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11. 发明授权

US09427165B2 Heuristic management of physiological data 有权
标题翻译：生理数据的启发式管理
公开(公告)号：US09427165B2
公开(公告)日：2016-08-30
申请号：US13782853
申请日：2013-03-01
申请人： Corventis, Inc.
发明人： Brion Finlay , Scott Williams , Richard Fogoros , Brett Landrum , Abhi Chavan
IPC分类号： A61B5/04 , A61B5/0432 , A61B5/00 , A61B5/08 , A61B5/01 , A61B5/0408
CPC分类号： A61B5/0432 , A61B5/0006 , A61B5/01 , A61B5/04012 , A61B5/04085 , A61B5/04087 , A61B5/0816 , A61B5/4875
摘要： Systems and methods for management of physiological data, for example data obtained from monitoring an electrocardiogram signal of a patient. In one example use, digital data is obtained and episodes of arrhythmias are detected. Snapshots of the digitized ECG signal may be stored for later physician review. One or more techniques may be used to avoid recording of redundant data, while ensuring that at least a minimum number of episodes of each detected arrhythmia can be stored. The system may automatically tailor its data collection to the cardiac characteristics of a particular patient. In one technique, memory is allocated to include for each detectable arrhythmia a memory segment designated to receive ECG snapshots representing only the respective arrhythmia. A shared memory pool may receive additional snapshots of as the designated memory segments fill.
摘要翻译：用于管理生理数据的系统和方法，例如从监测患者的心电图信号获得的数据。在一个示例中，获得数字数据并检测心律失常发作。可以存储数字化ECG信号的快照，供以后医师审查。可以使用一种或多种技术来避免记录冗余数据，同时确保可以存储每个检测到的心律失常的至少最少数量的发作。该系统可以根据特定患者的心脏特征自动调整其数据收集。在一种技术中，存储器被分配以包括针对每个可检测的心律失常的指定用于接收仅表示相应的心律失常的ECG快照的存储器段。共享内存池可以接收指定内存段填充的其他快照。

12. 发明申请

US20140330091A1 HEART FAILURE DECOMPENSATION PREDICTION BASED ON CARDIAC RHYTHM 审中-公开
标题翻译：心脏衰竭心脏衰竭预测
公开(公告)号：US20140330091A1
公开(公告)日：2014-11-06
申请号：US14271228
申请日：2014-05-06
申请人： Corventis, Inc.
发明人： Imad Libbus , Yatheendhar D. Manicka , Badri Amurthur , Scott T. Mazar
IPC分类号： A61B5/00 , A61B5/046 , A61B5/053 , A61B5/0205 , A61B5/0464
CPC分类号： A61B5/7275 , A61B5/0006 , A61B5/0022 , A61B5/0031 , A61B5/0205 , A61B5/02055 , A61B5/04085 , A61B5/046 , A61B5/0464 , A61B5/053 , A61B5/6833 , A61B5/7246 , A61B7/04 , A61B2560/0412 , G16H50/20 , G16H50/30
摘要： Systems and methods of detecting an impending cardiac decompensation of a patient measure an electrocardiogram signal of the patient. An incidence of cardiac arrhythmias is determined from the electrocardiogram signal. A risk of impending decompensation is determined in response to the incidence of cardiac arrhythmias. In many embodiments, the impending decompensation can be detected early enough to avoid, or at least delay, the impending decompensation, such that patient trauma and/or expensive ICU care can be avoided. Although embodiments make specific reference to monitoring electrocardiogram and other physiological signals with an adherent patch, the system methods and devices are applicable to many applications in which physiological monitoring is used, for example wireless physiological monitoring with implanted sensors for extended periods.
摘要翻译：检测患者即将到来的心脏代偿失调的系统和方法测量患者的心电图信号。由心电图信号确定心律失常的发生率。随着心律失常的发生，确定即将失代偿的风险。在许多实施方案中，可以提前检测即将发生的代偿失调，以避免或至少延迟即将发生的代偿失调，使得可以避免患者创伤和/或昂贵的ICU护理。尽管实施例特别参考了使用粘附贴片监测心电图和其他生理信号，但是系统方法和装置可应用于其中使用生理监测的许多应用，例如用植入式传感器进行长时间的无线生理监测。

