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11. 发明专利

CA2441119A1 ATRIAL FILTER IMPLANTS 未知
公开(公告)号：CA2441119A1
公开(公告)日：2002-09-19
申请号：CA2441119
申请日：2002-03-08
申请人： ATRITECH INC
发明人： PETERSON DEAN , WELCH JEFFREY , SUTTON GREGG S
IPC分类号： A61B17/00 , A61B17/12 , A61F2/01 , A61F2/02
摘要： Implant devices for filtering blood flowing through atrial appendage ostiums have elastic cover and anchoring substructures. The substructures may includ e reversibly folding tines or compressible wire braid structures. The devices are folded to fit in catheter tubes for delivery to the atrial appendages. T he devices elastically expand to their natural sizes when they are expelled fro m the catheter tubes. Filter elements in the covers block emboli from escaping through the ostiums. The devices with tine substructures may have H-shaped cross sections. These devices seal the appendages by pinching an annular region of ostium tissue between the cover and the anchoring substructures. T he shallow deployment depth of these H-shaped devices allows use of an universa l device size for atrial appendages of varying lengths. The devices may includ e remotely activated fixtures for refolding the tines for device recovery or position adjustment.

12. 发明专利

CA2388600A1 FILTER APPARATUS FOR OSTIUM OF LEFT ATRIAL APPENDAGE 未知
公开(公告)号：CA2388600A1
公开(公告)日：2001-05-03
申请号：CA2388600
申请日：2000-10-26
申请人： ATRITECH INC
发明人： WELCH JEFFREY , BORILLO THOMAS E , SUTTON GREGG S , SCHWARTZ ROBERT , HAUSER ROBERT G , VAN TASSEL ROBERT A , HOLMES DAVID
IPC分类号： A61M31/00 , A61B17/00 , A61B17/12 , A61F2/01 , A61L29/00 , A61L31/00
摘要： Apparatus for permanent placement across an ostium of a left atrial appendag e in a patient, which includes a filtering membrane configured to extend acros s the ostium of the left atrial appendage. The filtering membrane has a permeable structure which allows blood to flow through but substantially inhibits thrombus from passing therethrough. The apparatus also includes a support structure attached to the filtering membrane which retains the filtering membrane in position across the ostium of the left atrial appendag e by permanently engaging a portion of the interior wall of the left atrial appendage. The support structure may be radially expandable from a first configuration to a second configuration which engages the ostium or the interior wall of the left atrial appendage. The filtering membrane may defin e an opening therethrough that is configured to expand from a first size which inhibits the passage of thrombus therethrough to a second size which allows an interventional device, e.g., an expansion balloon, to pass therethrough, and wherein the opening is resiliently biased towards the first size.

13. 发明申请

WO2003063732A2 ATRIAL APPENDAGE BLOOD FILTRATION SYSTEMS 审中-公开
标题翻译： ATRIAL附录血液过滤系统
公开(公告)号：WO2003063732A2
公开(公告)日：2003-08-07
申请号：PCT/US2003/002395
申请日：2003-01-24
申请人： ATRITECH, INC.
发明人： SUTTON, Gregg, S. , WELCH, Jeffrey , PETERSON, Dean , BRIDGEMAN, John , YOUNGBERG, Bruce, R.
IPC分类号： A61F2/01
CPC分类号： A61F2/01 , A61B17/0057 , A61B17/12022 , A61B17/12122 , A61B17/12172 , A61B2017/00243 , A61B2017/00575 , A61B2017/12095 , A61F2002/011 , A61F2002/016 , A61F2002/018 , A61F2230/0006 , A61F2230/005 , A61F2230/008 , A61F2230/0093
摘要： Instrumentation for percutaneous delivery of blood filtration devices to atrial appendages includes a curved access sheath and a delivery tube. The curved access sheath is coursed through the patient's vasculature to gain transseptal access to a left atrial appendage. A compressed filter device attached to a tether wire is loaded in the delivery tube. The loaded delivery tube is advanced through the pre-positioned access sheath to place the device in a deployment position. The access sheath and the delivery tube can be mechanically locked and moved together to place the device in a suitable deployment position. The device is deployed by expelling it from the delivery tube either by retracting the delivery tube over the tether wire, or by moving the tether wire forward through the delivery tube. The expelled device, which is not constrained by the delivery tube walls, self expands to its useful size in the subject atrial appendage. A filter membrane in the deployed extends across the appendage ostium to filter blood flow through the ostium. The filter membrane is configured to present a flat surface to atrial blood flow past the ostium.
摘要翻译：用于将血液过滤装置经皮递送至心房附件的仪器包括弯曲通道护套和输送管。弯曲的通路护套通过患者的脉管系统通过，以获得左心耳通过的通路。附接到系绳的压缩过滤器装置装载在输送管中。装载的输送管通过预定位的进入护套前进，以将装置置于展开位置。进入护套和输送管可以机械地锁定并一起移动，以将装置放置在合适的展开位置。通过将输送管缩回到系绳上，或者通过将系绳向前移动通过输送管，将装置从输送管排出。不受输送管壁约束的排出的装置在主题心耳中自我膨胀到其有用的尺寸。所部署的过滤膜延伸穿过附属口，以过滤通过口的血液流。滤膜被配置成呈现出通过口的心房血流的平坦表面。

