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11. 发明申请

WO2008151146A2 PEPTIDE ARRAYS AND METHODS OF USE 审中-公开
标题翻译：肽类阵列和使用方法
公开(公告)号：WO2008151146A2
公开(公告)日：2008-12-11
申请号：PCT/US2008/065559
申请日：2008-06-02
申请人： DIGITAB, INC. , CHU, Keting
发明人： CHU, Keting
IPC分类号： G01N33/68
CPC分类号： G01N33/6845 , C07K1/047
摘要： Peptide arrays and uses thereof for diagnostics, therapeutics and research. Ultra high density peptide arrays are generated using photolithography, such as using photoresist techniques.
摘要翻译：肽阵列及其用途，用于诊断，治疗和研究。使用光刻法生产超高密度肽阵列，例如使用光致抗蚀剂技术。

12. 发明申请

WO2005005597A3 NOVEL MOUSE POLYPEPTIDES ENCODE BY POLYNUCLEOTIDES AND METHODS OF THEIR USE 审中-公开
标题翻译：多核苷酸编码的新型小鼠多糖及其使用方法
公开(公告)号：WO2005005597A3
公开(公告)日：2006-01-05
申请号：PCT/US0327106
申请日：2003-08-28
申请人： FIVE PRIME THERAPEUTICS INC , RIKEN , DNAFORM KK , WILLIAMS LEWIS T , CHU KETING , LEE ERNESTINE , HESTIR KEVIN , HAYASHIZAKI YOSHIHIDE , KAMIYA MAMORU
发明人： WILLIAMS LEWIS T , CHU KETING , LEE ERNESTINE , HESTIR KEVIN , HAYASHIZAKI YOSHIHIDE , KAMIYA MAMORU
IPC分类号： C12N20060101 , C12P21/06 , A61K39/395 , A61K45/00 , A61K48/00 , C07K1/00 , C12N5/00 , C12N15/00 , C12Q1/68
CPC分类号： C12N1/00
摘要： The invention provides novel polynucleotides, related polypeptides, related nucleic acid and polypeptide compositions, and related modulators, such as antibodies and small molecule modulators. The invention also provides methods to make and use these polynucleotides, polypeptides, related compositions, and modulators. These methods include diagnostic, prophylactic and therapeutic applications. The compositions, and methods of the invention are useful in treating proliferative disorders, e.g., cancers, and inflammatory, immune, bacterial, and viral disorders.
摘要翻译：本发明提供了新的多核苷酸，相关多肽，相关的核酸和多肽组合物以及相关的调节剂，例如抗体和小分子调节剂。本发明还提供了制备和使用这些多核苷酸，多肽，相关组合物和调节剂的方法。这些方法包括诊断，预防和治疗应用。本发明的组合物和方法可用于治疗增殖性疾病，例如癌症，炎性，免疫，细菌和病毒性疾病。

13. 发明申请

WO2005121174A2 NOVEL G-CSF POLYPEPTIDES, POLYNUCLEOTIDES, MODULATORS THEREOF, AND METHODS OF USE 审中-公开
标题翻译：新型G-CSF多肽，多核苷酸，其调节剂及其使用方法
公开(公告)号：WO2005121174A2
公开(公告)日：2005-12-22
申请号：PCT/US2005/019491
申请日：2005-06-03
申请人： FIVE PRIME THERAPEUTICS, INC. , LINNEMANN, Thomas , CHU, Keting , HESTIR, Kevin , LIN, Haishan , WILLIAMS, Lewis, T. , LEE, Ernestine
发明人： LINNEMANN, Thomas , CHU, Keting , HESTIR, Kevin , LIN, Haishan , WILLIAMS, Lewis, T. , LEE, Ernestine
IPC分类号： C07K14/535
CPC分类号： C07K14/535
摘要： Disclosed herein are two newly identified G-CSF splice variant molecules, their polypeptide sequences, the polynucleotides encoding the polypeptide sequences, and active fragments thereof. Also provided is a procedure for producing such polypeptides by recombinant techniques employing, for example, vectors and host cells. Also disclosed are methods for utilizing such polypeptides and modulators thereof for the treatment of diseases, including cancer, immune diseases, infectious diseases, and ischemic diseases.
摘要翻译：本文公开了两种新鉴定的G-CSF剪接变体分子，其多肽序列，编码多肽序列的多核苷酸及其活性片段。还提供了通过使用例如载体和宿主细胞的重组技术产生此类多肽的方法。还公开了利用这些多肽及其调节剂治疗疾病的方法，包括癌症，免疫疾病，感染性疾病和缺血性疾病。

