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11. 发明申请

WO2011130656A3 METHODS, DEVICES, AND APPARATUS FOR PERFORMING A VASCULAR ANASTOMOSIS 审中-公开
公开(公告)号：WO2011130656A3
公开(公告)日：2011-10-20
申请号：PCT/US2011/032723
申请日：2011-04-15
申请人： UNIVERSITY OF UTAH RESEARCH FOUNDATION , AGARWAL, Jayant, P. , GALE, Bruce, K. , NGUYEN, Lam , SHORR, Cory , STAUFFER, Brian , GEHRKE, Cody, Lee
发明人： AGARWAL, Jayant, P. , GALE, Bruce, K. , NGUYEN, Lam , SHORR, Cory , STAUFFER, Brian , GEHRKE, Cody, Lee
IPC分类号： A61B17/11 , A61B17/122 , A61B17/08 , A61F2/06
摘要： Methods, devices, apparatus, assemblies, and kits for performing a vascular anastomosis are disclosed. A device for a vascular anastomosis includes tissue engaging portions that can move between at least two configurations. In some embodiments, the tissue engaging portions move without the aid of moving parts, while in other embodiments the tissue engaging portions extend from one or more movable wings. The tissue engaging portions may be separated by a first distance when in a pre-deployment configuration and by a second distance when in a deployed configuration. A method includes engaging a plurality of tissue engaging members of a coupling device against first end tissue. After selectively engaging the tissue engaging members and first end tissue, the first end tissue is stretched by at least moving the tissue engaging members. The stretched first end tissue is coupled to second end tissue by mating the coupling device to a mating anastomosis device.

12. 发明申请

WO2006014460A3 SPOTTING DEVICE AND METHOD FOR HIGH CONCENTRATION SPOT DEPOSITION ON MICROARRAYS AND OTHER MICROSCALE DEVICES 审中-公开
标题翻译：微型装置和其他微型装置的高浓度点沉积物的分选装置和方法
公开(公告)号：WO2006014460A3
公开(公告)日：2006-06-29
申请号：PCT/US2005023895
申请日：2005-07-06
申请人： UNIV UTAH RES FOUND , GALE BRUCE , CHANG-YEN DAVID , MYSZKA DAVID
发明人： GALE BRUCE , CHANG-YEN DAVID , MYSZKA DAVID
IPC分类号： B01L3/02 , G01D15/00
CPC分类号： B01J19/0046 , B01J2219/00353 , B01J2219/00367 , B01J2219/00369 , B01J2219/00371 , B01J2219/00497 , B01J2219/00527 , B01J2219/00536 , B01J2219/00574 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00637 , B01J2219/00639 , B01J2219/00644 , B01J2219/00648 , B01J2219/00659 , B01J2219/00675 , B01J2219/00677 , B01J2219/00691 , B01J2219/00693 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01J2219/00734 , B01J2219/00736 , B01J2219/00743 , B01L3/0293 , B01L3/5027 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502761 , B01L2200/0647 , B01L2200/147 , B01L2300/0636 , B01L2300/0654 , B01L2300/0822 , B01L2300/0877 , B01L2300/1827 , B01L2400/0415 , B01L2400/0487 , B82Y30/00 , C12M23/16 , C40B50/14 , C40B60/14 , G01N35/1002 , G01N35/1065 , G01N35/1074 , G01N2035/00158 , G01N2035/1034 , G01N2035/1039 , Y10T29/49
摘要： Disclosed is a spotter device and methods for the formation of microassays, biochips, biosensors, and cell cultures. The spotter may be used to deposit highly concentrated spots of protein or other materials on a microarray a slide, wafer, or other substrate. The spotter uses microfluidic conduits and orifices to deposit proteins, other biomolecules, or chemicals on a spot on a substrate. Each orifice is part of a fluid pathways that includes an inlet and outlet conduit. When the spotter contacts a substrate a seal is formed between the orifices and the substrate.
摘要翻译：公开了一种用于形成微量测定器，生物芯片，生物传感器和细胞培养物的检测器装置和方法。斑点斑块可用于将高度浓缩的蛋白质或其他材料的斑点沉积在载玻片，晶片或其它基底的微阵列上。点样器使用微流体管道和孔口将蛋白质，其他生物分子或化学物质沉积在基底上的一个点上。每个孔是包括入口和出口导管的流体路径的一部分。当检测器接触基板时，在孔和基板之间形成密封。

