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11. 发明授权

US07863264B2 Stabilised compositions having antibacterial activity 失效
标题翻译：具有抗菌活性的稳定组合物
公开(公告)号：US07863264B2
公开(公告)日：2011-01-04
申请号：US10380471
申请日：2001-09-26
申请人： Jakob Vange , Brian Nielsen
发明人： Jakob Vange , Brian Nielsen
IPC分类号： A01N55/02 , A01N43/54 , A61K31/555 , C07D239/42 , C07D401/04
CPC分类号： A61L29/085 , A01N43/50 , A01N43/54 , A01N59/16 , A61L26/0066 , A61L29/16 , A61L2300/104 , A61L2300/404 , A61L2300/802 , C07D233/74 , C07D233/80 , C07D233/88 , C07D239/62 , A01N25/34 , A01N25/22 , A01N25/16 , A01N25/04 , A01N2300/00
摘要： A stabilised composition having antibacterial, antiviral and/or antifungal activity, said composition comprising silver ions and a ligand, characterised in that the composition comprises a complex of silver and a ligand selected from the group consisting of 5,5-disubstituted hydantoins in which the substituents do not comprise conjugated unsaturated bonds and barbituric acid and derivatives thereof stabilising silver ions against reduction to free silver in a hydrophilic environment, and that the composition has a solubility in water higher than 10 mg Ag/l is stable during sterilisation and retains the activity without giving rise to darkening or discoloration of the dressing during storage.
摘要翻译：一种具有抗细菌，抗病毒和/或抗真菌活性的稳定化组合物，所述组合物包含银离子和配体，其特征在于所述组合物包含银和选自5,5-二取代乙内酰脲的配体的配合物，其中取代基不包含共轭不饱和键和巴比妥酸及其衍生物稳定银离子以在亲水环境中还原成游离的银，并且该组合物在水中的溶解度高于10mg Ag / l在灭菌期间是稳定的并保持活性而不会在储存期间引起敷料变黑或变色。

12. 发明申请

US20090280154A1 Biodegradable Scaffold with ECM Material 失效
标题翻译：可生物降解脚手架与ECM材料
公开(公告)号：US20090280154A1
公开(公告)日：2009-11-12
申请号：US12083624
申请日：2006-10-26
申请人： Peter Sylvest Nielsen , Brian Nielsen , Lene Karin Jespersen , Hanne Everland , Lene Feldskov Nielsen
发明人： Peter Sylvest Nielsen , Brian Nielsen , Lene Karin Jespersen , Hanne Everland , Lene Feldskov Nielsen
IPC分类号： A61K47/30 , A61K35/12 , A61K47/42 , A61K47/36
CPC分类号： A61L27/3633 , A61L27/56 , A61L27/58
摘要： We add discontinuous regions of Extra Cellular Matrix (ECM) to a biodegradable scaffold. Hereby it is possible to combine the range of physical properties the scaffold can offer with the reconstructive properties of the ECM. The optimal amount of discrete ECM material for each application is disclosed and this concentration is equally distributed in the dressing hence avoiding unnecessary high concentrations of ECM. In addition to the effect of the ECM, the porous structure of the base material provides the cells with a structure for in-growth.
摘要翻译：我们将Extra Cellular Matrix（ECM）的不连续区域添加到可生物降解的支架中。因此，可以组合脚手架可以提供的物理范围与ECM的重建性质。公开了每种应用的离散ECM材料的最佳量，并且该浓度均匀分布在敷料中，从而避免不必要的高浓度的ECM。除了ECM的作用之外，基体材料的多孔结构为细胞提供了用于生长的结构。

