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11. 发明申请

US20130022615A1 Compositions and Methods for Antibodies Targeting Complement Protein C5 审中-公开
公开(公告)号：US20130022615A1
公开(公告)日：2013-01-24
申请号：US13535612
申请日：2012-06-28
申请人： Beate DIEFENBACH-STREIBER , Adina EBERTH , Braydon Charles GUILD , Yong-In KIM , Michael ROGUSKA , Igor SPLAWSKI
发明人： Beate DIEFENBACH-STREIBER , Adina EBERTH , Braydon Charles GUILD , Yong-In KIM , Michael ROGUSKA , Igor SPLAWSKI
IPC分类号： A61K39/395 , A61P27/02
CPC分类号： C07K16/18 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antibodies targeting complement protein C5 and compositions and methods of use thereof.

12. 发明申请

US20120276591A1 Compositions and Methods for Use for Antibodies Against Sclerostin 有权
标题翻译：用于抗硬皮蛋白抗体的组合物和方法
公开(公告)号：US20120276591A1
公开(公告)日：2012-11-01
申请号：US13547598
申请日：2012-07-12
申请人： Michaela Kneissel , Christine Halleux , Shou-Ih Hu , Beate Diefenbach-Streiber , Josef Prassler
发明人： Michaela Kneissel , Christine Halleux , Shou-Ih Hu , Beate Diefenbach-Streiber , Josef Prassler
IPC分类号： C12N15/13 , C12P21/00 , C12N5/10 , C12N15/63 , C12N1/21
CPC分类号： G01N33/6854 , A61K31/663 , A61K39/395 , A61K45/06 , A61K2039/505 , C07K16/22 , C07K2317/21 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N2333/51 , G01N2800/108 , A61K2300/00
摘要： The present invention relates to antibodies against sclerostin and compositions and methods of use for said antibodies to treat a pathological disorder that is mediated by sclerostin or disease related to bone abnormalities such as osteoporosis.
摘要翻译：本发明涉及抗硬化蛋白的抗体以及用于所述抗体治疗由硬化症介入的病理学疾病或与骨质异常如骨质疏松有关的疾病的组合物和方法。

13. 发明授权

US08241628B2 Compositions and methods for antibodies targeting complement protein C5 有权
标题翻译：针对补体蛋白C5的抗体的组合物和方法
公开(公告)号：US08241628B2
公开(公告)日：2012-08-14
申请号：US12535205
申请日：2009-08-04
申请人： Beate Diefenbach-Streiber , Adina Eberth , Braydon Charles Guild , Yong-In Kim , Michael Roguska , Igor Splawski
发明人： Beate Diefenbach-Streiber , Adina Eberth , Braydon Charles Guild , Yong-In Kim , Michael Roguska , Igor Splawski
IPC分类号： A61K39/395 , C07K16/18 , C07H21/00 , C12N15/74 , C12N5/16
CPC分类号： C07K16/18 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antibodies targeting complement protein C5 and compositions and methods of use thereof.
摘要翻译：本发明涉及靶向补体蛋白C5的抗体及其使用方法。

14. 发明授权

US08067197B2 Soluble recombinant αvβ3 adhesion receptor 有权
标题翻译：可溶性重组αv＆bgr 3粘附受体
公开(公告)号：US08067197B2
公开(公告)日：2011-11-29
申请号：US10460672
申请日：2003-06-13
申请人： Simon L. Goodman , Beate Diefenbach , Detelv Güssow , Raj Mehta , Eilish Cullen , Alex Brown
发明人： Simon L. Goodman , Beate Diefenbach , Detelv Güssow , Raj Mehta , Eilish Cullen , Alex Brown
IPC分类号： C12N15/09 , C07H21/04
CPC分类号： C07K14/70557 , C12N2799/026
摘要： The invention relates to a novel purified recombinant αVβ3 adhesion receptor which shows an unimpaired ligand binding activity, and a process for preparing said soluble non-membrane bound receptor in excellent yields by recombinant techniques using a baculovirus-insect cell expression system. The so-synthesized soluble receptor may be used very easily as screening tool for new therapeutic compounds which may inhibit the natural αVβ3 adhesion receptor. Such therapeutic compounds which can be discovered very easily, fast and without health risk by means of the soluble receptors according to the invention may be, for example, RGD peptides or non-peptidic compounds mimicking the natural ligand epitopes. The invention relates, furthermore, to a corresponding process for preparing recombinant full-length αVβ3 adhesion receptor in excellent yields, additionally using detergents to dissolve the membrane bound receptor from the surface of the host cell.
摘要翻译：本发明涉及一种新型纯化的重组αVb-3粘附受体，其显示出未受损的配体结合活性，以及通过使用杆状病毒 - 昆虫细胞表达系统的重组技术以优异的产率制备所述可溶性非膜结合受体的方法。如此合成的可溶性受体可以非常容易地用作可能抑制天然αV和bgr 3粘附受体的新的治疗化合物的筛选工具。可以通过本发明的可溶性受体非常容易，快速且没有健康风险发现的这种治疗化合物可以是例如RGD肽或模仿天然配体表位的非肽化合物。此外，本发明还涉及以优异的产率制备重组全长αV＆bgr 3粘附受体的相应方法，另外使用洗涤剂从宿主细胞表面溶解膜结合受体。

