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11. 发明申请

WO2006009869A1 COUMPOUNDS AND METHODS FOR INHIBITING THE INTERACTION OF BCL PROTEINS WITH BINDING PARTNERS 审中-公开
标题翻译：抑制BCL蛋白与结合合作伙伴相互作用的方法和方法
公开(公告)号：WO2006009869A1
公开(公告)日：2006-01-26
申请号：PCT/US2005/021524
申请日：2005-06-17
申请人： INFINITY PHARMACEUTICALS, INC. , CASTRO, Alfredo, C. , DENG, Wei , DEPEW, Kristopher, M. , FOLEY, Michael, A. , FRITZ, Christian, C. , GEORGES EVANGELINOS, Asimina, T. , GROGAN, Michael, J. , HAFEEZ, Nafeeza , HOLSON, Edward, B. , HOPKINS, Brian, T. , KONEY, Nii, O. , LIU, Tao , MANN, David, A. , MARCAURELLE, Lisa, A. , SNYDER, Daniel, A. , UNDERWOOD, Dennis, J. , WYLIE, Andrew, A. , YU, Lin-Chen , ZHANG, Linping
发明人： CASTRO, Alfredo, C. , DENG, Wei , DEPEW, Kristopher, M. , FOLEY, Michael, A. , FRITZ, Christian, C. , GEORGES EVANGELINOS, Asimina, T. , GROGAN, Michael, J. , HAFEEZ, Nafeeza , HOLSON, Edward, B. , HOPKINS, Brian, T. , KONEY, Nii, O. , LIU, Tao , MANN, David, A. , MARCAURELLE, Lisa, A. , SNYDER, Daniel, A. , UNDERWOOD, Dennis, J. , WYLIE, Andrew, A. , YU, Lin-Chen , ZHANG, Linping
IPC分类号： C07D261/02 , A61K31/42 , A61P35/00
CPC分类号： C07D261/02 , C07D261/18 , C07D413/10 , C07D413/12 , C07D417/12 , C07D498/04
摘要： One aspect of the present invention relates to isoxazoline derivatives that bind to bcl proteins and inhibit Bcl function. Another aspect of the present invention relates to compositions comprising an isoxazoline derivative of the invention. The present invention provides methods for treating and modulating disorders associated with hyperproliferation, such as cancer.
摘要翻译：本发明的一个方面涉及与bcl蛋白结合并抑制Bcl功能的异恶唑啉衍生物。本发明的另一方面涉及包含本发明的异恶唑啉衍生物的组合物。本发明提供了治疗和调节与过度增生相关的疾病如癌症的方法。

12. 发明申请

WO2005117847A3 METHODS AND COMPOUNDS FOR THE TREATMENT OF NEOPLASMS 审中-公开
公开(公告)号：WO2005117847A3
公开(公告)日：2005-12-15
申请号：PCT/US2005/019324
申请日：2005-06-01
申请人： COMBINATORX, INCORPORATED , KEITH, Curtis , LEE, Margaret, S. , FOLEY, Michael, A. , STOCKWELL, Brent, R.
发明人： KEITH, Curtis , LEE, Margaret, S. , FOLEY, Michael, A. , STOCKWELL, Brent, R.
IPC分类号： C07D279/26
摘要： The invention features compounds of 'formula (I) and their use in preparing 'medicaments for treating a patient having a cancer or other neoplasm. R' R9 R8 R N R7