13. 发明申请

US20090047322A1 Degradable Hydrophilic Block Copolymers with Improved Biocompatibility for Soft Tissue Regeneration 有权
标题翻译：可降解的亲水嵌段共聚物具有改善的生物相容性用于软组织再生
公开(公告)号：US20090047322A1
公开(公告)日：2009-02-19
申请号：US12224891
申请日：2007-03-07
申请人： Jakob Vange , Khadija Schwach-Abdellaoui , Hanne Everland , Peter Sylvest Nielsen , Brian Nielsen , Lene Karin Jespersen , Lene Feldskov Nielsen
发明人： Jakob Vange , Khadija Schwach-Abdellaoui , Hanne Everland , Peter Sylvest Nielsen , Brian Nielsen , Lene Karin Jespersen , Lene Feldskov Nielsen
IPC分类号： C08F283/01 , B32B5/22 , A61F2/02 , C12N5/06 , A61C13/00
CPC分类号： C08G63/664 , A61L15/26 , A61L15/425 , A61L27/18 , A61L27/56 , C08G2261/126 , C08J9/28 , C08J2201/0482 , C08J2201/0484 , C08J2367/04 , C12N5/0068 , C12N2533/30 , C12N2533/40 , Y10T428/249958 , C08L67/04
摘要： The present application discloses biodegradable polymers, to porous and other materials comprising such polymers, and to various medical uses of such materials, including use as a scaffold for supporting cell adhesion or the in-growth for regeneration of tissue. The polymer is of the formula A—O—(CHR1CHR2O)n-B wherein A is a poly(lactide-co-glycolide) residue, the molar ratio of (i) lactide units [—CH(CH3)—COO—] and (ii) glycolide units [—CH2—COO—] in the poly(lactide-co-glycolide) residue being in the range of 80:20 to 10:90, B is either a poly(lactide-co-glycolide) residue or hydrogen, C1-6-alkyl or hydroxy protecting groups, one of R1 and R2 is hydrogen or methyl, and the other is hydrogen, n is 10-1000, the molar ratio of (iii) polyalkylene glycol units [-(CHR1CHR2O)—] to the combined amount of (i) lactide units and (ii) glycolide units in the poly(lactide-co-glycolide) residue(s) is at the most 14:86, and the molecular weight of the copolymer is at least 20,000 g/mol.
摘要翻译：本申请公开了可生物降解的聚合物，包括这种聚合物的多孔和其它材料，以及这种材料的各种医学用途，包括用作支撑细胞粘附的支架或用于组织再生的生长的用途。聚合物具有式AO-（CHR1CHR2O）nB，其中A是聚（丙交酯 - 共 - 乙交酯）残基，（i）丙交酯单元[-CH（CH 3）-COO-]和（ii）乙交酯的摩尔比聚丙交酯 - 共 - 乙交酯残基中的单元[-CH2-COO-]为80:20至10:90，B为聚（丙交酯 - 共 - 乙交酯）残基或氢，C1- 6-烷基或羟基保护基，R1和R2之一是氢或甲基，另一个是氢，n是10-1000，（iii）聚亚烷基二醇单元[ - （CHR1CHR2O） - ]与组合的摩尔比（I）丙交酯单元和（ii）聚（丙交酯 - 共 - 乙交酯）残基中的乙交酯单元的量最多为14:86，共聚物的分子量为至少20,000g / mol。