14. 发明申请

WO02071977A3 ATRIAL FILTER IMPLANTS 审中-公开
标题翻译： ATRIAL过滤器
公开(公告)号：WO02071977A3
公开(公告)日：2003-06-26
申请号：PCT/US0207009
申请日：2002-03-08
申请人： ATRITECH INC
发明人： SUTTON GREGG S , PETERSON DEAN , WELCH JEFFREY
IPC分类号： A61B17/00 , A61B17/12 , A61F2/01 , A61F2/02
CPC分类号： A61B17/12045 , A61B17/12022 , A61B17/12122 , A61B17/12172 , A61B2017/00575 , A61B2017/00592 , A61B2017/00597 , A61B2017/00615 , A61B2017/00632 , A61B2017/1205 , A61B2017/12059 , A61B2017/12072 , A61F2/01 , A61F2002/018 , A61F2230/0006 , A61F2230/0076 , A61F2230/008 , A61F2230/0093
摘要： Implant devices for filtering blood flowing through atrial appendage ostiums have elastic cover and anchoring substructures. The substructures may include reversibly folding tines or compressible wire braid structures. The devices are folded to fit in catheter tubes for delivery to the atrial appendages. The devices elastically expand to their natural sizes when they are expelled from the catheter tubes. Filter elements in the covers block emboli from escaping through the ostiums. The devices with tine substructures may have H-shaped cross sections. These devices seal the appendages by pinching an annular region of ostium tissue between the cover and the anchoring substructures. The shallow deployment depth of these H-shaped devices allows use of an universal device size for atrial appendages of varying lengths. The devices may include remotely activated fixtures for refolding the tines for device recovery or position adjustment.
摘要翻译：用于过滤通过心耳附件的血液的植入装置具有弹性覆盖物和锚固子结构。子结构可以包括可逆地折叠齿或可压缩的线编织结构。这些装置被折叠以适合导管，用于递送到心房附件。当装置从导管管排出时，这些装置弹性膨胀至其自然尺寸。过滤元件在盖子阻塞栓塞从逃离通过口。具有叉形结构的装置可具有H形横截面。这些装置通过在盖和锚定子结构之间夹住口腔组织的环形区域来密封附件。这些H型装置的浅部署深度允许使用通用装置尺寸用于不同长度的心房附件。这些装置可以包括用于重新折叠齿的用于装置恢复或位置调整的远程激活的固定装置。

