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11. 发明申请

US20140288312A1 COMPOUNDS FOR THE TREATMENT OF INFLUENZA 有权
标题翻译：化合物治疗流感病毒
公开(公告)号：US20140288312A1
公开(公告)日：2014-09-25
申请号：US14354654
申请日：2012-10-29
申请人： CHRISTIAN-ALBRECHTS-UNIVERSITAT ZU KIEL
发明人： Bernd Clement , Joscha Kotthaus , Jurke Kotthaus , Dennis Schade
IPC分类号： C07C235/68 , C07D263/06 , C07C231/12
CPC分类号： C07C235/68 , C07C231/12 , C07C275/14 , C07C279/16 , C07C2601/16 , C07D263/06
摘要： The invention relates to oseltamivir derivatives as influenza neuraminidase inhibitors for treating influenza infections and to a method for producing said compounds.
摘要翻译：本发明涉及作为用于治疗流感感染的流感神经氨酸酶抑制剂的奥司他韦衍生物及其制备方法。

12. 发明申请

US20210371519A1 Suppressing IgE-Mediated Allergy by Desensitization with Monovalent Anti-FCeR1a Monoclonal Antibody 有权
公开(公告)号：US20210371519A1
公开(公告)日：2021-12-02
申请号：US17277071
申请日：2019-09-20
申请人： UNIVERSITY OF CINCINNATI , CHILDREN'S HOSPITAL MEDICAL CENTER , CHRISTIAN-ALBRECHTS-UNIVERSITAT ZU KIEL
发明人： Fred Finkelman , Suzanne Morris , Marat Khodoun , Crystal Potter , Elizabeth Angerman , Andrew Herr , Matthias Peipp
IPC分类号： C07K16/28 , A61P37/08
摘要： A monovalent monoclonal antibody is provided, the antibody including one light chain, one heavy chain, and one truncated heavy chain, wherein the truncated heavy chain lacks a variable domain and a CH1 domain and wherein the antibody specifically binds an epitope of FcεRIα. Also provided are methods of desensitizing a subject to an allergen, methods of treating an allergy, and methods of preventing an allergic reaction in a subject having an allergy.

13. 发明公开

US20230270709A1 ANTIVIRAL PHARMACEUTICAL COMPOSITION FOR TOPICAL ADMINISTRATION 审中-公开
公开(公告)号：US20230270709A1
公开(公告)日：2023-08-31
申请号：US18043609
申请日：2021-09-02
申请人： Christian-Albrechts-Universitat Zu Kiel
发明人： Dennis Schade , Regina Scherliess , Bernd Clement
IPC分类号： A61K31/245 , A61K9/00
CPC分类号： A61K31/245 , A61K9/0014
摘要： The present invention relates to a topical pharmaceutical composition comprising a serine protease inhibitor for use in the treatment or prevention of viral infections. The invention is further directed to serine protease inhibitors and a lozenge and a dry nasal preparation comprising the serine protease inhibitor.

14. 发明申请

US20150056406A1 ADHESIVE MICROSTRUCTURE 审中-公开
标题翻译：粘合微结构
公开(公告)号：US20150056406A1
公开(公告)日：2015-02-26
申请号：US14356176
申请日：2012-11-08
申请人： Technion R&D Foundation Ltd. , Christian-Albrechts-Universitat zu Kiel
发明人： Michael Varenberg , Stanislav Gorb
IPC分类号： C09J7/00 , B29C39/02
CPC分类号： B29C39/026 , B29C33/42 , B29C33/424 , B29C39/006 , B29C39/42 , B29K2083/00 , B29K2105/0097 , B29L2031/756 , C09J2201/626 , Y10T428/24174
摘要： A microstructure made of flexible material includes a plurality of projections extending from a common substrate. A distal end of each projection includes a resilient flap. All lateral dimensions of each of the projections increase monotonically with increased distance from a surface defined by distal ends of the flaps when the flaps are unbent. Each of the projections extends from the common substrate in a general direction that is locally substantially perpendicular to the surface defined by the ends of the flaps. When a shear force is applied to each of the flaps by relative motion between the flap and a cooperating surface in contact with the flap, the flap bends so as to increase the area of contact of that flap with the cooperating surface, affecting adhesion between the microstructure and the cooperating surface.
摘要翻译：由柔性材料制成的微结构包括从共同的衬底延伸的多个突起。每个突起的远端包括弹性翼片。每个突起的所有横向尺寸随着襟翼不弯曲时从与翼片的远端限定的表面的距离增加而单调增加。每个突起从共同的基板延伸，其大致方向基本上垂直于由翼片的端部限定的表面。当剪切力通过翼片与与翼片接触的协作表面之间的相对运动施加到每个翼片时，翼片弯曲以增加该翼片与协作表面的接触面积，从而影响微结构和配合表面。

15. 发明申请

US20220111013A1 COMPOUND DECREASING THE CONCENTRATION OF 2-HYDROXY-GLUTARATE 有权
公开(公告)号：US20220111013A1
公开(公告)日：2022-04-14
申请号：US17425137
申请日：2020-01-23
申请人： Universität Heidelberg , Christian-Albrechts-Universitat zu Kiel
发明人： Oliver MÜLLER , Hugo KATUS , Norbert FREY , Lin DING , Andreas JUNGMANN , Anca REMES , Philipp SCHATZ , Beate KAMLAGE , Philipp TERNES
IPC分类号： A61K38/44 , A61K9/51 , A61P9/04
摘要： The present invention relates to a compound decreasing the concentration of 2-hydroxy-glutarate (2HG) in a subject for use in treating, preventing, and/or preventing progression of cardiac remodeling, in particular cardiomyopathy and/or heart failure and to viral particles, compositions, uses and methods related thereto.