13. 发明申请

US20140012154A1 METHOD AND APPARATUS TO MEASURE BIOELECTRIC IMPEDANCE OF PATIENT TISSUE 有权
标题翻译：测量患者组织生物阻抗的方法和装置
公开(公告)号：US20140012154A1
公开(公告)日：2014-01-09
申请号：US13850678
申请日：2013-03-26
申请人： Corventis, Inc.
发明人： Scott T. Mazar
IPC分类号： A61B5/053 , A61B5/08 , A61B5/0408
CPC分类号： A61B5/04087 , A61B5/0002 , A61B5/0006 , A61B5/0205 , A61B5/0402 , A61B5/04085 , A61B5/0428 , A61B5/0531 , A61B5/0809 , A61B5/7257 , A61B7/00 , A61B2560/0223
摘要： A device to measure tissue impedance comprises drive circuitry coupled to calibration circuitry, such that a calibration signal from the calibration circuitry corresponds to the current delivered through the tissue. Measurement circuitry can be coupled to measurement electrodes and the calibration circuitry, such that the tissue impedance can be determined in response to the measured calibration signal from the calibration circuitry and the measured tissue impedance signal from the measurement electrodes. Processor circuitry comprising a tangible medium can be configured to determine a complex tissue impedance in response to the calibration signal and the tissue impedance signal. The processor can be configured to select a frequency for the drive current, and the amount of drive current at increased frequencies may exceed a safety threshold for the drive current at lower frequencies.
摘要翻译：测量组织阻抗的装置包括耦合到校准电路的驱动电路，使得来自校准电路的校准信号对应于通过组织递送的电流。测量电路可以耦合到测量电极和校准电路，使得可以响应于来自校准电路的测量的校准信号和来自测量电极的测量的组织阻抗信号来确定组织阻抗。包括有形介质的处理器电路可以被配置为响应于校准信号和组织阻抗信号来确定复合组织阻抗。处理器可以配置为选择驱动电流的频率，并且增加频率的驱动电流量可能会超过较低频率下驱动电流的安全阈值。

14. 发明授权

US09770182B2 Adherent device with multiple physiological sensors 有权
公开(公告)号：US09770182B2
公开(公告)日：2017-09-26
申请号：US14322435
申请日：2014-07-02
申请人： Corventis, Inc.
发明人： Mark J. Bly , Badri Amurthur , Kristofer J. James , Imad Libbus , Yatheendhar D. Manicka , Scott T. Mazar , Jerry S. Wang
IPC分类号： A61B5/04 , A61B5/0408 , A61B5/053 , A61B5/00 , A61B5/0205 , A61B5/024 , A61B5/08 , A61N1/04 , G06F19/00 , A61B5/046 , A61B5/0464 , A61B5/0472 , A61B5/0428 , A61B5/021 , A61B5/0245 , A61B5/0452 , A61B5/11 , A61B7/00 , A61N1/365
CPC分类号： A61B5/04087 , A61B5/0006 , A61B5/0205 , A61B5/02055 , A61B5/021 , A61B5/02405 , A61B5/02438 , A61B5/02455 , A61B5/04085 , A61B5/0428 , A61B5/0452 , A61B5/046 , A61B5/0464 , A61B5/0472 , A61B5/053 , A61B5/0535 , A61B5/0537 , A61B5/0806 , A61B5/0809 , A61B5/0816 , A61B5/11 , A61B5/1116 , A61B5/1118 , A61B5/443 , A61B5/4869 , A61B5/4875 , A61B5/6801 , A61B5/6833 , A61B5/7275 , A61B5/746 , A61B7/00 , A61B7/003 , A61B2560/0412 , A61B2562/0215 , A61N1/046 , A61N1/0476 , A61N1/0492 , A61N1/36521 , A61N1/36535 , A61N1/36542 , A61N1/36592 , G06F19/00 , G06F19/3418 , G16H15/00 , G16H50/30
摘要： An adherent device to monitor a patient for an extended period comprises a breathable tape. The breathable tape comprises a porous material with an adhesive coating to adhere the breathable tape to a skin of the patient. At least one electrode is affixed to the breathable tape and capable of electrically coupling to a skin of the patient. A printed circuit board is connected to the breathable tape to support the printed circuit board with the breathable tape when the tape is adhered to the patient. Electronic components electrically are connected to the printed circuit board and coupled to the at least one electrode to measure physiologic signals of the patient. A breathable cover and/or an electronics housing is disposed over the circuit board and electronic components and connected to at least one of the electronics components, the printed circuit board or the breathable tape.