14. 发明申请

WO2005076012A2 NOVEL SPLICE VARIANTS AND METHODS OF USE THEREOF 审中-公开
标题翻译：新的差距变体及其使用方法
公开(公告)号：WO2005076012A2
公开(公告)日：2005-08-18
申请号：PCT/US2005/002695
申请日：2005-01-31
申请人： FIVE PRIME THERAPEUTICS, INC. , CHU, Keting , COLLINS, Amy, L. Tsui , LEE, Ernestine , WONG, Justin, G.P.
发明人： CHU, Keting , COLLINS, Amy, L. Tsui , LEE, Ernestine , WONG, Justin, G.P.
IPC分类号： G01N33/68
CPC分类号： G01N33/5011 , C07K14/47 , C07K16/40 , G01N33/566 , G01N33/574
摘要： The present invention relates to splice variants of polypeptides that are highly expressed in tumor tissues. Such polypeptides are useful for therapeutic, diagnostic, and prophylactic purposes. In particular, the polypeptides herein are useful as targets for development of modulators for treatment of diseases.
摘要翻译：本发明涉及在肿瘤组织中高度表达的多肽的剪接变体。这样的多肽可用于治疗，诊断和预防目的。特别地，本文的多肽可用作开发用于治疗疾病的调节剂的靶标。

15. 发明申请

WO2004020595A8 NOVEL HUMAN POLYPEPTIDES ENCODED BY POLYNUCLEOTIDES 审中-公开
标题翻译：由多核苷酸编码的新型人多肽
公开(公告)号：WO2004020595A8
公开(公告)日：2004-07-15
申请号：PCT/US0327107
申请日：2003-08-28
申请人： FIVE PRIME THERAPEUTICS INC , RIKEN THE INST OF PHYSICAL AND , DNAFORM KK , WILLIAMS LEWIS T , CHU KETING , LEE ERNESTINE , HESTIR KEVIN
发明人： WILLIAMS LEWIS T , CHU KETING , LEE ERNESTINE , HESTIR KEVIN
IPC分类号： C07K14/47 , A61K48/00 , C07H21/04 , C12N1/21 , C12N5/10 , C12N15/63 , C12N15/64
CPC分类号： C07K14/47
摘要： The invention provides novel polynucleotides, related polypeptides, related nucleic acid and polypeptide compositions, and related modulators, such as antibodies and small molecule modulators. The compositions of the invention are useful' in treating proliferative disorders, e.g., cancers, and inflammatory, immune, bacterial, and viral disorders.
摘要翻译：本发明提供新的多核苷酸，相关多肽，相关核酸和多肽组合物以及相关的调节剂，例如抗体和小分子调节剂。本发明的组合物可用于治疗增殖性疾病，例如癌症和炎性，免疫，细菌和病毒性疾病。

