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11. 发明申请

US20040029097A1 Addition of glycolysis inhibitor to a pathogen reduction and storage solution 审中-公开
标题翻译：将糖酵解抑制剂添加到病原体还原和储存溶液中
公开(公告)号：US20040029097A1
公开(公告)日：2004-02-12
申请号：US10417925
申请日：2003-04-16
申请人： Gambro, Inc.
发明人： Laura Goodrich , Raymond P. Goodrich
IPC分类号： A01N001/02 , A61K031/70
CPC分类号： A61L2/08 , A61L2/0011 , A61L2/0082 , A61L2/10 , A61L2/16 , A61M1/0272 , A61M1/3681 , A61M1/3683 , A61M2202/0275
摘要： This invention relates to the addition of glycolytic inhibitors to solutions used in the pathogen reduction and subsequent storage of platelets. More particularly, the invention relates to the addition of 2-deoxy-D-glucose and sodium succinate to a platelet pathogen reduction and storage solution.
摘要翻译：本发明涉及将糖酵解抑制剂加入用于减少血小板的病原体和随后储存的溶液中。更具体地，本发明涉及向血小板病原体还原和储存溶液中加入2-脱氧-D-葡萄糖和琥珀酸钠。

12. 发明申请

US20030201160A1 Removal of adenine during a process of pathogen reducing blood and blood components 有权
标题翻译：在病原体减少血液和血液成分的过程中去除腺嘌呤
公开(公告)号：US20030201160A1
公开(公告)日：2003-10-30
申请号：US10423200
申请日：2003-04-24
申请人： Gambro, Inc.
发明人： Raymond P. Goodrich , Suzann K. Doane
IPC分类号： C07C001/00 , C07C006/00
CPC分类号： A61L2/084 , A01N1/0205 , A01N1/0215 , A01N1/0294 , A01N43/90 , A61K35/18 , A61K41/0019 , A61L2/0005 , A61L2/0011 , A61L2/0082 , A61L2/0088 , A61L2/08 , A61L2/10 , A61L2/16 , A61L2202/22
摘要： The methods of this invention involve preventing the formation of a complex between adenine and riboflavin by reducing the amount of adenine in a solution containing blood or blood components to be pathogen reduced.
摘要翻译：本发明的方法涉及通过减少含有血液或血液成分的溶液中的腺嘌呤的量减少而防止腺嘌呤和核黄素之间的复合物的形成。

13. 发明申请

US20020061808A1 Centrifuge and container system for treatment of blood and blood components 有权
标题翻译：离心机和集装箱系统用于治疗血液和血液成分
公开(公告)号：US20020061808A1
公开(公告)日：2002-05-23
申请号：US10054484
申请日：2002-01-22
申请人： Gambro, Inc.
发明人： Peter Unger , Eric Westberg
IPC分类号： B04B007/08
CPC分类号： B04B5/0428
摘要： A centrifuge with an associated container system in the form of cassettes for separation and/or treatment of blood or blood components. The centrifuge comprises a rotor (1) having a central compartment in the form of a tubular shaft cavity (6) extending concentrically with the axis of rotation of the rotor and an annular separation compartment (5) which is arranged around said cavity at a the upper part thereof. A first container system to be arranged in said rotor and intended for e.g. washing of blood cells, comprises a round bag (13) and two or more flexible secondary containers (14, 15) connected thereto, of which at least one contains a treatment liquid, and a tubular sleeve (17) adapted to the shaft cavity of the rotor. The secondary containers are arranged standing in the sleeve resting against each other, and the round bag is mounted on a projecting flange (22) at the upper part of the sleeve. A second container system to be arranged in said rotor and intended for e.g. separation of a thrombocyte suspension differs from the above by the fact that the sleeve (39) has a smaller diameter than the shaft cavity of the rotor and is adapted to be centered in the center of the cavity. An initially empty secondary container (41) for receiving the separated components from the round bag is arranged in the centered sleeve.
摘要翻译：具有用于分离和/或治疗血液或血液成分的盒形式的相关联的容器系统的离心机。离心机包括转子（1），其具有与转子的旋转轴线同心地延伸的管状轴腔（6）形式的中心隔室和环形分隔室（5），环形隔室其上部。布置在所述转子中的第一容器系统，血液细胞的洗涤包括圆形袋（13）和连接到其上的两个或更多个柔性二次容器（14,15），其中至少一个包含处理液体，以及管状套筒（17），其适于轴腔转子。副容器被布置成立在彼此靠在的套筒中，并且圆形袋安装在套筒上部的突出的凸缘（22）上。布置在所述转子中的第二容器系统，血栓细胞悬浮液的分离与上述不同之处在于，套筒（39）具有比转子的轴腔更小的直径并且适于在腔的中心居中。用于从圆形袋中接收分离的部件的初始空的副容器（41）布置在中心套筒中。

