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11. 发明专利

JP2009180742A Medical measuring device and removable cover thereof 有权
标题翻译：医疗测量装置及其可拆卸盖
公开(公告)号：JP2009180742A
公开(公告)日：2009-08-13
申请号：JP2009119558
申请日：2009-05-18
申请人： Bayer Corp , バイエルコーポレーション
发明人： MOLLER ANDREAS , SCHLAGHECK JULIAN , STEINBERG KLAUS , DUNWALD CHRISTOPH
IPC分类号： G01N33/66 , G01N35/00 , A61B5/00 , A61B5/145 , C12M1/34
CPC分类号： A61B5/14532 , A61B2562/247
摘要： PROBLEM TO BE SOLVED: To provide medical measuring system, including a cover which can protect the medical measuring device from damages and which can also be attached removably.
SOLUTION: The medical measuring system includes the medical measuring device 30, including a housing 31 with front surface 32;a face plate 70 removably accepted on at least partial area of the front surface 32 to include face plate surface 84 for correcting the housing 31 of the medical measuring device 30; and the cover 20 with an attaching member 60 for removably attaching the cover to the front surface 32 of the medical measuring device 30. The face plate 70 is located between the cover 20 and the front surface 32 of the medical measuring device 30, while the cover 20 demarcates an aperture 52 so that the face plate surface 84 is visible through the cover 20.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供医疗测量系统，包括可以保护医疗测量装置免受损坏并且可拆卸地附接的盖子。解决方案：医疗测量系统包括医疗测量装置30，其包括具有前表面32的壳体31;可拆卸地接纳在前表面32的至少部分区域上的面板70，以包括面板表面84，用于校正医疗测量装置30的壳体31; 盖20具有用于将盖可拆卸地附接到医疗测量装置30的前表面32的附接构件60.面板70位于盖20和医疗测量装置30的前表面32之间，盖20限定孔52，使得面板表面84通过盖20可见。版权所有：（C）2009，JPO＆INPIT

12. 发明专利

JP2009052053A Light-stable polyurethane-urea elastomer and its production process 有权
标题翻译：光稳定的聚氨酯 - 尿素弹性体及其制备方法
公开(公告)号：JP2009052053A
公开(公告)日：2009-03-12
申请号：JP2008284332
申请日：2008-11-05
申请人： Bayer Corp , バイエル・コーポレーシヨンBayer Corporation
发明人： MARKUSCH PETER H , CLINE ROBERT L , PANTONE RICHARD S , GUETHER RALF , SEKELIK THOMAS L , HAIDER KARL W
IPC分类号： C08G18/72 , B32B17/10 , C08G18/10 , C08G18/65 , C08G18/73 , C08G18/75 , C08G18/79
CPC分类号： C08G18/758 , B32B17/1077 , C08G18/10 , C08G18/73 , C08G18/755 , C08G18/6674 , C08G18/6685
摘要： PROBLEM TO BE SOLVED: To provide a process of producing an optically bright, light-stable polyurethane-urea elastomer which has an on-set softening point of at least 130°C. SOLUTION: The method comprises a step of reacting a liquid polyisocyanate or its prepolymer (A) with a component (B) reactive with the isocyanate in the presence of an organometallic catalyst (C) and a step of casting these components into a mold with an isocyanate index of 95 to 120, wherein the component (A) contains a reaction product of a specific (cyclo) aliphatic polyisocyanate (A) (1) and a specific organic compound (A) (2) having at least two OH groups and the component (B) contains an organic compound (B) (1) having at least two aromatic amine groups and a specific molecular weight and a specific organic compound (B) (2) having at least two OH groups. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种制备具有至少130℃的固化软化点的光学亮度轻的聚氨酯 - 脲弹性体的方法。解决方案：该方法包括使液体多异氰酸酯或其预聚物（A）与在有机金属催化剂（C）的存在下与异氰酸酯反应的组分（B）反应的步骤和将这些组分投入异氰酸酯指数为95〜120的模具，其中组分（A）含有特定（环）脂族多异氰酸酯（A）（1）和具有至少两个OH的特定有机化合物（A）（2））的反应产物基团和组分（B）含有具有至少两个芳族胺基团和特定分子量的有机化合物（B）（1）和具有至少两个OH基团的特定有机化合物（B）（2）。版权所有（C）2009，JPO＆INPIT

