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11. 发明授权

US06113886A Bioluminescent novelty items 有权
标题翻译：生物发光新奇物品
公开(公告)号：US06113886A
公开(公告)日：2000-09-05
申请号：US447208
申请日：1999-11-22
申请人： Bruce Bryan
发明人： Bruce Bryan
IPC分类号： F41B9/00 , A23G3/00 , A23G3/36 , A23G3/50 , A23G9/32 , A23G9/36 , A23G9/44 , A23L1/00 , A23L1/03 , A23L1/27 , A23L1/30 , A23L2/38 , A23L2/52 , A23L2/58 , A23L2/66 , A23P1/04 , A24D3/14 , A45D34/00 , A61K8/00 , A61K8/64 , A61K8/66 , A61K8/98 , A61K8/99 , A61Q11/00 , A61Q19/00 , B05B7/04 , B05B7/24 , B05B15/00 , B05C17/005 , B65D65/38 , C07K14/435 , C11D9/00 , C12C5/04 , C12C12/00 , C12G1/00 , C12G3/02 , C12N9/02 , C12N15/09 , C12N15/82 , C12Q1/26 , D06Q1/00 , F21K2/00 , F21K2/06 , F21K99/00 , F21S8/00 , F21V33/00 , A61K7/16 , A61K7/021 , A61K7/035 , A61K7/075
CPC分类号： F21V33/0028 , A23G3/366 , A23G3/50 , A23G9/363 , A23G9/44 , A23K20/00 , A23K20/189 , A23K50/80 , A23L17/00 , A23L17/30 , A23L2/38 , A23L2/58 , A23L29/06 , A23L29/065 , A23P10/30 , A24D3/14 , A61K8/64 , A61Q19/00 , B05B7/0408 , B05B7/2416 , B05B7/2472 , B05C17/00553 , C07K14/43595 , C12C12/004 , C12C12/006 , C12G1/00 , C12N15/8212 , C12N9/0069 , C12N9/0071 , F21K2/00 , F21K2/06 , F21S8/00 , F41B9/004 , A23V2002/00 , A45D34/00 , A61K2800/434 , A61Q11/00 , F21W2121/02 , F21W2131/401 , Y10S493/955
摘要： Novelty items that are combinations of articles of manufacture with bioluminescence generating systems and/or fluorescent proteins are provided. These novelty items, which are articles of manufacture, are designed for entertainment, recreation and amusement, and include toys, personal items, such as cosmetics, bath powders, body lotions, gels, powders and creams, toothpastes and other dentifrices, soaps, body paints, and bubble bath, fountains, including liquid "fireworks" and other such jets or sprays or aerosols of compositions that are solutions, mixtures, suspensions, powders, pastes, particles or other formulations.
摘要翻译：提供了与生物发光生成系统和/或荧光蛋白质的制品组合的新颖物品。这些新产品是制造品，专为娱乐，娱乐和娱乐而设计，包括玩具，个人用品，如化妆品，浴粉，身体乳液，凝胶，粉末和霜，牙膏和其他洁齿剂，肥皂，身体油漆和泡泡浴，喷泉，包括液体“烟花”和其他溶液，混合物，悬浮液，粉末，糊剂，颗粒或其他配方的喷雾或喷雾剂或喷雾剂或气溶胶。

