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11. 发明申请

WO2003100013A3 NON-REVERTIBLE β-OXIDATION BLOCKED CANDIDA TROPICALIS 审中-公开
公开(公告)号：WO2003100013A3
公开(公告)日：2003-12-04
申请号：PCT/US2003/016453
申请日：2003-05-22
申请人： COGNIS CORPORATION
发明人： CRAFT, David, L.
IPC分类号： C12P1/00
摘要： Genetically modified strains of C. tropicalis, which will not revert to wild-type activity at the POX 4 and/or POX 5 locus, are disclosed. The strains are β -oxidation blocked and have been transformed through homologous recombination with a construct which deletes a portion of the POX 4 and/or POX 5 gene. The modified strains may be used to increase yields of dicarboxylic acids produced in host cells of the strains. Methods for blocking the β -oxidation pathway in a C. tropicalis host cell are also provided.

12. 发明申请

WO2003088902A3 VEGETABLE SUBSTITUTE FOR LANOLIN 审中-公开
公开(公告)号：WO2003088902A3
公开(公告)日：2003-10-30
申请号：PCT/US2003/011285
申请日：2003-04-11
申请人： COGNIS CORPORATION
发明人： DEE, Gary, J. , MILSTEIN, Norman , SALKA, Barry, A.
IPC分类号： A61K7/48
摘要： Lanolin-free lanolin substitute compositions comprising: A) from about 50 to about 95% by weight, of at least one plant sterol fatty acid ester; B) from about 1 to about 10% by weight, of at least one polyglyceryl di-polyhydroxy fatty acid ester; C) from about 1 to about 10% by weight, of at least one polyglyceryl di-fatty acid ester; and D) from about 0.25 to about 2% by weight of at least one glyceryl fatty acid ester.

13. 发明申请

WO2003074991A3 METHOD AND SAMPLING DEVICE FOR DETECTION OF LOW LEVELS OF A PROPERTY/QUALITY TRAIT PRESENT IN AN INHOMOGENEOUSLY DISTRIBUTED SAMPLE SUBSTRATE 审中-公开
公开(公告)号：WO2003074991A3
公开(公告)日：2003-09-12
申请号：PCT/US2003/005710
申请日：2003-02-25
申请人： COGNIS CORPORATION
发明人： TSENG, Ching-Hui , MA, Kangming , WANG, Nan , MCFADDEN, Daniel
IPC分类号： B01L3/00
摘要： A process for detecting low levels of a predetermined quality trait in an inhomogeneously distributed particulate substrate (22) involving the steps of: (a) providing a particulate substrate (22) to be analyzed; (b) providing a spectrometer (12) with an electromagnetic detector capable of performing spectroscopic measurements with electromagnetic radiation; (c) providing a rotatable sample holder (14) having a transparent area through which electromagnetic radiation may pass; (d) providing a tumbling member (18) located within the rotatable sample holder (14) for tumbling the particulate substrate (22) contained therein; (e) introducing the particulate substrate (22) into the rotatable sample holder (14); (f) simultaneously rotating and tumbling the particulate substrate (22) contained within the rotatable sample holder (14); and (g) activating the spectrophotometer (12).

14. 发明申请

WO2003031596A2 PRODUCTION OF A HIGHLY ACTIVE, SOLUBLE FORM OF THE CYTOCHROME P450 REDUCTASE (CPR A) FROM CANDIDA TROPICALIS 审中-公开
标题翻译：从坎迪达热带生产CYTOCHROME P450还原酶（CPR A）的高活性，可溶性形式
公开(公告)号：WO2003031596A2
公开(公告)日：2003-04-17
申请号：PCT/US2002/032939
申请日：2002-10-15
申请人： COGNIS CORPORATION
发明人： DONNELLY, Mark
IPC分类号： C12N
CPC分类号： C12N9/0042
摘要： The present invention provides soluble cytochrome p450 reductase (CPR) proteins from Candida sp. having an altered N-terminal region which results in reduced hydrophobicity of the N-terminal region. Also provided are host cells comprising the subject soluble CPR proteins. In addition, the present invention provides nucleotide and corresponding amino acid sequences for soluble CPR proteins and vectors comprising the nucleotide sequences. Methods for producing a soluble CPR, for increasing production of a dicarboxylic acid, and for detecting a cytochrome P450 are also provided.
摘要翻译：本发明提供了具有改变的N末端区域的可疑细胞色素p450还原酶（CPR）蛋白质，其具有改变的N-末端区域，导致N-末端区域的疏水性降低。还提供了包含受试者可溶性CPR蛋白质的宿主细胞。此外，本发明提供可溶性CPR蛋白质的核苷酸和相应的氨基酸序列以及包含该核苷酸序列的载体。还提供了生产可溶性CPR，用于增加二羧酸生产和检测细胞色素P450的方法。