13. 发明专利

JP2008051823A Biosensor 有权
标题翻译：生物传感器
公开(公告)号：JP2008051823A
公开(公告)日：2008-03-06
申请号：JP2007276177
申请日：2007-10-24
申请人： Bayer Corp , バイエルコーポレーション
发明人： BUSSMANN STEPHEN A , RUGGIERO JOSEPH E , TRIPPEL CHRISTINE G
IPC分类号： G01N27/28 , G01N33/483 , B01L99/00 , C12M1/00 , C12Q1/00 , C12Q1/54 , G01N27/416 , G01N33/487 , G01N35/00
CPC分类号： C12Q1/001 , G01N33/48771 , G01N35/00732 , G01N2035/00782 , Y10S435/817
摘要： PROBLEM TO BE SOLVED: To solve many constitutional defects of conventional techniques by eliminating or minimizing the need for key switches, in a device for marking prescribed phenomena (such as glucose value in a bodily fluid) through the use of a biosensor.
SOLUTION: The biosensor includes both a sensor for detecting measurement values (such as, as resistance value) of spokes 36A-36D, which have received a user sample to be measured and a microprocessor 52 for measuring prescribed parameter values by executing prescribed test sequences. A memory 54 is coupled to the processor 52 for storing the prescribed parameter values. For selectively marking one among a plurality of prescribed phenomena through the use of the stored prescribed parameter values, a marker member having the spokes 36A-36D is manually coupled to the processor 52 by user.
COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：通过消除或最小化对钥匙开关的需要，通过使用生物传感器来标记规定的现象（例如体液中的葡萄糖值）的装置来解决常规技术的许多结构缺陷。解决方案：生物传感器包括用于检测已经接收到要测量的用户样本的辐条36A-36D的测量值（例如电阻值）的传感器和用于通过执行规定来测量规定参数值的微处理器52 测试序列。存储器54耦合到处理器52以存储规定的参数值。为了通过使用存储的规定参数值来选择性地标记多个规定现象中的一个，具有轮辐36A-36D的标记构件由用户手动地耦合到处理器52。版权所有（C）2008，JPO＆INPIT

14. 发明专利

JP2006328075A Diphenylurea derivative as raf kinase inhibitor 有权
标题翻译：二氢呋喃衍生物作为RAF激酶抑制剂
公开(公告)号：JP2006328075A
公开(公告)日：2006-12-07
申请号：JP2006190034
申请日：2006-07-11
申请人： Bayer Corp , バイエルコーポレイションBayer corporation
发明人： RIEDL BERND , DUMAS JACQUES , KHIRE UDAY , LOWINGER TIMOTHY B , SCOTT WILLIAM J , SMITH ROGER A , WOOD JILL E , MONAHAN MARY-KATHERINE , NATERO REINA , JOEL RENICK , SIBLEY ROBERT N
IPC分类号： C07C275/36 , C07D295/12 , A61K20060101 , A61K31/17 , A61K31/18 , A61K31/24 , A61K31/341 , A61K31/40 , A61K31/4035 , A61K31/44 , A61K31/4406 , A61K31/4409 , A61K31/4439 , A61K31/4453 , A61K31/495 , A61K31/496 , A61K31/5355 , A61K31/5375 , A61K31/5377 , A61P35/00 , A61P43/00 , C07C20060101 , C07C275/28 , C07C275/30 , C07C275/32 , C07C275/40 , C07C291/12 , C07C311/16 , C07C311/29 , C07C317/22 , C07D20060101 , C07D207/09 , C07D209/46 , C07D209/48 , C07D213/74 , C07D213/75 , C07D213/76 , C07D213/78 , C07D213/79 , C07D213/81 , C07D213/82 , C07D295/13 , C07D295/135 , C07D295/18 , C07D295/192 , C07D307/14 , C07D401/12 , C07F7/18
CPC分类号： C07D295/192 , A61K31/17 , A61K31/18 , A61K31/24 , A61K31/341 , A61K31/40 , A61K31/4035 , A61K31/44 , A61K31/4439 , A61K31/4453 , A61K31/495 , A61K31/496 , A61K31/5375 , A61K31/5377 , C07C275/28 , C07C275/30 , C07C275/32 , C07C275/36 , C07C275/40 , C07C311/29 , C07C317/22 , C07D209/46 , C07D209/48 , C07D209/50 , C07D213/75 , C07D213/80 , C07D213/81 , C07D295/073 , C07D295/12 , C07D295/13 , C07D295/135 , C07D295/18 , C07D401/12 , C07F7/1852 , C07F7/1856
摘要： PROBLEM TO BE SOLVED: To provide a diphenylurea derivative having raf kinase inhibiting action. SOLUTION: The diphenylurea derivative has a structure obtained by substituting one phenyl group of diphenylurea with a specific substituent and substituting the other phenyl group with pyridyloxy group or pyridylthio group having carbamoyl group or N-substituted carbamoyl group. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：提供具有raf激酶抑制作用的二苯基脲衍生物。解决方案：二苯基脲衍生物具有通过用特定取代基取代一个苯基的二苯基脲和用具有氨基甲酰基或N-取代氨基甲酰基的吡啶氧基或吡啶硫基取代另一苯基而获得的结构。版权所有（C）2007，JPO＆INPIT

