专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明授权

US5567434A Preparation of liposome and lipid complex compositions 失效
标题翻译：脂质体和脂质复合物组合物的制备
公开(公告)号：US5567434A
公开(公告)日：1996-10-22
申请号：US480227
申请日：1995-06-07
申请人： Francis C. Szoka, Jr.
发明人： Francis C. Szoka, Jr.
IPC分类号： A61K9/127 , A61K9/16 , A61K47/48 , A61K51/12 , B01J13/02
CPC分类号： A61K47/48053 , A61K9/1277 , A61K9/1617 , Y10S436/829
摘要： Liposome and lipidic particle formulations of compounds are prepared by dissolving in a solution of liposome-forming lipids in an aprotic solvent such as DMSO, optionally containing a lipid-solubilizing amount of a lower alkanol, and either injecting the resulting solution into an aqueous solution, or the aqueous solution into the resulting solution. The resulting liposome or lipidic particle suspension may then be dialyzed or otherwise concentrated. This method is particularly useful for compounds which are poorly-soluble in aqueous solution, but is generally useful for any compound or combination of compounds which can be dissolved in the aprotic solvent or aprotic solvent/lower alkanol mixture.
摘要翻译：通过将脂质体形成脂质溶解在非质子溶剂如DMSO中，任选地含有脂溶性量的低级链烷醇，并将所得溶液注入水溶液中制备化合物的脂质体和脂质颗粒制剂，或将水溶液加入到所得溶液中。然后可以将所得的脂质体或脂质颗粒悬浮液透析或以其它方式浓缩。该方法对于难溶于水溶液的化合物特别有用，但通常可用于可溶于非质子溶剂或非质子溶剂/低级链烷醇混合物中的任何化合物或化合物的组合。

12. 发明授权

US4394448A Method of inserting DNA into living cells 失效
标题翻译：将DNA插入活细胞的方法
公开(公告)号：US4394448A
公开(公告)日：1983-07-19
申请号：US143455
申请日：1980-04-24
申请人： Francis C. Szoka, Jr. , Demetrios P. Papahadjopoulos
发明人： Francis C. Szoka, Jr. , Demetrios P. Papahadjopoulos
IPC分类号： A61K9/127 , C12N15/88 , C12N15/00
CPC分类号： C12N15/88 , A61K9/127 , Y10S435/82
摘要： A method of inserting deoxyribonucleic acid or fragments thereof into a living cell, which comprises; encapsulating the DNA or fragment in a lipid vesicle and bringing the vesicle in contact with said cell, whereby insertion occurs.
摘要翻译：将脱氧核糖核酸或其片段插入活细胞的方法，其包括：将DNA或片段包封在脂质囊泡中并使囊泡与所述细胞接触，从而进行插入。

13. 发明授权

US4394149A Plant nutriment compositions and method of their application 失效
标题翻译：植物营养成分及其应用方法
公开(公告)号：US4394149A
公开(公告)日：1983-07-19
申请号：US149516
申请日：1980-05-13
申请人： Francis C. Szoka, Jr. , Demetrios P. Papahadjopoulos
发明人： Francis C. Szoka, Jr. , Demetrios P. Papahadjopoulos
IPC分类号： A61K9/127 , C05C9/00 , C05G3/00
CPC分类号： C05C9/005 , A61K9/127 , C05G3/007 , Y10S71/02
摘要： The disclosure is of the use of plant nutriments encapsulated in synthetic lipid vesicles to nourish plants. SPCROSS-REFERENCE TO RELATED APPLICATIONThis application is a Continuation-in-Part of our copending application Ser. No. 881,116 filed Feb. 24, 1978 and now U.S. Pat. No. 4,235,871.
摘要翻译：本公开是使用包封在合成脂质囊泡中的植物营养物来滋养植物。

14. 发明申请

US20170231910A1 PHARMACEUTICAL FORMULATIONS OF CHELATING AGENTS AS A METAL REMOVAL TREATMENT SYSTEM 审中-公开
公开(公告)号：US20170231910A1
公开(公告)日：2017-08-17
申请号：US15503001
申请日：2015-08-12
申请人： Mark E. HAYES , Charles O. NOBLE , Francis C. SZOKA, JR. , ZONEONE PHARMA, INC.
发明人： Mark E. HAYES , Charles O. NOBLE , Francis C. SZOKA, JR.
IPC分类号： A61K9/127 , B01J13/08 , B01J13/20 , A61K31/16 , A61K31/4196
CPC分类号： A61K9/127 , A61K9/1272 , A61K31/16 , A61K31/195 , A61K31/4196 , A61K31/663 , A61K31/704 , B01J13/08 , B01J13/203
摘要： The present invention provides liposomes loaded with chelating agents, pharmaceutical formulations including these liposomes and methods of making chelating agent liposomes. Because the chelating agents are loaded in the liposome with high efficiencies, the liposomes are of use in treatment of metal ion overload in subjects. The liposomes can also contain essential trace metals to compensate for the off target effect of removal of endogenous non-target trace metals by administration of the chelator. The liposomes can include two or more different chelating agents of different structures and affinities for metal ions.