12. 发明授权

US5876995A Bioluminescent novelty items 失效
标题翻译：生物发光新奇物品
公开(公告)号：US5876995A
公开(公告)日：1999-03-02
申请号：US757046
申请日：1996-11-25
申请人： Bruce Bryan
发明人： Bruce Bryan
IPC分类号： F41B9/00 , A23G3/00 , A23G3/36 , A23G3/50 , A23G9/32 , A23G9/36 , A23G9/44 , A23L1/00 , A23L1/03 , A23L1/27 , A23L1/30 , A23L2/38 , A23L2/52 , A23L2/58 , A23L2/66 , A23P1/04 , A24D3/14 , A45D34/00 , A61K8/00 , A61K8/64 , A61K8/66 , A61K8/98 , A61K8/99 , A61Q11/00 , A61Q19/00 , B05B7/04 , B05B7/24 , B05B15/00 , B05C17/005 , B65D65/38 , C07K14/435 , C11D9/00 , C12C5/04 , C12C12/00 , C12G1/00 , C12G3/02 , C12N9/02 , C12N15/09 , C12N15/82 , C12Q1/26 , D06Q1/00 , F21K2/00 , F21K2/06 , F21K99/00 , F21S8/00 , F21V33/00 , A23L2/00
CPC分类号： F21V33/0028 , A23G3/366 , A23G3/50 , A23G9/363 , A23G9/44 , A23K20/00 , A23K20/189 , A23K50/80 , A23L17/00 , A23L17/30 , A23L2/38 , A23L2/58 , A23L29/06 , A23L29/065 , A23P10/30 , A24D3/14 , A61K8/64 , A61Q19/00 , B05B7/0408 , B05B7/2416 , B05B7/2472 , B05C17/00553 , C07K14/43595 , C12C12/004 , C12C12/006 , C12G1/00 , C12N15/8212 , C12N9/0069 , C12N9/0071 , F21K2/00 , F21K2/06 , F21S8/00 , F41B9/004 , A23V2002/00 , A45D34/00 , A61K2800/434 , A61Q11/00 , F21W2121/02 , F21W2131/401 , Y10S493/955
摘要： Systems and apparatus for generating bioluminescence, and combinations of these systems and apparatus with inanimate articles of manufacture to produce novelty items are provided. These novelty items, which are articles of manufacture, are designed for entertainment, recreation and amusement, and include toys, paints, slimy play material, textiles, particularly clothing, bubbles in bubble making toys and other toys that produce bubbles, balloons, personal items, such as bath powders, body lotions, gels, powders and creams, toothpastes and other dentifrices, soaps, body paints, and bubble bath, foods, such as gelatins, icings and frostings, beverages such as beer, wine, champagne, soft drinks, and glowing ice, fountains, including liquid "fireworks" and other such jets or sprays or aerosols of compositions that are solutions, mixtures, suspensions, powders, pastes, particles or other suitable formulation. Cartridges for charging and/or recharging the novelty items with bioluminescence generating systems are also provided.
摘要翻译：提供了用于产生生物发光的系统和装置，以及这些系统和装置与无生命制品的组合以产生新颖物品。这些新品是制作娱乐，娱乐和娱乐的新奇物品，包括玩具，油漆，泥土玩具材料，纺织品，特别是服装，气泡制作玩具中的气泡，以及产生气泡，气球，个人物品的其他玩具例如浴粉，身体乳液，凝胶，粉末和乳膏，牙膏和其他洁牙剂，肥皂，身体涂料和泡泡浴，食品如明胶，结冰和结霜，饮料如啤酒，葡萄酒，香槟，软饮料，以及发光的冰，喷泉，包括液体“烟花”和其它溶液，混合物，悬浮液，粉末，糊剂，颗粒或其他合适制剂的组合物的喷射或喷雾或喷雾剂。还提供了用于利用生物发光生成系统对新颖物品进行充电和/或再充电的墨盒。

13. 发明申请

US20130058872A1 Bioluminescent Endoscopy Methods and Compounds 审中-公开
标题翻译：生物发光内窥镜检查方法和化合物
公开(公告)号：US20130058872A1
公开(公告)日：2013-03-07
申请号：US13610242
申请日：2012-09-11
申请人： Philip T. Neff , Bruce Bryan , Randall B. Murphy
发明人： Philip T. Neff , Bruce Bryan , Randall B. Murphy
IPC分类号： A61K49/00
CPC分类号： G01N21/763 , C07D487/04 , G01N21/6456
摘要： Bioluminescent endoscopy methods in which bioluminescent generating system components are combined ex vivo immediately prior to injection or infusion into a tissue area of interest to enable bioluminescent viewing of the tissue. The bioluminescent generating system components are combined by simultaneous injection into a Y tube or other in-line mixing chamber receiving fluid inputs from two or more fluid conduits and providing a fluid output to at least one fluid conduit. The mixed components which are the output of such multi lumen mixing system is injected into a hollow viscus organ or otherwise applied to organs and/or tissues of the body.
摘要翻译：生物发光内窥镜检查方法，其中将生物发光发生系统组分在注射或注射到目的组织区域之前离体组合以使组织的生物发光观察。生物发光发生系统部件通过同时注射到Y管或其它在线混合室中，从两个或更多个流体导管接收流体输入，并向至少一个流体导管提供流体输出。作为这种多腔混合系统的输出的混合成分被注射到空心粘液器官中或以其它方式施加到身体的器官和/或组织上。

