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11. 发明申请

WO2016118403A1 FACTOR XIA INHIBITORS 审中-公开
标题翻译：因子XIA抑制剂
公开(公告)号：WO2016118403A1
公开(公告)日：2016-07-28
申请号：PCT/US2016/013507
申请日：2016-01-15
申请人： MERCK SHARP & DOHME CORP. , MERTZ, Eric , LIU, Weiguo , EDMONDSON, Scott, D. , ALI, Amjad , GAO, Ying-Duo , NEELAMKAVIL, Santhosh, F. , SO, Sung-Sau , MONINGKA, Remond , SUN, Wanying , HRUZA, Alan , BROCKUNIER, Linda, L.
发明人： MERTZ, Eric , LIU, Weiguo , EDMONDSON, Scott, D. , ALI, Amjad , GAO, Ying-Duo , NEELAMKAVIL, Santhosh, F. , SO, Sung-Sau , MONINGKA, Remond , SUN, Wanying , HRUZA, Alan , BROCKUNIER, Linda, L.
IPC分类号： A61K31/4375 , C07D471/00
CPC分类号： A61K31/435 , A61K31/195 , A61K31/4375 , A61P7/02 , A61P7/04 , C07D221/04 , C07D221/18 , C07D401/10
摘要： The present invention provides a compound of Formula (I) and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing thromboses, embolisms, hypercoagulability or fibrotic changes. The compounds are selective Factor XIa inhibitors or dual inhibitors of Factor XIa and plasma kallikrein.
摘要翻译：本发明提供式（I）的化合物和包含一种或多种所述化合物的药物组合物，以及使用所述化合物治疗或预防血栓形成，栓塞，高凝状态或纤维变化的方法。该化合物是选择性因子XIa抑制剂或因子XIa和血浆激肽释放酶的双重抑制剂。

12. 发明申请

WO2013074388A1 SUBSTITUTED CYCLOPROPYL COMPOUNDS USEFUL AS GPR119 AGONISTS 审中-公开
标题翻译：取代的环丙基化合物可用作GPR119激动剂
公开(公告)号：WO2013074388A1
公开(公告)日：2013-05-23
申请号：PCT/US2012/064274
申请日：2012-11-09
申请人： MERCK SHARP & DOHME CORP. , EDMONDSON, Scott , HU, Zhiyong , LIU, Ping , MORRIELLO, Gregori, J. , SZEWCZYK, Jason, W. , WANG, Bowei , WANG, Liping , WOOD, Harold, B. , ZHU, Cheng , ZHU, Yuping , GUO, Zhiqiang
发明人： EDMONDSON, Scott , HU, Zhiyong , LIU, Ping , MORRIELLO, Gregori, J. , SZEWCZYK, Jason, W. , WANG, Bowei , WANG, Liping , WOOD, Harold, B. , ZHU, Cheng , ZHU, Yuping , GUO, Zhiqiang
IPC分类号： C07D401/00
CPC分类号： C07D513/04 , C07D239/42 , C07D401/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D498/04
摘要： Substituted cyclopropyl compounds of the formula (I): and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR-119. Pharmaceutical compositions and methods of treatment are also included
摘要翻译：披露式（I）的取代的环丙基化合物及其药学上可接受的盐可用于治疗或预防2型糖尿病和类似病状。该化合物可用作G蛋白偶联受体GPR-119的激动剂。还包括药物组合物和治疗方法

13. 发明申请

WO2013008000A3 FEED COMPACTOR VARIABLE ORIFICE OUTLET 审中-公开
标题翻译：进料压实机变量出风口
公开(公告)号：WO2013008000A3
公开(公告)日：2013-04-04
申请号：PCT/GB2012051618
申请日：2012-07-09
申请人： NEW EARTH ADVANCED THERMAL TECHNOLOGIES LTD , EDMONDSON SCOTT , TOASE BRUCE
发明人： EDMONDSON SCOTT , TOASE BRUCE
IPC分类号： C10J3/30 , B01J8/00 , B30B11/22 , C10J3/50 , F23K3/00
CPC分类号： B01J8/002 , B01J8/0045 , B01J2208/00752 , B01J2208/00761 , B30B11/225 , C10J3/30 , C10J3/506 , F23G5/444 , F23G2900/50209 , F23K3/00
摘要： A feed compactor outlet (2) comprising a passage wall defining a passage adapted to discharge material from a feed compactor to a reactor (12), wherein the passage wall comprises a moveable portion (4), the moveable portion (4) being moveable with respect to a longitudinal axis of the feed compactor outlet (2) to vary a throat area of the passage.
摘要翻译： 1。一种包括通道壁的进料压实机出口（2），所述通道壁限定适于将材料从进料压实机排出到反应器（12）的通道，其中所述通道壁包括可移动部分（4），所述可移动部分（4）相对于所述进料压实机出口（2）的纵向轴线改变所述通道的喉部面积。