15. 发明申请

US20130216607A1 ZWITTERIONIC LIPIDS 有权
标题翻译： ZWITTERICIC LIPIDS
公开(公告)号：US20130216607A1
公开(公告)日：2013-08-22
申请号：US13816882
申请日：2011-08-15
申请人： Francis C. Szoka, JR. , Colin Walsh , Vincent Venditto , Juliane Nguyen , Emily Perttu
发明人： Francis C. Szoka, JR. , Colin Walsh , Vincent Venditto , Juliane Nguyen , Emily Perttu
IPC分类号： C07C229/12 , A61K9/127 , A61K47/18 , C07J9/00 , A61K47/28
CPC分类号： C07C229/12 , A61K9/1272 , A61K47/186 , A61K47/28 , C07C279/14 , C07C309/14 , C07F9/091 , C07F9/54 , C07F9/650952 , C07J9/00 , C07J41/0055 , C40B40/04
摘要： In various embodiments, the present invention provides zwitterionic lipids, encapsulants incorporating these zwitterionic lipids and such encapsulants encapsulating one or more bioactive agent. An exemplary bioactive agent is a nucleic acid. Also provided are pharmaceutical formulations of the encapsulants and methods of using such formulations to deliver a bioactive agent to a subject in treating or diagnosing disease in that subject.
摘要翻译：在各种实施方案中，本发明提供两性离子脂质，包含这些两性离子性脂质的密封剂和封装一种或多种生物活性剂的这种密封剂。示例性的生物活性剂是核酸。还提供了密封剂的药物制剂和使用这些制剂将生物活性剂递送到受试者以治疗或诊断该受试者的疾病的方法。

16. 发明授权

US07323297B1 Stabilized polynucleotide complexes and methods 失效
标题翻译：稳定的多核苷酸复合物和方法
公开(公告)号：US07323297B1
公开(公告)日：2008-01-29
申请号：US08485430
申请日：1995-06-07
申请人： Francis C. Szoka, Jr. , Jinkang Wang
发明人： Francis C. Szoka, Jr. , Jinkang Wang
IPC分类号： C12Q1/68 , A01N43/04 , A61K31/70
CPC分类号： A61K31/70
摘要： The invention comprises stabilized polynucleotide complexes that have a cryoprotectant and are lyophilized. Cryoprotectant compounds comprise carbohydrates or sugars, preferably lactose and sucrose, but also glucose, maltodextrins, mannitol, sorbitol, trehalose, and others. Other suitable cryoprotectants include amino acids such as betaines and prolines. Polynucleotide complexes stabilized according to the invention can be used for transfection, and exhibit improved tranfection efficiency with respect to polynucleotide complexes without cryoprotection.
摘要翻译：本发明包括具有冷冻保护剂并被冻干的稳定的多核苷酸复合物。冷冻保护剂化合物包含碳水化合物或糖，优选乳糖和蔗糖，还包括葡萄糖，麦芽糖糊精，甘露醇，山梨醇，海藻糖等。其他合适的冷冻保护剂包括氨基酸，例如甜菜碱和脯氨酸。根据本发明稳定的多核苷酸复合物可用于转染，并且相对于没有冷冻保护的多核苷酸复合物显示出改善的转染效率。

17. 发明授权

US5830730A Enhanced adenovirus-assisted transfection composition and method 失效
标题翻译：增强腺病毒辅助转染组合物和方法
公开(公告)号：US5830730A
公开(公告)日：1998-11-03
申请号：US852934
申请日：1997-05-08
申请人： Michael S. German , Francis C. Szoka, Jr.
发明人： Michael S. German , Francis C. Szoka, Jr.
IPC分类号： A61K48/00 , C12N15/861 , C12N15/87 , C12N15/63 , C12N7/00 , C12N15/11
CPC分类号： C12N15/86 , A61K48/00 , C12N15/87 , C12N2710/10343
摘要： A composition for transfecting eukaryotic cells comprising a cationic polymer which has protonatable groups which serve to buffer the acidic endosome, protecting the endocytosed polynucleotide from degradation and a viral agent is used to target uptake into and/or lysis from endosomes in the desired eukaryotic cell. By co-infecting the eukaryotic cells with cationic polymer, polynucleotide, and the viral agent, the polynucleotide is brought into the cell and then released. Preferably, polyamidoamine dendrimers are used as the cationic polymer and adenovirus is used as the viral agent. The dendrimers help associate plasmid DNA with the adenovirus, which then provokes receptor-mediated endocytosis. Within the endosome, the tertiary amine groups of the dendrimer buffer the pH change in the endosome. Then, the endosomalytic activity of the adenovirus releases the plasmid DNA into the cell. Also preferably, the adenovirus and the dendrimers are mixed before addition to the polynucleotide and the cells are washed after about 1.5 hours of incubation.
摘要翻译：用于转染真核细胞的组合物包含阳离子聚合物，其具有用于缓冲酸性内体的可质子基团，保护内吞多核苷酸免于降解和病毒剂的阳离子聚合物用于靶向所需真核细胞内内体的摄取和/或裂解。通过用阳离子聚合物，多核苷酸和病毒剂共同感染真核细胞，将多核苷酸引入细胞中，然后释放。优选使用聚酰胺胺树枝状大分子作为阳离子聚合物，并使用腺病毒作为病毒剂。树枝状大分子帮助质粒DNA与腺病毒相关联，其然后引发受体介导的内吞作用。在内体内，树状聚合物的叔胺基团缓冲了内体内的pH变化。然后，腺病毒的内分泌活性将质粒DNA释放到细胞中。还优选地，在加入多核苷酸之前将腺病毒和树枝状大分子混合，并在孵育约1.5小时后洗涤细胞。