15. 发明授权

US6001961A Cyclic adhesion inhibitors 失效
标题翻译：环状粘连抑制剂
公开(公告)号：US6001961A
公开(公告)日：1999-12-14
申请号：US694387
申请日：1996-09-16
申请人： Alfred Jonczyk , Simon Goodman , Beate Diefenbach , Arne Sutter , Gunter Holzemann , Horst Kessler , Michael Dechantsreiter
发明人： Alfred Jonczyk , Simon Goodman , Beate Diefenbach , Arne Sutter , Gunter Holzemann , Horst Kessler , Michael Dechantsreiter
IPC分类号： A61K38/00 , A61K38/04 , A61K38/12 , A61P9/00 , A61P31/04 , A61P35/00 , A61P35/04 , A61P39/00 , A61P43/00 , C07K1/113 , C07K7/64 , C07K7/00
CPC分类号： C07K7/64 , A61K38/00
摘要： The invention relates to novel cyclopeptides of the formula Icyclo-(nArg-nGly-nAsp-nD-nE) I,in whichD and E in each case independently of one another are Gly, Ala, .beta.-Ala, Asn, Asp, Asp(OR), Arg, Cha, Cys, Gln, Glu, His, Ile, Leu, Lys, Lys(Ac), Lys(AcNH.sub.2), Lys(AcSH), Met, Nal, Nle, Orn, Phe, 4-Hal-Phe, homo-Phe, Phg, Pro, Pya, Ser, Thr, Tia, Tic, Trp, Tyr or Val, which amino acid residues can also be derivatized,R is alkyl having 1-18 carbon atoms,Hal is F, Cl, Br, I,Ac is alkanoyl having 1-10 carbon atoms, aroyl having 7-11 carbon atoms or aralkanoyl having 8-12 carbon atoms,n denotes no substituent or an alkyl radical R, benzyl or an aralkyl radical having 7-18 carbon atoms on the alpha-amino function of the relevant amino acid residue,with the proviso that at least one amino acid residue has a substituent n and that, where residues of optically active amino acids and amino acid derivatives are involved, both the D and the L forms are included, and also their physiologically acceptable salts.These compounds act as integrin inhibitors and can be used in particular for the prophylaxis and treatment of disorders of the circulation, angiogenic disorders, microbial infections and in tumor therapy.
摘要翻译：本发明涉及式I环 - （nArg-nGly-nAsp-nD-nE）I的新型环肽，其中D和E各自独立地为Gly，Ala，β-Ala，Asn，Asp，Asp （OR），Arg，Cha，Cys，Gln，Glu，His，Ile，Leu，Lys，Lys（Ac），Lys（AcNH 2），Lys（AcSH），Met，Nal，Nle，Orn， -Phe，Phe-Phe，Phg，Pro，Pya，Ser，Thr，Tia，Tic，Trp，Tyr或Val，该氨基酸残基也可被衍生化，R是具有1-18个碳原子的烷基，Hal是F， Cl，Br，I，Ac是具有1-10个碳原子的烷酰基，具有7-11个碳原子的芳酰基或具有8-12个碳原子的芳烷酰基，n表示没有取代基或烷基R，苄基或具有7- 相关氨基酸残基的α-氨基官能团上的18个碳原子，条件是至少一个氨基酸残基具有取代基n，并且当涉及光学活性氨基酸和氨基酸衍生物的残基时，D 并且包括L形式，也包括它们的生理学可接受的盐。这些化合物用作整联蛋白抑制剂，特别可用于预防和治疗循环障碍，血管生成障碍，微生物感染和肿瘤治疗。

16. 发明申请

US20160031975A1 Compositions and Methods for Antibodies Targeting Complement Protein C5 审中-公开
公开(公告)号：US20160031975A1
公开(公告)日：2016-02-04
申请号：US14698039
申请日：2015-04-28
申请人： Beate DIEFENBACH-STREIBER , Adina EBERTH , Braydon Charles GUILD , Yong-In KIM , Michael ROGUSKA , Igor SPLAWSKI
发明人： Beate DIEFENBACH-STREIBER , Adina EBERTH , Braydon Charles GUILD , Yong-In KIM , Michael ROGUSKA , Igor SPLAWSKI
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antibodies targeting complement protein C5 and compositions and methods of use thereof.