15. 发明申请

US20150073252A1 METHOD AND APPARATUS TO MEASURE BIOELECTRIC IMPEDANCE OF PATIENT TISSUE 有权
标题翻译：测量患者组织生物阻抗的方法和装置
公开(公告)号：US20150073252A1
公开(公告)日：2015-03-12
申请号：US14542097
申请日：2014-11-14
申请人： Corventis, Inc.
发明人： Scott T. MAZAR
IPC分类号： A61B5/0408 , A61B5/0428 , A61B5/0205 , A61B5/00
CPC分类号： A61B5/04087 , A61B5/0002 , A61B5/0006 , A61B5/0205 , A61B5/0402 , A61B5/04085 , A61B5/0428 , A61B5/0531 , A61B5/0809 , A61B5/7257 , A61B7/00 , A61B2560/0223
摘要： A device to measure tissue impedance comprises drive circuitry coupled to calibration circuitry, such that a calibration signal from the calibration circuitry corresponds to the current delivered through the tissue. Measurement circuitry can be coupled to measurement electrodes and the calibration circuitry, such that the tissue impedance can be determined in response to the measured calibration signal from the calibration circuitry and the measured tissue impedance signal from the measurement electrodes. Processor circuitry comprising a tangible medium can be configured to determine a complex tissue impedance in response to the calibration signal and the tissue impedance signal. The processor can be configured to select a frequency for the drive current, and the amount of drive current at increased frequencies may exceed a safety threshold for the drive current at lower frequencies.
摘要翻译：测量组织阻抗的装置包括耦合到校准电路的驱动电路，使得来自校准电路的校准信号对应于通过组织递送的电流。测量电路可以耦合到测量电极和校准电路，使得可以响应于来自校准电路的测量的校准信号和来自测量电极的测量的组织阻抗信号来确定组织阻抗。包括有形介质的处理器电路可以被配置为响应于校准信号和组织阻抗信号来确定复合组织阻抗。处理器可以配置为选择驱动电流的频率，并且增加频率的驱动电流量可能会超过较低频率下驱动电流的安全阈值。

16. 发明申请

US20150015417A1 PATIENT MONITORING SYSTEMS AND METHODS 有权
标题翻译：患者监测系统和方法
公开(公告)号：US20150015417A1
公开(公告)日：2015-01-15
申请号：US14340418
申请日：2014-07-24
申请人： Corventis, Inc.
发明人： Imad LIBBUS , Badri AMURTHUR , Yatheendhar D. MANICKA , Scott T. MAZAR , Matt MERKERT , Brett A. LANDRUM
IPC分类号： A61B5/00 , A61B5/11
CPC分类号： A61B5/0002 , A61B5/0006 , A61B5/002 , A61B5/01 , A61B5/02055 , A61B5/04085 , A61B5/0537 , A61B5/085 , A61B5/1115 , A61B5/1117 , A61B5/1455 , A61B5/4818 , A61B5/6833 , A61B2562/0219 , G06F19/00 , G06Q50/22 , Y10S128/903
摘要： An adherent patient device is configured to adhere to the skin of the patient and measure electrocardiogram data, impedance data, accelerometer data, blood oxygen data and temperature data. The adherent device can communicate wirelessly with gateways and a local processor system, such that the patient can wander about the hospital and update the monitoring station with the patient data when the patient is ambulatory. The local processor system can be configured to customize alerts for the patient, for example to notify automatically a specialist in response to a special condition of the patient. The adherent device may comprise a unique adherent device identifier such that the customized alert can be sent based on the unique device identifier. Each of the gateways can be carried and may comprise a unique gateway identifier, such that the unique device identifier and the unique gateway identifier can be used to locate the ambulatory patient.
摘要翻译：附着的患者装置被配置为粘附到患者的皮肤并测量心电图数据，阻抗数据，加速度计数据，血氧数据和温度数据。附着设备可以与网关和本地处理器系统进行无线通信，使得患者可以在医院漫游并且当病人走动时用患者数据更新监测站。本地处理器系统可以被配置为为患者定制警报，例如，以响应患者的特殊状况自动通知专家。附着设备可以包括唯一的附着设备标识符，使得可以基于唯一的设备标识符来发送定制的警报。可以携带每个网关，并且可以包括唯一的网关标识符，使得可以使用唯一的设备标识符和唯一的网关标识符来定位移动患者。