15. 发明申请

WO2003029364A1 INK COMPOSITIONS AND METHODS OF USE THEREFOR 审中-公开
标题翻译：墨水组合物及其使用方法
公开(公告)号：WO2003029364A1
公开(公告)日：2003-04-10
申请号：PCT/US2002/030663
申请日：2002-09-26
申请人： COGNIS CORPORATION
发明人： BROWN, David, W. , BREINDEL, Kenneth , BROADBENT, Ronald, W. , WIGGINS, Michael, S.
IPC分类号： C09D11/00
CPC分类号： C09D11/30 , C09D11/03 , C09D11/16 , C09D11/18
摘要： Ink compositions containing a surfactant-effective and/or defoaming-effective quantity of at least one reaction product comprising the following reactants: A) at least one compound of formula (I): R 1 (X) 3 wherein each X group is a halogen atom or one X group is a halogen atom and two X groups represent an epoxy oxygen atom, which is attached to two adjacent carbon atoms in the R 1 group to form an epoxy group, and R 1 is an alkanetriyl group containing from 3 to 10 carbon atoms; and B) at least one compound having the formula (II) : R 2 X(OA) n Y wherein R 2 is a substituted or unsubstituted, saturated or unsaturated, organic group having from 1 to 36 carbon atoms; X is -O-, -S-, or NR 3 - where R 3 is hydrogen or a C 1 -C 18 group; each AO group is independently an ethyleneoxy, 1,2-propyleneoxy, or 1,2-butyleneoxy group, n is a number of from 0 to 200, preferably from 1 to 100, more preferably from 2 to 20; and Y is hydrogen, or Y can be a mercapto group or an amino group in place of a terminal -OH group, provided that when Y is mercapto or an amino group, n is at least 1.
摘要翻译：含有表面活性剂有效和/或消泡有效量的至少一种包含以下反应物的反应产物的油墨组合物：A）至少一种式（I）化合物：R 1（X）3，其中每个X基团为卤素原子或一个X基团是卤素原子，两个X基团表示环氧氧原子，其与R 1基团中的两个相邻的碳原子连接以形成环氧基，并且R 1是烷基三含3至10个碳原子的基团; 和B）至少一种具有式（II）的化合物：R 2 X（OA）n Y其中R 2是具有1至36个碳原子的取代或未取代的饱和或不饱和的有机基团 ; X是-O-，-S-或NR 3 - ，其中R 3是氢或C 1 -C 18基团; 每个AO基团独立地为乙烯氧基，1,2-亚丙氧基或1,2-亚丁氧基，n为0至200，优选1至100，更优选2至20的数; Y是氢，Y可以是巯基或氨基代替末端-OH基团，条件是当Y是巯基或氨基时，n至少为1。

16. 发明申请

WO2002092738A1 HIGH-FOAMING NON-ANIONIC SURFACTANT COMPOSITIONS 审中-公开
标题翻译：高发泡非阳离子表面活性剂组合物
公开(公告)号：WO2002092738A1
公开(公告)日：2002-11-21
申请号：PCT/US2002/015272
申请日：2002-05-13
申请人： COGNIS CORPORATION
发明人： LAZAROWITZ, Virginia
IPC分类号： C11D1/62
CPC分类号： C11D3/0094 , C11D1/42 , C11D1/662 , C11D1/835 , C11D1/88 , C11D1/90 , C11D1/94
摘要： A surfactant composition containing: (a) from at least about 0.1 to at most about 50% by weight of an alkyl polyglycoside corresponding to formula (I): R 1 O(Z) a (I) wherein R 1 is a monovalent organic radical having from about 8 to about 16 carbon atoms; Z is a saccharide residue having 5 or 6 carbon atoms; a is a number having a value of from about 1.4 to about 1.6; and (b) from at least about 0.1 to at most about 30% by weight of a co-surfactant selected from the group consisting of a betaine, an amphoacetate, a primary alkyl amine and/or its salt derivative, and mixtures thereof, all weights being based on the total weight of the composition, and wherein the composition is free of anionic surfactants.
摘要翻译：一种表面活性剂组合物，其包含：（a）至少约0.1至至多约50重量％的对应于式（I）的烷基多糖苷：R1O（Z）a（I）其中R1是具有约 8至约16个碳原子; Z是具有5或6个碳原子的糖残基; a为约1.4至约1.6的数值; 和（b）从至少约0.1至至多约30重量％的选自甜菜碱，二乙酸酯，伯烷基胺和/或其盐衍生物的组合物及其混合物，所有重量基于组合物的总重量，并且其中组合物不含阴离子表面活性剂。

