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11. 发明申请

US20110293579A1 Bi-specific fusion proteins 有权
标题翻译：双特异融合蛋白
公开(公告)号：US20110293579A1
公开(公告)日：2011-12-01
申请号：US13068808
申请日：2011-05-20
申请人： Ulrik Nielsen , Thomas Wickham , Birgit Schoeberl , Brian Harms , Bryan Linggi , Matthew Onsum , Byron DeLaBarre , Shaun Lippow
发明人： Ulrik Nielsen , Thomas Wickham , Birgit Schoeberl , Brian Harms , Bryan Linggi , Matthew Onsum , Byron DeLaBarre , Shaun Lippow
IPC分类号： A61K35/12 , A61P43/00 , A61K38/02 , C07H21/00 , C07K19/00
CPC分类号： C07K16/44 , A61K38/00 , A61K45/06 , A61K47/66 , A61K47/6811 , A61K47/6891 , B82Y5/00 , C07K14/47 , C07K14/475 , C07K14/485 , C07K14/65 , C07K16/46 , C07K2317/31 , C07K2317/76 , C07K2319/00 , C07K2319/80 , C12N15/62
摘要： Bi-specific fusion proteins with therapeutic uses are provided, as well as pharmaceutical compositions comprising such fusion proteins, and methods for using such fusion proteins to repair or regenerate damaged or diseased tissue. The bi-specific fusion proteins generally comprise: (a) a targeting polypeptide domain that binds to a target molecule; and (b) an activator domain that detectably modulates tissue regeneration.
摘要翻译：提供了具有治疗用途的双特异性融合蛋白，以及包含这种融合蛋白的药物组合物，以及使用这种融合蛋白修复或再生受损或患病组织的方法。双特异性融合蛋白通常包含：（a）靶向靶分子结合的靶向多肽结构域; 和（b）可检测地调节组织再生的活化剂结构域。

12. 发明授权

US06831940B2 System and method for narrowing the range of frequency uncertainty of a doppler shifted signal 失效
标题翻译：用于缩小多普勒偏移信号的频率不确定度范围的系统和方法
公开(公告)号：US06831940B2
公开(公告)日：2004-12-14
申请号：US09885755
申请日：2001-06-19
申请人： Brian Harms , Sherman A. Gregory , Brian K. Butler , Avneesh Agrawal
发明人： Brian Harms , Sherman A. Gregory , Brian K. Butler , Avneesh Agrawal
IPC分类号： H04B1500
CPC分类号： H04B7/216 , G01S19/29 , H04B1/707 , H04L2027/0034
摘要： A system and method for narrowing the range of frequency uncertainty of a Doppler shifted pilot signal in a satellite or other communications system with relative signal source and receiver motion. The satellite communications system includes a user terminal (for example, a mobile wireless telephone), a gateway (terrestrial base station), and at least one satellite with unknown position and unknown relative velocity. The method includes the steps of shifting the pilot signal over a plurality of frequency hypotheses, coherently accumulating samples of the pilot signal over a plurality of chips, measuring the energy of the accumulated pilot signal samples, accumulating the energy measurements over a plurality of chips to produce an energy accumulation value, and determining which of the plurality of frequency hypotheses results in the highest energy accumulation value.
摘要翻译：一种用于在具有相对信号源和接收机运动的卫星或其他通信系统中缩小多普勒频移导频信号的频率不确定度的范围的系统和方法。卫星通信系统包括用户终端（例如，移动无线电话），网关（地面基站）和至少一个具有未知位置和未知相对速度的卫星。该方法包括以下步骤：通过多个频率假设移位导频信号，通过多个码片相干累加导频信号的采样，测量累积的导频信号样本的能量，将多个码片上的能量测量累积到产生能量累积值，并且确定多个频率假设中的哪一个导致最高的能量积累值。

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