14. 发明申请

US20040249332A1 Extra-corporeal Dual Stage Blood Processing Method and Apparatus 有权
标题翻译：超身体双阶段血液处理方法和装置
公开(公告)号：US20040249332A1
公开(公告)日：2004-12-09
申请号：US10709194
申请日：2004-04-20
申请人： GAMBRO, INC.
发明人： Marlene Bainbridge , Muriel Keller , Timothy M. Gordon , Michael J. McAteer , Scott D. Butzke
IPC分类号： A61M037/00 , B01D033/15
CPC分类号： A61M1/3693 , A61M1/30 , A61M1/303 , A61M1/308 , A61M1/3692 , A61M1/3696 , G06F19/00
摘要： Methods and apparatus particularly involving the separation of blood into blood components and the collection of such components are disclosed. In one aspect, an extra-corporeal method for the collection of plasma and red blood cells is provided, wherein the collection of plasma and red blood cells may occur simultaneously or subsequently utilizing the same dual stage blood processing vessel. The flow of blood to the blood processing vessel and return of uncollected blood components may be provided via a single needle, wherein blood is removed from and returned to a donor/patient during alternating blood removal and blood return submodes. Platelet separation and collection options are also described. In either case, prior to red blood cell collection, a set-up phase may be carried out to set a predetermined hematocrit and AC ratio. Replacement fluid delivery may optionally also be provided either substantially continuously during any collection phase(s) and/or in a bolus mode.
摘要翻译：公开了特别涉及将血液分离成血液成分并收集这些组分的方法和装置。一方面，提供了用于收集血浆和红细胞的额外体外方法，其中血浆和红细胞的收集可以同时发生或随后使用相同的双级血液处理容器。可以经由单个针提供血液加工血液到血液处理容器的流动和未收集的血液成分的返回，其中在交替的血液清除和血液返回子模式期间从血液中取出血液并返回给供体/患者。还描述了血小板分离和收集选项。在任一种情况下，在红细胞收集之前，可以进行设置阶段以设定预定的血细胞比容和AC比。替代流体输送可以任选地在任何收集阶段和/或以推注模式中基本连续地提供。

15. 发明申请

US20040195157A1 Purified Water Supply System for High Demand Devices and Applications 有权
标题翻译：用于高需求设备和应用的净化供水系统
公开(公告)号：US20040195157A1
公开(公告)日：2004-10-07
申请号：US10709530
申请日：2004-05-12
申请人： GAMBRO, INC.
发明人： Stephen M. Mullins , Douglas A. Luehmann , John D. Bielefeld
IPC分类号： B01D035/14
CPC分类号： B01D61/145 , A61M1/1656 , A61M1/1668 , A61M2205/84 , B01D61/02 , B01D61/025 , B01D61/08 , B01D61/10 , B01D61/58 , C02F1/44 , C02F1/441 , C02F1/444 , Y10T137/0318 , Y10T137/0396 , Y10T137/0402 , Y10T137/85954 , Y10T137/86035
摘要： A water supply sub-system for connection to a main water supply system includes a storage tank having an inlet with a flow control valve for connection to the main water supply system. The sub-system may be disconnected from the main system and configured as a closed system for disinfecting the sub-system. An outlet line connects the storage tank to a pump that pumps water from the tank to a sub-system supply line. One or more branch connections may connect the sub-system supply line to high-demand water using devices, such as dialysis machines. The supply line may be a feedback loop. A shunt feedback loop parallel to the feedback loop of the supply line has a pressure control valve that regulates pressure in the supply line feedback loop. A filtration device may also be included to ensure the purity of the water circulating through the sub-system.
摘要翻译：用于连接到主供水系统的供水子系统包括具有入口的储罐，该入口具有用于连接到主供水系统的流量控制阀。子系统可能与主系统断开连接，并配置为用于对子系统进行消毒的封闭系统。出口管路将储罐连接到将水从水箱泵送到子系统供水管线的泵。一个或多个分支连接可以将子系统供应管线连接到高需求用水的设备，例如透析机。电源线可以是反馈回路。与供电线路的反馈环路并联的分流反馈回路具有调节供应线路反馈回路中的压力的压力控制阀。还可以包括过滤装置以确保通过子系统循环的水的纯度。

