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11. 发明授权

US08898069B2 Devices and methods for detecting an analyte in salivary fluid 有权
标题翻译：用于检测唾液中分析物的装置和方法
公开(公告)号：US08898069B2
公开(公告)日：2014-11-25
申请号：US12584055
申请日：2009-08-28
申请人： Leroy E. Hood , Edward K. Y. Jung , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, Jr.
发明人： Leroy E. Hood , Edward K. Y. Jung , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, Jr.
IPC分类号： G06Q10/00 , G06Q50/00 , G06Q50/24 , A61B5/00
CPC分类号： A61B5/0002 , A61B5/00 , A61B5/411 , G01N33/14 , G06F19/00 , G06Q50/24 , Y02A90/22 , Y02A90/26 , Y10T436/163333
摘要： Methods and systems are described herein for detecting one or more analyte in salivary fluid. Systems include: a discrete oral component configured for complete enclosure in a human oral cavity; at least one sensor configured to detect one or more analyte in salivary fluid; and an external device including a port configured for communication with the discrete oral component. Methods include: detecting one or more analyte within salivary fluid with at least one sensor integral to a discrete oral component, wherein the discrete oral component is configured to be completely enclosed in the oral cavity and includes one or more flavorant; and communicating information from the discrete oral component to at least one external device.
摘要翻译：本文描述了用于检测唾液中一种或多种分析物的方法和系统。系统包括：配置成完全封闭在人类口腔中的离散口腔部件; 至少一个传感器被配置成检测唾液中的一种或多种分析物; 以及包括被配置为与离散口头部件通信的端口的外部设备。方法包括：用至少一个与离散的口服组分成一体的传感器检测唾液中的一种或多种分析物，其中所述离散的口服组分构造成完全封闭在口腔中，并且包括一种或多种调味剂; 以及将信息从离散口头部件传送到至少一个外部装置。

12. 发明授权

US08858912B2 Frozen compositions and methods for piercing a substrate 有权
公开(公告)号：US08858912B2
公开(公告)日：2014-10-14
申请号：US12586077
申请日：2009-09-15
申请人： Edward S. Boyden , Daniel B. Cook , Roderick A. Hyde , Eric C. Leuthardt , Nathan P. Myhrvold , Elizabeth A. Sweeney , Lowell L. Wood, Jr.
发明人： Edward S. Boyden , Daniel B. Cook , Roderick A. Hyde , Eric C. Leuthardt , Nathan P. Myhrvold , Elizabeth A. Sweeney , Lowell L. Wood, Jr.
IPC分类号： A61K49/00 , B26D7/00 , A61K9/12 , A61K9/19 , C07K16/28 , A61K9/24 , A61K45/06 , A61K9/20 , G06F19/00 , A61K38/48 , A61M37/00 , C07K16/30 , A61K9/16 , A61K39/145 , A61K31/74 , A61K33/00 , A61K31/337 , A61K9/14 , A61K31/00 , C07K16/22 , A61K9/08 , A61K38/38 , A61K31/7088 , A61K9/28 , A61K9/00 , A61K41/00 , A61K31/70 , A61K39/00
CPC分类号： A61K9/0021 , A61K9/0019 , A61K9/007 , A61K9/08 , A61K9/12 , A61K9/143 , A61K9/1611 , A61K9/1641 , A61K9/1664 , A61K9/1688 , A61K9/19 , A61K9/209 , A61K9/2095 , A61K9/2866 , A61K31/00 , A61K31/337 , A61K31/505 , A61K31/519 , A61K31/59 , A61K31/70 , A61K31/7088 , A61K31/74 , A61K33/00 , A61K38/38 , A61K38/4833 , A61K38/4886 , A61K39/00 , A61K39/12 , A61K39/145 , A61K41/0004 , A61K45/06 , A61K2039/505 , A61K2039/54 , A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2205/02 , B33Y80/00 , C07K16/22 , C07K16/283 , C07K16/2842 , C07K16/2878 , C07K16/30 , C12N2760/16034 , G06F19/00 , G06F19/3456 , G16H50/50 , Y02A50/464 , Y02A50/466 , Y02A50/472 , Y02A90/26 , Y10T83/222 , A61K2300/00
摘要： Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.

