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    • 17. 发明申请
    • Functionalization of polyglycolides by
    • 通过“点击”化学功能化聚乙交酯
    • US20090054619A1
    • 2009-02-26
    • US12229544
    • 2008-08-25
    • Gregory L. BakerMilton R. Smith, IIIXuwei JiangErin B. Vogel
    • Gregory L. BakerMilton R. Smith, IIIXuwei JiangErin B. Vogel
    • C08G63/08
    • C08G63/08C08G63/823
    • Poly(glycolide) polymers are disclosed. The polymers generally include a polymerized alkynyl-substituted glycolide having a polymer backbone with one or more alkynyl groups appended thereto. The alkynyl groups provide reactive sites for further functionalization of the polymer, for example by reaction with azide derivatives (e.g., azide-substituted organic compounds). Alkynyl and azide groups react via the “click” chemistry mechanism to form functional groups covalently bonded to the polymer via a triazole link. The polymers are biodegradable and can be used to deliver drugs or other therapeutic substances (e.g., large biomolecules such as single strand RNA) at targeted locations in a patient's body and/or at controlled release rates.
    • 公开了聚(乙交酯)聚合物。 聚合物通常包括聚合的炔基取代的乙交酯,其具有带有一个或多个炔基的聚合物主链。 炔基提供用于聚合物进一步官能化的反应位点,例如通过与叠氮化物衍生物(例如叠氮取代的有机化合物)反应。 炔基和叠氮基通过“点击”化学机理反应以形成通过三唑连接共价键合到聚合物上的官能团。 聚合物是可生物降解的,并且可以用于在患者身体的目标位置和/或以控制释放速率递送药物或其它治疗物质(例如大的生物分子,例如单链RNA)。