14. 发明申请

US20080184875A1 Valve assembly and a hydraulic actuator comprising the valve assembly 有权
标题翻译：阀组件和包括阀组件的液压致动器
公开(公告)号：US20080184875A1
公开(公告)日：2008-08-07
申请号：US11703430
申请日：2007-02-07
申请人： Brian Nielsen
发明人： Brian Nielsen
IPC分类号： F15B13/16
CPC分类号： F15B11/003 , F15B11/006 , F15B20/002 , F15B20/008 , F15B2211/30505 , F15B2211/30575 , F15B2211/328 , F15B2211/6333 , F15B2211/6652 , F15B2211/6656 , F16H61/433
摘要： A valve assembly (2) forming a bridge circuit and a hydraulic actuator comprising at least one valve assembly (2) are disclosed. The valve assembly (2) is fluidly connectable between a fluid source (3) and a fluid drain (4). The valve assembly (2) comprises a first valve (8) fluidly connected between the fluid source (3) and a first diagonal point (12) of the bridge circuit, a second valve (9) fluidly connected between the fluid source (3) and a second diagonal point (13) of the bridge circuit, a third valve (10) fluidly connected between the first diagonal point (12) and the fluid drain (4), and a fourth valve (11) fluidly connected between the second diagonal point (13) and the fluid drain (4). The valves (8, 9, 10, 11) are such that in the case of a power cut off, flows of fluid away from the diagonal points (12, 13) are prevented. Thereby a hydraulic servomotor (5) connected across the diagonal points (12, 13) will be hydraulically locked in its instantaneous position, and a safety feature is accordingly provided. The first valve (8) and the second valve (9) are furthermore of a kind which is closed in an energized state. Thereby it is possible to control the valve assembly (2) in such a manner that a piston member (14) of a servomotor (5) connected across the diagonal points (12, 13) can be moved at a high velocity, thereby providing a servomotor (5) having a quick response time.
摘要翻译：公开了形成桥接电路的阀组件（2）和包括至少一个阀组件（2）的液压致动器。阀组件（2）可流体地连接在流体源（3）和流体排放口（4）之间。阀组件（2）包括流体连接在流体源（3）和桥接电路的第一对角线点（12）之间的第一阀（8），流体连接在流体源（3）之间的第二阀（9）和桥接电路的第二对角点（13），流体连接在第一对角点（12）和流体排放口（4）之间的第三阀（10）和流体连接在第二对角线点（13）和流体排出口（4）。阀（8,9,10,11）使得在断电的情况下，防止流体离开对角线点（12,13）。由此，连接在对角点（12,13）上的液压伺服电动机（5）将被液压地锁定在其瞬时位置，并且因此提供安全特征。此外，第一阀（8）和第二阀（9）处于通电状态下是闭合的。因此，可以以这样的方式控制阀组件（2），使得能够以高速度移动跨过对角点（12,13）连接的伺服电动机（5）的活塞构件（14），从而提供伺服电机（5）具有快速响应时间。

15. 发明授权

US07329417B2 Medical dressing comprising an antimicrobial silver compound 有权
标题翻译：包含抗微生物银化合物的医用敷料
公开(公告)号：US07329417B2
公开(公告)日：2008-02-12
申请号：US10451380
申请日：2002-02-08
申请人： Brian Nielsen
发明人： Brian Nielsen
IPC分类号： A61F13/00 , A61K9/70 , A61L15/16 , A61L15/00
CPC分类号： A61L28/0038 , A61L15/18 , A61L15/44 , A61L15/46 , A61L26/0066 , A61L27/14 , A61L2300/102 , A61L2300/104 , A61L2300/404 , A61L2300/602 , C08L69/00
摘要： A medical dressing comprising a complex of silver and being capable of releasing antimicrobial silver ion activity, the complex comprising silver ion, a transition element of Group IV of the periodic system of elements, cation, phosphate and hydrogen to enable a controlled release of silver ion activity to a wound bed.
摘要翻译：包含银络合物并且能够释放抗微生物银离子活性的医用敷料，所述复合物包含银离子，元素周期性系统的第IV族的过渡元素，阳离子，磷酸盐和氢，以使得能够控制释放银离子活动到伤口床。

16. 发明申请

US20060211972A1 Wound dressing 审中-公开
标题翻译：伤口敷料
公开(公告)号：US20060211972A1
公开(公告)日：2006-09-21
申请号：US10550734
申请日：2004-03-24
申请人： Brian Nielsen , Maria Severin
发明人： Brian Nielsen , Maria Severin
IPC分类号： A61F13/00
CPC分类号： A61L15/60 , A61L15/28 , A61L15/44 , A61L2300/104 , A61L2300/402 , A61L2300/404
摘要： A wound dressing comprising a web of gel-forming fibers or fibers soluble in wound exudates, attached to a reinforcing layer wherein the density of the web is in the range of 5-60 g/m2. The dressing may serve as a wound-contacting layer, providing moist wound healing combined with easy, non-traumatic removal from the wound site. The dressing may further comprise one or more active ingredients.
摘要翻译：一种伤口敷料，其包含凝胶形成纤维的纤维网或可溶于伤口渗出物的纤维，其附着于增强层，其中幅材的密度在5-60g / m 2范围内。敷料可以用作伤口接触层，提供潮湿的伤口愈合以及从创伤部位容易的非创伤性去除。敷料还可以包含一种或多种活性成分。

