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11. 发明申请

US20100015723A1 Antagonists of Interleukin-15 失效
标题翻译：白细胞介素15拮抗剂
公开(公告)号：US20100015723A1
公开(公告)日：2010-01-21
申请号：US11805835
申请日：2007-05-23
申请人： Kenneth H. Grabstein , Dean K. Pettit , Raymond J. Paxton
发明人： Kenneth H. Grabstein , Dean K. Pettit , Raymond J. Paxton
IPC分类号： G01N33/566
CPC分类号： C07K16/244 , A61K38/00 , A61K47/60 , C07K14/5443 , C07K2317/76
摘要： Antagonists of mammalian interleukin-15 (“IL-15”) are disclosed and include muteins of IL-15 and modified IL-15 molecules that are each capable of binding to the IL-15Rα-subunit and that are incapable of transducing a signal through either the β- or γ-subunits of the IL-15 receptor complex. Also included are monoclonal antibodies against IL-15 that prevent IL-15 from effecting signal transduction through either the β- or γ-subunits of the IL-15 receptor complex. Methods of treating various disease states are disclosed, including treating allograft rejection and graft-versus-host disease.
摘要翻译：公开了哺乳动物白细胞介素-15（“IL-15”）的拮抗剂，并且包括IL-15和修饰的IL-15分子的突变蛋白，其各自能够结合IL-15Rα-亚基并且不能通过 IL-15受体复合物的β亚基或γ亚基。还包括针对IL-15的单克隆抗体，其阻止IL-15通过IL-15受体复合物的β亚基或γ亚基进行信号转导。公开了治疗各种疾病状态的方法，包括治疗同种异体移植排斥和移植物抗宿主病。

12. 发明授权

US06433158B1 Site specific protein modification 有权
标题翻译：位点特异性蛋白质修饰
公开(公告)号：US06433158B1
公开(公告)日：2002-08-13
申请号：US09580235
申请日：2000-05-26
申请人： Dean K. Pettit
发明人： Dean K. Pettit
IPC分类号： C07K100
CPC分类号： C07K1/1077 , A61K47/60 , A61K47/62 , C07K14/7151
摘要： Processes for conjugating proteins with polyethylene glycol are disclosed. The disclosed processes provide modified proteins having little or no decrease in their activity and include the steps of deleting at least one amino acid residue on the protein, replacing the at least one amino acid residue with an amino acid residue that does not react with, polyethylene glycol, and contacting the protein with polyethylene glycol under conditions sufficient to conjugate the polyethylene glycol to the protein. This advantageous retention of a desired protein activity is attributed to the availability of one or more protein binding sites which is unaltered in the conjugation process and thus remains free to interact with a binding partner ligand or cognate subsequent to the conjugation process.
摘要翻译：公开了将蛋白质与聚乙二醇缀合的方法。所公开的方法提供了其活性几乎没有或没有降低的修饰的蛋白质，包括删除蛋白质上的至少一个氨基酸残基的步骤，用与聚乙烯不反应的氨基酸残基替换至少一个氨基酸残基乙二醇，并且在足以使聚乙二醇与蛋白质缀合的条件下使蛋白质与聚乙二醇接触。所需蛋白质活性的这种有利的保留归因于在缀合过程中未改变的一个或多个蛋白质结合位点的可用性，因此在缀合过程之后保持与结合配偶体配体或同源物相互作用。

13. 发明授权

US4888013A Haptic to optic attachment for a soft iol 失效
标题翻译：触觉光学附件为软的iol
公开(公告)号：US4888013A
公开(公告)日：1989-12-19
申请号：US228955
申请日：1988-08-04
申请人： Albert C. Ting , Timothy R. Willis , F. Richard Christ , Steven R. Bacich , Dean K. Pettit , Stanley L. Van Gent , Jeffrey C. Day
发明人： Albert C. Ting , Timothy R. Willis , F. Richard Christ , Steven R. Bacich , Dean K. Pettit , Stanley L. Van Gent , Jeffrey C. Day
IPC分类号： A61F2/16
CPC分类号： A61F2/1613 , A61F2/1608
摘要： A method of making an intraocular lens including providing a fixation member having a proximal end portion with the proximal end portion including an elongated filament, converting a region of said filament at said proximal end portion from a first configuration into a second configuration which is adapted to provide a mechanical interlock and molding an optic about the proximal end portion of the fixation member to form a mechanical interlock between the second configuration and the optic and to attach the fixation member to the optic.
摘要翻译：一种制造眼内透镜的方法，包括提供具有近端部分的固定构件，其基端部分包括细长细丝，将所述近端部分处的所述细丝的区域从第一构型转换成适于提供机械互锁并围绕固定构件的近端部分模制光学器件，以在第二构造和光学元件之间形成机械互锁并将固定构件附接到光学元件。