13. 发明申请

WO2015100251A1 VASCULAR COUPLING DEVICE 审中-公开
标题翻译：血管联接装置
公开(公告)号：WO2015100251A1
公开(公告)日：2015-07-02
申请号：PCT/US2014/071930
申请日：2014-12-22
申请人： AGARWAL, Jayant, P. , GALE, Bruce, K. , LI, Huizhong , SANT, Himanshu, J.
发明人： AGARWAL, Jayant, P. , GALE, Bruce, K. , LI, Huizhong , SANT, Himanshu, J.
IPC分类号： A61B17/11
CPC分类号： A61B17/11 , A61B2017/00004 , A61B2017/1107 , A61B2017/1132
摘要： Implementations of the present disclosure relate to apparatuses, systems, and methods for anastomosing vascular systems in medical procedures. A pair of similar or identical coupling devices may be disposed at the ends of two vessels, either natural or synthetic. The coupling devices may be capable of hermaphroditically connecting to one another to provide a simple and secure connection which promotes growth of the vessels between the bio-absorbable coupling devices.
摘要翻译：本公开的实施方式涉及用于在医疗过程中吻合血管系统的装置，系统和方法。一对相似或相同的耦合装置可以设置在两个容器的端部，天然的或合成的。联接装置可能能够彼此相互连接以提供促进生物可吸收耦合装置之间的容器生长的简单和可靠的连接。

14. 发明申请

WO2010034010A3 MICROASSAY WITH INTERNAL REFERENCING 审中-公开
标题翻译： MICROASSAY与内部参考
公开(公告)号：WO2010034010A3
公开(公告)日：2010-07-08
申请号：PCT/US2009057901
申请日：2009-09-22
申请人： WASATCH MICROFLUIDICS , MYSZKA DAVID , GALE BRUCE K , ECKMAN JOSHUA WAYNE , NATARAJAN SRIRAM
发明人： MYSZKA DAVID , GALE BRUCE K , ECKMAN JOSHUA WAYNE , NATARAJAN SRIRAM
IPC分类号： G01N33/48 , G01N33/50
CPC分类号： C40B60/12 , B01J2219/0036 , B01J2219/00385 , B01J2219/00527 , B01J2219/00596 , B01J2219/00702 , B01J2219/00725 , B01L3/0262 , B01L3/5027 , B01L2200/0689 , B01L2300/0819 , B01L2300/0877 , B01L2400/0487 , G01N33/54366
摘要： Specialized microfluidic networks are utilized to deposit substances on sensor surfaces. In particular, a flow-based microfluidic printhead is used as an interface to deliver multiple analytes to a sensor for simultaneous analysis. Furthermore, internal referencing is incorporated into sensor regions for improved sensitivity.
摘要翻译：利用专门的微流体网络将物质沉积在传感器表面上。特别是，基于流动的微流体打印头被用作将多种分析物传送到传感器以进行同时分析的接口。此外，内部参考被纳入传感器区域以提高灵敏度。