16. 发明申请

WO0228481A9 METHODS OF THERAPY FOR B-CELL MALIGNANCIES USING ANTAGONIST ANTI-CD40 ANTIBODIES 审中-公开
标题翻译：使用拮抗剂抗CD40抗体治疗B细胞恶性肿瘤的方法
公开(公告)号：WO0228481A9
公开(公告)日：2003-07-03
申请号：PCT/US0130963
申请日：2001-10-02
申请人： CHIRON CORP , CHU KETING , MASUOKA LORIANNE
发明人： CHU KETING , MASUOKA LORIANNE
IPC分类号： C12N15/09 , A61K39/395 , A61P1/04 , A61P17/06 , A61P19/02 , A61P25/00 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/02 , A61P37/06 , A61P43/00 , C07K16/18 , C07K16/28 , C07K16/30 , C12N15/13 , C12P21/08
CPC分类号： C07K16/2878 , A01K2217/05 , A61K2039/505 , C07K2317/21 , C12N2799/026
摘要： Methods of therapy for B-cell malignancies are provided. The methods comprise administering a therapeutically effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment thereof to a patient in need thereof. The antagonist anti-CD40 antibody or antigen-binding fragment thereof is free of significant agonist activity when the antibody binds a CD40 antigen on a normal human B cell, exhibits antagonist activity when the antibody binds a CD40 antigen on a malignant human B cell, and can exhibit antagonist activity when the antibody binds a CD40 antigen on a normal human B cell. Antagonist activity of the anti-CD40 antibody or antigen-binding fragment thereof beneficially inhibits proliferation and/or differentiation of malignant human B cells.
摘要翻译：提供了B细胞恶性肿瘤治疗方法。所述方法包括向有需要的患者施用治疗有效量的拮抗性抗CD40抗体或其抗原结合片段。当抗体结合正常人B细胞上的CD40抗原时，拮抗性抗CD40抗体或其抗原结合片段没有显着的激动剂活性，当抗体结合恶性人B细胞上的CD40抗原时，拮抗剂抗CD40抗体或其抗原结合片段，当抗体结合正常人B细胞上的CD40抗原时，可以显示拮抗剂活性。抗CD40抗体或其抗原结合片段的拮抗作用有益地抑制恶性人B细胞的增殖和/或分化。

17. 发明申请

WO2003028809A1 METHODS OF THERAPY FOR B-CELL MALIGNANCIES 审中-公开
标题翻译： B细胞恶性肿瘤治疗方法
公开(公告)号：WO2003028809A1
公开(公告)日：2003-04-10
申请号：PCT/US2001/030960
申请日：2001-10-02
申请人： CHIRON CORPORATION , CHU, Keting , MASUOKA, Lorianne
发明人： CHU, Keting , MASUOKA, Lorianne
IPC分类号： A61P35/00
CPC分类号： C07K16/2878
摘要： Methods of therapy for B-cell malignancies are provided. The methods comprise administering a therapeutically effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment thereof to a patient in need thereof. The antagonist anti-CD40 antibody or antigen-binding fragment thereof is free of significant agonist activity when the antibody binds a CD40 antigen on a normal human B cell, exhibits antagonist activity when the antibody binds a CD40 antigen on a malignant human B cell, and can exhibit antagonist activity when the antibody binds a CD40 antigen on a normal human B cell. Antagonist activity of the anti-CD40 antibody or antigen-binding fragment thereof beneficially inhibits proliferation and/or differentiation of malignant human B cells.
摘要翻译：提供了B细胞恶性肿瘤治疗方法。所述方法包括向有需要的患者施用治疗有效量的拮抗性抗CD40抗体或其抗原结合片段。当抗体结合正常人B细胞上的CD40抗原时，拮抗性抗CD40抗体或其抗原结合片段没有显着的激动剂活性，当抗体结合恶性人B细胞上的CD40抗原时，拮抗剂抗CD40抗体或其抗原结合片段，当抗体结合正常人B细胞上的CD40抗原时，可以显示拮抗剂活性。抗CD40抗体或其抗原结合片段的拮抗作用有益地抑制恶性人B细胞的增殖和/或分化。

18. 发明申请

WO2009079308A2 COMPOSITION AND METHOD OF USE OF SHEEP FAB PHAGE DISPLAY LIBRARY 审中-公开
标题翻译：羊FAB显示文库的组成和使用方法
公开(公告)号：WO2009079308A2
公开(公告)日：2009-06-25
申请号：PCT/US2008086289
申请日：2008-12-10
申请人： DIGITAB INC , CHU KETING , YANG RANDY , WANG JIANFU JEFFREY
发明人： CHU KETING , YANG RANDY , WANG JIANFU JEFFREY
IPC分类号： C07K16/18 , C12N7/01 , C12N15/10
CPC分类号： C07K16/005 , C07K16/18 , C07K2317/21 , C07K2317/55 , C12N15/1037
摘要： The present invention discloses methods of producing sheep monoclonal antibodies by expanding mRNA. One method involves the construction of sheep monoclonal Fab antibodies by phage display. The present invention also discloses antibodies produced by the methods disclosed herein. Other methods of the present invention involve using the antibodies produced by the methods of the present invention to treat patients, perform diagnostic procedures, and/or conduct research.
摘要翻译：本发明公开了通过扩增mRNA产生绵羊单克隆抗体的方法。一种方法涉及通过噬菌体展示构建绵羊单克隆Fab抗体。本发明还公开了通过本文公开的方法产生的抗体。本发明的其他方法涉及使用通过本发明的方法产生的抗体来治疗患者，执行诊断程序和/或进行研究。