17. 发明申请

US20050051024A1 Valve arrangement and hydraulic drive 有权
标题翻译：阀门布置和液压驱动
公开(公告)号：US20050051024A1
公开(公告)日：2005-03-10
申请号：US10930332
申请日：2004-08-31
申请人： Brian Nielsen , Poul Hansen , Torben Andersen
发明人： Brian Nielsen , Poul Hansen , Torben Andersen
IPC分类号： F15B11/00 , F15B11/042 , F15B11/044 , F15B13/04
CPC分类号： F15B11/044 , F15B11/042 , F15B2211/30505 , F15B2211/30525 , F15B2211/327 , F15B2211/40515 , F15B2211/426 , F15B2211/46 , F15B2211/6313 , F15B2211/7053
摘要： The invention concerns a valve arrangement for controlling a hydraulic drive having a first working connection (A) and a second working connection (B), and being connectable with or separable from a pressure source (P), the supply and the outflow of the hydraulic drive being separately controllable. It is endeavoured to improve the energetic efficiency of the valve arrangement. For this purpose, the first working connection (A) is connected with a first control valve and the second working connection (B) is connected with a second control valve, the first and the second control valves being connected with each other and with a third control valve, which is connected with a tank.
摘要翻译：本发明涉及一种用于控制具有第一工作连接（A）和第二工作连接（B）的液压驱动器的阀装置，并且可与压力源（P）连接或分离，液压供应和流出驱动器可单独控制。努力提高阀门装置的能量效率。为此，第一工作连接（A）与第一控制阀连接，第二工作连接（B）与第二控制阀连接，第一和第二控制阀彼此连接，并与第三工作连接与油箱连接的控制阀。

18. 发明授权

US06845272B1 Skin electrode 失效
标题翻译：皮肤电极
公开(公告)号：US06845272B1
公开(公告)日：2005-01-18
申请号：US09979270
申请日：1999-05-25
申请人： Steen Thomsen , Brian Nielsen , Laila Busk Gothjælpsen
发明人： Steen Thomsen , Brian Nielsen , Laila Busk Gothjælpsen
IPC分类号： A61B5/0408 , A61N1/04
CPC分类号： A61N1/046 , A61B5/04087 , A61N1/0452 , A61N1/0456 , A61N1/048 , A61N1/0496
摘要： An electrode for establishing electrical contact with the skin is disclosed, said electrode having a low impedance and comprising an electrically conductive metallic layer (4) and an electrically conductive gel (12) attached to said metallic layer, wherein the pH of the electrically conductive gel (12) is chosen so as to provide a corrosion of the metallic layer (4).
摘要翻译：公开了一种用于与皮肤建立电接触的电极，所述电极具有低阻抗并且包括连接到所述金属层的导电金属层（4）和导电凝胶（12），其中导电凝胶的pH （12），以便提供金属层（4）的腐蚀。