13. 发明授权

US08790400B2 Breast implant with covering and analyte sensors responsive to external power source 有权
标题翻译：乳房植入物，覆盖物和分析物传感器响应外部电源
公开(公告)号：US08790400B2
公开(公告)日：2014-07-29
申请号：US13495288
申请日：2012-06-13
申请人： Edward S. Boyden , Gregory J. Della Rocca , Daniel Hawkins , Roderick A. Hyde , Robert Langer , Eric C. Leuthardt , Terence Myckatyn , Parag Jitendra Parikh , Dennis J. Rivet , Joshua S. Shimony , Michael A. Smith , Elizabeth A. Sweeney , Clarence T. Tegreene
发明人： Edward S. Boyden , Gregory J. Della Rocca , Daniel Hawkins , Roderick A. Hyde , Robert Langer , Eric C. Leuthardt , Terence Myckatyn , Parag Jitendra Parikh , Dennis J. Rivet , Joshua S. Shimony , Michael A. Smith , Elizabeth A. Sweeney , Clarence T. Tegreene
IPC分类号： A61F2/12
CPC分类号： A61B5/686 , A61B5/076 , A61B5/4312 , A61B5/4848 , A61B5/4851 , A61F2/12
摘要： Breast implants including sensor modules and related methods are described herein. Breast implants include those with: a shell configured to be substantially filled with a viscous material; at least one fluid-permeable cover, the cover completely enveloping the shell; and a plurality of sensor modules attached to the shell and positioned at a distance from each other, each of the sensor modules oriented to detect one or more analytes in a fluid between the shell and the cover, wherein each of the plurality of sensor modules includes a unique identifier and is configured to utilize energy transmitted from an external source.
摘要翻译：本文描述了包括传感器模块和相关方法的乳房植入物。乳房植入物包括具有：壳体被构造为基本上被粘性材料填充的植入物; 至少一个流体可透过的盖，所述盖完全包围所述壳; 以及多个传感器模块，其附接到壳体并且彼此间隔一定距离，每个传感器模块被定向成检测壳体和盖子之间的流体中的一种或多种分析物，其中多个传感器模块中的每一个包括唯一的标识符并被配置为利用从外部源发送的能量。

14. 发明授权

US08788212B2 Compositions and methods for biological remodeling with frozen particle compositions 失效
标题翻译：用冷冻颗粒组合物进行生物重塑的组合物和方法
公开(公告)号：US08788212B2
公开(公告)日：2014-07-22
申请号：US12384218
申请日：2009-03-31
申请人： Edward S. Boyden , Daniel B. Cook , Roderick A. Hyde , Eric C. Leuthardt , Nathan P. Myhrvold , Elizabeth A. Sweeney , Lowell L. Wood, Jr.
发明人： Edward S. Boyden , Daniel B. Cook , Roderick A. Hyde , Eric C. Leuthardt , Nathan P. Myhrvold , Elizabeth A. Sweeney , Lowell L. Wood, Jr.
IPC分类号： G06F19/00 , A61K35/12 , C07K16/28 , A61K31/00 , A61K38/38 , A61K9/00 , A61K35/32 , A61K38/48 , A61K31/70 , A61K35/16 , A61K51/12 , A61K35/28 , A61K31/7088 , A61K9/16 , A61K9/08 , A61K33/00 , A61K35/34 , A61K9/19 , A61K41/00 , A61K45/06 , C07K16/30 , A61K31/337 , A61K9/14 , A61K9/70 , A61K39/00 , A61K38/00
CPC分类号： G06F19/00 , A61K9/0014 , A61K9/0019 , A61K9/0021 , A61K9/007 , A61K9/08 , A61K9/14 , A61K9/143 , A61K9/1611 , A61K9/1641 , A61K9/1664 , A61K9/1688 , A61K9/19 , A61K9/7015 , A61K31/00 , A61K31/337 , A61K31/70 , A61K31/7088 , A61K33/00 , A61K35/16 , A61K35/28 , A61K35/32 , A61K35/33 , A61K35/34 , A61K38/00 , A61K38/38 , A61K38/4833 , A61K39/00 , A61K41/0004 , A61K45/06 , A61K51/1244 , A61K2039/505 , A61M5/3015 , A61M2005/005 , A61M2205/3306 , B33Y80/00 , C07K16/2809 , C07K16/283 , C07K16/2848 , C07K16/2863 , C07K16/2878 , C07K16/30 , C07K2317/31 , G06F19/3456 , G06F19/3468 , G06F19/36 , G16H50/20 , G16H50/50 , Y02A90/26 , A61K2300/00
摘要： Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.
摘要翻译：本文公开的某些实施方案涉及关于冷冻颗粒的组合物，方法，装置，系统和产品。在某些实施方案中，冷冻颗粒包括低温下的材料。在某些实施方案中，冷冻颗粒提供用于递送特定试剂的载体。在某些实施方案中，将冷冻颗粒施用于至少一种生物组织。