17. 发明申请

US20150005590A1 MULTI-SENSOR PATIENT MONITOR TO DETECT IMPENDING CARDIAC DECOMPENSATION 有权
标题翻译：多传感器患者监测器检测进行心脏衰竭
公开(公告)号：US20150005590A1
公开(公告)日：2015-01-01
申请号：US14325968
申请日：2014-07-08
申请人： Corventis, Inc.
发明人： Imad LIBBUS , Mark J. BLY , Kristofer J. JAMES , Scott T. MAZAR , Jerry S. WANG
IPC分类号： A61B5/0205 , A61B5/00 , A61B5/044 , A61B5/02 , A61B5/04 , A61B5/0408 , A61B5/11
CPC分类号： A61B5/02028 , A61B5/0002 , A61B5/0004 , A61B5/0006 , A61B5/0008 , A61B5/01 , A61B5/02055 , A61B5/02405 , A61B5/0245 , A61B5/04012 , A61B5/04085 , A61B5/04087 , A61B5/044 , A61B5/0452 , A61B5/0531 , A61B5/0535 , A61B5/0537 , A61B5/08 , A61B5/0816 , A61B5/1114 , A61B5/1116 , A61B5/1118 , A61B5/443 , A61B5/4875 , A61B5/6833 , A61B5/6843 , A61B5/6885 , A61B5/7264 , A61B5/7275 , A61B5/7282 , A61B5/746 , A61B2560/0412 , A61B2560/0468 , A61B2562/0209 , A61B2562/0214 , A61B2562/043 , A61B2562/164 , G06F19/00 , G06F19/3418 , G16H50/30
摘要： Systems and methods of detecting an impending cardiac decompensation of a patient measure at least two of an electrocardiogram signal of the patient, a hydration signal of the patient, a respiration signal of the patient or an activity signal of the patient. The at least two of the electrocardiogram signal, the hydration signal, the respiration signal or the activity signal are combined with an algorithm to detect the impending cardiac decompensation.
摘要翻译：检测患者即将到来的心脏代偿失调的系统和方法测量患者的心电图信号，患者的水合信号，患者的呼吸信号或患者的活动信号中的至少两个。将心电图信号，水合信号，呼吸信号或活动信号中的至少两个与算法组合以检测即将进行的心脏代偿失调。

18. 发明申请

US20130331665A1 SYSTEM AND METHODS FOR WIRELESS BODY FLUID MONITORING 审中-公开
标题翻译：无线体液监测的系统与方法
公开(公告)号：US20130331665A1
公开(公告)日：2013-12-12
申请号：US13751858
申请日：2013-01-28
申请人： Corventis, Inc.
发明人： Imad Libbus , Mark J. Bly
IPC分类号： A61B5/053 , A61B5/0408
CPC分类号： A61B5/6843 , A61B5/01 , A61B5/0245 , A61B5/04085 , A61B5/04087 , A61B5/0537 , A61B5/443 , A61B5/6833 , A61B2560/0412 , A61B2562/0215 , A61B2562/043 , G06F19/3418 , G16H50/30
摘要： An adherent device to monitor a tissue hydration of a patient comprises an adhesive patch to adhere to a skin of the patient. At least four electrodes are connected to the patch and capable of electrically coupling to the patient. Impedance circuitry is coupled to the at least four electrodes to measure a tissue resistance of the patient, where the circuitry is configured to determine the tissue hydration in response to tissue resistance. The circuitry may comprise a processor system and the tissue resistance may correspond to a change in patient body fluid. The impedance circuitry is configured to measure the hydration signal using at least one low measurement frequency, which may be in the range of 0 to 10 kHz. Multiple measurement frequencies may be used and the hydration signal may include a tissue reactance measurement.
摘要翻译：用于监测患者的组织水合的粘附装置包括粘附到患者皮肤上的粘合贴片。至少四个电极连接到贴片并且能够电耦合到患者。阻抗电路耦合到至少四个电极以测量患者的组织电阻，其中电路被配置为响应于组织电阻确定组织水合。电路可以包括处理器系统，并且组织电阻可以对应于患者体液的变化。阻抗电路被配置为使用至少一个低测量频率来测量水合信号，该低测量频率可以在0至10kHz的范围内。可以使用多个测量频率，并且水合信号可以包括组织电抗测量。