13. 发明申请

WO2004109280A3 SYSTEM AND METHOD FOR MULTIDIMENSIONAL EVALUATION OF COMBINATIONS OF COMPOSITIONS 审中-公开
标题翻译：用于组合物组合多元评估的系统和方法
公开(公告)号：WO2004109280A3
公开(公告)日：2005-10-13
申请号：PCT/US2004018155
申请日：2004-06-07
申请人： COMBINATORX INC , ZIMMERMANN GRANT , MOLNAR RAYMOND A , LEHAR JOSEPH , FONG JASON , KEITH CURTIS T , SERBEDZIJA GEORGE , LEE MARGARET S , JOST-PRICE EDWARD R , HURST NICOLE , BORISY ALEXIS , FOLEY MICHAEL A , STOCKWELL BRENT
发明人： ZIMMERMANN GRANT , MOLNAR RAYMOND A , LEHAR JOSEPH , FONG JASON , KEITH CURTIS T , SERBEDZIJA GEORGE , LEE MARGARET S , JOST-PRICE EDWARD R , HURST NICOLE , BORISY ALEXIS , FOLEY MICHAEL A , STOCKWELL BRENT
IPC分类号： C07B61/00 , C12Q1/68 , G01N33/48 , G01N33/50 , G01N33/53 , G06F19/00
CPC分类号： C40B30/04 , B01J2219/00315 , B01J2219/00527 , B01J2219/00659 , B01J2219/00702 , B01J2219/00756 , C40B20/04
摘要： Embodiments of the invention are directed toward methods and devices for constructing assay arrays including a combination of constituent compositions from constituent arrays. The combined compositions are evaluated, in some embodiments of the invention, to identify combinations with a combination effect. Other embodiments of the invention are directed toward constructing constituent arrays in various configurations to facilitate the production of assay arrays. Such embodiments include : constructing constituent arrays and assay arrays with corresponding composition and assay control sets; constructing constituent arrays with a unique set of origin locations and corresponding sets of derivative locations; varying the concentrations utilized for a constituent composition; and composing assay arrays corresponding to a virtual sparse assay array. Other embodiments of the invention are directed towards systems and method of evaluating the activity of combined compositions in an assay array.
摘要翻译：本发明的实施方案涉及用于构建测定阵列的方法和装置，包括组成阵列的组成组合物的组合。在本发明的一些实施方案中，评估组合的组合物以鉴定具有组合效应的组合。本发明的其它实施方案涉及以各种构型构建组成阵列以促进测定阵列的制备。这些实施方案包括：用相应的组成和测定对照组构建组成阵列和测定阵列; 用独特的原始位置集合和相应的导数位置组构建组成数组; 改变用于组成成分的浓度; 并组成对应于虚拟稀疏测定阵列的测定数组。本发明的其它实施方案涉及评估测定阵列中组合组合物的活性的系统和方法。

14. 发明申请

WO2004006906A3 METHODS FOR THE TREATMENT OF NEOPLASMS 审中-公开
标题翻译：治疗肿瘤的方法
公开(公告)号：WO2004006906A3
公开(公告)日：2004-03-04
申请号：PCT/US0322026
申请日：2003-07-15
申请人： COMBINATORX INC , LEE MARGARET S , KEITH CURTIS , AUSPITZ BENJAMIN A , ZIMMERMANN GRANT R , NICHOLS M JAMES , FOLEY MICHAEL A
发明人： LEE MARGARET S , KEITH CURTIS , AUSPITZ BENJAMIN A , ZIMMERMANN GRANT R , NICHOLS M JAMES , FOLEY MICHAEL A
IPC分类号： A61K31/165
CPC分类号： A61K31/609 , A61K31/337 , A61K31/4745 , A61K31/5415 , A61K31/7048 , A61K31/7068 , A61K45/06 , A61K2300/00
摘要： The invention features a method for treating a patient having a cancer or other neoplasm by administering to the patient a niclosamide, or a structural or functional analog thereof, and, optionally, one or more antiproliferative agents in an amount effective to inhibit the growth of the neoplasm.
摘要翻译：本发明的特征在于通过给予患者氯硝柳胺或其结构或功能类似物以及任选的一种或多种抗增殖剂来治疗患有癌症或其他肿瘤的患者的方法，所述氯硝柳胺或其结构或功能类似物以及任选的一种或多种抗增殖剂，肿瘤。

15. 发明申请

WO1993021787A1 SURFACE STERILISATION BY LASER TREATMENT 审中-公开
标题翻译：激光治疗的表面消毒
公开(公告)号：WO1993021787A1
公开(公告)日：1993-11-11
申请号：PCT/GB1993000872
申请日：1993-04-27
申请人： THE MINISTER OF AGRICULTURE, FISHERIES AND FOOD ... , FOLEY, Michael, Francis , CLEMENT, Robert, Marc , LEDGER, Neville, Richard
发明人： THE MINISTER OF AGRICULTURE, FISHERIES AND FOOD ...
IPC分类号： A23L03/26
CPC分类号： A23L3/26 , A23L3/005 , A23L3/0055 , A61L2/08
摘要： The present invention relates to a method of treating substrates for the purpose of reducing the population of contaminant organisms associated with them; particularly to treatment of foodstuffs, propagative materials and items intended for use in veterinary and medical applications. The method directs laser radiation at the substrate whereby the type and amount of laser radiation are selected such as to render organisms associated with the substrate inviable while leaving the desired properties of the substrate itself substantially unchanged. Apparatus suitable for treating a variety of substrates are disclosed, with a source of laser radiation (9, 28) and means (26, 27, 29) for handling the substrate (24).
摘要翻译：本发明涉及一种处理底物以减少与其相关的污染生物群体的方法; 特别是处理食品，传播材料和用于兽医和医疗应用的物品。该方法将激光辐射引导到衬底，从而选择激光辐射的类型和量，以使得与衬底相关联的生物体可以被允许，同时留下衬底本身的期望性质基本上不变。公开了适用于处理各种基板的装置，具有用于处理基板（24）的激光辐射源（9,28）和装置（26,27,29）。

