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11. 发明授权

US06423948B1 Microtiter plate with integral heater 有权
公开(公告)号：US06423948B1
公开(公告)日：2002-07-23
申请号：US10012560
申请日：2001-12-12
申请人： Joseph Kwasnoski , F. Raymond Salemme
发明人： Joseph Kwasnoski , F. Raymond Salemme
IPC分类号： B01L700
CPC分类号： B01L3/50851 , Y10S435/809
摘要： A microtiter plate system includes an integral heater. In an embodiment, the integral heater includes a heater plate. In another embodiment, the integral heater includes resistive heater wires positioned beneath and/or between the wells of a microtiter plate. In an embodiment, the microtiter plate system includes optically clear well bottoms that permit sensing and measurement of samples through the optically clear well bottoms. In an implementation, an optically clear heater is positioned beneath the optically clear well bottoms. In an alternative implementation, resistive heater wires are positioned between the wells. In an embodiment, the microtiter plate system includes a microtiter plate lid with an integral heater, which can be implemented using a heater plate, resistive wires, and the like. In an embodiment, the microtiter plate system includes an integral non-contact heater, such as a ferrous plate and/or ferrous particles, powder and/or fibers, which generate heat when subjected to an electromagnetic field. An electromagnetic field can be generated by an inductive coil or the like. In an embodiment, the microtiter plate system includes an integral non-contact heater which generates heat when subjected to microwave radiation from a microwave generator. In an embodiment, the microtiter plate system includes an integral thermostat that maintains a substantially constant temperature in the microtiter plate system.

12. 发明授权

US09102526B2 Node polypeptides for nanostructure assembly 有权
标题翻译：用于纳米结构组装的节点多肽
公开(公告)号：US09102526B2
公开(公告)日：2015-08-11
申请号：US12892911
申请日：2010-09-28
申请人： F. Raymond Salemme , Patricia C. Weber , Mark A. Rould
发明人： F. Raymond Salemme , Patricia C. Weber , Mark A. Rould
IPC分类号： B82Y30/00
CPC分类号： B82Y30/00
摘要： Engineered proteins are used in the assembly of two-dimensional and three-dimensional nanostructure assemblies, based on systematic design and production of protein node structures that can be interconnected, for example, with streptavidin or streptavidin-incorporating struts to produce structures with defined dimensions and geometry. Nanostructure assemblies having utility as functional devices or as resists for the patterning of substrates have architectures including polygons, polyhedra, two-dimensional lattices, and three-dimensional lattices.
摘要翻译：基于可以互连的蛋白质节点结构的系统设计和生产，使用工程化蛋白质用于二维和三维纳米结构组件的组装，例如与链霉亲和素或链霉抗生物素蛋白结合的支柱相互连接以产生具有限定尺寸的结构，几何。具有作为功能器件的有用的纳米结构组件或用于衬底的图案化的抗蚀剂具有包括多边形，多面体，二维晶格和三维晶格的结构。

13. 发明申请

US20120230922A1 Novel Polymorphs of Rebaudioside C and Methods for Making and Using the Same 审中-公开
标题翻译：雷鲍迪苷C的新型多态性及其制备与使用方法
公开(公告)号：US20120230922A1
公开(公告)日：2012-09-13
申请号：US13497619
申请日：2010-09-22
申请人： F. Raymond Salemme , Robert A. Daines
发明人： F. Raymond Salemme , Robert A. Daines
IPC分类号： A23L1/236 , A23L2/60 , C07H15/24 , A61Q11/00 , A61K47/26 , A61K8/60 , A61P3/02 , A23L1/30 , C07H1/08
CPC分类号： A61K8/60 , A23L27/36 , A23V2002/00 , A61K8/602 , A61K47/26 , A61K2800/10 , A61Q11/00 , A61Q19/00 , C07H15/24 , A23V2250/258
摘要： Embodiments of this invention encompass a method for producing and purifying rebaudioside C. In particular, this invention relates to a method for purifying rebaudioside C compositions to obtain a substantially pure rebaudioside C product using one or more crystallization steps. Resulting polymorphic forms of rebaudioside C, substantially pure rebaudioside C compositions and their uses are disclosed.
摘要翻译：本发明的实施方案包括用于生产和纯化新蛇菊苷C的方法。特别地，本发明涉及一种纯化新蛇菊苷C组合物以使用一种或多种结晶步骤获得基本上纯的莱鲍迪甙C产物的方法。公开了莱鲍迪苷C，基本上纯的莱鲍迪甙C组合物及其用途的所得多晶型物。

14. 发明申请

US20120164083A1 Sweetness Enhancers Including Rebaudioside A or D 审中-公开
标题翻译：甜度增强剂包括雷鲍迪苷A或D
公开(公告)号：US20120164083A1
公开(公告)日：2012-06-28
申请号：US13393942
申请日：2010-08-31
申请人： R. Kyle Palmer , F. Raymond Salemme
发明人： R. Kyle Palmer , F. Raymond Salemme
IPC分类号： A23L1/236 , A61K8/60 , A61Q11/00 , A61K47/26
CPC分类号： A23L2/52 , A23K20/10 , A23K20/111 , A23K20/121 , A23K50/40 , A23K50/42 , A23L2/60 , A23L27/33 , A23L27/34 , A23V2002/00 , A23V2200/132 , A23V2250/258 , A23V2250/262
摘要： The present invention is directed to the use of rebaudioside A or rebaudioside D in combination with one or more compounds of Formula (I), or a stereoisomer thereof, wherein R2 is rhamnose, and R and R1 are each independently selected from the group consisting of hydrogen, glucose, and beta-sophorose, for enhancing the sweet taste of carbohydrate sweeteners, such as sucrose and fructose. The present invention is also directed to consumables which include a combination of a carbohydrate sweetener, rebaudioside A or rebaudioside D, and one or more compounds of Formula (I), or a stereoisomer thereof.
摘要翻译：本发明涉及新蛇菊苷A或莱鲍迪苷D与一种或多种式（I）化合物或其立体异构体的组合的用途，其中R 2是鼠李糖，R 1和R 2各自独立地选自氢，葡萄糖和β-槐糖，用于增强碳水化合物甜味剂如蔗糖和果糖的甜味。本发明还涉及包含碳水化合物甜味剂，新蛇菊苷A或莱鲍迪甙D以及一种或多种式（I）化合物或其立体异构体的组合的消耗品。