15. 发明申请

WO2007117335A2 HIGH FIELD STRENGTH MAGNETIC FIELD GENERATION SYSTEM AND ASSOCIATED METHODS 审中-公开
标题翻译：高强度磁场发生系统及相关方法
公开(公告)号：WO2007117335A2
公开(公告)日：2007-10-18
申请号：PCT/US2007/000217
申请日：2007-01-04
申请人： UNIVERSITY OF UTAH RESEARCH FOUNDATION , STEPHENSON, James, C. , GALE, Bruce, K. , FURSE, Cynthia
发明人： STEPHENSON, James, C. , GALE, Bruce, K. , FURSE, Cynthia
IPC分类号： H01F7/08
CPC分类号： H01F7/0284 , G01R33/3806 , G01R33/383
摘要： A magnetic field generation system can comprise first (28a) and second (28b) magnetic flux concentrators each spaced apart to form a sample volume (30). The first (28a) and second (28b) magnetic flux concentrators can be formed of a material having a magnetic field saturation. A first set of auxiliary permanent magnets (10a, 10b) can be symmetrically oriented about a portion of the first magnetic flux concentrator (28a) and can be in substantial contact with the first magnetic flux concentrator. Similarly, a second set of auxiliary permanent magnets (1 Oc, 1 Od) can be symmetrically oriented about a portion of the second magnetic flux concentrator (28b) and can be in substantial contact with the second magnetic flux concentrator. Generally, the first set (10a,10b) and second set (10c,10d) of auxiliary permanent magnets can be remote from the sample volume (30). Each of the first set and second set of auxiliary permanent magnets can be oriented in a magnetically repulsive orientation with respect to at least one other member of their respective sets. The first (10a,10b) and second (10c,10d) sets of auxiliary magnets can be magnetically associated via the first (28a) and second (28b) magnetic flux concentrators. The present invention can further be configured to allow variation of the magnetic field strength across the sample volume by disrupting the field flux across the magnetic flux concentrators. This can be accomplished by orienting one or more magnetically soft shunts (38) in a sufficient proximity to at least one of the magnetic flux concentrators (28a,28b).
摘要翻译：磁场产生系统可以包括第一（28a）和第二（28b）磁通量聚集器，每个间隔开以形成样品体积（30）。第一（28a）和第二（28b）磁通量聚集器可以由具有磁场饱和的材料形成。第一组辅助永久磁铁（10a，10b）可围绕第一磁通量聚集器（28a）的一部分对称地取向，并且可以与第一磁通集中器实质接触。类似地，第二组辅助永磁体（1 Oc，1 Od）可以围绕第二磁通量聚集器（28b）的一部分对称地定向，并且可以与第二磁通量集中器实质接触。通常，辅助永磁体的第一组（10a，10b）和第二组（10c，10d）可以远离样品体积（30）。第一组和第二组辅助永磁体中的每一个可以相对于它们各自的组的至少一个其它构件以磁性排斥取向定向。第一（10a，10b）和第二（10c，10d）组辅助磁体可以经由第一（28a）和第二（28b）磁通量集中器磁性地相关联。本发明还可以被配置为允许通过扰乱磁通集中器上的磁场通量来改变跨样品体积的磁场强度。这可以通过将一个或多个磁软分流器（38）定向到至少一个磁通量聚集器（28a，28b）的足够接近来实现。

16. 发明申请

WO2011130656A2 METHODS, DEVICES, AND APPARATUS FOR PERFORMING A VASCULAR ANASTOMOSIS 审中-公开
标题翻译：用于执行血管分析的方法，装置和装置
公开(公告)号：WO2011130656A2
公开(公告)日：2011-10-20
申请号：PCT/US2011032723
申请日：2011-04-15
申请人： UNIV UTAH RES FOUND , AGARWAL JAYANT P , GALE BRUCE K , NGUYEN LAM , SHORR CORY , STAUFFER BRIAN , GEHRKE CODY LEE
发明人： AGARWAL JAYANT P , GALE BRUCE K , NGUYEN LAM , SHORR CORY , STAUFFER BRIAN , GEHRKE CODY LEE
IPC分类号： A61B17/11 , A61B17/08 , A61B17/122 , A61F2/06
CPC分类号： A61B17/11 , A61B2017/00004 , A61B2017/00349 , A61B2017/00477 , A61B2017/00867 , A61B2017/00893 , A61B2017/1103 , A61B2017/1107 , A61B2017/1121 , A61B2017/1125 , A61B2017/1132
摘要： Methods, devices, apparatus, assemblies, and kits for performing a vascular anastomosis are disclosed. A device for a vascular anastomosis includes tissue engaging portions that can move between at least two configurations. In some embodiments, the tissue engaging portions move without the aid of moving parts, while in other embodiments the tissue engaging portions extend from one or more movable wings. The tissue engaging portions may be separated by a first distance when in a pre-deployment configuration and by a second distance when in a deployed configuration. A method includes engaging a plurality of tissue engaging members of a coupling device against first end tissue. After selectively engaging the tissue engaging members and first end tissue, the first end tissue is stretched by at least moving the tissue engaging members. The stretched first end tissue is coupled to second end tissue by mating the coupling device to a mating anastomosis device.
摘要翻译：公开了用于执行血管吻合术的方法，装置，装置，组件和试剂盒。用于血管吻合的装置包括可在至少两种构型之间移动的组织接合部分。在一些实施例中，组织接合部分不借助移动部件移动，而在其它实施例中，组织接合部分从一个或多个活动翼部延伸。当处于部署前的配置中时，组织接合部分可以分开第一距离，并且当处于展开配置时，组织接合部分可以分开第一距离。一种方法包括将联接装置的多个组织接合构件抵靠第一端组织接合。在选择性地接合组织接合构件和第一端部组织之后，通过至少移动组织接合构件来拉伸第一端部组织。拉伸的第一端组织通过将联接装置配合到配合的吻合装置而耦合到第二端组织。