19. 发明申请

WO2004020595A3 Novel human polypeptides encoded by polynucleotides 审中-公开
标题翻译：由多核苷酸编码的新型人多肽
公开(公告)号：WO2004020595A3
公开(公告)日：2006-05-04
申请号：PCT/US0327107
申请日：2003-08-28
申请人： FIVE PRIME THERAPEUTICS INC , RIKEN THE INST OF PHYSICAL AND , DNAFORM KK , WILLIAMS LEWS T , CHU KETING , LEE ERNESTINE , HESTIR KEVIN
发明人： WILLIAMS LEWIS T , CHU KETING , LEE ERNESTINE , HESTIR KEVIN
IPC分类号： C07K14/47 , A61K48/00 , C07H21/04 , C12N1/21 , C12N5/10 , C12N15/63 , C12N15/64
CPC分类号： C07K14/47
摘要： The invention provides novel polynucleotides, related polypeptides, related nucleic acid and polypeptide compositions, and related modulators, such as antibodies and small molecule modulators. The compositions of the invention are useful' in treating proliferative disorders, e.g., cancers, and inflammatory, immune, bacterial, and viral disorders.
摘要翻译：本发明提供了新的多核苷酸，相关多肽，相关的核酸和多肽组合物以及相关的调节剂，例如抗体和小分子调节剂。本发明的组合物可用于治疗增殖性疾病，例如癌症和炎性，免疫，细菌和病毒性疾病。

20. 发明申请

WO2005070448A2 METHODS OF USE FOR SECRETED FRIZZLED-RELATED PROTEIN 3 (SFRP-3) IN THE PREVENTION AND TREATMENT OF DISEASE 审中-公开
标题翻译：用于分泌的相关蛋白3（SFRP-3）在预防和治疗疾病中的使用方法
公开(公告)号：WO2005070448A2
公开(公告)日：2005-08-04
申请号：PCT/US2005/001886
申请日：2005-01-21
申请人： FIVE PRIME THERAPEUTICS, INC. , PIERCE, Kristen , COLLINS, Amy, L., Tsui , ZHANG, Hongbing , WILLIAMS, Lewis, Thomas , BEAURANG, Pierre, Alvaro , LIN, Haishan , CHU, Keting , WANG, Yan
发明人： PIERCE, Kristen , COLLINS, Amy, L., Tsui , ZHANG, Hongbing , WILLIAMS, Lewis, Thomas , BEAURANG, Pierre, Alvaro , LIN, Haishan , CHU, Keting , WANG, Yan
IPC分类号： A61K38/00
CPC分类号： C07K14/71 , A61K38/1709 , G01N33/574 , G01N2500/00
摘要： Compositions containing sFRP-3 polypeptides, polynucleotides, and modulators thereof, such as antibodies thereto, are provided. Such compositions are useful for the treatment, prevention, and diagnosis of diseases. Such diseases include immune and proliferative diseases. Methods for utilizing these polypeptides, polynucleotides, and modulators aredisclosed; they include methods for treating proliferative, inflammatory, and bone and cartilage diseases.
摘要翻译：提供了含有sFRP-3多肽，多核苷酸及其调节剂的组合物，例如其抗体。这样的组合物可用于治疗，预防和诊断疾病。这些疾病包括免疫和增殖性疾病。利用这些多肽，多核苷酸和调节剂的方法是公开的; 它们包括治疗增殖性，炎性和骨骼和软骨疾病的方法。

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