15. 发明授权

US08784385B2 Frozen piercing implements and methods for piercing a substrate 失效
标题翻译：冷冻穿孔工具和穿孔基材的方法
公开(公告)号：US08784385B2
公开(公告)日：2014-07-22
申请号：US12586076
申请日：2009-09-15
申请人： Edward S. Boyden , Daniel B. Cook , Roderick A. Hyde , Eric C. Leuthardt , Nathan P. Myhrvold , Elizabeth A. Sweeney , Lowell L. Wood, Jr.
发明人： Edward S. Boyden , Daniel B. Cook , Roderick A. Hyde , Eric C. Leuthardt , Nathan P. Myhrvold , Elizabeth A. Sweeney , Lowell L. Wood, Jr.
IPC分类号： A61M37/00 , A61K9/00 , A61K9/14 , C07K16/28 , C07K16/30 , A61K31/505 , A61K31/519 , A61K39/00 , A61K9/12 , C07K16/22 , A61K31/59
CPC分类号： A61K9/0021 , A61K9/0019 , A61K9/007 , A61K9/08 , A61K9/12 , A61K9/143 , A61K9/1611 , A61K9/1641 , A61K9/1664 , A61K9/1688 , A61K9/19 , A61K9/209 , A61K9/2095 , A61K9/2866 , A61K31/00 , A61K31/337 , A61K31/505 , A61K31/519 , A61K31/59 , A61K31/70 , A61K31/7088 , A61K31/74 , A61K33/00 , A61K38/38 , A61K38/4833 , A61K38/4886 , A61K39/00 , A61K39/12 , A61K39/145 , A61K41/0004 , A61K45/06 , A61K2039/505 , A61K2039/54 , A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2205/02 , B33Y80/00 , C07K16/22 , C07K16/283 , C07K16/2842 , C07K16/2878 , C07K16/30 , C12N2760/16034 , G06F19/00 , G06F19/3456 , G16H50/50 , Y02A50/464 , Y02A50/466 , Y02A50/472 , Y02A90/26 , Y10T83/222 , A61K2300/00
摘要： Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one biological tissue.
摘要翻译：本文公开的某些实施方案涉及关于冷冻颗粒的组合物，方法，装置，系统和产品。在某些实施方案中，冷冻颗粒包括低温下的材料。在某些实施方案中，冷冻颗粒提供用于递送特定试剂的载体。在某些实施方案中，将冷冻颗粒施用于至少一种生物组织。

16. 发明授权

US08784368B2 Device, system, and method for targeted delivery of anti-inflammatory medicaments to a mammalian subject 失效
标题翻译：用于向哺乳动物受试者靶向递送抗炎药物的装置，系统和方法
公开(公告)号：US08784368B2
公开(公告)日：2014-07-22
申请号：US12590856
申请日：2009-11-13
申请人： Philip A. Eckhoff , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Eric C. Leuthardt , Dennis J. Rivet , Elizabeth A. Sweeney , Lowell L. Wood, Jr. , Victoria Y. H. Wood
发明人： Philip A. Eckhoff , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Eric C. Leuthardt , Dennis J. Rivet , Elizabeth A. Sweeney , Lowell L. Wood, Jr. , Victoria Y. H. Wood
IPC分类号： A61M5/30
CPC分类号： A61K31/192 , A61B5/1116 , A61B5/112 , A61B5/1126 , A61B5/4528 , A61K31/195 , A61M37/0015 , A61M2005/3022 , A61M2037/0007 , A61M2037/0023 , A61M2037/0061
摘要： A device, a system, or a method is described for treating a disease or a condition of one or more joints of articulating bone in a mammalian subject. The device provides one or more medicaments to one or more joints of the mammalian subject. A device is described that includes one or more sheaths configured to contact one or more body contours in proximity to one or more joints of articulating bone of a mammalian subject; one or more sensors configured to detect one or more physiological conditions of the one or more joints; and one or more applicators supported by the one or more sheaths and configured to respond to the one or more sensors by injecting one or more medicaments to the one or more joint tissues of the mammalian subject.
摘要翻译：描述了用于治疗哺乳动物受试者中关节骨的一个或多个关节的疾病或病症的装置，系统或方法。该装置向哺乳动物受试者的一个或多个关节提供一种或多种药物。描述了一种装置，其包括构造成接触哺乳动物受试者的关节骨的一个或多个关节附近的一个或多个身体轮廓的一个或多个护套; 一个或多个传感器被配置为检测所述一个或多个关节的一个或多个生理状况; 以及由所述一个或多个护套支撑并且被配置为通过将一种或多种药物注射到哺乳动物受试者的一个或多个关节组织来响应所述一个或多个传感器的一个或多个施用器。