15. 发明专利

JP2006217925A Reduction of nonspecific hybridization by using new base-pairing schemes 审中-公开
标题翻译：通过使用新的配对方案减少非特异性杂交
公开(公告)号：JP2006217925A
公开(公告)日：2006-08-24
申请号：JP2006130869
申请日：2006-05-09
申请人： Bayer Corp , バイエルコーポレイション
发明人： COLLINS MARK L , HORN THOMAS , SHERIDAN PATRICK E , WARNER BRIAN D , URDEA MICHAEL S
IPC分类号： C12N15/09 , C07H19/16 , C07H19/173 , C07H19/20 , C07H21/00 , C12N15/113 , C12Q1/68
CPC分类号： C12N15/113 , C07H19/16 , C07H19/20 , C07H21/00 , C12N2310/322 , C12N2310/336 , C12Q1/68 , C12Q1/6811 , C12Q1/6813 , C12Q1/682 , C12Q1/6832 , C12Q1/6837 , C12Q2527/107 , C12Q2525/117 , C12Q2525/113
摘要： PROBLEM TO BE SOLVED: To provide methods for reducing background noises and enhancing the accuracy of detection and determination of analytes in nucleic acid hybridization assays. SOLUTION: Disclosed is a nucleic acid hybridization assay for detecting nucleic acid analytes in samples by using a plurality of assay components, wherein the each of a plurality of assay components comprises at least one hybridizable oligonucleotide segment and the nucleic acid hybridization assay comprises an improved step incorporating into at least one hybridizable oligonucleotide segment a first nucleotide unit which does not effectively form base pair with adenosine (A), thymidine (T), cytidine (C), guanosine (G) or uridine (U) under the condition that A-T and G-C base pairs are formed. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供降低背景噪声并提高核酸杂交测定中分析物检测和测定精度的方法。解决方案：公开了一种用于通过使用多个测定组分检测样品中的核酸分析物的核酸杂交测定法，其中多个测定组分中的每一个包含至少一个可杂交的寡核苷酸片段，并且核酸杂交测定法包括一种改进的步骤，其在至少一个可杂交的寡核苷酸区段内，在条件下不能有效形成与腺苷（A），胸苷（T），胞苷（C），鸟苷（G）或尿苷（U））的碱基对的第一核苷酸单元形成AT和GC碱基对。版权所有（C）2006，JPO＆NCIPI