16. 发明申请

US20040162209A1 Centrifuge for processing blood and blood components in ring-type blood processing bags 有权
标题翻译：离心机用于处理环型血液处理袋中的血液和血液成分
公开(公告)号：US20040162209A1
公开(公告)日：2004-08-19
申请号：US10627029
申请日：2003-07-24
申请人： Gambro, Inc.
发明人： Niclas Hogberg , Emanuel Hallgren , Peter Pihlstedt
IPC分类号： B04B011/00
CPC分类号： A61M1/3693 , A61M1/0209 , A61M1/3696 , B04B5/0428 , B04B2013/006
摘要： The claimed invention refers to a centrifuge intended for processing blood and blood components and with its function based on the effective utilisation of ring type blood processing bags with associated secondary bags and other accessories. The most outstanding feature of the centrifuge, in accordance with the claimed invention, is that its rotor, at the same intended height of the ring bag (22) inner periphery, shows at least three supports (9-11) arranged along this periphery and intended to locate the ring bag's inner strengthened periphery edge on guide holes at the same time as the centrifuge and its rotor is equipped with a joint rotating inner lid (6) which includes a clamp function (7) that clamps ring bag (22) securely along and between supports (9-11). Furthermore, in the invention these supports (9-11) have, on the one hand, built-in valve functions for communication between the ring bag and the respective secondary bags can be actively controlled and, on the other hand, sterile welding functions for communication between ring bag (22) and the respective secondary bags when interruption and blocking is required.
摘要翻译：所要求保护的发明是指旨在用于处理血液和血液成分的离心机，并且其功能基于有效利用具有相关次级袋和其它附件的环型血液处理袋。根据要求保护的发明，离心机的最突出的特征是其在环袋（22）内周边的相同预期高度处的转子显示出沿着这个周边布置的至少三个支撑件（9-11）旨在将离心机和其转子配备有接合旋转内盖（6）的同时定位在引导孔上的环袋的内部加强的周边边缘，其包括夹紧功能（7），该夹紧功能（7）牢固地夹紧环形袋（22）在支撑（9-11）之间和之间。此外，在本发明中，这些支撑件（9-11）一方面可以主动地控制环袋和相应的次级袋之间的连通的内置阀功能，另一方面，用于当需要中断和阻塞时，环袋（22）和各个次级袋之间的通信。

17. 发明申请

US20040147387A1 Centrifuge and container system for treatment of blood and blood components 有权
标题翻译：离心机和集装箱系统用于治疗血液和血液成分
公开(公告)号：US20040147387A1
公开(公告)日：2004-07-29
申请号：US10759767
申请日：2004-01-16
申请人： Gambro, Inc.
发明人： Peter Unger , Eric Westberg
IPC分类号： B04B007/12
CPC分类号： B04B5/0428
摘要： A Centrifuge for the separation and/or treatment of cells in a substantially annular or partially annular separation bag having a rotor with rotor shaft with a hollow upper portion defining a central compartment and a rotor bowl for the separation bag and a container system including the separation bag for use therewith.

18. 发明申请

US20040096814A1 Apparatus for producing blood component products 有权
标题翻译：用于生产血液成分产品的装置
公开(公告)号：US20040096814A1
公开(公告)日：2004-05-20
申请号：US10699358
申请日：2003-10-30
申请人： Gambro, Inc.
发明人： Robert Warner Langley , Larry Joe Dumont
IPC分类号： A01N001/02 , G06F019/00 , G01N033/48 , G01N033/50
CPC分类号： A61M1/385 , A61M1/02 , A61M1/30 , A61M1/303 , A61M1/3696 , A61M2202/0415 , A61M2205/50 , Y10T436/101666 , Y10T436/115831 , Y10T436/25 , Y10T436/25375
摘要： A method and apparatus for producing blood component products. In one embodiment, a plurality of a predetermined type of blood component is harvested from a source of whole blood. At least two on-line yield determination techniques are utilized to determine the yield for the harvested blood components. One is a predetermined yield prediction technique and the second is a predetermined yield monitoring technique, each of which are individually calibrated in relation to a predetermined off-line yield determination technique. The predetermined yield prediction and monitoring techniques each provide the yield for the harvested blood components and each is then utilized to provide a determined yield. Consequently, when the harvested blood components are packaged the determined yield my be associated therewith, thereby providing a blood component product.
摘要翻译：用于生产血液成分产品的方法和装置。在一个实施例中，从全血源收集多个预定类型的血液成分。使用至少两种在线产量测定技术来确定收获的血液成分的产量。一种是预定的产量预测技术，第二种是预定的产量监测技术，每种都是相对于预定的离线产量确定技术单独校准的。预定的产量预测和监测技术各自提供收获的血液成分的产量，然后利用每个产量来提供确定的产量。因此，当收集的血液成分被包装时，确定的产量与之相关联，从而提供血液成分产品。

