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11. 发明申请

WO2003018004A3 ANALGETIC PYRROLINE DERIVATIVES 审中-公开
公开(公告)号：WO2003018004A3
公开(公告)日：2003-03-06
申请号：PCT/US2002/027936
申请日：2002-08-29
申请人： ENDO PHARMACEUTICALS, INC. , SMITH-CARLISS, Richard , CARUSO, Frank, S. , CROOKS, PhD, Peter , KELLAR, Kenneth, J. , XIAO, Yingxian
发明人： SMITH-CARLISS, Richard , CARUSO, Frank, S. , CROOKS, PhD, Peter , KELLAR, Kenneth, J. , XIAO, Yingxian
IPC分类号： A61K31/40
摘要： A method for inducing analgesia and/or inhibiting abuse of abusive substances includes administration of d-methadone metabolites or their structural analogs. The d-methadone metabolites, EMDP and EDDP, and their structural analogs may be incorporated into a suitable pharmaceutical composition for administration to patients. The invention includes the method itself, certain structural analogs, and pharmaceutical compositions for use in accordance with the method.

12. 发明申请

WO2002092060A1 ABUSE-RESISTANT CONTROLLED-RELEASE OPIOID DOSAGE FORM 审中-公开
标题翻译：耐药控制释放OPIOID剂型
公开(公告)号：WO2002092060A1
公开(公告)日：2002-11-21
申请号：PCT/US2002/015022
申请日：2002-05-10
申请人： ENDO PHARMACEUTICALS, INC. , CARUSO, Frank, S. , KAO, Huai-Hung
发明人： CARUSO, Frank, S. , KAO, Huai-Hung
IPC分类号： A61K9/20
CPC分类号： A61K31/485 , A61K9/0002 , A61K9/0053 , A61K9/20 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/48 , A61K9/4858 , A61K9/4866 , A61K31/46 , A61K2300/00
摘要： Abuse-resistant, controlled release opioid tablets in combination containing an opioid antagonist such as naloxone at a level above that needed to suppress the euphoric effect of the opioid, if the combination were crushed to break the controlled release properties causing the opioid and opioid antagonist to be released as a immediate release product as a single dose. The controlled release nature of the table prevents the accumulation of orally effective amounts of opioid antagonist when taken normally. The opioid antagonist is contained in a controlled-release matrix and released, over time, with the opioid.
摘要翻译：滥用耐药，控制释放的阿片样物质组合含有阿片样物质拮抗剂如纳洛酮，其水平高于抑制阿片样物质的欣快作用所需的水平，如果组合被粉碎以破坏控制释放性质，导致阿片样物质和阿片样物质拮抗剂作为单次剂量的即时释放产品释放。表格的受控释放性质可防止口服有效量的阿片样物质拮抗剂在正常使用时积聚。阿片类拮抗剂包含在控释基质中，随着时间的推移与阿片样物质一起释放。