16. 发明专利

JP2006113076A Improved method for measuring concentration of leukocyte in body fluid by colorimetric method 有权
标题翻译：通过彩色方法测量人体液中浓度浓度的改进方法
公开(公告)号：JP2006113076A
公开(公告)日：2006-04-27
申请号：JP2005353416
申请日：2005-12-07
申请人： Bayer Corp , バイエルコーポレーション
发明人： NOFFSINGER JAMES , PUGIA MICHAEL J , SMITH MELVIN D
IPC分类号： G01N33/48 , G01N33/52 , C12Q1/37 , C12Q1/44 , G01N21/78 , G01N33/483 , G01N33/50
CPC分类号： C12Q1/37 , C12Q1/44 , C12Q2334/00 , C12Q2334/70 , G01N33/5094 , G01N2333/966 , Y10S435/963 , Y10S435/97
摘要： PROBLEM TO BE SOLVED: To provide a composition capable of restraining the diazonium coupling of the background and a color change thereof to a minimum, when measuring an analyte selected from among leukocyte, esterase and protease in a sample, and to provide a testing tool and a testing method that uses the same.
SOLUTION: The composition for measuring the presence of the analyte is a composition containing diazonium salt, ester hydrolyzed in the presence of the leukocyte, esterase or protease, and salt of an alkaline earth metal, and the testing tool and a testing method using the same are provided also.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：当测量样品中白细胞，酯酶和蛋白酶的分析物时，提供能够将背景的重氮偶合和其变色抑制到最小的组合物，并提供一种测试工具和使用相同的测试方法。解决方案：用于测量分析物存在的组合物是含有重氮盐的组合物，在白细胞，酯酶或蛋白酶和碱土金属的盐存在下水解的酯，以及测试工具和测试方法也提供使用相同的。版权所有（C）2006，JPO＆NCIPI

17. 发明专利

JP2006075163A Quantitation of enzyme activity using planar waveguide 审中-公开
标题翻译：使用平面波导的酶活性定量
公开(公告)号：JP2006075163A
公开(公告)日：2006-03-23
申请号：JP2005259715
申请日：2005-09-07
申请人： Bayer Corp , バイエルコーポレイション
发明人： HATCH RICHARD G
IPC分类号： C12M1/34 , C12Q1/25 , G01N21/64 , G01N21/78
CPC分类号： C12Q1/001 , G01N33/54373 , G01N33/573
摘要： PROBLEM TO BE SOLVED: To provide an enzyme activity sensor providing many advantages, including small scale of operation, speed, sensitivity, specificity, and ease of production.
SOLUTION: The enzyme activity sensor has a planar waveguide containing a substrate for the enzyme. In the enzyme activity sensor, (1) the substrate contains a detectable label or (2) the substrate is modified so that the activity of the enzyme can modify the substrate to include the detectable label. The method for detecting the enzymatic activity involves (a) a step for exposing the planar wave guide of the enzyme activity sensor to a sample to be tested under a condition allowing the enzyme to act on the substrate, (b) a step for irradiating the planar waveguide to form an attenuation field, and (c) a step for examining the attenuation field as for the presence of the detectable label.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供具有许多优点的酶活性传感器，包括操作规模小，速度快，灵敏度高，特异性高，易于生产。酶活性传感器具有含有酶底物的平面波导。在酶活性传感器中，（1）底物含有可检测标记，或（2）修饰底物使得酶的活性可以修饰底物以包括可检测标记。用于检测酶活性的方法包括：（a）在允许酶作用在基材上的条件下，将酶活性传感器的平面波导暴露于待测试样品的步骤，（b）平面波导形成衰减场，以及（c）用于检测衰减场的步骤，用于存在可检测标记。版权所有（C）2006，JPO＆NCIPI