19. 发明申请

US20030205454A1 Fluid mixing and irradiation device and method especially for biological fluids 审中-公开
标题翻译：流体混合和照射装置和方法特别适用于生物流体
公开(公告)号：US20030205454A1
公开(公告)日：2003-11-06
申请号：US10427260
申请日：2003-04-30
申请人： Gambro, Inc.
发明人： Dennis Hlavinka , Michael A. Martinez
IPC分类号： B01J019/08 , C07C001/00
CPC分类号： B01F5/0615 , A61K41/0019 , A61L2/0005 , A61L2/0011 , A61L2/0047 , A61L2/0052 , A61L2/0064 , A61L2/0082 , A61L2/08 , A61L2/084 , A61L2/10 , A61L2/12 , A61M1/32 , A61M1/3681 , A61M1/3683 , A61M2202/0208 , A61M2202/0275 , A61M2206/14 , B01F3/22 , B01F3/2292 , B01F15/00857 , H05B3/0085
摘要： The present invention relates to a method and/or apparatus suitable for use in reduction of any pathogens in a fluid such as a biological fluid, or a fraction or component thereof, which may contain pathogens. The device may include a vessel having an inlet and an outlet and a passage which extends therebetween. The passage may have a wall which is substantially transparent to a pathogen reduction radiation. The passage contains a static mixer system which is formed and arranged for thoroughly mixing the fluid in use of the device so as to bring substantially the whole of the fluid into an irradiation zone extending along and in substantially direct proximity to the passage walls during passage between the inlet and the outlet to be expose the fluid to a similar substantial level of irradiation. The static mixer may include light transmissive blades.
摘要翻译：本发明涉及适用于减少可能含有病原体的流体如生物流体或其部分或组分中的任何病原体的方法和/或装置。该装置可以包括具有入口和出口的容器以及在它们之间延伸的通道。通道可具有对病原体还原辐射基本透明的壁。该通道包含静态混合器系统，其形成并布置成在使用该装置时使流体充分混合，从而使整个流体进入沿着通道壁延伸并基本上直接接近通道壁的照射区域入口和出口将液体暴露于类似的显着水平的照射。静态混合器可以包括透光叶片。

20. 发明申请

US20030195455A1 Extracorporeal blood processing methods and apparatus 有权
公开(公告)号：US20030195455A1
公开(公告)日：2003-10-16
申请号：US10407591
申请日：2003-04-03
申请人： Gambro, Inc.
发明人： Marlene Adele Bainbridge , Brian M. Holmes
IPC分类号： A61M037/00 , B01D033/15
CPC分类号： A61M1/3624 , A61M1/30 , A61M1/303 , A61M1/308 , A61M1/3639 , A61M1/3641 , A61M1/3652 , A61M1/3692 , A61M1/3693 , A61M1/3696 , A61M2205/12 , A61M2205/123 , A61M2205/125 , A61M2205/128 , A61M2205/14 , A61M2205/3382 , A61M2205/3386 , A61M2205/505 , B04B5/0442 , B04B9/08 , B04B2005/045
摘要： An extracorporeal blood processing system is disclosed which includes a variety of novel components and which may be operated in accordance with a variety of novel methodologies. For instance, the system includes a graphical operator interface which directs the operator through various aspects of the apheresis procedure. Moreover, the system also includes a variety of features relating to loading a blood processing vessel into a blood processing channel and removing the same after completion of the procedure. Furthermore, the system also includes a variety of features relating to utilizing a blood priming of at least portions of the apheresis system in preparation for the procedure. In addition, the system includes a variety of features enhancing the performance of the apheresis system, including the interrelationship between the blood processing vessel and the blood processing vessel and the utilization of high packing factors for the procedure.

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