专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明申请

WO2012088007A1 FLUORESCENT COMPOUNDS 审中-公开
标题翻译：荧光化合物
公开(公告)号：WO2012088007A1
公开(公告)日：2012-06-28
申请号：PCT/US2011/065975
申请日：2011-12-20
申请人： PIERCE BIOTECHNOLOGY, INC. , DYOMICS GMBH, , HERMANSON, Greg , CZERNEY, Peter, T. , DESAI, Surbhi , WENZEL, Matthias, S. , DWORECKI, Boguslawa , LEHMANN, Frank, G.
发明人： HERMANSON, Greg , CZERNEY, Peter, T. , DESAI, Surbhi , WENZEL, Matthias, S. , DWORECKI, Boguslawa , LEHMANN, Frank, G.
IPC分类号： C07D209/10 , C07D403/06
CPC分类号： C07D403/06 , C07D209/10
摘要： Compounds used as labels with properties comparable to known fluorescent compounds. The compounds can be conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non- limiting examples of each are provided.
摘要翻译：用作具有与已知荧光化合物相当的特性的标签的化合物。这些化合物可以与蛋白质和核酸结合，用于生物成像和分析。提供化合物的合成，共轭化合物的形成和用途，以及各自的具体非限制性实例。

12. 发明公开

US20230159484A1 FLUORESCENT DYES HAVING HIGH STOKES SHIFT, ON THE BASIS OF BRIDGED BENZOPYRYLIUM SALTS 审中-公开
公开(公告)号：US20230159484A1
公开(公告)日：2023-05-25
申请号：US17995356
申请日：2021-04-01
申请人： DYOMICS GmbH
发明人： Bernd SCHWEDER , Frank LEHMANN , Matthias WENZEL , Peter CZERNEY
IPC分类号： C07D311/86 , C09B57/02 , C09B57/00 , C07D311/88 , C07C43/00 , C07D311/82 , C07D405/12 , C07D491/052 , C07D405/14 , C07D405/06 , C07D213/46 , C07D405/04 , C07D493/04
CPC分类号： C07D311/86 , C09B57/02 , C09B57/00 , C07D311/88 , C07C43/00 , C07D311/82 , C07D405/12 , C07D491/052 , C07D405/14 , C07D405/06 , C07D213/46 , C07D405/04 , C07D493/04
摘要： The invention relates to novel, water-soluble fluorescent dyes with high fluorescence quantum yield based on oxygen-containing heterocycles, their reactive derivatives and dye conjugates, and their use for labelling samples and detecting analytes. The compounds of the new dye class are compatible with commercial excitation light sources and are characterised by Stokes shifts of more than 50 nm.

13. 发明授权

US10351551B2 Fluorescent compounds 有权
公开(公告)号：US10351551B2
公开(公告)日：2019-07-16
申请号：US15817561
申请日：2017-11-20
申请人： PIERCE BIOTECHNOLOGY, INC. , Dyomics GmbH
发明人： Greg Hermanson , Peter T. Czerney , Surbhi Desai , Matthias S. Wenzel , Boguslawa Dworecki , Frank G. Lehmann
IPC分类号： A61B10/00 , A61B5/00 , A61B8/00 , C07D403/06 , C07D209/10
摘要： Compounds used as labels with properties comparable to known fluorescent compounds. The compounds can be conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided.

14. 发明授权

US10174045B2 Benzopyrylium compounds 有权
公开(公告)号：US10174045B2
公开(公告)日：2019-01-08
申请号：US15493208
申请日：2017-04-21
申请人： Pierce Biotechnology, Inc. , Dyomics GmbH
发明人： Greg Hermanson , Peter T. Czerney , Surbhi Desai , Matthias S. Wenzel , Frank G. Lehmann , Marie Christine Nlend
IPC分类号： C07D491/147 , A61K49/00 , G01N33/58 , C07D405/14 , C07D405/06 , C07D491/052 , C07D491/16 , C09B23/06 , C09B23/04 , C09B23/08 , C09B69/00
摘要： Compounds used as labels with properties comparable to known fluorescent compounds. The compounds are conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided.