15. 发明申请

WO0215793A3 EXPANDABLE IMPLANT DEVICES FOR FILTERING BLOOD FLOW FROM ATRIAL APPENDAGES 审中-公开
标题翻译：用于从ATRIAL附件过滤血液的可扩展植入装置
公开(公告)号：WO0215793A3
公开(公告)日：2002-08-29
申请号：PCT/US0125920
申请日：2001-08-17
申请人： ATRITECH INC
发明人： BORILLO THOMAS E , PETERSON DEAN , SUTTON GREGG S , WELCH JEFFREY
IPC分类号： A61B17/00 , A61B17/12 , A61F2/01
CPC分类号： A61F2/013 , A61B17/12022 , A61B17/12122 , A61B17/12136 , A61B17/12159 , A61B17/12172 , A61B2017/00575 , A61F2/01 , A61F2002/015 , A61F2002/016 , A61F2002/018 , A61F2230/0006 , A61F2230/0069 , A61F2230/008
摘要： Implant devices for filtering blood flowing through the ostium of an atrial appendage have component structures one or more of which are expandable. Devices with component structures in their unexpanded state have a compact size suitable for intra-cutaneous delivery to an atrial appendage situs. The expandable component structures are expanded in situ to deploy the devices. A device may have sufficiently short axial length so that most or almost all of the device length may fit within the ostium region. An expandable component structure in the device may include a blood-permeable filter element. The device may be deployed so that this component structure covers the ostium so as to direct the blood flow to pass through the filter element. The filter elements used in the devices may have hole size distributions selected to filter out harmful-size emboli. The filter elements may be embedded in elastic material so that hole-size distributions remain substantially unaffected by expansion of the device structures. Anchors attached to a component structure engage tissue surrounding the device and maintain the devices in position. The anchors may include inflatable anchors which engage interior walls of the atrial appendage.
摘要翻译：用于过滤血流通过心房的口的植入装置具有其中一个或多个可膨胀的部件结构。具有未膨胀状态的组件结构的装置具有适合于皮内递送至心房附属部位的紧凑尺寸。可扩展组件结构在现场扩展以部署设备。装置可以具有足够短的轴向长度，使得装置长度的大部分或几乎全部可以适合于口腔区域。该装置中的可扩张组件结构可包括透血过滤元件。该装置可以部署成使得该部件结构覆盖口，以引导血液流过过滤元件。在装置中使用的过滤器元件可以具有选择用于过滤有害尺寸栓塞的孔尺寸分布。过滤元件可以嵌入弹性材料中，使得孔尺寸分布基本上不受设备结构的膨胀的影响。附接到部件结构的锚点接合设备周围的组织并将设备维持在适当位置。锚定器可以包括接合心房内壁附近的充气锚。

16. 发明申请

WO0130266A9 FILTER APPARATUS FOR OSTIUM OF LEFT ATRIAL APPENDAGE 审中-公开
标题翻译：过滤装置用于左心室附件
公开(公告)号：WO0130266A9
公开(公告)日：2002-08-15
申请号：PCT/US0029489
申请日：2000-10-26
申请人： ATRITECH INC , VAN TASSEL ROBERT A , HAUSER ROBERT G , SCHWARTZ ROBERT , HOLMES DAVID , SUTTON GREGG S , BORILLO THOMAS E , WELCH JEFFREY
发明人： VAN TASSEL ROBERT A , HAUSER ROBERT G , SCHWARTZ ROBERT , HOLMES DAVID , SUTTON GREGG S , BORILLO THOMAS E , WELCH JEFFREY
IPC分类号： A61M31/00 , A61B17/00 , A61B17/12 , A61F2/01 , A61L29/00 , A61L31/00
CPC分类号： A61F2/01 , A61B17/00234 , A61B17/0057 , A61B17/12122 , A61B17/12136 , A61B17/12159 , A61B17/12172 , A61B2017/00243 , A61B2017/00597 , A61B2017/00619 , A61B2017/00632 , A61B2017/1205 , A61F2002/018 , A61F2230/0006 , A61F2230/005 , A61F2230/0067 , A61F2230/0069 , A61F2230/0076 , A61F2230/0078 , A61F2230/008 , A61F2230/0093
摘要： Apparatus for permanent placement across an ostium of a left atrial appendage in a patient, which includes a filtering membrane configured to extend across the ostium of the left atrial appendage. The filtering membrane has a permeable structure which allows blood to flow through but substantially inhibits thrombus from passing therethrough. The apparatus also includes a support structure attached to the filtering membrane which retains the filtering membrane in position across the ostium of the left atrial appendage by permanently engaging a portion of the interior wall of the left atrial appendage. The support structure may be radially expandable from a first configuration to a second configuration which engages the ostium or the interior wall of the left atrial appendage. The filtering membrane may define an opening therethrough that is configured to expand from a first size which inhibits the passage of thrombus therethrough to a second size which allows an interventional device, e.g., an expansion balloon, to pass therethrough, and wherein the opening is resiliently biased towards the first size.
摘要翻译：用于永久性放置在患者左心耳的口上的装置，其包括配置成延伸穿过左心耳的口的过滤膜。过滤膜具有允许血液流过但可以基本上抑制血栓通过的可渗透结构。该装置还包括附接到过滤膜的支撑结构，其通过永久地接合左心耳内壁的一部分而将过滤膜保持在左心耳的口处的适当位置。支撑结构可以从第一构型径向扩张到接合左心耳的口或内壁的第二构型。过滤膜可以限定穿过其中的开口，其被构造成从阻止血栓通过的第一尺寸膨胀到允许介入装置（例如膨胀气囊）穿过其中的第二尺寸，并且其中开口是弹性的偏向于第一大小。

