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11. 发明申请

WO2003047582A1 QUINOLINE DERIVATIVES AS ANTITUMOUR AGENTS 审中-公开
标题翻译：喹啉衍生物作为抗菌剂
公开(公告)号：WO2003047582A1
公开(公告)日：2003-06-12
申请号：PCT/GB2002/005496
申请日：2002-12-05
申请人： ASTRAZENECA AB , ASTRAZENECA UK LIMITED , HENNEQUIN, Laurent, François, André , GIBSON, Keith, Hopkinson , FOOTE, Kevin, Michael
发明人： HENNEQUIN, Laurent, François, André , GIBSON, Keith, Hopkinson , FOOTE, Kevin, Michael
IPC分类号： A61K31/4709
CPC分类号： A61K31/4709
摘要： The invention concerns quinoline derivatives of Formula (I), wherein each of Z, m, R 1 , n and R 3 have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an anti-invasive agent in the containment and/or treatment of solid tumour disease.
摘要翻译：本发明涉及式（I）的喹啉衍生物，其中Z，m，R 1，n和R 3各自具有本说明书中定义的任何含义; 其制备方法，含有它们的药物组合物及其在制备用作在实体瘤疾病的遏制和/或治疗中作为抗侵入剂的药物的用途。

12. 发明申请

WO2001094341A1 QUINAZOLINE DERIVATIVES FOR THE TREATMENT OF TUMOURS 审中-公开
标题翻译：用于治疗肿瘤的喹诺酮衍生物
公开(公告)号：WO2001094341A1
公开(公告)日：2001-12-13
申请号：PCT/GB2001/002424
申请日：2001-06-01
申请人： ASTRAZENECA AB , ASTRAZENECA UK LIMITED , HENNEQUIN, Laurent, François, André , PLE, Patrick
发明人： HENNEQUIN, Laurent, François, André , PLE, Patrick
IPC分类号： C07D413/12
CPC分类号： C07D401/14 , C07D231/12 , C07D233/56 , C07D239/94 , C07D249/08 , C07D401/12 , C07D405/12 , C07D405/14
摘要： The invention concerns quinazoline derivatives of Formula (I) wherein each of Q 1 , Z, m, R 1 , R 2 , R 3 and Q 2 have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an anti-invasive agent in the containment and/or treatment of solid tumour disease.
摘要翻译：本发明涉及式（I）的喹唑啉衍生物，其中Q 1，Z，m，R 1，R 2，R 3和Q 2中的每一个具有在说明书中定义的任何含义 ; 其制备方法，含有它们的药物组合物及其在制备用作在实体瘤疾病的遏制和/或治疗中作为抗侵入剂的药物的用途。

13. 发明申请

WO1997032856A1 4-ANILINOQUINAZOLINE DERIVATIVES 审中-公开
标题翻译： 4-苯胺氮杂环丁烷衍生物
公开(公告)号：WO1997032856A1
公开(公告)日：1997-09-12
申请号：PCT/GB1997000550
申请日：1997-02-28
申请人： ZENECA LIMITED , ZENECA PHARMA S.A. , THOMAS, Andrew, Peter , HENNEQUIN, Laurent, François, André , JOHNSTONE, Craig
发明人： ZENECA LIMITED , ZENECA PHARMA S.A.
IPC分类号： C07D239/94
CPC分类号： C07D239/94
摘要： The invention relates to quinazoline derivatives of formula (I) (wherein: R represents hydrogen or methoxy; R represents methoxy, ethoxy, 2-methoxyethoxy, 3-methoxypropoxy, 2-ethoxyethoxy, trifluoromethoxy, 2,2,2-trifluoroethoxy, 2-hydroxyethoxy, 3-hydroxypropoxy, 2-(N,N-dimethylamino)ethoxy, 3-(N,N-dimethylamino)propoxy, 2-morpholinoethoxy, 3-morpholinopropoxy, 4-morpholinobutoxy, 2-piperidinoethoxy, 3-piperidinopropoxy, 4-piperidinobutoxy, 2-(piperazin-1-yl)ethoxy, 3-(piperazin-1-yl)propoxy, 4-(piperazin-1-yl)butoxy, 2-(4-methylpiperazin-1-yl)ethoxy, 3-(4-methylpiperazin-1-yl)propoxy or 4-(4-methylpiperazin-1-yl)butoxy; the phenyl group bearing (R )2 is selected from: 2-fluoro-5-hydroxyphenyl, 4-bromo-2-fluorophenyl, 2,4-difluorophenyl, 4-chloro-2-fluorophenyl, 2-fluoro-4-methylphenyl, 2-fluoro-4-methoxyphenyl, 4-bromo-3-hydroxyphenyl, 4-fluoro-3-hydroxyphenyl, 4-chloro-3-hydroxyphenyl, 3-hydroxy-4-methylphenyl, 3-hydroxy-4-methoxyphenyl and 4-cyano-2-fluorophenyl); and salts thereof, processes for their preparation and pharmaceutical compositions containing a compound of formula (I) or a pharmaceutically acceptable salt thereof as active ingredient. The compounds of formula (I) and the pharmaceutically acceptable salts thereof inhibit the effects of VEGF, a property of value in the treatment of a number of disease states including cancer and rheumatoid arthritis.
摘要翻译：本发明涉及式（I）的喹唑啉衍生物（其中：R 1表示氢或甲氧基; R 2表示甲氧基，乙氧基，2-甲氧基乙氧基，3-甲氧基丙氧基，2-乙氧基乙氧基，三氟甲氧基， 2-（N，N-二甲基氨基）乙氧基，3-（N，N-二甲氨基）丙氧基，2-吗啉代乙氧基，3-吗啉代丙氧基，4-吗啉代丁氧基，2-哌啶子基乙氧基， 3-哌啶基丁氧基，2-（哌嗪-1-基）乙氧基，3-（哌嗪-1-基）丙氧基，4-（哌嗪-1-基）丁氧基，2-（4-甲基哌嗪-1-基）乙氧基，3-（4-甲基哌嗪-1-基）丙氧基或4-（4-甲基哌嗪-1-基）丁氧基;带有（R 3）2的苯基选自：2-氟-5 4-羟基苯基，4-溴-2-氟苯基，2,4-二氟苯基，4-氯-2-氟苯基，2-氟-4-甲基苯基，2-氟-4-甲氧基苯基，4-溴-3-羟基苯基，4 4-氟-3-羟基苯基，3-羟基-4-甲基苯基，3-羟基-4-甲氧基苯基和4-氰基-2-氟苯基）。及其盐，其制备方法和含有式（I）化合物或其药学上可接受的盐作为活性成分的药物组合物。式（I）化合物及其药学上可接受的盐抑制VEGF的作用，其在治疗许多疾病状态（包括癌症和类风湿性关节炎）中是有价值的。

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