13. 发明申请

WO2002074431A1 HOLLOW SPHERES FROM LAYERED PRECURSOR DEPOSITION ON SACRIFICIAL COLLOIDAL CORE PARTICLES 审中-公开
标题翻译：来自层状前体沉积物的深色球体对极性胶体核心颗粒
公开(公告)号：WO2002074431A1
公开(公告)日：2002-09-26
申请号：PCT/EP2002/003127
申请日：2002-03-20
申请人： MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN , CARUSO, Frank
发明人： CARUSO, Frank
IPC分类号： B01J13/22
CPC分类号： B82Y30/00 , B01J13/02 , B01J13/22 , C01G1/02 , C01G23/053 , C01P2002/60 , C01P2002/72 , C01P2002/88 , C01P2004/03 , C01P2004/04 , C01P2004/32 , C01P2004/34 , C01P2004/61 , C01P2004/62 , C01P2004/64 , C01P2004/84 , C01P2006/60 , C09C1/3607
摘要： The preparation of monodisperse hollow titania spheres with defined diameter, wall thickness and crystal phase is reported. The hollow spheres have been produced by the layered deposition of a water-soluble titania precursor, e.g. titanium(IV) bis (ammonium lactato) dihydroxide (TALH), in alternation with poly(diallydimethylammonium chloride) (PDADMAC) onto submicrometer-sized template particles e.g. polystyrene (PS) particles, followed by calcination at elevated temperatures. the layer-by-layer growth of the coating on the colloid particles was observed by microelectrophoresis and transmission electron microscopy (TEM). Calcination of the TALH/PDADMAC-coated particles resulted in intact, hollow titania spheres, as confirmed by scanning electron microscopy (SEM) and TEM. Calcining the coated particles at 450 or 950° C resulted in hollow sphere consisting of titania in anatase or rutile form, respectively. Nanometer-level control over the sphere wall thickness was achieved by varying the number of layers deposited on the PS particles. The hollow titania spheres produced can be used in photonic applications, where hollow spheres of high refractive index materials are desired, and in catalysis.
摘要翻译：报道了制备具有规定直径，壁厚和结晶相的单分散中空二氧化钛球体。中空球体已经通过水溶性二氧化钛前体的分层沉积来制备。与二（二烯丙基二甲基氯化铵）（PDADMAC）交替的亚硫酸铵（IV）双（乳酸铵）二氢氧化物（TALH）转移到亚微米尺寸的模板颗粒上。聚苯乙烯（PS）颗粒，然后在升高的温度下煅烧。通过微电泳和透射电子显微镜（TEM）观察胶体颗粒上涂层的逐层生长。通过扫描电子显微镜（SEM）和TEM证实，TALH / PDADMAC涂覆的颗粒的煅烧导致完整的中空二氧化钛球体。在450或950℃下煅烧涂覆的颗粒，分别导致由锐钛矿或金红石形式的二氧化钛组成的空心球体。通过改变沉积在PS颗粒上的层数来实现球体壁厚的纳米级控制。所生产的空心二氧化钛球体可用于需要高折射率材料的空心球体和催化剂的光子学应用中。

14. 发明申请

WO2005077330A1 ELECTROMAGNETIC RADIATION ADDRESSABLE MATERIALS 审中-公开
标题翻译：电磁辐射可寻址材料
公开(公告)号：WO2005077330A1
公开(公告)日：2005-08-25
申请号：PCT/AU2005/000203
申请日：2005-02-17
申请人： THE UNIVERSITY OF MELBOURNE , CARUSO, Frank , RADT, Benno
发明人： CARUSO, Frank , RADT, Benno
IPC分类号： A61K9/00
CPC分类号： A61K9/0009 , A61K41/0042 , B82Y5/00 , B82Y10/00
摘要： A process for the controlled release of at least one entity, said process including the steps of: (a) providing a core-shell material comprising: (i) a core comprising at least one releasable entity; (ii) a shell encapsulating the core; and (iii) at least one electromagnetic radiation absorbing material incorporated into the shell, and having tuneable absorption properties; and (b) exposing the core-shell material to electromagnetic radiation of a predetermined wavelength and/or intensity wherein the shell is ruptured upon exposure to the electromagnetic radiation causing the release of the at least one entity.
摘要翻译：一种用于控制释放至少一个实体的方法，所述方法包括以下步骤：（a）提供核 - 壳材料，其包括：（i）包含至少一个可释放实体的芯; （ii）封装所述芯的外壳; 和（iii）并入壳中的至少一种电磁辐射吸收材料，并且具有可调吸收特性; 和（b）将核 - 壳材料暴露于预定波长和/或强度的电磁辐射，其中在暴露于导致至少一个实体的释放的电磁辐射时壳体破裂。

15. 发明申请

WO2003090920A1 CORE-ASSISTED FORMATION OF MICROCAPSULES 审中-公开
标题翻译：核心辅助形成微生物
公开(公告)号：WO2003090920A1
公开(公告)日：2003-11-06
申请号：PCT/EP2003/004324
申请日：2003-04-25
申请人： MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN , KHOPADE, Ajay, J. , CARUSO, Frank
发明人： KHOPADE, Ajay, J. , CARUSO, Frank
IPC分类号： B01J13/02
CPC分类号： B01J13/02 , B01J13/22
摘要： The invention refers to a process for producing nanocapsules or/and microcapsules by contacting templates consisting of a core material with a polyelectrolyte.
摘要翻译：本发明涉及通过使由核心材料与聚电解质组成的模板接触来制造纳米胶囊或/和微胶囊的方法。