17. 发明申请

WO2009111461A2 MICROFLUIDIC FLOW CELL 审中-公开
标题翻译：微流感细胞
公开(公告)号：WO2009111461A2
公开(公告)日：2009-09-11
申请号：PCT/US2009/035859
申请日：2009-03-03
申请人： UNIVERSITY OF UTAH RESEARCH FOUNDATION , SUNDBERG, Scott, O. , WITTNER, Carl, T. , GALE, Bruce, K.
发明人： SUNDBERG, Scott, O. , WITTNER, Carl, T. , GALE, Bruce, K.
IPC分类号： C12M1/10
CPC分类号： C12Q1/6844 , B01L3/50273 , B01L3/50851 , B01L7/52 , B01L2200/0642 , B01L2300/0806 , B01L2300/0887 , B01L2400/0409
摘要： A microfluidic flow cell having a body with a fluid transport channel disposed therein, the fluid transport channel having a proximal end and a distal end defining a fluid flow path, a fluid inlet port disposed at the proximal end of the fluid transport channel at a central portion of the body and an outlet port disposed at the distal end of the fluid transport channel at an outer portion of the body, and a plurality sample wells disposed in the fluid transport channel substantially perpendicular to the fluid flow path in the fluid transport channel. The microfluidic flow cell may have hundreds or thousands of individual, sub-microliter sample wells. The microfluidic flow cell can be filled by applying a flowable liquid to the inlet port and spinning the flow cell to cause fluid to flow into fluid transport channel. The microfluidic flow cells described herein can be used in a variety of applications where small sample size and/or a large number of replicates are desirable.
摘要翻译：一种微流体流动池，其具有设置在其中的流体输送通道的主体，所述流体输送通道具有限定流体流动路径的近端和远端;流体入口，其设置在所述流体输送通道的近端处的中心主体的一部分和设置在主体的外部部分处的流体输送通道的远端处的出口端口以及设置在流体输送通道中的基本上垂直于流体输送通道中的流体流动路径的多个样本阱。微流体流动池可以具有数百或数千个单独的亚微升样品孔。可以通过将可流动的液体施加到入口端口并旋转流动池以使流体流入流体输送通道来填充微流体流动池。本文所述的微流体流动池可以用于需要小样品量和/或大量重复的各种应用中。

18. 发明申请

WO2008061129A2 METHODS AND COMPOSITIONS RELATED TO CONTINUOUS FLOW THERMAL GRADIENT PCR 审中-公开
标题翻译：与连续流动热梯度PCR相关的方法和组合
公开(公告)号：WO2008061129A2
公开(公告)日：2008-05-22
申请号：PCT/US2007/084652
申请日：2007-11-14
申请人： UNIVERSITY OF UTAH RESEARCH FOUNDATION , GALE, Bruce, Kent , CREWS, Niel, Davenport , WITTWER, Carl, Thomas
发明人： GALE, Bruce, Kent , CREWS, Niel, Davenport , WITTWER, Carl, Thomas
IPC分类号： C12Q1/68 , C12M3/00
CPC分类号： G01N21/6456 , B01L3/502707 , B01L7/525 , B01L7/54 , B01L2300/0816 , B01L2300/0861 , B01L2300/1822 , B01L2300/1827 , B01L2400/0487 , G01N21/6428 , Y10T156/1056 , Y10T156/1062
摘要： Disclosed are compositions and a method for amplification and detection of nucleic acid sequences based on continuous flow thermal gradient PCR.
摘要翻译：公开了基于连续流动热梯度PCR扩增和检测核酸序列的组合物和方法。