14. 发明申请

WO2013021181A1 A DRIVE ARRANGEMENT FOR A WIND TURBINE 审中-公开
标题翻译：风力发电机的驱动装置
公开(公告)号：WO2013021181A1
公开(公告)日：2013-02-14
申请号：PCT/GB2012/051893
申请日：2012-08-03
申请人： DAVID BROWN GEAR SYSTEMS LIMITED , DEWAR, Alan Bradley , EDMONDSON, Scott Douglas , TRAN, Scott
发明人： DEWAR, Alan Bradley , EDMONDSON, Scott Douglas , TRAN, Scott
IPC分类号： F03D11/00 , F16H1/46 , F16H1/28
CPC分类号： H02K7/116 , F03D9/25 , F03D15/00 , F03D15/10 , F03D80/70 , F05B2260/40311 , F16H1/2818 , F16H1/46 , F16H37/041 , F16H57/021 , Y02E10/721 , Y02E10/722 , Y02E10/726
摘要： The invention relates to a drive arrangement for a wind turbine, and to a wind turbine incorporating a drive arrangement. In one embodiment, a drive arrangement (12) for a wind turbine (10) is disclosed which comprises a rotor shaft (20); a gearbox assembly (22) for transferring torque from the rotor shaft to an electrical power generator (18), the gearbox assembly comprising: an input shaft (40); an output shaft (42); a primary gear stage (44); and a secondary gear stage (46), each gear stage having a plurality of planet gears (52; 58) positioned around the output shaft, an annular gear (84; 86) meshed with the planet gears, and a sun gear (82; 88) meshed with the planet gears and arranged to transfer torque to the output shaft. The drive arrangement also comprises a drive transfer mechanism (24) for transferring torque from the rotor shaft into the gearbox assembly via the input shaft; and a primary load carrying member (56) for releasably mounting the gearbox assembly to a housing (34) of the wind turbine. The rotor shaft is at least partly hollow, having an internal cavity (28) in which at least part of the gearbox assembly and at least part of the drive transfer mechanism are located. The gearbox assembly comprising the input shaft, output shaft, primary and secondary gear stages is mountable within the rotor shaft as a single unit by means of the primary load carrying member.
摘要翻译：本发明涉及一种用于风力涡轮机的驱动装置和涉及驱动装置的风力涡轮机。在一个实施例中，公开了一种用于风力涡轮机（10）的驱动装置（12），其包括转子轴（20）; 用于将扭矩从转子轴传递到发电机（18）的变速箱组件（22），所述变速箱组件包括：输入轴（40）; 输出轴（42）; 主齿轮级（44）; 和副齿轮级（46），每个齿轮级具有围绕输出轴定位的多个行星齿轮（52; 58），与行星齿轮啮合的环形齿轮（84; 86）和太阳齿轮（82; 88）与行星齿轮啮合并布置成将扭矩传递到输出轴。驱动装置还包括用于经由输入轴将转矩从转子轴传递到齿轮箱组件中的驱动传递机构（24）以及用于将所述齿轮箱组件可释放地安装到所述风力涡轮机的壳体（34）的主负载承载构件（56）。转子轴至少部分是中空的，具有内腔（28），齿轮箱组件的至少一部分和驱动传递机构的至少一部分位于其中。包括输入轴，输出轴，初级和次级齿轮级的变速箱组件可通过主负载承载构件作为单个单元安装在转子轴内。

