratio of larger-diameter openings to smaller-diameter openings is desired to be in the range of 1:0.01 to 1:0.5) or a pressureproof supporting plate having in one surface thereof inclined liquid flow grooves arranged in a radial pattern and concentric circular liquid flow grooves adapted to intersect the radially arranged liquid flow grooves and a membrane filter disposed on the surface of the supporting plate containing larger-diameter openings or liquid flow grooves. This filter unit is ideally used for finely dividing and uniformly sizing suspended lipid particles assuming a definite average particle size and a specific particle size distribution. The high-pressure sizing apparatus and the method for production of suspended lipid particles utilize the filter unit constructed as described above and rely essentially for their operation on effecting fine division of lipid particles in the suspension by supplying the suspension of lipid particles from the membrane filter side under pressure and causing the suspension to pass through the membrane filter. Thus, they constitute themselves effective measures for pharmacological products and cosmetic products which are in need of lipid particles assuming a definite average particle size and a specific particle size distribution.
摘要翻译：过滤器单元包括金属支撑板，其具有在一个主表面中具有较大直径的阶梯状通孔，并且在另一个主表面中具有较小直径（其中大直径开口与较小直径开口的直径比期望为在1：0.01〜1：0.5的范围内）或者在一个表面上具有倾斜的液体流槽的径向图案的压力支撑板和适于与径向布置的液体流槽相交的同心圆形液体流动槽过滤器设置在包含较大直径开口或液体流动槽的支撑板的表面上。这种过滤器单元理想地用于假定具有确定的平均粒度和特定的粒度分布的悬浮脂质颗粒的细分和均匀的尺寸。高压施胶装置和悬浮脂质颗粒的生产方法利用如上所述构造的过滤器单元，并且主要依靠它们的操作来通过从膜过滤器中提供脂质颗粒的悬浮液来实现悬浮液中脂质颗粒的精细分配并使悬浮液通过膜过滤器。因此，它们构成了需要脂质颗粒的药理产品和化妆品的有效措施，其具有确定的平均粒度和特定的粒度分布。

20. 发明授权

US4960595A Lipid membrane structures 失效
标题翻译：脂质膜结构
公开(公告)号：US4960595A
公开(公告)日：1990-10-02
申请号：US222309
申请日：1987-11-16
申请人： Sadao Hirota , Hiroshi Kikuchi , Hitoshi Yamauchi , Munehiro Tomikawa
发明人： Sadao Hirota , Hiroshi Kikuchi , Hitoshi Yamauchi , Munehiro Tomikawa
IPC分类号： A61K31/70 , A61K9/00 , A61K9/127 , A61P1/16
CPC分类号： A61K9/1272 , Y10T428/249997
摘要： Lipid membrane structures containing a lactose monofatty acid ester or amide are disclosed. The lipid membrane structures are delivered preferentially to the liver parenchymal cells and are useful as carriers of drugs.
摘要翻译：公开了含有乳糖单脂肪酸酯或酰胺的脂质膜结构。脂质膜结构优先递送到肝实质细胞，并且可用作药物的载体。

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