16. 发明申请

WO2017208262A1 SYSTEM AND METHOD FOR WIRELESSLY MANAGING A PLURALITY OF FUNCTIONAL UNITS USING A COMPUTING DEVICE 审中-公开
标题翻译：使用计算设备无线地管理多个功能单元的系统和方法
公开(公告)号：WO2017208262A1
公开(公告)日：2017-12-07
申请号：PCT/IN2017/050219
申请日：2017-06-01
申请人： RODNEY FOLEY, Michael Victor
发明人： RODNEY FOLEY, Michael Victor
IPC分类号： G08C17/02 , G05B15/02
CPC分类号： G08C17/02 , G08C2201/31 , H04L12/2803
摘要： A system for wirelessly managing the functional units (110A-N) using a computing device that includes a modular base station (106), a first functional unit (110A), a second functional unit (110B) and a computing device (118). The modular base station (106) includes a first induction coil (402), a second induction coil (404), a signal receiver (406) and a signal transmitter (408). The first induction coil (402) and second induction coil (404) generates a first and second set of electromagnetic waves respectively. The first functional unit (110A) includes a first receiver coil (112A), and a first power conversion unit (114A). The second functional unit (110B) includes a second receiver coil (112B) and a second power conversion unit (114B). The first power conversion unit (114A) converts first set of electromagnetic waves into a first control signal. The second power conversion unit (114B) converts second set of electromagnetic waves into a second control signal.
摘要翻译：一种使用计算设备无线地管理功能单元（110A-N）的系统，所述计算设备包括模块化基站（106），第一功能单元（110A），第二功能单元（110B）和计算设备（118）。模块化基站（106）包括第一感应线圈（402），第二感应线圈（404），信号接收器（406）和信号发射器（408）。第一感应线圈（402）和第二感应线圈（404）分别产生第一组和第二组电磁波。第一功能单元（110A）包括第一接收线圈（112A）和第一功率转换单元（114A）。第二功能单元（110B）包括第二接收线圈（112B）和第二功率转换单元（114B）。第一电力转换单元（114A）将第一组电磁波转换为第一控制信号。第二电力转换单元（114B）将第二组电磁波转换为第二控制信号。

17. 发明申请

WO2007127394A2 MARINE RISER ASSEMBLY 审中-公开
标题翻译：海上升降机组
公开(公告)号：WO2007127394A2
公开(公告)日：2007-11-08
申请号：PCT/US2007/010285
申请日：2007-04-27
申请人： RTI ENERGY SYSTEMS, INC. , BEARD, Michael, E. , COLE, David, J. , CALDWELL, Christopher, S. , FOLEY, Michael, B.
发明人： BEARD, Michael, E. , COLE, David, J. , CALDWELL, Christopher, S. , FOLEY, Michael, B.
IPC分类号： F16L21/06
CPC分类号： E21B17/085 , F16L37/138
摘要： A marine riser assembly having a first tubular member having an external surface with a plurality of first axially spaced formations, a second tubular member having an external surface with a plurality of second axially spaced formations thereon, a segmented ring in surrounding relationship to the first and second tubular members, the segmented ring having an inner surface with a plurality of formations engageable with the formations on the first and second tubular members, the engageable formations serving to urge the.first and second tubular members toward each other when the segmented ring is subjected to radially inwardly directed compressive forces, a sleeve in surrounding relationship to force the engageable formations together and a seal assembly for sealing against external and internal pressure.
摘要翻译：一种具有第一管状构件的海洋提升管组件，该第一管状构件具有多个第一轴向间隔的结构的外表面，第二管状构件，具有在其上具有多个第二轴向间隔的结构的外表面，与第一和第所述分段环具有内表面，所述内表面具有可与所述第一和第二管状构件上的结构接合的多个结构，所述可接合结构用于当所述分段环受到所述第一和第二管状构件时朝向彼此推动所述第一和第二管状构件径向向内的压缩力，围绕关系的套筒，以迫使可接合的结构在一起，以及用于密封抵抗外部和内部压力的密封组件。