15. 发明申请

WO2013008000A2 FEED COMPACTOR VARIABLE ORIFICE OUTLET 审中-公开
标题翻译：进料压路机可变零件出口
公开(公告)号：WO2013008000A2
公开(公告)日：2013-01-17
申请号：PCT/GB2012/051618
申请日：2012-07-09
申请人： NEW EARTH ADVANCED THERMAL TECHNOLOGIES LIMITED , EDMONDSON, Scott , TOASE, Bruce
发明人： EDMONDSON, Scott , TOASE, Bruce
CPC分类号： B01J8/002 , B01J8/0045 , B01J2208/00752 , B01J2208/00761 , B30B11/225 , C10J3/30 , C10J3/506 , F23G5/444 , F23G2900/50209 , F23K3/00
摘要： A feed compactor outlet (2) comprising a passage wall defining a passage adapted to discharge material from a feed compactor to a reactor (12), wherein the passage wall comprises a moveable portion (4), the moveable portion (4) being moveable with respect to a longitudinal axis of the feed compactor outlet (2) to vary a throat area of the passage.
摘要翻译：一种饲料压实机出口（2），包括限定通道的通道壁，所述通道适于将材料从进料压实机排放到反应器（12），其中所述通道壁包括可移动部分（4），所述可移动部分（4）相对于进料压实器出口（2）的纵向轴线以改变通道的喉部区域。

16. 发明申请

WO2012173917A1 SUBSTITUTED CYCLOPROPYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS, AND METHODS OF TREATMENT 审中-公开
标题翻译：取代的环丙基化合物，包含这些化合物的组合物和处理方法
公开(公告)号：WO2012173917A1
公开(公告)日：2012-12-20
申请号：PCT/US2012/041847
申请日：2012-06-11
申请人： MERCK SHARP & DOHME CORP. , MILLER, Michael , STAMFORD, Andrew , BASU, Kallol , WOOD, Harold, B. , DEMONG, Duane , SUN, Wanying , GARFUNKLE, Joie , MOYES, Christopher , HU, Zhiyong , LIU, Ping , EDMONDSON, Scott, D. , DAI, Xing , DUBOIS, Byron Gabriel
发明人： MILLER, Michael , STAMFORD, Andrew , BASU, Kallol , WOOD, Harold, B. , DEMONG, Duane , SUN, Wanying , GARFUNKLE, Joie , MOYES, Christopher , HU, Zhiyong , LIU, Ping , EDMONDSON, Scott, D. , DAI, Xing , DUBOIS, Byron Gabriel
IPC分类号： A01N43/40 , A61K31/445
CPC分类号： C07D211/24 , C07D211/22 , C07D401/04 , C07D401/14 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/14
摘要： Substituted cyclopropyl compounds of the formula I: and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR-119. Pharmaceutical compositions and methods of treatment are also included.
摘要翻译：公开了取代的式I的环丙基化合物及其药学上可接受的盐可用于治疗或预防2型糖尿病和类似病症。该化合物可用作G蛋白偶联受体GPR-119的激动剂。还包括药物组合物和治疗方法。

17. 发明申请

WO2012058130A1 NOVEL PYRROLIDINE DERIVED BETA 3 ADRENERGIC RECEPTOR AGONISTS 审中-公开
标题翻译：新型吡咯烷衍生的BETA 3 ADRENERGIC RECEPTOR AGONISTS
公开(公告)号：WO2012058130A1
公开(公告)日：2012-05-03
申请号：PCT/US2011/057417
申请日：2011-10-24
申请人： MERCK SHARP & DOHME CORP. , MORRIELLO, Gregori, J. , CHANG, Lehua , EDMONDSON, Scott, D.
发明人： MORRIELLO, Gregori, J. , CHANG, Lehua , EDMONDSON, Scott, D.
IPC分类号： A61K31/40 , A61K31/445
CPC分类号： A61K31/506 , A61K31/40 , A61K31/41 , A61K31/445 , A61K31/454 , A61K45/06 , C07D401/14 , C07D403/14 , A61K2300/00
摘要： The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of b3-adrenoceptor.Formula (I).
摘要翻译：本发明提供式（I）的化合物，其药物组合物及其用于治疗或预防由活化b3-肾上腺素能受体介导的疾病的方法。（I）。