14. 发明授权

US4790846A Haptic to optic attachment for a soft IOL 失效
公开(公告)号：US4790846A
公开(公告)日：1988-12-13
申请号：US96745
申请日：1987-09-15
申请人： F. Richard Christ , Dean K. Pettit , Jeffrey C. Day
发明人： F. Richard Christ , Dean K. Pettit , Jeffrey C. Day
IPC分类号： A61F2/16 , B29D11/00
CPC分类号： A61F2/1613 , A61F2002/1686
摘要： A method of making an intraocular lens including providing a fixation member having a proximal end portion with the proximal end portion including an elongated filament, converting a region of said filament at said proximal end portion from a first configuration into a second configuration which is adapted to provide a mechanical interlock and molding an optic about the proximal end portion of the fixation member to form a mechanical interlock between the second configuration and the optic and to attach the fixation member to the optic.

15. 发明申请

US20080299071A1 Stable aqueous solutions of granulocyte macrophage colony-stimulating factor 审中-公开
标题翻译：稳定的粒细胞巨噬细胞集落刺激因子水溶液
公开(公告)号：US20080299071A1
公开(公告)日：2008-12-04
申请号：US11900786
申请日：2007-09-12
申请人： Dean K. Pettit , Claudia M. Jochheim
发明人： Dean K. Pettit , Claudia M. Jochheim
IPC分类号： A61K38/19 , C07K14/52 , A61P37/02
CPC分类号： A61K47/183 , A61K9/0019 , A61K9/19 , A61K38/193 , A61K47/18
摘要： The invention provides formulations of GM-CSF to which a chelating agent has been provided to stabilize the GM-CSF against N-terminal degradation.
摘要翻译：本发明提供了GM-CSF的制剂，其中提供了螯合剂以稳定GM-CSF以防N-端降解。

16. 发明授权

US06441136B1 Site specific protein modification 有权
公开(公告)号：US06441136B1
公开(公告)日：2002-08-27
申请号：US09580181
申请日：2000-05-26
申请人： Dean K. Pettit
发明人： Dean K. Pettit
IPC分类号： C07K100
CPC分类号： C07K1/1077 , A61K47/60 , A61K47/62 , C07K14/7151
摘要： Processes for conjugating proteins with polyethylene glycol are disclosed. The disclosed processes provide modified proteins having little or no decrease in their activity and include the steps of deleting at least one amino acid residue on the protein, replacing the at least one amino acid residue with an amino acid residue that does not react with, polyethylene glycol, and contacting the protein with polyethylene glycol under conditions sufficient to conjugate the polyethylene glycol to the protein. This advantageous retention of a desired protein activity is attributed to the availability of one or more protein binding sites which is unaltered in the conjugation process and thus remains free to interact with a binding partner ligand or cognate subsequent to the conjugation process.

17. 发明授权

US4938767A Haptic to optic attachment for a soft iol 失效
标题翻译：触觉光学附件为软的iol
公开(公告)号：US4938767A
公开(公告)日：1990-07-03
申请号：US343045
申请日：1989-04-25
申请人： Albert C. Ting , Timothy R. Willis , F. Richard Christ , Steven R. Bacich , Dean K. Pettit , Stanley L. Van Gent , Jeffrey C. Day
发明人： Albert C. Ting , Timothy R. Willis , F. Richard Christ , Steven R. Bacich , Dean K. Pettit , Stanley L. Van Gent , Jeffrey C. Day
IPC分类号： A61F2/16
CPC分类号： A61F2/1613 , A61F2002/1686
摘要： A method of making an intraocular lens including providing a fixation member having a proximal end portion with the proximal end portion including an elongated filament, converting a region of said filament at said proximal end portion from a first configuration into a second configuration which is adapted to provide a mechanical interlock and molding an optic about the proximal end portion of the fixation member to form a mechanical interlock between the second configuration and the optic and to attach the fixation member to the optic.
摘要翻译：一种制造眼内透镜的方法，包括提供具有近端部分的固定构件，其基端部分包括细长细丝，将所述近端部分处的所述细丝的区域从第一构型转换成适于提供机械互锁并围绕固定构件的近端部分模制光学器件，以在第二构造和光学元件之间形成机械互锁并将固定构件附接到光学元件。