17. 发明申请

WO2002081538A1 FURTHER REACTED HALOGEN OR EPOXY LINKER-ALKOXY COMPOUND PRODUCT AS SUFACTANT 审中-公开
标题翻译：进一步反应的卤化物或环氧连接体 - 烷氧基化合物产品作为反应物
公开(公告)号：WO2002081538A1
公开(公告)日：2002-10-17
申请号：PCT/US2002/010330
申请日：2002-04-04
申请人： COGNIS CORPORATION
发明人： WIGGINS, Michael, S. , BROADBENT, Ronald, W. , NARAYAN, Ramesh, L. , KHAN, Ayaz
IPC分类号： C08G18/48
CPC分类号： C08G65/337 , C08G18/283 , C08G65/327 , C08G65/329 , C08G65/3322 , C08G65/33348 , C08L71/02 , C08L63/00
摘要： Compounds useful in the dual function as surfactants as well as defoaming agents and wetting agents are prepared from the reaction of (I) the reaction product of A) a linking agent of formula 1 R 4 (Y) 3 wherein each Y group is a halogen atom or one Y group is a halogen atom and two Y groups represent an oxygen atom, which is attached to two adjacent carbon atoms in the R 4 group to form an epoxy group, and R 4 is an alkanetriyl group containing from 3 to 10 carbon atoms; and B) a compound formula (II) R 3 (EO) n (PO) m (BO) p X wherein R 3 is a substituted or unsubstituted, saturated or unsaturated, aliphatic or araliphatic oxy or thio group having from 1 to 36 carbon atoms or a secondary amino group having from 2 to 36 carbon atoms; n is a number of from 0 to 50; m is a number of from 0 to 50; p is a number of from 0 to 50; and X is hydrogen, or a mercapto or amino group in place of a terminal -OH group, provided that when X is mercapto or amino; the sum of n, m, and p must be at least one; the mole ratio of A:B is from about 0:2:1 to about 5:1; and (II) an epoxy compound, isocyanate, phosphate compound, sulfate compound, organic acid, acrylate or methylol urea as a reactant.
摘要翻译：通过（I）A）式1 R 4（Y）3的连接剂的反应产物的反应制备用作表面活性剂和消泡剂和润湿剂的双重功能的化合物，其中每个Y基团为卤素原子或一个Y基团是卤素原子，两个Y基团表示氧原子，其与R 4基团中的两个相邻的碳原子连接以形成环氧基团，并且R 4是烷三基含有3至10个碳原子; 和B）化合物式（II）R 3（EO）n（PO）m（BO）pX其中R 3是具有1至36个碳的取代或未取代的饱和或不饱和的脂族或芳脂族氧基或硫基原子或具有2至36个碳原子的仲氨基; n为0〜50的数; m是从0到50的数字; p是从0到50的数字; X为氢或巯基或氨基而不是末端-OH基团，条件是当X为巯基或氨基时; n，m和p的和必须至少为1; A：B的摩尔比为约0:2:1至约5:1; 和（II）作为反应物的环氧化合物，异氰酸酯，磷酸酯化合物，硫酸酯化合物，有机酸，丙烯酸酯或羟甲基脲。

18. 发明申请

WO2005062852A2 COMPOSITIONS CONTAINING d-TOCOPHEROL COMPOUND POLYBASIC ACID PARTIAL ESTERS 审中-公开
标题翻译：含有d-TOCOPHEROL化合物的组合物多糖酸部分酯
公开(公告)号：WO2005062852A2
公开(公告)日：2005-07-14
申请号：PCT/US2004/042919
申请日：2004-12-21
申请人： COGNIS CORPORATION , HUNSICKER, Jeffrey, C.
发明人： HUNSICKER, Jeffrey, C.
IPC分类号： A61K31/355 , C07D311/72
CPC分类号： A61K31/355 , C07D311/72
摘要： Compositions comprising a salt of a d -tocopherol compound polybasic acid partial ester of the general formula: [(R-O t (O)C) z -A x -(C(O)O - y ] n [M n+ ] y wherein each R represents a dextrorotatory tocopherol compound moiety and O t represents the 6-hydroxyl oxygen atom of the dextrorotatory tocopherol compound moiety, A represents a polyvalent hydrocarbon group having from 1 to 44 carbon atoms which can be linear, branched, cyclic or polycyclic, aliphatic or aromatic, saturated or unsaturated and substituted or unsubstituted, x represents 0 or 1, y and z each independently represent a number of from 1 to 4 wherein the sum of y and z equals a number of from 2 to 6, n represents an integer of from 1 to 6 and M represents a metal ion, with the proviso that where x equals zero both y and z each equal 1; and wherein the composition contains an amount of one or more l -tocopherol compounds which is less than 50% by weight of the total tocopherol compound content in the composition.
摘要翻译：包含以下通式的d-生育酚化合物多元酸偏酯的盐的组合物：[（RO（O）C）z-Ax-（C（O）O] n [M