14. 发明申请

US20070186474A1 Plasma assisted conversion of carbonaceous materials into a gas 失效
标题翻译：等离子体辅助将碳质材料转化成气体
公开(公告)号：US20070186474A1
公开(公告)日：2007-08-16
申请号：US11451512
申请日：2006-06-12
申请人： Iosif K. Rabovitser , Serguei Nester , Bruce Bryan
发明人： Iosif K. Rabovitser , Serguei Nester , Bruce Bryan
IPC分类号： B01J19/08
CPC分类号： B01J19/088 , B01J2219/00006 , B01J2219/0884 , B01J2219/0896 , C01B3/342 , C01B2203/043 , C01B2203/06 , C01B2203/0861 , C01B2203/1252 , C01B2203/142 , C01B2203/86 , C10J3/00 , C10J3/86 , C10J2300/0903 , C10J2300/093 , C10J2300/1238 , C10J2300/165 , C10J2300/1675 , C10J2300/1687 , Y02P20/133 , Y02P30/30
摘要： A method and system for producing product gases in which a carbonaceous material and at least one oxygen carrier are introduced into a non-thermal plasma reactor at a temperature in the range of about 300° C. to about 700° C. and a pressure in a range of about atmospheric to about 70 atmospheres and a non-thermal plasma discharge is generated within the non-thermal plasma reactor. The carbonaceous material and the oxygen carrier are exposed to the non-thermal plasma discharge, resulting in the formation of a product gas in the non-thermal plasma reactor, which product gas comprises substantial amounts of hydrocarbons, such as methane, hydrogen and/or carbon monoxide.
摘要翻译：一种用于生产产物气体的方法和系统，其中碳质材料和至少一种氧载体在约300℃至约700℃的温度范围内引入非热等离子体反应器中，在非热等离子体反应器内产生约大气至约70个大气压的范围和非热等离子体放电。碳质材料和氧载体暴露于非热等离子体放电，导致在非热等离子体反应器中形成产物气体，该产物气体包含大量的烃，例如甲烷，氢气和/或一氧化碳。

15. 发明授权

US08431698B2 Bioluminescent endoscopy methods and compounds 有权
标题翻译：生物发光内窥镜检查方法和化合物
公开(公告)号：US08431698B2
公开(公告)日：2013-04-30
申请号：US12201680
申请日：2008-08-29
申请人： Philip T. Neff , Randall B. Murphy , Bruce Bryan
发明人： Philip T. Neff , Randall B. Murphy , Bruce Bryan
IPC分类号： C07D491/00 , C07D495/00 , C07D497/00
CPC分类号： G01N21/763 , C07D487/04 , G01N21/6456
摘要： Bioluminescent endoscopy methods and compounds, wherein an anatomical object is examined by means of filling, perfusing, intubating, injecting, or otherwise administering a solution containing a bioluminescent substance or a mixture of luciferin and luciferase which produces bioluminescence, wherein a color or monochrome image of the object is constituted using the images and information based on bioluminescent emitted by the bioluminescent substance. Procedures are demonstrated which allow bioluminescent solutions to be perfused into certain tissue regions, such as but not limited to the common biliary duct, genitourinary tract, gastro-intestinal tract, cardiovascular system and lymphatic system wherein said structures may be conveniently visualized during surgery to avoid damage to these structures. Such images may also be combined with visual light images. Methods of detection of cancer cells using bioluminescence are provided. Preferred embodiments disclosed include membrane permeant coelenterazine analogs.
摘要翻译：生物发光内窥镜检查方法和化合物，其中通过填充，灌注，插管，注射或以其他方式施用含有生物发光物质或产生生物发光的荧光素和荧光素酶的混合物的溶液来检查解剖学对象，其中，使用基于由生物发光物质发射的生物发光的图像和信息构成该对象。证明了允许将生物发光溶液灌注到某些组织区域中的程序，例如但不限于常见的胆管，泌尿生殖道，胃肠道，心血管系统和淋巴系统，其中所述结构可在手术期间方便地可视化以避免损坏这些结构。这些图像也可以与视觉光图像组合。提供了使用生物发光检测癌细胞的方法。公开的优选实施方案包括膜渗透性肠溶纤维素类似物。

