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12. 发明授权

US4308280A Treatment of shock 失效
标题翻译：治疗休克
公开(公告)号：US4308280A
公开(公告)日：1981-12-29
申请号：US162008
申请日：1980-06-23
申请人： Giancarlo Sportoletti , Alessandro Baglioni
发明人： Giancarlo Sportoletti , Alessandro Baglioni
IPC分类号： A61K31/22 , A61P3/00 , A61P7/02 , A61P7/10 , A61P9/00 , A61P11/00 , A61P37/08
CPC分类号： A61K31/22 , Y10S514/87
摘要： Pharmaceutical compositions for use in the relief of acute pulmonary edema, different types of shock including anaphylactic shock, shock induced by bacterial endotoxins, and hyperfibrinolysis induced by substances which activate plasminogen, consist of solutions of an ester of L-arginine with an aliphatic alcohol in water at a pH between 5.5 and 8.5. The compositions may be provided in unit dosage form containing 0.25-100 mg of active substance and are administered through the parenteral route. The esters may be provided in the form of a salt with a pharmaceutically acceptable organic or inorganic acid. The esters may be with methyl or ethyl alcohol. The compositions are more effective than aspirin and aprotinin.
摘要翻译：用于缓解急性肺水肿的药物组合物，不同类型的休克，包括过敏性休克，由细菌内毒素引起的休克，以及激活纤溶酶原的物质引起的超纤维蛋白溶解，由L-精氨酸与脂肪醇的酯溶液组成 pH在5.5和8.5之间的水。组合物可以以含有0.25-100mg活性物质的单位剂型提供，并通过肠胃外途径施用。酯可以以药学上可接受的有机酸或无机酸的形式提供。酯可以与甲基或乙醇一起使用。组合物比阿司匹林和抑肽酶更有效。

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