16. 发明授权

US09828333B2 Compounds for the treatment of influenza 有权
公开(公告)号：US09828333B2
公开(公告)日：2017-11-28
申请号：US14354654
申请日：2012-10-29
申请人： CHRISTIAN-ALBRECHTS-UNIVERSITAT ZU KIEL
发明人： Bernd Clement , Joscha Kotthaus , Jurke Kotthaus , Dennis Schade
IPC分类号： C07C235/68 , C07C231/12 , A61K31/165 , A61K31/192 , A61K31/609 , C07C275/14 , C07C279/16 , C07D263/06
CPC分类号： C07C235/68 , C07C231/12 , C07C275/14 , C07C279/16 , C07C2601/16 , C07D263/06
摘要： The invention relates to oseltamivir derivatives as influenza neuraminidase inhibitors for treating influenza infections and to a method for producing said compounds.

17. 发明授权

US11046693B2 Pyrido-phenanthroline derivatives, production and use thereof as medicaments 有权
公开(公告)号：US11046693B2
公开(公告)日：2021-06-29
申请号：US16465258
申请日：2017-11-24
申请人： Christian-Albrechts-Universitat Zu Kiel
发明人： Bernd Clement , Christopher Meier , Tamara Natalie Steinhauer
IPC分类号： C07D471/14 , A61P35/00
摘要： The invention relates to novel pyrido-phenanthroline derivatives, to the production and use thereof in the field of medicine, in particular for cancer therapy.

18. 发明申请

WO2013069013A1 ADHESIVE MICROSTRUCTURE 审中-公开
标题翻译：粘合微结构
公开(公告)号：WO2013069013A1
公开(公告)日：2013-05-16
申请号：PCT/IL2012/050445
申请日：2012-11-08
申请人： TECHNION R&D FOUNDATION lTD. , CHRISTIAN-ALBRECHTS-UNIVERSITAT ZU KIEL
发明人： VARENBERG, Michael , GORB, Stanislav
IPC分类号： C09J7/00 , B82Y30/00
CPC分类号： C09J7/10
摘要： A microstructure made of flexible material includes a plurality of projections extending from a common substrate. A distal end of each projection includes a resilient flap. All lateral dimensions of each of the projections increase monotonically with increased distance from a surface defined by distal ends of the flaps when the flaps are unbent. Each of the projections extends from the common substrate in a general direction that is locally substantially perpendicular to the surface defined by the ends of the flaps. When a shear force is applied to each of the flaps by relative motion between the flap and a cooperating surface in contact with the flap, the flap bends so as to increase the area of contact of that flap with the cooperating surface, affecting adhesion between the microstructure and the cooperating surface.
摘要翻译：由柔性材料制成的微结构包括从共同的衬底延伸的多个突起。每个突起的远端包括弹性翼片。每个突起的所有横向尺寸随着襟翼不弯曲时从与翼片的远端限定的表面的距离增加而单调增加。每个突起从共同的基板延伸，其大致方向基本上垂直于由翼片的端部限定的表面。当通过翼片与与翼片接触的协作表面之间的相对运动将剪切力施加到每个翼片时，翼片弯曲以增加该翼片与协作表面的接触面积，从而影响微结构和配合表面。

19. 发明申请

WO2020061441A1 SUPPRESSING IgE-MEDIATED ALLERGY BY DESENSITIZATION WITH MONOVALENT ANTI-FC MONOCLONAL ANTIBODY 审中-公开
公开(公告)号：WO2020061441A1
公开(公告)日：2020-03-26
申请号：PCT/US2019/052132
申请日：2019-09-20
申请人： UNIVERSITY OF CINCINNATI , CHILDREN'S HOSPITAL MEDICAL CENTER , CHRISTIAN-ALBRECHTS-UNIVERSITAT ZU KIEL
发明人： FINKELMAN, Fred , MORRIS, Suzanne , KHODOUN, Marat , POTTER, Crystal , ANGERMAN, Elizabeth , HERR, Andrew , PEIPP, Matthias
IPC分类号： A61K39/395 , A61P37/08 , C07K16/28
摘要： A monovalent monoclonal antibody is provided, the antibody including one light chain, one heavy chain, and one truncated heavy chain, wherein the truncated heavy chain lacks a variable domain and a CH1 domain and wherein the antibody specifically binds an epitope of FcεRIα. Also provided are methods of desensitizing a subject to an allergen, methods of treating an allergy, and methods of preventing an allergic reaction in a subject having an allergy.

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