18. 发明授权

US07235240B2 Antagonists of interleukin-15 失效
标题翻译：白细胞介素15的拮抗剂
公开(公告)号：US07235240B2
公开(公告)日：2007-06-26
申请号：US11221399
申请日：2005-09-07
申请人： Kenneth H. Grabstein , Dean K. Pettit , Raymond J. Paxton
发明人： Kenneth H. Grabstein , Dean K. Pettit , Raymond J. Paxton
IPC分类号： A61K39/00 , A61K39/38 , A01N37/18
CPC分类号： C07K16/244 , A61K38/00 , A61K47/60 , C07K14/5443 , C07K2317/76
摘要： Antagonists of mammalian interleukin-15 (“IL-15”) are disclosed and include muteins of IL-15 and modified IL-15 molecules that are each capable of binding to the IL-15Rα-subunit and that are incapable of transducing a signal through either the β- or γ-subunits of the IL-15 receptor complex. Also included are monoclonal antibodies against IL-15 that prevent IL-15 from effecting signal transduction through either the β- or γ-subunits of the IL-15 receptor complex. Methods of treating various disease states are disclosed, including treating allograft rejection and graft-versus-host disease,
摘要翻译：公开了哺乳动物白细胞介素-15（“IL-15”）的拮抗剂，并且包括IL-15和修饰的IL-15分子的突变蛋白，其各自能够结合IL-15Rα-亚基并且不能通过 IL-15受体复合物的β亚基或γ亚基。还包括针对IL-15的单克隆抗体，其阻止IL-15通过IL-15受体复合物的β亚基或γ亚基进行信号转导。公开了治疗各种疾病状态的方法，包括治疗同种异体移植排斥和移植物抗宿主病，

19. 发明授权

US07129203B2 Site specific protein modification 有权
公开(公告)号：US07129203B2
公开(公告)日：2006-10-31
申请号：US10243230
申请日：2002-09-12
申请人： Dean K. Pettit
发明人： Dean K. Pettit
IPC分类号： A61K45/00 , A61K38/19 , C07K14/715
CPC分类号： C07K1/1077 , A61K47/60 , A61K47/62 , C07K14/7151
摘要： Processes for conjugating proteins with polyethylene glycol are disclosed. The disclosed processes provide modified proteins having little or no decrease in their activity and include the steps of deleting at least one amino acid residue on the protein, replacing the at least one amino acid residue with an amino acid residue that does not react with polyethylene glycol, and contacting the protein with polyethylene glycol under conditions sufficient to conjugate the polyethylene glycol to the protein. This advantageous retention of a desired protein activity is attributed to the availability of one or more protein binding sites which is unaltered in the conjugation process and thus remains free to interact with a binding partner ligand or cognate subsequent to the conjugation process.

20. 发明授权

US06177079B1 Antagonists of interleukin-15 有权
标题翻译：白细胞介素15的拮抗剂
公开(公告)号：US06177079B1
公开(公告)日：2001-01-23
申请号：US09196427
申请日：1998-11-20
申请人： Kenneth H. Grabstein , Dean K. Pettit , Raymond J. Paxton
发明人： Kenneth H. Grabstein , Dean K. Pettit , Raymond J. Paxton
IPC分类号： A61K39395
CPC分类号： C07K16/244 , A61K38/00 , A61K2039/505 , C07K14/5443
摘要： Antagonists of mammalian interleukin-15 (“IL-15”) are disclosed and include muteins of IL-15 and modified IL-15 molecules that are each capable of binding to the IL-15R&agr;-subunit and that are incapable of transducing a signal through either the &bgr;- or &ggr;-subunits of the IL-15 receptor complex. Also included are monoclonal antibodies against IL-15 that prevent IL-15 from effecting signal transduction through either the B- or &ggr;subunits of the IL-15 receptor complex. Methods of treating various disease states are disclosed. including treating allograft rejection and graft-versus-host disease.
摘要翻译：公开了哺乳动物白细胞介素-15（“IL-15”）的拮抗剂，并且包括IL-15和修饰的IL-15分子的突变蛋白，其各自能够结合IL-15Rα-亚基并且不能通过 IL-15受体复合物的β亚基或γ亚基。还包括针对IL-15的单克隆抗体，其阻止IL-15通过IL-15受体复合物的B-或gammasubunits进行信号转导。公开了治疗各种疾病状态的方法。包括治疗同种异体移植排斥和移植物抗宿主病。

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