16. 发明申请

US20090081129A1 Bioluminescent Endoscopy Methods And Compounds 有权
标题翻译：生物发光内窥镜检查方法和化合物
公开(公告)号：US20090081129A1
公开(公告)日：2009-03-26
申请号：US12201680
申请日：2008-08-29
申请人： Philip T. Neff , Randall B. Murphy , Bruce Bryan
发明人： Philip T. Neff , Randall B. Murphy , Bruce Bryan
IPC分类号： A61K49/00 , C07D487/02 , C12Q1/66
CPC分类号： G01N21/763 , C07D487/04 , G01N21/6456
摘要： Bioluminescent endoscopy methods and compounds, wherein an anatomical object is examined by means of filling, perfusing, intubating, injecting, or otherwise administering a solution containing a bioluminescent substance or a mixture of luciferin and luciferase which produces bioluminescence, wherein a color or monochrome image of the object is constituted using the images and information based on bioluminescent emitted by the bioluminescent substance. Procedures are demonstrated which allow bioluminescent solutions to be perfused into certain tissue regions, such as but not limited to the common biliary duct, genitourinary tract, gastro-intestinal tract, cardiovascular system and lymphatic system wherein said structures may be conveniently visualized during surgery to avoid damage to these structures. Such images may also be combined with visual light images. Methods of detection of cancer cells using bioluminescence are provided. Preferred embodiments disclosed include membrane permeant coelenterazine analogs.
摘要翻译：生物发光内窥镜检查方法和化合物，其中通过填充，灌注，插管，注射或以其他方式施用含有生物发光物质或产生生物发光的荧光素和荧光素酶的混合物的溶液来检查解剖学对象，其中，使用基于由生物发光物质发射的生物发光的图像和信息构成该对象。证明了允许将生物发光溶液灌注到某些组织区域中的程序，例如但不限于常见的胆管，泌尿生殖道，胃肠道，心血管系统和淋巴系统，其中所述结构可在手术期间方便地可视化以避免损坏这些结构。这些图像也可以与视觉光图像组合。提供了使用生物发光检测癌细胞的方法。公开的优选实施方案包括膜渗透性肠溶纤维素类似物。

17. 发明授权

US06416960B1 Detection and visualization of neoplastic tissues and other tissues 失效
标题翻译：肿瘤组织和其他组织的检测和可视化
公开(公告)号：US06416960B1
公开(公告)日：2002-07-09
申请号：US08908909
申请日：1997-08-08
申请人： Bruce Bryan
发明人： Bruce Bryan
IPC分类号： G01N33574
CPC分类号： A61K49/0013 , A61K47/6851 , C12Q1/66 , G01N33/533 , G01N33/574 , G01N33/581 , G01N33/582
摘要： Diagnostic systems that rely on bioluminescence for visualizing tissues in situ are provided. The systems are particularly useful for visualizing and detecting neoplastic tissue and specialty tissue during surgical procedures. Kits that provide the components of the systems and methods using the systems for visualizing the tissue are also provided. The systems include compositions containing conjugates that include a tissue specific, particularly a tumor-specific, targeting agent linked to a targeted agent, a luciferase or luciferin. The systems also include a second composition that contains the remaining components of a bioluminescence generating reaction. Administration of the compositions results production of light by targeted tissues that permits the detection and localization of neoplastic tissue for surgical removal. Therapeutic methods in which photosensitizing compounds are administered are also provided.
摘要翻译：提供了依靠生物发光来原位观察组织的诊断系统。该系统在外科手术过程中可视化和检测肿瘤组织和特殊组织特别有用。还提供了提供使用用于可视化组织的系统的系统和方法的组件的套件。该系统包括含有缀合物的组合物，其包含组织特异性，特别是与靶向药剂，荧光素酶或荧光素相连的肿瘤特异性靶向剂。该系统还包括含有生物发光反应的剩余组分的第二组合物。组合物的施用导致通过靶组织产生光，其允许检测和定位肿瘤组织用于手术切除。还提供了施用光敏化合物的治疗方法。