15. 发明申请

US20180134689A1 BENZOCYANINE COMPOUNDS 审中-公开
公开(公告)号：US20180134689A1
公开(公告)日：2018-05-17
申请号：US15641376
申请日：2017-07-05
申请人： PIERCE BIOTECHNOLOGY, INC. , DYOMICS GMBH
发明人： Greg Hermanson , Peter T. Czerney , Surbhi Desai , Matthias S. Wenzel , Boguslawa R. Dworecki , Frank G. Lehmann , Marie Christine Nlend
IPC分类号： C07D403/14 , G01N33/58 , C07K19/00 , G01N33/533 , A61K49/00 , C07D209/60 , G01N33/543
CPC分类号： C07D403/14 , A61K49/0032 , A61K49/0058 , C07D209/60 , C07K19/00 , G01N33/533 , G01N33/54346 , G01N33/582
摘要： Compounds useful as labels with properties comparable to known fluorescent compounds. The compounds are conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided.

16. 发明申请

US20150175591A1 MARKER DYES FOR UV AND SHORT WAVE EXCITATION WITH HIGH STOKES SHIFT BASED ON BENZOXAZOLES 有权
标题翻译：紫外线和短波激发标记基于苯并噻唑的高转录
公开(公告)号：US20150175591A1
公开(公告)日：2015-06-25
申请号：US14579169
申请日：2014-12-22
申请人： Dyomics GmbH
发明人： Bernd G. SCHWEDER , Matthias S. WENZEL , Wilhelm G. FRANK , Frank G. LEHMANN , Peter T. CZERNEY
IPC分类号： C07D413/14 , G01N33/58 , C07D413/06
CPC分类号： C07D413/14 , C07D413/04 , C07D413/06 , C09B57/00 , C09B62/00 , C09B69/00 , G01N33/582
摘要： The invention concerns compounds based on benzoxazoles wherein selected substituents are each a reactive group A bound via a linker L and adapted to covalently bond a compound of the invention to a to-be-marked molecule K, wherein A is an amine, hydroxy or phosphoramidite function, a carboxylic acid, an alkyl or active ester derived therefrom; a carboxylic acid hydrazide; or a carboxylic acid amide whereK is a covalently bound component selected from the group haptenes−, proteins (antibodies), low molecular weight drug compounds, peptides, nucleotides, nucleosides, DNA oligomers, polymers, and t is from 1 to 10, and L is a linker selected from a group featuring —(CH2)s—, —[(CH2)m—O]p—(CH2)m—, —NR10-(CH2)s—, —O—(CH2)s—, —S—(CH2)s—, —NR10-C(O)—(CH2)s—, —NR10-C(O)—O—(CH2)s—, —NR10-C(O)—NR11-(CH2)s— or —SO2—NR10-(CH2)s—, wherein R10 and R11 are each independently hydrogen, alkyl and alkoxy-alkyl (—[(CH2)m—O]p—CH3), ω-sulfoalkyl (—(CH2)r—SO3), m represents the numbers of 2-5, p, r and s each independently represent the number of 1-10.
摘要翻译：本发明涉及基于苯并恶唑的化合物，其中选择的取代基各自为通过连接体L结合的适于共价键合本发明化合物与待标记分子K的反应性基团A，其中A为胺，羟基或亚磷酰胺官能团，羧酸，由其衍生的烷基或活性酯; 羧酸酰肼; 或羧酸酰胺，其中K是选自组合半聚体 - 蛋白质（抗体），低分子量药物化合物，肽，核苷酸，核苷，DNA寡聚物，聚合物和t的共价结合组分，其为1至10，以及 L是选自 - （CH 2）s - ， - [（CH 2）m -O] p - （CH 2）m - ， - NR 10 - （CH 2）s - ， - O-（CH 2）， - （CH2）s - ，-NR10-C（O） - （CH2）s-，-NR10-C（O）-O-（CH2）s-，-NR10-C（O）（CH 2）s - 或-SO 2 -NR 10 - （CH 2）s - ，其中R 10和R 11各自独立地为氢，烷基和烷氧基 - 烷基（ - [（CH 2）m -O] p -CH 3），ω-磺基烷基 - （CH 2）r -SO 3），m表示2-5的数，p，r和s各自独立地表示1-10的数。