19. 发明申请

WO2007102932A3 ENHANCED FILL-FACTOR NMR COILS AND ASSOCIATED METHODS 审中-公开
标题翻译：增强填充因子NMR线圈及相关方法
公开(公告)号：WO2007102932A3
公开(公告)日：2008-05-08
申请号：PCT/US2007000243
申请日：2007-01-04
申请人： UNIV UTAH RES FOUND , STEPHENSON JAMES C , GALE BRUCE K , FURSE CYNTHIA
发明人： STEPHENSON JAMES C , GALE BRUCE K , FURSE CYNTHIA
IPC分类号： G01V3/00
CPC分类号： G01R33/34046 , G01R33/34007 , G01R33/34053 , G01R33/34092
摘要： An NMR probe which includes a probe matrix (24) having a void sample (28) volume therein. A conductive coil (16, 26) can be at least partially embedded in the probe matrix (24). By embedding the conductive coil (16, 26) in the probe matrix (24), the fill-factor can be significantly increased. NMR probes can be formed by a method which includes wrapping a conductive wire (16) around a coil form (18) to produce a coil precursor assembly. The probe matrix (24) can be formed around the conductive wire and coil form with a matrix material using any suitable technique such as soft lithography and/or molding. The coil form can be removed from the probe matrix leaving a void sample volume (28) in the probe matrix. Advantageously, the NMR probes of the present invention allow for fill-factors approaching and achieving 100%.
摘要翻译： NMR探针，其包括其中具有空隙样品（28）体积的探针基质（24）。导电线圈（16,26）可以至少部分地嵌入在探针基体（24）中。通过将导电线圈（16,26）嵌入探针基体（24）中，填充因子可以显着增加。 NMR探针可以通过包括围绕线圈形式（18）缠绕导线（16）以产生线圈前体组件的方法形成。探针矩阵（24）可以使用诸如软光刻和/或模制之类的任何合适的技术在基体材料周围形成导电线和线圈形式。可以从探针基质中除去线圈形式，留下探针基质中的空隙样品体积（28）。有利地，本发明的NMR探针允许填充因子接近并达到100％。

20. 发明申请

WO2007100356A3 A MICROFLUIDIC INTERFACE FOR HIGHLY PARALLEL ADDRESSING OF SENSING ARRAYS 审中-公开
标题翻译：用于感测阵列高度并行寻址的微流体接口
公开(公告)号：WO2007100356A3
公开(公告)日：2007-12-13
申请号：PCT/US2006038505
申请日：2006-10-02
申请人： UNIV UTAH RES FOUND , GALE BRUCE K , MYSZKA DAVID , CHANG-YEN DAVID A , NATARAJAN SRIRAM , ECKMAN JOSH
发明人： GALE BRUCE K , MYSZKA DAVID , CHANG-YEN DAVID A , NATARAJAN SRIRAM , ECKMAN JOSH
IPC分类号： B01L3/02 , G01N1/10
CPC分类号： G01N33/553 , B01J19/0046 , B01L3/0293 , B01L3/5025 , B01L3/502715 , B01L3/50273 , B01L2200/021 , B01L2300/0636 , B01L2300/0819 , B01L2300/0822 , B01L2300/0877 , B01L2400/0487 , C12N15/1093 , G01N35/1074 , G01N2035/00158 , G01N2035/1039 , Y10T436/2575
摘要： Disclosed is a spotter device and methods for the formation of microassays, biochips, biosensors, and cell cultures. The spotter (10) may be used to deposit highly concentrated spots of protein or other materials on a microarray slide, wafer, or other surface. It may also be used to perform various chemistry steps on the same spots. The spotter increases the surface density of substances at each spot by directing a flow the desired substance (or a solution thereof) over the spot area until surface saturation is accomplished. The spotter may be loaded by well plate handling equipment. The spotter uses wells (22, 24), microfluidic conduits, and orifices to deposit proteins, other biomolecules, or chemicals on a spot on a separate surface. Each orifice is connect to two wells via microconduits (26, 28). When the spotter contacts a surface (30), a seal is formed between th orifices (27) and the surface. The same or different substances may be flowed across each orifice. Any numb of orifices may be incorporated into a spotter. The spotter is particularly useful for depositing proteins in high concentrations on a surface, since the spotter may be placed on a surface for an extended period of time.
摘要翻译：公开了一种用于形成微量测定器，生物芯片，生物传感器和细胞培养物的检测器装置和方法。斑点（10）可用于将高度浓缩的蛋白质或其他材料的斑点沉积在微阵列载玻片，晶片或其它表面上。它也可以用于在同一点上执行各种化学步骤。点样器通过将所需物质（或其溶液）流过斑点区域直到达到表面饱和为止，增加每个斑点处物质的表面密度。识别器可以由井板处理设备装载。点样器使用井（22,24），微流体导管和孔口将蛋白质，其他生物分子或化学品沉积在单独表面上的一个点上。每个孔通过微管连接到两个孔（26,28）。当检测器接触表面（30）时，在孔口（27）和表面之间形成密封。相同或不同的物质可能流过每个孔口。任何麻木的孔都可以并入到一个点样器中。鉴定器对于在表面上沉积高浓度的蛋白质是特别有用的，因为可以将定位器放置在表面上较长时间。

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