19. 发明授权

US09668667B2 Method and apparatus to measure bioelectric impedance of patient tissue 有权
公开(公告)号：US09668667B2
公开(公告)日：2017-06-06
申请号：US14542097
申请日：2014-11-14
申请人： Corventis, Inc.
发明人： Scott T. Mazar
IPC分类号： A61B5/00 , A61B5/0408 , A61B5/053 , A61B5/08 , A61B5/0205 , A61B5/0428 , A61B5/0402 , A61B7/00
CPC分类号： A61B5/04087 , A61B5/0002 , A61B5/0006 , A61B5/0205 , A61B5/0402 , A61B5/04085 , A61B5/0428 , A61B5/0531 , A61B5/0809 , A61B5/7257 , A61B7/00 , A61B2560/0223
摘要： A device to measure tissue impedance comprises drive circuitry coupled to calibration circuitry, such that a calibration signal from the calibration circuitry corresponds to the current delivered through the tissue. Measurement circuitry can be coupled to measurement electrodes and the calibration circuitry, such that the tissue impedance can be determined in response to the measured calibration signal from the calibration circuitry and the measured tissue impedance signal from the measurement electrodes. Processor circuitry comprising a tangible medium can be configured to determine a complex tissue impedance in response to the calibration signal and the tissue impedance signal. The processor can be configured to select a frequency for the drive current, and the amount of drive current at increased frequencies may exceed a safety threshold for the drive current at lower frequencies.

20. 发明授权

US08903484B2 Method and apparatus to measure bioelectric impedance of patient tissue 有权
标题翻译：测量患者组织生物电阻抗的方法和装置
公开(公告)号：US08903484B2
公开(公告)日：2014-12-02
申请号：US13850678
申请日：2013-03-26
申请人： Corventis, Inc.
发明人： Scott T. Mazar
IPC分类号： A61B5/00
CPC分类号： A61B5/04087 , A61B5/0002 , A61B5/0006 , A61B5/0205 , A61B5/0402 , A61B5/04085 , A61B5/0428 , A61B5/0531 , A61B5/0809 , A61B5/7257 , A61B7/00 , A61B2560/0223
摘要： A device to measure tissue impedance comprises drive circuitry coupled to calibration circuitry, such that a calibration signal from the calibration circuitry corresponds to the current delivered through the tissue. Measurement circuitry can be coupled to measurement electrodes and the calibration circuitry, such that the tissue impedance can be determined in response to the measured calibration signal from the calibration circuitry and the measured tissue impedance signal from the measurement electrodes. Processor circuitry comprising a tangible medium can be configured to determine a complex tissue impedance in response to the calibration signal and the tissue impedance signal. The processor can be configured to select a frequency for the drive current, and the amount of drive current at increased frequencies may exceed a safety threshold for the drive current at lower frequencies.
摘要翻译：测量组织阻抗的装置包括耦合到校准电路的驱动电路，使得来自校准电路的校准信号对应于通过组织递送的电流。测量电路可以耦合到测量电极和校准电路，使得可以响应于来自校准电路的测量的校准信号和来自测量电极的测量的组织阻抗信号来确定组织阻抗。包括有形介质的处理器电路可以被配置为响应于校准信号和组织阻抗信号来确定复合组织阻抗。处理器可以配置为选择驱动电流的频率，并且增加频率的驱动电流量可能会超过较低频率下驱动电流的安全阈值。

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