17. 发明申请

US20140011698A1 SIMULTANEOUS DETECTION OF BIOMOLECULES IN SINGLE CELLS 审中-公开
标题翻译：同时检测单细胞中的生物分子
公开(公告)号：US20140011698A1
公开(公告)日：2014-01-09
申请号：US13989814
申请日：2011-11-30
申请人： Markus Enzelberger , Andreas Boll , Beate Diefenbach-Streiber , Guenter Roth , Felix von Stetten , Fabian Stumpf
发明人： Markus Enzelberger , Andreas Boll , Beate Diefenbach-Streiber , Guenter Roth , Felix von Stetten , Fabian Stumpf
IPC分类号： G01N33/53
CPC分类号： G01N33/5308 , C12Q1/6834 , C12Q1/6869 , C12Q2523/303 , C12Q2527/109 , C12Q2527/119 , C12Q2531/113 , C12Q2563/149 , C12Q2563/159 , G01N33/543 , G01N33/6842
摘要： The present invention provides methods, immunoassays, kits and devices pertaining to the detection of multiple biomolecules from single cells or other biological entities. It also enables the highly parallel detection of interacting biomolecules from such entities.
摘要翻译：本发明提供了与从单细胞或其他生物实体检测多种生物分子有关的方法，免疫测定，试剂盒和装置。它还能够高度平行地检测来自这些实体的相互作用的生物分子。

18. 发明授权

US08246953B2 Compositions and methods for use for antibodies against sclerostin 有权
标题翻译：用于抗硬化性抗体的组合物和方法
公开(公告)号：US08246953B2
公开(公告)日：2012-08-21
申请号：US12944019
申请日：2010-11-11
申请人： Michaela Kniessel , Christine Halleux , Shou-Ih Hu , Beate Diefenbach-Streiber , Josef Prassler
发明人： Michaela Kniessel , Christine Halleux , Shou-Ih Hu , Beate Diefenbach-Streiber , Josef Prassler
IPC分类号： A61K39/00 , A61K39/395 , C07K16/00 , C07K16/18 , C07K16/22 , C07K16/24 , C07K16/26 , C12N15/13 , C12N15/63 , G01N33/53
CPC分类号： G01N33/6854 , A61K31/663 , A61K39/395 , A61K45/06 , A61K2039/505 , C07K16/22 , C07K2317/21 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N2333/51 , G01N2800/108 , A61K2300/00
摘要： The present invention relates to antibodies against sclerostin and compositions and methods of use for said antibodies to treat a pathological disorder that is mediated by sclerostin or disease related to bone abnormalities such as osteoporosis.
摘要翻译：本发明涉及抗硬化蛋白的抗体以及用于所述抗体治疗由硬化症介入的病理学疾病或与骨质异常如骨质疏松有关的疾病的组合物和方法。

19. 发明申请

US20100034809A1 Compositions and Methods for Antibodies Targeting Complement Protein C5 有权
标题翻译：靶向补体蛋白C5的抗体的组合物和方法
公开(公告)号：US20100034809A1
公开(公告)日：2010-02-11
申请号：US12535205
申请日：2009-08-04
申请人： Beate Diefenbach-Streiber , Adina Eberth , Braydon Charles Guild , Yong-In Kim , Michael Roguska , Igor Splawski
发明人： Beate Diefenbach-Streiber , Adina Eberth , Braydon Charles Guild , Yong-In Kim , Michael Roguska , Igor Splawski
IPC分类号： A61K39/395 , C07K16/18 , C07H21/00 , C12N15/74 , C12N5/16 , A61P25/28
CPC分类号： C07K16/18 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antibodies targeting complement protein C5 and compositions and methods of use thereof.
摘要翻译：本发明涉及靶向补体蛋白C5的抗体及其使用方法。

20. 发明授权

US06559144B2 Bicyclic amino acids 失效
标题翻译：双环氨基酸
公开(公告)号：US06559144B2
公开(公告)日：2003-05-06
申请号：US09842004
申请日：2001-04-26
申请人： Beate Diefenbach , Simon L. Goodman , Joachim März , Peter Raddatz , Friedrich Rippmann , Matthias Wiesner
发明人： Beate Diefenbach , Simon L. Goodman , Joachim März , Peter Raddatz , Friedrich Rippmann , Matthias Wiesner
IPC分类号： A61K31536
CPC分类号： C07D405/12 , C07D265/36 , C07D319/20 , C07D413/12
摘要： Compounds of the formula I in which X, Y, Z, R1, R2, R3, R4, R5, R7, R8, R11, m and n have the meanings stated in claim 1, and their physiologically acceptable salts can be used as integrin inhibitors, in particular for the prophylaxis and treatment of circulatory disorders, for thrombosis, myocardial infarct, coronary heart disease, arteriosclerosis, osteoporosis, for pathological processes maintained or propagated by angiogenesis, and in tumour therapy.
摘要翻译： X，Y，Z，R 1，R 2，R 3，R 4，R 5，R 7，R 8，R 11，m和n具有权利要求1所述含义的式Iin化合物，其生理学上可接受的盐可用作整联蛋白抑制剂，特别是用于预防和治疗循环系统疾病，血栓形成，心肌梗塞，冠心病，动脉硬化，骨质疏松症，通过血管发生维持或繁殖的病理过程以及肿瘤治疗。

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