16. 发明申请

WO03018004A2 ANALGESICS AND METHODS OF USE 审中-公开
标题翻译：使用的方法和方法
公开(公告)号：WO03018004A2
公开(公告)日：2003-03-06
申请号：PCT/US0227936
申请日：2002-08-29
申请人： ENDO PHARMACEUTICALS INC , SMITH-CARLISS RICHARD , CARUSO FRANK S , CROOKS PHD PETER , KELLAR KENNETH J , XIAO YINGXIAN
发明人： SMITH-CARLISS RICHARD , CARUSO FRANK S , CROOKS PHD PETER , KELLAR KENNETH J , XIAO YINGXIAN
IPC分类号： A61K31/40 , A61K31/4015 , A61K31/44 , A61K31/4439 , A61P25/04 , C07D207/06 , C07D207/20 , C07D207/22 , C07D207/26 , C07D207/267 , C07D209/96 , C07D401/04
CPC分类号： C07D207/267 , A61K31/40 , A61K31/44 , C07D207/06 , C07D207/20 , C07D207/22 , C07D209/96 , C07D401/04
摘要： A method for inducing analgesia and/or inhibiting abuse of abusive substances includes administration of d-methadone metabolites or their structural analogs. The d-methadone metabolites, EMDP and EDDP, and their structural analogs may be incorporated into a suitable pharmaceutical composition for administration to patients. The invention includes the method itself, certain structural analogs, and pharmaceutical compositions for use in accordance with the method.
摘要翻译：用于诱导镇痛和/或抑制滥用滥用物质的方法包括给予美沙酮代谢物或其结构类似物。 d美沙酮代谢物，EMDP和EDDP及其结构类似物可以并入用于给予患者的合适的药物组合物中。本发明包括方法本身，某些结构类似物和根据该方法使用的药物组合物。

17. 发明申请

WO2006069419A1 NANOPARTICLE COMPOSITION AND METHODS FOR SYNTHESIS THEREOF 审中-公开
标题翻译：纳米材料组合物及其合成方法
公开(公告)号：WO2006069419A1
公开(公告)日：2006-07-06
申请号：PCT/AU2005/001977
申请日：2005-12-30
申请人： ICEUTICA PTY LTD , PAYNE, Trevor , MEISER, Felix , POSTMA, Almar , CAMMARANO, Raffaele , CARUSO, Frank , WILLIAMS, James , MCCORMICK, Paul , DODD, Aaron
发明人： PAYNE, Trevor , MEISER, Felix , POSTMA, Almar , CAMMARANO, Raffaele , CARUSO, Frank , WILLIAMS, James , MCCORMICK, Paul , DODD, Aaron
IPC分类号： A61K9/51 , A61K31/192 , A61K31/196 , A61K31/4985 , A61K31/5513 , A61P15/10 , A61P25/18 , A61P29/00
CPC分类号： A61K9/5123 , A61K9/5192 , A61K31/192 , A61K31/196 , A61K31/4985 , A61K31/5513
摘要： The present invention relates to improved therapeutically active nanocomposite microstructure compositions, including nanoparticle compositions and nanoparticle preparations. Preferred embodiments include nanoparticle compositions comprising nanoparticles of a therapeutically active agent dispersed in a carrier matrix. The invention also relates to a method for preparing said compositions and preparations using solid-state mechanochemical synthesis. Further, it relates to therapeutic products produced using said compositions and to methods of treatment using the compositions.
摘要翻译：本发明涉及改进的治疗活性纳米复合微结构组合物，包括纳米颗粒组合物和纳米颗粒制剂。优选的实施方案包括纳米颗粒组合物，其包含分散在载体基质中的治疗活性剂的纳米颗粒。本发明还涉及使用固态机械化学合成制备所述组合物和制剂的方法。此外，它涉及使用所述组合物生产的治疗产品和使用该组合物的治疗方法。