17. 发明申请

US20160066922A1 DEVICE AND METHOD FOR OCCLUDING THE LEFT ATRIAL APPENDAGE 审中-公开
标题翻译：用于阻止左心耳附件的装置和方法
公开(公告)号：US20160066922A1
公开(公告)日：2016-03-10
申请号：US14940887
申请日：2015-11-13
申请人： ATRITECH, INC.
发明人： John B. Bridgeman , Gregg Sutton , Christopher J. Clark
IPC分类号： A61B17/12 , A61B17/00
CPC分类号： A61B17/12122 , A61B17/0057 , A61B17/12172 , A61B2017/00601 , A61B2017/00632
摘要： An implantable medical device for insertion in the left atrial appendage includes a cap coupled to a frame. The cap constrains movement of the legs of the frame during collapse and expansion of the device, such that the device can be deployed, recalled and redeployed without the device being damaged or the legs of the frame getting tangled.
摘要翻译：用于插入左心耳中的可植入医疗装置包括联接到框架的盖。盖子在装置的折叠和膨胀期间限制框架的腿的运动，使得可以部署，召回和重新部署装置，而不会损坏装置或框架的腿变得纠结。

18. 发明申请

US20150374491A1 INTRACARDIAC CAGE AND METHOD OF DELIVERING SAME 审中-公开
标题翻译：沙门氏菌卵囊及其传递方法
公开(公告)号：US20150374491A1
公开(公告)日：2015-12-31
申请号：US14846127
申请日：2015-09-04
申请人： ATRITECH, INC.
发明人： Marc S. Kreidler
IPC分类号： A61F2/24
CPC分类号： A61B17/0057 , A61B17/12022 , A61B17/12122 , A61B17/12172 , A61B2017/00243 , A61B2017/00575 , A61B2017/00579 , A61B2017/00592 , A61B2017/00597 , A61B2017/00606 , A61B2017/00615 , A61B2017/00623 , A61F2/01 , A61F2/2427 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/0071 , A61F2230/0076
摘要： A method of preventing ingress of material into the left atrium of a heart includes providing a delivery sheath, advancing the sheath distal end through an opening between the right atrium and the left atrium of the heart, providing an expandable cage, delivering the expandable cage to the left atrium, and expanding the expandable cage within the left atrium. The expandable cage includes a proximal end, a distal end, and a plurality of supports extending therebetween. The expandable cage also includes a first membrane provided at its proximal end and a second membrane provided at its distal end. The expandable cage has a collapsed configuration so that it can be received within the lumen of the delivery sheath, and an expanded configuration for deployment within the heart. When expanded, the first membrane is positioned at an opening between the left and right atria of the heart, and the second membrane is positioned at the ostium of the left atrial appendage. The first membrane substantially prevents passage of blood between the atria and the second membrane prevents passage of embolic material from the left atrial appendage into the left atrium of the heart.
摘要翻译：防止材料进入心脏左心房的方法包括提供输送护套，使护套远端穿过心脏的右心房和左心房之间的开口，提供可扩张的笼，将可扩张的笼子传送到左心房，并扩大左心房内的可扩张笼。可膨胀笼包括近端，远端以及在其间延伸的多个支撑件。可膨胀笼还包括在其近端处设置的第一膜和在其远端处设置的第二膜。可膨胀保持架具有收缩构型，使得其可以容纳在输送护套的内腔中，并且扩展构型用于在心脏内展开。当扩张时，第一膜位于心脏左心房和右心房之间的开口处，第二膜位于左心耳的口处。第一膜基本上防止血液在心房和第二膜之间通过，阻止栓塞材料从左心耳通过到心脏的左心房。

