专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

11. 发明申请

WO2008012071A2 PHARMACEUTICAL COMPOSITIONS OF NICOTINE AND METHODS OF USE THEREOF 审中-公开
标题翻译：烟碱的药物组合物及其使用方法
公开(公告)号：WO2008012071A2
公开(公告)日：2008-01-31
申请号：PCT/EP2007/006579
申请日：2007-07-24
申请人： ANTARES PHARMA IPL AG , R. CARRARA, Dario, Norberto , GRENIER, Arnaud , BESSE, Celine
发明人： R. CARRARA, Dario, Norberto , GRENIER, Arnaud , BESSE, Celine
IPC分类号： A61K9/06 , A61P25/34
CPC分类号： A61K9/0014 , A61K9/7015 , A61K47/10
摘要： The present invention comprises non occlusive compositions for transdermal delivery of nicotine, and more particularly pharmaceutically acceptable salts thereof, and methods of making same. The composition may, for example, be a gel suitable for transdermal or transmucosal applications. The compositions of the present invention typically comprise a mixture of water and alcohol, and a solvent system having a mono alkyl ether of diethylene glycol and a glycol present in specified ratios and in specific amounts, wherein the pH of the gel is usually between about pH 5.5 and about pH 6.5. The compositions may include further components, for example, the hydroalcoholic vehicle may further comprise additional penetration enhancer(s), buffering agent(s), antioxidant(s), stabilizer(s) and/or gelling agent(s). The invention also relates to a method for the sustained delivery of nicotine pharmaceutically acceptable salts to treat a variety of conditions and disorders.
摘要翻译：本发明包括用于透皮递送尼古丁的非闭合性组合物，更特别是其药学上可接受的盐及其制备方法。例如，该组合物可以是适用于透皮或透粘膜应用的凝胶。本发明的组合物通常包含水和醇的混合物以及具有以特定比例和特定量存在的二甘醇和二醇的单烷基醚的溶剂体系，其中凝胶的pH通常在约pH 5.5和约pH 6.5。组合物可以包含其他组分，例如，水醇载体可以进一步包含另外的渗透增强剂，缓冲剂，抗氧化剂，稳定剂和/或胶凝剂。本发明还涉及持续输送尼古丁药学上可接受的盐以治疗多种病症和病症的方法。

IPRDB

热门服务

关于我们

友情链接

联系方式