18. 发明授权

US6152358A Bioluminescent novelty items 有权
标题翻译：生物发光新奇物品
公开(公告)号：US6152358A
公开(公告)日：2000-11-28
申请号：US135988
申请日：1998-08-17
申请人： Bruce Bryan
发明人： Bruce Bryan
IPC分类号： F41B9/00 , A23G3/00 , A23G3/36 , A23G3/50 , A23G9/32 , A23G9/36 , A23G9/44 , A23L1/00 , A23L1/03 , A23L1/27 , A23L1/30 , A23L2/38 , A23L2/52 , A23L2/58 , A23L2/66 , A23P1/04 , A24D3/14 , A45D34/00 , A61K8/00 , A61K8/64 , A61K8/66 , A61K8/98 , A61K8/99 , A61Q11/00 , A61Q19/00 , B05B7/04 , B05B7/24 , B05B15/00 , B05C17/005 , B65D65/38 , C07K14/435 , C11D9/00 , C12C5/04 , C12C12/00 , C12G1/00 , C12G3/02 , C12N9/02 , C12N15/09 , C12N15/82 , C12Q1/26 , D06Q1/00 , F21K2/00 , F21K2/06 , F21K99/00 , F21S8/00 , F21V33/00
CPC分类号： F21V33/0028 , A23G3/366 , A23G3/50 , A23G9/363 , A23G9/44 , A23K20/00 , A23K20/189 , A23K50/80 , A23L17/00 , A23L17/30 , A23L2/38 , A23L2/58 , A23L29/06 , A23L29/065 , A23P10/30 , A24D3/14 , A61K8/64 , A61Q19/00 , B05B7/0408 , B05B7/2416 , B05B7/2472 , B05C17/00553 , C07K14/43595 , C12C12/004 , C12C12/006 , C12G1/00 , C12N15/8212 , C12N9/0069 , C12N9/0071 , F21K2/00 , F21K2/06 , F21S8/00 , F41B9/004 , A23V2002/00 , A45D34/00 , A61K2800/434 , A61Q11/00 , F21W2121/02 , F21W2131/401 , Y10S493/955
摘要： Novelty items that are combinations of articles of manufacture with bioluminescence generating systems and/or fluorescent proteins are provided. These novelty items, which are articles of manufacture, are designed for entertainment, recreation and amusement, and include toys, paints, slimy play material, textiles, particularly clothing, bubbles in bubble making toys and other toys that produce bubbles, balloons, personal items, such as cosmetics, bath powders, body lotions, gels, powders and creams, toothpastes and other dentifrices, soaps, body paints, and bubble bath, foods, such as gelatins, icings and frostings, beverages such as beer, wine, champagne, soft drinks, and glowing ice, fountains, including liquid "fireworks" and other such jets or sprays or aerosols of compositions that are solutions, mixtures, suspensions, powders, pastes, particles or other suitable formulation.
摘要翻译：提供了与生物发光生成系统和/或荧光蛋白质的制品组合的新颖物品。这些新品是制作娱乐，娱乐和娱乐的新奇物品，包括玩具，油漆，泥土玩具材料，纺织品，特别是服装，气泡制作玩具中的气泡，以及产生气泡，气球，个人物品的其他玩具例如化妆品，浴粉，身体乳液，凝胶，粉末和乳膏，牙膏和其他洁牙剂，肥皂，身体油漆和泡泡浴，食品如明胶，结冰和结霜，饮料如啤酒，葡萄酒，香槟，软饮料和发光的冰，喷泉，包括液体“烟花”和其他溶液，混合物，悬浮液，粉末，糊剂，颗粒或其他合适制剂的喷雾或喷雾剂或喷雾剂或气溶胶。

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