15. 发明申请

US20110085939A1 NODE POLYPEPTIDES FOR NANOSTRUCTURE ASSEMBLY 有权
标题翻译：用于纳米结构的聚合物多孔体
公开(公告)号：US20110085939A1
公开(公告)日：2011-04-14
申请号：US12892911
申请日：2010-09-28
申请人： F. Raymond Salemme , Patricia C. Weber , Mark A. Rould
发明人： F. Raymond Salemme , Patricia C. Weber , Mark A. Rould
IPC分类号： G01N33/00 , C07K14/00 , C12N9/90 , C12N9/88 , C12N9/04 , C07K14/195 , C12N9/12 , C12N9/02 , C07K14/36 , C12N9/96 , C07K19/00 , G03F7/20 , B05D1/36 , B05D3/06 , B05D3/10 , B05D3/02 , B82Y15/00 , B82Y40/00
CPC分类号： B82Y30/00
摘要： Engineered proteins are used in the assembly of two-dimensional and three-dimensional nanostructure assemblies, based on systematic design and production of protein node structures that can be interconnected, for example, with streptavidin or streptavidin-incorporating struts to produce structures with defined dimensions and geometry. Nanostructure assemblies having utility as functional devices or as resists for the patterning of substrates have architectures including polygons, polyhedra, two-dimensional lattices, and three-dimensional lattices.
摘要翻译：基于可以互连的蛋白质节点结构的系统设计和生产，使用工程化蛋白质用于二维和三维纳米结构组件的组装，例如与链霉亲和素或链霉抗生物素蛋白结合的支柱相互连接以产生具有限定尺寸的结构，几何。具有作为功能器件的有用的纳米结构组件或用于衬底的图案化的抗蚀剂具有包括多边形，多面体，二维晶格和三维晶格的结构。

16. 发明申请

US20080306030A1 Use of a TRPM5 Inhibitor to Regulate Insulin and GLP-1 Release 有权
标题翻译：使用TRPM5抑制剂调节胰岛素和GLP-1释放
公开(公告)号：US20080306030A1
公开(公告)日：2008-12-11
申请号：US12025488
申请日：2008-02-04
申请人： S. Paul Lee , Peihong Zhou , M.N. Tulu Buber , Rok Cerne , Robert Bryant , F. Raymond Salemme , Gillian Morgan
发明人： S. Paul Lee , Peihong Zhou , M.N. Tulu Buber , Rok Cerne , Robert Bryant , F. Raymond Salemme , Gillian Morgan
IPC分类号： A61K31/15 , A61K31/655 , A61K31/47 , A61K31/4409 , A61K31/438 , A61P3/00 , A61P1/00 , C12N5/00 , A61K31/5375 , A61K31/165 , A61K31/404
CPC分类号： A61K31/397 , Y10S514/866
摘要： The present invention is directed to methods of enhancing insulin release, GLP-1 release, and insulin sensitivity, methods of increasing insulin gene expression, methods of decreasing gastric secretion and emptying and glucagons secretion, and methods of inhibiting food intake, and methods of treating diabetes mellitus, insulin resistance syndrome, hyperglycemia, and obesity comprising administering to a subject an effective amount of a TRPM5 inhibitor.
摘要翻译：本发明涉及增强胰岛素释放，GLP-1释放和胰岛素敏感性的方法，增加胰岛素基因表达的方法，减少胃分泌和排空以及胰高血糖素分泌的方法，以及抑制食物摄取的方法以及治疗方法糖尿病，胰岛素抵抗综合征，高血糖症和肥胖症，包括向受试者施用有效量的TRPM5抑制剂。

17. 发明授权

US07039621B2 System, method, and computer program product for representing object relationships in a multidimensional space 失效
公开(公告)号：US07039621B2
公开(公告)日：2006-05-02
申请号：US09814160
申请日：2001-03-22
申请人： Dimitris K. Agrafiotis , Dmitri N. Rassokhin , Victor S. Lobanov , F. Raymond Salemme
发明人： Dimitris K. Agrafiotis , Dmitri N. Rassokhin , Victor S. Lobanov , F. Raymond Salemme
IPC分类号： G06E1/00
CPC分类号： G06Q10/10 , G06K9/6232 , G06K9/6253 , G06N99/005
摘要： A method and computer product is presented for mapping n-dimensional input patterns into an m-dimensional space so as to preserve relationships that may exist in the n-dimensional space. A subset of the input patterns is chosen and mapped into the m-dimensional space using an iterative nonlinear mapping process. A set of locally defined neural networks is created, then trained in accordance with the mapping produced by the iterative process. Additional input patterns not in the subset are mapped into the m-dimensional space by using one of the local neural networks. In an alternative embodiment, the local neural networks are only used after training and use of a global neural network. The global neural network is trained in accordance with the mapping produced by the iterative process. Input patterns are initially projected into the m-dimensional space using the global neural network. Local neural networks are then used to refine the results of the global network.

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