17. 发明申请

US20140188492A1 FORECASTING FEES AND COSTS TO COMPLETE DELIVERY OF A HEALTHCARE SERVICE TO A PATIENT 审中-公开
标题翻译：预计费用和成本完成向患者提供医疗服务
公开(公告)号：US20140188492A1
公开(公告)日：2014-07-03
申请号：US13728843
申请日：2012-12-27
申请人： Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Eric C. Leuthardt , Elizabeth A. Sweeney , Lowell L. Wood, Jr.
发明人： Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Eric C. Leuthardt , Elizabeth A. Sweeney , Lowell L. Wood, Jr.
IPC分类号： G06Q30/02 , G06Q50/22
CPC分类号： G06Q30/0206 , G06Q50/22
摘要： Described embodiments include a computer-implemented method, device, and computer program product. A computer-implemented method includes electronically receiving a request for information indicative of future fees and costs to be incurred by a particular patient presently undergoing a diagnosis, treatment, or prevention of a particular disease, illness, injury, or other physical or mental impairment (hereafter “healthcare service”). The computer-implemented method includes electronically receiving data at least partially indicative of the healthcare service provided to the patient as of receipt of the request for information. The computer-implemented method includes forecasting probable fees and costs to complete delivery of the healthcare service to the patient. The forecasting is responsive to the received data and on a characteristic of the healthcare service. The computer-implemented method includes outputting in substantially real time information indicative of the probable future fees and costs to complete delivery of the healthcare service to the patient.
摘要翻译：所描述的实施例包括计算机实现的方法，设备和计算机程序产品。计算机实现的方法包括以电子方式接收表示目前正在进行特定疾病，疾病，损伤或其他身体或精神障碍的诊断，治疗或预防的特定患者将来的费用和费用的信息的请求（以下简称“医疗服务”）。计算机实现的方法包括电子地接收至少部分地指示在接收到信息请求时提供给患者的保健服务的数据。计算机实现的方法包括预测可能的费用和成本，以完成向患者提供医疗服务。预测响应于所接收的数据和医疗保健服务的特征。计算机实现的方法包括基本上实时地输出指示可能的未来费用和成本的信息，以完成医疗服务到患者的传送。