17. 发明申请

US20040260093A1 Compound, especially marker-dye on the basis of polymethines 有权
标题翻译：化合物，特别是在聚甲基化的基础上的标记染料
公开(公告)号：US20040260093A1
公开(公告)日：2004-12-23
申请号：US10846789
申请日：2004-05-14
申请人： Dyomics GmbH
发明人： Peter Czerney , Matthias Wenzel , Bernd Schweder , Frank Lehmann
IPC分类号： C12Q001/68 , C07D41/02 , C07D43/02
CPC分类号： C09B23/107 , C09B57/02
摘要： The invention relates to fluorescent dyes (fluorophores) based on polymethines for use in optical measurement and detection procedures, in particular those employing fluorescence, for example in medicine, in pharmacology and in the biological, materials and environmental sciences. The objective was to create fluorophores based on polymethines that have a large Stokes shift, high photostability, long storage life and a high fluorescent quantum yield, and that can be excited in the simplest possible manner by white-light sources or laser radiation in the UV, visible or NIR spectral region. According to the invention dyes on the basis of polymethines having the general formulas I, II or III 1 are employed.
摘要翻译：本发明涉及基于用于光学测量和检测程序的聚甲基化的荧光染料（荧光团），特别是使用荧光的那些，例如在医学，药理学以及生物，材料和环境科学中。目的是基于具有大的斯托克斯位移，高光稳定性，长存储寿命和高荧光量子产率的聚甲基化产生荧光团，并且可以以最简单的方式通过白光源或UV中的激光辐射来激发荧光团，可见光或近红外光谱区。根据本发明，采用基于具有通式I，II或III的聚甲基的染料。

18. 发明授权

US10730857B2 Benzocyanine compounds 有权
公开(公告)号：US10730857B2
公开(公告)日：2020-08-04
申请号：US16141534
申请日：2018-09-25
申请人： Pierce Biotechnology, Inc. , Dyomics GmbH
发明人： Greg Hermanson , Peter T. Czerney , Surbhi Desai , Matthias S. Wenzel , Boguslawa Dworecki , Frank G. Lehmann , Marie Christine Nlend
IPC分类号： C07D403/06 , C07D495/04 , G01N33/53 , A61K49/00 , C09B23/08 , C07H3/00 , C07H21/00 , C07K14/00 , C07K14/475 , C07K14/575 , C07K16/00
摘要： Compounds useful as labels with properties comparable to known fluorescent compounds. The compounds are conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided.

19. 发明授权

US10526317B2 Benzocyanine compounds 有权
公开(公告)号：US10526317B2
公开(公告)日：2020-01-07
申请号：US15641376
申请日：2017-07-05
申请人： PIERCE BIOTECHNOLOGY, INC. , DYOMICS GMBH
发明人： Greg Hermanson , Peter T. Czerney , Surbhi Desai , Matthias S. Wenzel , Boguslawa R. Dworecki , Frank G. Lehmann , Marie Christine Nlend
IPC分类号： G01N33/533 , A61K49/00 , C07D403/14 , C07D209/60 , C07K19/00 , G01N33/58 , G01N33/543
摘要： Compounds useful as labels with properties comparable to known fluorescent compounds. The compounds are conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided.

20. 发明申请

US20190084964A1 Benzocyanine Compounds 审中-公开
公开(公告)号：US20190084964A1
公开(公告)日：2019-03-21
申请号：US16141534
申请日：2018-09-25
申请人： Pierce Biotechnology, Inc. , Dyomics GmbH
发明人： Greg Hermanson , Peter T. Czerney , Surbhi Desai , Matthias S. Wenzel , Boguslawa Dworecki , Frank G. Lehmann , Marie Christine Nlend
IPC分类号： C07D403/06 , C07K16/00 , C07K14/575 , C07K14/475 , G01N33/53 , C07H21/00 , C09B23/08 , C07D495/04 , C07K14/00 , A61K49/00 , C07H3/00
摘要： Compounds useful as labels with properties comparable to known fluorescent compounds. The compounds are conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式