18. 发明授权

US5549910A Preparation of liposome and lipid complex compositions 失效
公开(公告)号：US5549910A
公开(公告)日：1996-08-27
申请号：US179291
申请日：1994-01-10
申请人： Francis C. Szoka, Jr.
发明人： Francis C. Szoka, Jr.
IPC分类号： A61K9/127 , A61K9/16 , A61K47/48 , A61K51/02 , B01J13/02 , B01J13/20
CPC分类号： A61K47/48053 , A61K9/1277 , A61K9/1617 , Y10S436/829
摘要： Liposome and lipidic particle formulations of compounds are prepared by dissolving in a solution of liposome-forming lipids in an aprotic solvent such as DMSO, optionally containing a lipid-solubilizing amount of a lower alkanol, and either injecting the resulting solution into an aqueous solution, or the aqueous solution into the resulting solution. The resulting liposome or lipidic particle suspension may then be dialyzed or otherwise concentrated. This method is particularly useful for compounds which are poorly-soluble in aqueous solution, but is generally useful for any compound or combination of compounds which can be dissolved in the aprotic solvent or aprotic solvent/lower alkanol mixture.

19. 发明授权

US5077057A Preparation of liposome and lipid complex compositions 失效
标题翻译：脂质体和脂质复合物组合物的制备
公开(公告)号：US5077057A
公开(公告)日：1991-12-31
申请号：US605155
申请日：1990-10-29
申请人： Francis C. Szoka, Jr.
发明人： Francis C. Szoka, Jr.
IPC分类号： A61K9/127 , A61K9/16 , A61K47/48
CPC分类号： A61K9/1617 , A61K9/1277 , Y10S436/829
摘要： Liposome and lipidic particle formulations of compounds are prepared by dissolving in a solution of liposome-forming lipids in an aprotic solvent such as DMSO, optionally containing a lipid-solubilizing amount of a lower alkanol, and injecting the resulting solution into an aqueous solution. The resulting liposome or lipidic particle suspension may then be dialyzed or otherwise concentrated. This method is particularly useful for compounds which are poorly-soluble in aqueous solution, but is generally useful for any compound or combination of compounds which can be dissolved in the aprotic solvent or aprotic solvent/lower alkanol mixture.
摘要翻译：通过将脂质体形成脂质溶解在非质子溶剂如DMSO中，任选地含有脂溶性量的低级链烷醇，并将所得溶液注入水溶液中来制备化合物的脂质体和脂质颗粒制剂。然后可以将所得的脂质体或脂质颗粒悬浮液透析或以其它方式浓缩。该方法对于难溶于水溶液的化合物特别有用，但通常可用于可溶于非质子溶剂或非质子溶剂/低级链烷醇混合物中的任何化合物或化合物的组合。

20. 发明授权

US4235871A Method of encapsulating biologically active materials in lipid vesicles 失效
公开(公告)号：US4235871A
公开(公告)日：1980-11-25
申请号：US881116
申请日：1978-02-24
申请人： Demetrios P. Papahadjopoulos , Francis C. Szoka, Jr.
发明人： Demetrios P. Papahadjopoulos , Francis C. Szoka, Jr.
IPC分类号： A61K9/127 , C12N1/04 , C12N9/98 , C12N15/88 , A61K9/10 , A61K9/66 , A61K37/48 , A61K39/02
CPC分类号： C12N1/04 , A61K9/127 , A61K9/1277 , C12N15/88 , C12N9/98 , Y10S424/812 , Y10T428/2984
摘要： The disclosure is of a method for encapsulating biologically active materials in synthetic, oligolamellar lipid vesicles (liposomes). The method comprises providing a mixture of lipid in organic solvent and an aqueous mixture of the material for encapsulation, emulsifying the provided mixture, removing the organic solvent and suspending the resultant gel in water. The method of the invention is advantageous over prior art methods of encapsulating biologically active materials in that it provides a means for a relatively high capture efficiency of the material for encapsulation. The disclosure is also of intermediate compositions in the encapsulation method, the product vesicles, compositions including the product vesicles as an active ingredient and their use.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式