18. 发明专利

AT233840T 未知
公开(公告)号：AT233840T
公开(公告)日：2003-03-15
申请号：AT99901321
申请日：1999-01-13
申请人： CARUSO FRANK
发明人： CARUSO FRANK
IPC分类号： D06B15/00 , D06C5/00 , D06C21/00
摘要： A cylindrical shaped mandrel is used as a support inside the sleeve of tubular knit fabric, for maintaining the cylindrical shape of the fabric during extraction and compacting processes. Encasing the fabric and the mandrel is a larger diameter cylindrical ring member which presses the fabric against the mandrel in order to perform the extraction and compaction processes. The ring member extends for some distance in the longitudinal direction of travel of the knit fabric and contains a mechanism, such as a detent, for retaining the mandrel in place. A rope of tubular fabric is conveyed into the mandrel/ring assembly by an endless conveyor or belt made from a flexible material such as rubber. As the fabric is fed onto the mandrel, the belt forms a cylindrical sleeve around the fabric and the mandrel and is compressed by the cylindrical ring.

19. 发明专利

AU2104799A Finishing machine for tubular knit fabric 未知
公开(公告)号：AU2104799A
公开(公告)日：1999-08-09
申请号：AU2104799
申请日：1999-01-13
申请人： CARUSO FRANK
发明人： CARUSO FRANK
IPC分类号： D06B15/00 , D06C5/00 , D06C21/00
摘要： A cylindrical shaped mandrel is used as a support inside the sleeve of tubular knit fabric, for maintaining the cylindrical shape of the fabric during extraction and compacting processes. Encasing the fabric and the mandrel is a larger diameter cylindrical ring member which presses the fabric against the mandrel in order to perform the extraction and compaction processes. The ring member extends for some distance in the longitudinal direction of travel of the knit fabric and contains a mechanism, such as a detent, for retaining the mandrel in place. A rope of tubular fabric is conveyed into the mandrel/ring assembly by an endless conveyor or belt made from a flexible material such as rubber. As the fabric is fed onto the mandrel, the belt forms a cylindrical sleeve around the fabric and the mandrel and is compressed by the cylindrical ring.

20. 发明申请

WO2011156831A1 FORMATION OF NUCLEIC ACID WITHIN A POLYMERIC CAPSULE 审中-公开
标题翻译：在聚合胶囊中形成核酸
公开(公告)号：WO2011156831A1
公开(公告)日：2011-12-22
申请号：PCT/AU2010/000756
申请日：2010-06-17
申请人： COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION , THE UNIVERSITY OF MELBOURNE , WARK, Kim , CARUSO, Frank , PRICE, Andrew , ZELIKIN, Alexander N.
发明人： WARK, Kim , CARUSO, Frank , PRICE, Andrew , ZELIKIN, Alexander N.
IPC分类号： C12N11/04 , C12N15/11 , C12N11/08 , C12N15/113
CPC分类号： C12P19/34 , C12N15/111 , C12N2310/127 , C12N2310/141 , C12N2310/531 , C12N2320/32 , C12N2330/30 , C12N2330/50
摘要： The present invention provides method of producing a nucleic acid molecule within a polymeric capsule. The method comprises providing a polymeric capsule having entrapped therein a DNA molecule and mixing the capsule with a polymerase and nucleotides, wherein the polymerase and the nucleotides can diffuse into the capsule, to form a reactant mixture. The reactant mixture is then incubated for a time and under conditions such as to allow the de novo synthesis of a nucleic acid molecule within the capsule. The method is particularly useful for the preparation of encapsulated RNAs such as miRNA.
摘要翻译：本发明提供了在聚合物胶囊内产生核酸分子的方法。该方法包括提供其中包含DNA分子并将胶囊与聚合酶和核苷酸混合的聚合物胶囊，其中聚合酶和核苷酸可以扩散到胶囊中以形成反应物混合物。然后将反应混合物温育一段时间并在条件下进行，以允许从胶囊内重新合成核酸分子。该方法对于制备包封的RNA如miRNA是特别有用的。

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