19. 发明申请

US20150230909A1 METHOD AND APPARATUS FOR DELIVERING AN IMPLANT WITHOUT BIAS TO A LEFT ATRIAL APPENDAGE 审中-公开
标题翻译：用于递送植入物的方法和装置，而不偏向左侧的附件
公开(公告)号：US20150230909A1
公开(公告)日：2015-08-20
申请号：US14705561
申请日：2015-05-06
申请人： ATRITECH, INC.
发明人： Steve Zaver , Kevin Anderson , Kevin Cowden , Chris Quinn , Brian Watschke
IPC分类号： A61F2/01
CPC分类号： A61B17/12022 , A61B17/0057 , A61B17/12122 , A61B17/12172 , A61B2017/00477 , A61B2017/00575 , A61B2017/00579 , A61B2017/00592 , A61B2017/00597 , A61B2017/00619 , A61B2017/00623 , A61B2017/00632 , A61B2017/00986 , A61B2017/0412 , A61B2017/0427 , A61B2017/0464 , A61B2017/1205 , A61B2017/12054 , A61B2017/12095 , A61B2017/22038 , A61F2/01 , A61F2002/011
摘要： An implant delivery system, comprising: an implantable device comprising a plurality of supports extending between a proximal end and a distal end, the supports being moveable between a collapsed configuration and an expanded configuration, a proximal guide tube at the proximal end of the supports extending toward the distal end, and a distal guide tube at the distal end of the supports extending toward the proximal end, wherein the proximal and distal guide tubes are telescoping and become further engaged as the supports move from the collapsed to the expanded configuration.
摘要翻译：一种植入物递送系统，包括：可植入装置，其包括在近端和远端之间延伸的多个支撑件，所述支撑件可在收缩构型和扩张构型之间移动，所述支撑件的近端处的近端引导管延伸并且远端引导管在支撑件的远端朝向近端延伸，其中近端和远端引导管是伸缩的并且随着支撑件从塌陷部移动到扩张构型而进一步接合。

20. 发明授权

US09089313B2 Method of closing an opening in a wall of the heart 有权
公开(公告)号：US09089313B2
公开(公告)日：2015-07-28
申请号：US14101112
申请日：2013-12-09
申请人： ATRITECH, INC.
发明人： Chad C. Roue , Andrew G. C. Frazier , Michael D. Lesh , Erik J. van der Burg
IPC分类号： A61B17/00 , A61B17/04 , A61B17/12 , A61B17/064 , A61F2/24
CPC分类号： A61B17/0057 , A61B17/00234 , A61B17/0401 , A61B17/064 , A61B17/0644 , A61B17/12122 , A61B2017/00243 , A61B2017/00292 , A61B2017/00575 , A61B2017/00579 , A61B2017/00632 , A61B2017/00668 , A61B2017/0409 , A61B2017/0412 , A61B2017/0414 , A61B2017/0417 , A61B2017/042 , A61B2017/0437 , A61B2017/0445 , A61B2017/0454 , A61B2017/0458 , A61B2017/0464 , A61B2017/0472 , A61B2017/0477 , A61B2017/048 , A61B2017/0488 , A61B2017/0645 , A61B2017/0647 , A61F2/24 , A61F2/2427 , A61F2/2487 , Y10S606/907
摘要： Disclosed is a closure catheter, for closing a tissue opening such as an atrial septal defect, patent foreman ovale, or the left atrial appendage of the heart. The closure catheter carries a plurality of tissue anchors, which may be deployed into tissue surrounding the opening, and used to draw the opening closed. Methods are also disclosed.

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