18. 发明申请

WO2006074963A3 LENTIVIRAL GENE TRANSFERT SYSTEM FOR RIBOZYME MEDIATED RNA-REPAIR 审中-公开
标题翻译：用于RIBOZYME介导的RNA修复的生物基因转移系统
公开(公告)号：WO2006074963A3
公开(公告)日：2007-01-04
申请号：PCT/EP2006000358
申请日：2006-01-17
申请人： GENEERING GMBH , FOLEY MICHAEL
发明人： FOLEY MICHAEL
IPC分类号： C12N15/867
CPC分类号： C12N15/111 , A61K35/76 , A61K48/005 , C12N15/86 , C12N2310/111 , C12N2310/121 , C12N2330/30 , C12N2740/15032 , C12N2740/15043
摘要： The invention relates to a safer and efficient recombinant gene transfer system for ribozyme mediated repair of a target RNAin non-dividing and dividing cells, based on the Visna lentivirus (VLV) comprising: (a) a first plasmid comprising a sequence encoding the VLV Gag, (b) a second plasmid as transfer plasmid comprising a ribozyme cassette th the catalytic domain of a self-splizing ribozyme (class I intron) and a sequence encoding for the accurate counterpart of the target RNA to be repaired, (c) a third plasmid comprising a sequence encoding VLV Pol, (d) a fourth plasmid comprising sequences encoding VLV Vif, Rev and Tat, (e) a fifth plasmid comprising a sequence encoding an envelope protein Env, which is not derived from VLV, wherein the plasmids a and c to e do not encode for other VLV proteins and do not contain a competent packaging signal.
摘要翻译：本发明涉及一种基于Visna慢病毒（VLV）的用于核酶介导的靶分化不分裂和分裂细胞的核酶介导的修复的重组基因转移系统，其包含：（a）包含编码VLV Gag的序列的第一质粒（b）作为转移质粒的第二质粒，其包含自分支核酶（I类内含子）的催化结构域的核酶盒和编码待修复的靶RNA的准确对应物的序列，（c）第三质粒包含编码VLV Pol的序列的质粒，（d）包含编码VLV Vif，Rev和Tat的序列的第四质粒，（e）包含不衍生自VLV的编码包膜蛋白Env的序列的第五质粒，其中质粒a 并且c至e不对其他VLV蛋白编码，并且不包含有效的包装信号。

19. 发明申请

WO2004006849A2 COMBINATIONS OF DRUGS FOR THE TREATMENT OF NEOPLASMS 审中-公开
标题翻译：药物治疗神经元的组合
公开(公告)号：WO2004006849A2
公开(公告)日：2004-01-22
申请号：PCT/US2003/021984
申请日：2003-07-15
申请人： COMBINATORX, INCORPORATED , BORISY, Alexis , KEITH, Curtis , FOLEY, Michael, A. , STOCKWELL, Brent, R. , GAW, Debra, A.
发明人： BORISY, Alexis , KEITH, Curtis , FOLEY, Michael, A. , STOCKWELL, Brent, R. , GAW, Debra, A.
IPC分类号： A61K
CPC分类号： A61K45/06 , A61K31/00 , A61K2300/00
摘要： The invention features a method for treating a patient having a cancer or other neoplasm, by administering to the patient (i) a benzimidazole or a metabolite or analog thereof; and (ii) pentamidine or a metabolite or analog thereof simultaneously or within 14 days of each other in amounts sufficient to inhibit the growth of the neoplasm.
摘要翻译：本发明的特征在于通过给予患者（i）苯并咪唑或其代谢物或类似物来治疗患有癌症或其他肿瘤的患者的方法; 和（ii）戊脒或其代谢物或类似物同时或彼此之间的14天内以足以抑制肿瘤生长的量。

20. 发明申请

WO2002058697A1 COMBINATIONS OF DRUGS (E.G., A BENZIMIDAZOLE AND PENTAMIDINE) FOR THE TREATMENT OF NEOPLASTIC DISORDERS 审中-公开
标题翻译：用于治疗神经障碍的药物（E.G.，苯并咪唑和丁胺）的组合
公开(公告)号：WO2002058697A1
公开(公告)日：2002-08-01
申请号：PCT/US2002/001707
申请日：2002-01-22
申请人： COMBINATORX, INCORPORATED , BORISY, Alexis , KEITH, Curtis , FOLEY, Michael, A. , STOCKWELL, Brent, R.
发明人： BORISY, Alexis , KEITH, Curtis , FOLEY, Michael, A. , STOCKWELL, Brent, R.
IPC分类号： A61K31/415
CPC分类号： A61K31/415 , A61K31/135 , A61K2300/00
摘要： The invention features a method for treating a patient having a cancer or other neoplasm, by administering to the patient (1) a benzimidazole or a metabolite or analog therof; and (ii) pentamidine or a metaboliter or analog thereof simultaneously or within 14 days of each other in amounts sufficient to inhibit the growth of the neoplasm.
摘要翻译：本发明的特征在于通过给予患者（1）苯并咪唑或代谢物或类似物来治疗患有癌症或其他肿瘤的患者的方法; 和（ii）戊脒或其代谢产物或类似物，其量以足以抑制肿瘤生长的量相互之间或14天内。

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