18. 发明授权

US08753677B2 Ex vivo modifiable multiple medicament final dosage form 失效
标题翻译：体外可修改的多种药物最终剂型
公开(公告)号：US08753677B2
公开(公告)日：2014-06-17
申请号：US12387325
申请日：2009-04-29
申请人： Mahalaxmi Gita Bangera , Edward S. Boyden , Roderick A. Hyde , Muriel Y. Ishikawa , Dennis J. Rivet , Elizabeth A. Sweeney , Lowell L. Wood, Jr. , Victoria Y. H. Wood
发明人： Mahalaxmi Gita Bangera , Edward S. Boyden , Roderick A. Hyde , Muriel Y. Ishikawa , Dennis J. Rivet , Elizabeth A. Sweeney , Lowell L. Wood, Jr. , Victoria Y. H. Wood
IPC分类号： A61K9/48 , A61K9/52
CPC分类号： G06F19/3456 , A61K9/06 , A61K9/127 , A61K9/4891 , A61K9/51 , G06F19/00
摘要： Described embodiments include a final dosage form for administering a medicament to an animal, an article of manufacture, and method. A described final dosage form includes a dosage portion having a medicament and a release element in a first medicament-release state. The medicament has a first bioavailability to the animal. The release element is modifiable ex vivo to a second medicament-release state by an exposure to a stimulus, wherein the medicament has a second bioavailability to the animal. The final dosage form includes another dosage portion having another medicament and another release element in another first medicament-release state. In the another first medicament-release state, the another medicament has another first bioavailability to the animal. The another release element is modifiable ex vivo to another second medicament-release state by an exposure to another stimulus, wherein the another medicament has another second bioavailability to the animal.
摘要翻译：描述的实施方案包括用于向动物施用药物的最终剂型，制品和方法。描述的最终剂型包括具有药物和处于第一药物释放状态的释放元件的剂量部分。药物对动物具有第一生物利用度。释放元件通过暴露于刺激物离体修饰成第二药物释放状态，其中药物对动物具有第二生物利用度。最终剂型包括具有另一药物的另一剂量部分和处于另一第一药物释放状态的另一释放元件。在另一第一药物释放状态中，另一种药物对动物具有另一种第一生物利用度。另一种释放元件可通过暴露于另一种刺激物离体修饰成另一种第二药物释放状态，其中另一种药物对动物具有另一种第二生物利用度。

19. 发明授权

US08706211B2 Systems, devices, and methods including catheters having self-cleaning surfaces 有权
标题翻译：系统，装置和方法，包括具有自清洁表面的导管
公开(公告)号：US08706211B2
公开(公告)日：2014-04-22
申请号：US12927287
申请日：2010-11-10
申请人： Ralph G. Dacey, Jr. , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Michael A. Smith , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, Jr. , Victoria Y. H. Wood
发明人： Ralph G. Dacey, Jr. , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Michael A. Smith , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, Jr. , Victoria Y. H. Wood
IPC分类号： A61M5/00 , A61B5/00
CPC分类号： A61F2/30 , A61F2/32 , A61F2002/30087 , A61F2002/30668 , A61F2002/3067 , A61F2002/30677 , A61F2002/48 , A61F2002/481 , A61F2002/482 , A61F2250/0001 , A61F2250/0002 , A61F2310/0097 , A61L2/0011 , A61L2/08 , A61L2/14 , A61L2202/14 , A61L2202/24 , A61M5/001 , A61N1/205 , A61N1/37252 , A61N1/3785 , A61N1/3787
摘要： Systems, devices, methods, and compositions are described for providing an actively-controllable disinfecting implantable device configured to, for example, treat or prevent an infection in a biological subject.
摘要翻译：描述了用于提供主动控制的消毒可植入装置的系统，装置，方法和组合物，其被配置为例如治疗或预防生物学对象中的感染。

20. 发明授权

US08682687B2 Methods and systems for presenting a combination treatment 有权
标题翻译：用于呈现组合治疗的方法和系统
公开(公告)号：US08682687B2
公开(公告)日：2014-03-25
申请号：US12315072
申请日：2008-11-26
申请人： Roderick A. Hyde , Muriel Y. Ishikawa , Eric C. Leuthardt , Royce A. Levien , Robert W. Lord , Mark A. Malamud , Elizabeth A. Sweeney , Lowell L. Wood, Jr. , Victoria Y. H. Wood
发明人： Roderick A. Hyde , Muriel Y. Ishikawa , Eric C. Leuthardt , Royce A. Levien , Robert W. Lord , Mark A. Malamud , Elizabeth A. Sweeney , Lowell L. Wood, Jr. , Victoria Y. H. Wood
IPC分类号： G06Q10/00 , G06N3/00 , A61B5/08
CPC分类号： A61M31/002 , A61B5/00 , A61B5/411 , A61B5/415 , A61B5/416 , A61B5/418 , A61B5/4839 , A61M35/00 , G06F19/00 , G06F19/3456
摘要： Methods, computer program products, and systems are described that include accepting an indication of a schedule for administration of a bioactive agent to an individual and presenting an indication of an artificial sensory experience at least partly based on the accepting an indication of the schedule for administration of the bioactive agent to the individual.
摘要翻译：描述了方法，计算机程序产品和系统，其包括接受用于向个体施用生物活性剂的时间表的指示，并至少部分地基于接受管理时间表的指示来呈现人造感官体验的指示的生物活性剂给个体。

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