18. 发明申请

WO2011043942A1 COMBINATION THERAPY USING A BETA 3 ADRENERGIC RECEPTOR AGONIST AND AN ANTIMUSCARINIC AGENT 审中-公开
标题翻译：使用BETA 3抗原激素受体激动剂和抗精神病药物的联合治疗
公开(公告)号：WO2011043942A1
公开(公告)日：2011-04-14
申请号：PCT/US2010/050328
申请日：2010-09-27
申请人： MERCK SHARP & DOHME CORP. , NAGABUKURO, Hiroshi , EDMONDSON, Scott, D. , SINHAROY, Mary, Struthers , DENNEY, William, S. , FRENKL, Tara, L.
发明人： NAGABUKURO, Hiroshi , EDMONDSON, Scott, D. , SINHAROY, Mary, Struthers , DENNEY, William, S. , FRENKL, Tara, L.
IPC分类号： A01N57/00
CPC分类号： A61K45/06 , A61K31/137 , A61K31/221 , A61K31/4025 , A61K2300/00
摘要： Described herein is an improved method of treating overactive bladder, wherein the method comprises administering to a patient in need thereof a beta 3 adrenergic receptor agonist, an antimuscarinic agent, and an optional selective M 2 antagonist. Such combination therapy provides improved efficacy and/or reduced side effects.
摘要翻译：本文描述的是治疗膀胱过度活动症的改进方法，其中所述方法包括向有需要的患者施用β3肾上腺素能受体激动剂，抗毒蕈碱剂和任选的选择性M2拮抗剂。这种联合治疗提供改善的功效和/或减少的副作用。

19. 发明申请

WO2008091631A1 SUBSTITUTED AMINOPYRIMIDINES AS CHOLECYSTOKININ-1 RECEPTOR MODULATORS 审中-公开
标题翻译：作为选择性蛋白-1受体调节剂的取代的氨基酰亚胺
公开(公告)号：WO2008091631A1
公开(公告)日：2008-07-31
申请号：PCT/US2008/000866
申请日：2008-01-22
申请人： MERCK & CO., INC. , EDMONDSON, Scott , KAELIN, David, E. , SWEIS, Randy
发明人： EDMONDSON, Scott , KAELIN, David, E. , SWEIS, Randy
IPC分类号： A61K31/505
CPC分类号： A61K31/505 , C07D239/42 , C07D401/12 , C07D403/12 , C07D471/04
摘要： Certain novel substituted aminopyrimidines are ligands of the human cholecystokinin receptor and, in particular, are selective ligands of the human cholecystokinin-1 receptor (CCK-1R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of CCK-1R, such as obesity, and diabetes.
摘要翻译：某些新型取代的氨基嘧啶是人胆囊收缩素受体的配体，特别是人胆囊收缩素-1受体（CCK-1R）的选择性配体。因此，它们可用于治疗，控制或预防对调节CCK-1R（例如肥胖症和糖尿病）的疾病和病症。

20. 发明申请

WO2007024993A2 FUSED AMINOPIPERIDINES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES 审中-公开
标题翻译：融合氨基哌啶作为二磷酸二肽酶IV抑制剂治疗或预防糖尿病
公开(公告)号：WO2007024993A2
公开(公告)日：2007-03-01
申请号：PCT/US2006/032989
申请日：2006-08-22
申请人： MERCK & CO., INC. , COX, Jason, M. , EDMONDSON, Scott, D. , MASTRACCHIO, Anthony
发明人： COX, Jason, M. , EDMONDSON, Scott, D. , MASTRACCHIO, Anthony
IPC分类号： A61K31/4745 , C07D487/14
CPC分类号： C07D471/14
摘要： The present invention is directed to novel substituted fused aminopiperidines which are inhibitors of the dipeptidyl peptidase-IV enzyme ("DPP-IV inhibitors") and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
摘要翻译：本发明涉及作为二肽基肽酶-IV酶（“DPP-IV抑制剂”）抑制剂的新型取代的稠合氨基哌啶，其可用于治疗或预防其中涉及二肽基肽酶-IV酶，如糖尿病，特别是2型糖尿病。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。

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