19. 发明授权

US08877223B2 Degradable hydrophilic block copolymers with improved biocompatibility for soft tissue regeneration 有权
标题翻译：可降解的亲水嵌段共聚物具有改善的生物相容性，用于软组织再生
公开(公告)号：US08877223B2
公开(公告)日：2014-11-04
申请号：US12224891
申请日：2007-03-07
申请人： Jakob Vange , Khadija Schwach-Abdellaoui , Hanne Everland , Peter Sylvest Nielsen , Brian Nielsen , Lene Karin Jespersen , Lene Feldskov Nielsen
发明人： Jakob Vange , Khadija Schwach-Abdellaoui , Hanne Everland , Peter Sylvest Nielsen , Brian Nielsen , Lene Karin Jespersen , Lene Feldskov Nielsen
IPC分类号： A61F2/00 , A61K9/14 , B32B5/14 , C12N5/00 , C12N5/02 , C08L67/00 , C08G63/91 , C08G63/664 , A61L15/26 , A61L15/42 , A61L27/18 , A61L27/56
CPC分类号： C08G63/664 , A61L15/26 , A61L15/425 , A61L27/18 , A61L27/56 , C08G2261/126 , C08J9/28 , C08J2201/0482 , C08J2201/0484 , C08J2367/04 , C12N5/0068 , C12N2533/30 , C12N2533/40 , Y10T428/249958 , C08L67/04
摘要： The present application discloses biodegradable polymers, to porous and other materials comprising such polymers, and to various medical uses of such materials, including use as a scaffold for supporting cell adhesion or the in-growth for regeneration of tissue. The polymer is of the formula A-O—(CHR1CHR2O)n—B wherein A is a poly(lactide-co-glycolide) residue, the molar ratio of (i) lactide units [—CH(CH3)—COO—] and (ii) glycolide units [—CH2—COO—] in the poly(lactide-co-glycolide) residue being in the range of 80:20 to 10:90, B is either a poly(lactide-co-glycolide) residue or hydrogen, C1-6-alkyl or hydroxy protecting groups, one of R1 and R2 is hydrogen or methyl, and the other is hydrogen, n is 10-1000, the molar ratio of (iii) polyalkylene glycol units [—(CHR1CHR2O)—] to the combined amount of (i) lactide units and (ii) glycolide units in the poly(lactide-co-glycolide) residue(s) is at the most 14:86, and the molecular weight of the copolymer is at least 20,000 g/mol.
摘要翻译：本申请公开了可生物降解的聚合物，包括这种聚合物的多孔和其它材料，以及这种材料的各种医学用途，包括用作支撑细胞粘附的支架或用于组织再生的生长的用途。聚合物具有式AO-（CHR1CHR2O）n-B，其中A是聚（丙交酯 - 共 - 乙交酯）残基，（i）丙交酯单元[-CH（CH 3）-COO-]和（ii ）乙交酯单元[-CH2-COO-]在80:20至10:90的范围内，B是聚（丙交酯 - 共 - 乙交酯）残基或氢， C 1-6 - 烷基或羟基保护基，R 1和R 2之一为氢或甲基，另一个为氢，n为10-1000，（iii）聚亚烷基二醇单元[ - （CHR1CHR2O） - ] - 聚（丙交酯 - 共 - 乙交酯）残基中（i）丙交酯单元和（ii）乙交酯单元的总量最多为14:86，共聚物的分子量为至少20,000g / mol。

20. 发明授权

US08821916B2 Medical dressing comprising an antimicrobial silver compound 有权
标题翻译：包含抗微生物银化合物的医用敷料
公开(公告)号：US08821916B2
公开(公告)日：2014-09-02
申请号：US12007053
申请日：2008-01-04
申请人： Brian Nielsen
发明人： Brian Nielsen
IPC分类号： A61F13/00 , A61K9/70 , A61L15/00 , A61L15/16 , A61F13/02 , A61L28/00 , A61L15/18 , A61L15/44 , A61L27/14 , A61L26/00 , A61L15/46
CPC分类号： A61L28/0038 , A61L15/18 , A61L15/44 , A61L15/46 , A61L26/0066 , A61L27/14 , A61L2300/102 , A61L2300/104 , A61L2300/404 , A61L2300/602 , C08L69/00
摘要： A medical dressing comprising a complex of silver and being capable of releasing antimicrobial silver ion activity, said complex comprising silver and a transition element of Group IV of the periodic system of elements enables a controlled release of silver ion activity to a wound bed.
摘要翻译：包含银络合物并能够释放抗微生物银离子活性的医用敷料，所述复合物包含银和元素周期元素系统的IV族的过渡元素使得能够将受控的银离子活性释放到伤口床上。

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