19. 发明申请

WO2005019395A1 COMPLEX POLYOL ESTERS WITH IMPROVED PERFORMANCE 审中-公开
标题翻译：具有改进性能的复合多糖酯
公开(公告)号：WO2005019395A1
公开(公告)日：2005-03-03
申请号：PCT/US2004/025816
申请日：2004-08-10
申请人： COGNIS CORPORATION , ZEHLER, Eugene , COSTELLO, Christopher
发明人： ZEHLER, Eugene , COSTELLO, Christopher
IPC分类号： C10M105/36
CPC分类号： C10M105/38 , C10M2207/2835 , C10N2230/26 , C10N2230/64
摘要： A biodegradable lubricant composition containing a complex polyol ester having a polyfunctional alcohol residue and a saturated or unsaturated dicarboxylic acid residue having from about 9 to about 22 carbon atoms.
摘要翻译：一种可生物降解的润滑剂组合物，其含有具有多官能醇残基和具有约9至约22个碳原子的饱和或不饱和二羧酸残基的复合多元醇酯。

20. 发明申请

WO2004106297A2 NONIONIC SURFACTANT COMPOSITIONS 审中-公开
标题翻译：非离子表面活性剂组合物
公开(公告)号：WO2004106297A2
公开(公告)日：2004-12-09
申请号：PCT/US2004/017221
申请日：2004-05-28
申请人： COGNIS CORPORATION , BROWN, David, W. , BREINDEL, Kenneth , BROADBENT, Ronald, W. , WIGGINS, Michael, S.
发明人： BROWN, David, W. , BREINDEL, Kenneth , BROADBENT, Ronald, W. , WIGGINS, Michael, S.
IPC分类号： C07D
CPC分类号： A61K31/40 , C11D1/662 , C11D1/72 , C11D1/825
摘要： Surfactant concentrates containing the following components: I) at least one base-catalyzed reaction product of reactants comprising: A) at least one compound of formula I R 1 (X) 3 (I) wherein each X group is a halogen atom or one X group is a halogen atom and two X groups represent an epoxy oxygen atom, which is attached to two adjacent carbon atoms in the R 1 group to form an epoxy group, and R 1 is an alkanetriyl group containing from 3 to 10 carbon atoms; and B) at least one compound having the formula II R 2 X(AO) n Y (II) wherein R 2 is a substituted or unsubstituted, saturated or unsaturated, organic group having from 1 to 36 carbon atoms; X is -0-, -S-, or -NR 3 - where R 3 is hydrogen or a C1-C18 alkyl group; each AO group is independently an ethyleneoxy, 1,2-propyleneoxy, or 1,2-buyleneoxy group, n is a number of from 0 to 200, preferably from 1 to 100, more preferably from 2 to 20; and Y is hydrogen, or Y can be a mercapto group or an amino group (amino or C i-C6 alkylamino group) in place of the terminal -OH group, provided that when Y is mercapto, amino, or a C1-C6 alkylamino group, n is at least 1; and II) at least one nonionic surfactant other than nonionic surfactants of component I).
摘要翻译：含有以下组分的表面活性剂浓缩物：I）反应物的至少一种碱催化反应产物，其包含：A）至少一种式IR 1（X）3（I）的化合物，其中每个X基团是卤素原子或一个 X基是卤素原子，两个X基团表示环氧氧原子，其与R 1基团中的两个相邻的碳原子连接以形成环氧基，R 1是含有3〜 10个碳原子; 和B）至少一种具有式II R 2 X（AO）n Y（II）的化合物，其中R 2是具有1至36个碳原子的取代或未取代的饱和或不饱和的有机基团; X是-O - ， - S-或-NR 3 - ，其中R 3是氢或C 1 -C 18烷基; 每个AO基团独立地为亚乙氧基，1,2-亚丙氧基或1,2-二烃基氧基，n为0至200，优选1至100，更优选2至20的数; Y是氢，Y可以是巯基或氨基（氨基或C 1 -C 6烷基氨基）代替末端-OH基团，条件是当Y是巯基，氨基或C 1 -C 6烷基氨基组，n至少为1; 和II）除了组分I）的非离子表面活性剂之外的至少一种非离子表面活性剂。

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