18. 发明专利

JP2006020649A Solution phase nucleic acid sandwich assay having reduced background noise 审中-公开
标题翻译：具有降低背景噪音的相位核酸三氯甲烷测定方法
公开(公告)号：JP2006020649A
公开(公告)日：2006-01-26
申请号：JP2005272934
申请日：2005-09-20
申请人： Bayer Corp , バイエルコーポレイション
发明人： URDEA MICHAEL S , FULTZ TIMOTHY , WARNER BRIAN D , COLLINS MARK
IPC分类号： C12Q1/68 , G01N33/543 , C12N15/09 , F02B75/02 , G01N33/53 , G01N33/566
CPC分类号： C12Q1/6813 , C12Q1/682 , F02B2075/027 , Y10S435/808 , Y10S435/81
摘要： PROBLEM TO BE SOLVED: To provide a new techniques for substantially reducing background signals encountered in solution phase hybridization assays and provide the techniques premised on eliminating or significantly reducing the phenomena of nonspecific hybridization and nonspecific binding, so as to provide a detectable signal which is produced only in the presence of the target polynucleotide of the interest, and provide kits for carrying out the new assays as well. SOLUTION: The improved solution phase nucleic acid sandwich assay comprises the following steps: the step where the analyte is connected to a solid support, the step where the analyte is marked and the step where the mark on the support is detected. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：提供用于在溶液相杂交测定中遇到的背景信号的基本上减少的新技术，并且提供了基于消除或显着减少非特异性杂交和非特异性结合现象的技术，从而提供可检测信号其仅在感兴趣的靶多核苷酸的存在下产生，并且还提供用于进行新测定的试剂盒。解决方案：改进的溶液相核酸夹心测定法包括以下步骤：将分析物连接到固体支持物的步骤，标记分析物的步骤和检测载体上标记的步骤。版权所有（C）2006，JPO＆NCIPI

19. 发明专利

JP2004340949A Electrochemical sensor 审中-公开
公开(公告)号：JP2004340949A
公开(公告)日：2004-12-02
申请号：JP2004117096
申请日：2004-04-12
申请人： Bayer Corp , バイエルコーポレーション
发明人： MALEY THOMAS C , BODEN MARK W , D ORAZIO PAUL A , DALZELL BONNIE C , EDELMAN PETER G , FLAHERTY JAMES E , GREEN ROBERT B , LEPKE STEVEN C , MASON RICHARD W , MCCAFFREY ROBERT R , ZALENSKI JOHN A
IPC分类号： G01N27/28 , C08L1/00 , C08L1/12 , C12Q1/00 , G01N27/30 , G01N27/327 , G01N27/40 , G01N27/416 , G01N33/483 , G01N37/00
CPC分类号： C12Q1/006 , C12Q1/001 , Y10S435/817 , Y10T29/49117 , Y10T29/49204 , Y10T29/53261 , Y10T29/53265
摘要： PROBLEM TO BE SOLVED: To provide a method for compounding cellulose acetate for use in an electrode in a pasty state. SOLUTION: This compounding method for cellulose acetate includes a process for forming paste having a high viscosity by mixing cellulose acetate with a solvent of low vapor pressure. COPYRIGHT: (C)2005,JPO&NCIPI

20. 发明专利

JP2004264315A Solid-state planar oxygen sensor 有权
公开(公告)号：JP2004264315A
公开(公告)日：2004-09-24
申请号：JP2004186253
申请日：2004-06-24
申请人： Bayer Corp , Novartis Ag , ノヴァーティスアーゲー , バイエルコーポレーション
发明人： FOOS JOSEPH S , EDELMAN PETER G , FLAHERTY JAMES E , BERGER JOSEPH , BODEN MARK W
IPC分类号： G01N27/404 , B01D63/00 , C08F20/12 , C08F20/44 , C08F220/14 , G01N27/40 , G01N27/407 , G01N27/416 , G01N27/48 , G01N27/49 , G01N33/49
CPC分类号： C08F220/14 , G01N27/404 , G01N33/4925 , Y10T29/49117 , Y10T29/5313 , Y10T29/5317 , Y10T29/532 , Y10T29/53204
摘要： PROBLEM TO BE SOLVED: To provide an electrochemical sensor which is non-depleting with respect to active species to be measured, and has a relatively long lifetime. SOLUTION: The sensor comprises a non-conductive substrate 32, a first conductive material, a second conductive material, a semi-permeable membrane 60, a cover member 64, and a gasket 66. When a sample to be measured is introduced into a sample chamber 62, active species to be measured and water vapor quickly permeate the membrane 60, to be brought into contact with an electrolyte 58. The electrolyte 58 swells through the action of the water vapor, and the active species transport ions up to an acting electrode 54. COPYRIGHT: (C)2004,JPO&NCIPI

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