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11. 发明申请

WO1993006133A1 IMMUNOASSAY FOR IDENTIFYING ALCOHOLICS AND MONITORING ALCOHOL CONSUMPTION 审中-公开
标题翻译：用于识别酒精和监测酒精消费的免疫
公开(公告)号：WO1993006133A1
公开(公告)日：1993-04-01
申请号：PCT/US1992008136
申请日：1992-09-25
申请人： MAKHLOUF, Samar , PANKOW, Mark, L. , ANDERSON, Byron, E. , BEAN, Pamela
IPC分类号： C07K15/00
CPC分类号： G01N33/68 , C07K14/79 , C07K16/18 , Y10S436/811
摘要： The invention provides an antibody which reacts selectively with a transferrin homolog found in alcoholics but in non-alcoholics. The invention also provides methods of making the antibody and hybridomas producing the antibody. Finally, the invention provides an immunoassay which utilizes the antibody to detect or quantitate the alcoholic transferrin homolog and a kit for an immunoassay which comprises a container of the antibody.
摘要翻译：本发明提供了一种抗体，其选择性地与酗酒者中发现的转铁蛋白同源物反应，但是在非酒精中。本发明还提供了制备抗体和产生抗体的杂交瘤的方法。最后，本发明提供一种利用该抗体检测或定量该醇转运蛋白同源物的免疫测定法和一种包含抗体容器的免疫测定试剂盒。

12. 发明专利

DE69229230T2 未知
公开(公告)号：DE69229230T2
公开(公告)日：2000-01-27
申请号：DE69229230
申请日：1992-09-25
申请人： MAKHLOUF SAMAR , PANKOW MARK LEE , ANDERSON BYRON E , BEAN PAMELA
发明人： MAKHLOUF SAMAR , PANKOW MARK LEE , ANDERSON BYRON E , BEAN PAMELA
IPC分类号： C07K7/08 , C07K14/79 , C07K16/00 , C07K16/18 , C12N5/10 , C12N5/20 , C12N15/02 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/68 , G01N33/577
摘要： The invention provides an antibody which reacts selectively with a transferrin homolog found in alcoholics but not in non-alcoholics. The invention also provides methods of making the antibody and hybridomas producing the antibody. Finally, the invention provides an immunoassay which utilizes the antibody to detect or quantitate the alcoholic transferrin homolog and a kit for an immunoassay which comprises a container of the antibody.

13. 发明专利

AU2558497A A synthetic peptide and its uses 未知
公开(公告)号：AU2558497A
公开(公告)日：1997-10-29
申请号：AU2558497
申请日：1997-04-04
申请人： ANDERSON BYRON E , BAUMANN MICHAEL A , FRYER JONATHAN P
发明人： ANDERSON BYRON E , BAUMANN MICHAEL A , FRYER JONATHAN P
IPC分类号： A61K38/00 , A61K38/16 , A61K38/17 , C07K14/31 , C07K14/47 , G01N33/564 , A61K38/10
摘要： The invention provides a fragment of C1q which is characterized in that a plurality of such fragments selectively binds immune complexes or aggregated immunoglobulins in the presence of monomeric immunoglobulin. The invention also provides a synthetic peptide comprising the sequence: - Leu Glu Gln Gly Glu Asn Val Phe Leu Gln Ala Thr - 1 5 10 - [SEQ ID NO 2] - or variants thereof capable of binding immunoglobulin. Like the C1q fragment, a plurality of the peptides can selectively bind immune complexes or aggregated immunoglobulins in the presence of monomeric immunoglobulin. As a result of this property, the fragments and peptides are well-adapted for removing immune complexes and aggregated immunoglobulins from fluids containing monomeric immunoglobulin, and for detecting or quantitating immune complexes in such fluids. The invention also provides a binding material for removing immune complexes or aggregated immunoglobulins from a fluid. The binding material comprises plural binding peptides, the peptides being characterized in that a plurality of them selectively binds immune complexes and aggregated immunoglobulins in the presence of monomeric immunoglobulin. The invention also provides methods of treating an inflammatory response and prolonging the survival of transplanted tissue.

14. 发明专利

AT134880T 未知
公开(公告)号：AT134880T
公开(公告)日：1996-03-15
申请号：AT89904944
申请日：1989-03-31
申请人： POTEMPA LAWRENCE A , ANDERSON BYRON E
发明人： POTEMPA LAWRENCE A , ANDERSON BYRON E
IPC分类号： A61M1/36 , A61M1/14 , A61K39/385 , A61K39/395 , C07K1/00 , C07K16/06 , C07K16/18 , G01N33/564 , G01N33/566

15. 发明专利

AT180282T 未知
公开(公告)号：AT180282T
公开(公告)日：1999-06-15
申请号：AT92921176
申请日：1992-09-25
申请人： MAKHLOUF SAMAR , PANKOW MARK LEE , ANDERSON BYRON E , BEAN PAMELA
发明人： MAKHLOUF SAMAR , PANKOW MARK LEE , ANDERSON BYRON E , BEAN PAMELA
IPC分类号： C07K7/08 , C07K14/79 , C07K16/00 , C07K16/18 , C12N5/10 , C12N5/20 , C12N15/02 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/68 , G01N33/577
摘要： The invention provides an antibody which reacts selectively with a transferrin homolog found in alcoholics but not in non-alcoholics. The invention also provides methods of making the antibody and hybridomas producing the antibody. Finally, the invention provides an immunoassay which utilizes the antibody to detect or quantitate the alcoholic transferrin homolog and a kit for an immunoassay which comprises a container of the antibody.

16. 发明专利

AU7466998A Method and material for inhibiting complement 未知
公开(公告)号：AU7466998A
公开(公告)日：1998-11-11
申请号：AU7466998
申请日：1998-04-14
申请人： ANDERSON BYRON E , FRYER JONATHAN P
发明人： ANDERSON BYRON E , FRYER JONATHAN P
IPC分类号： A61K38/05 , A61K47/48 , A61K38/00
摘要： The invention provides a method of inhibiting complement in a mammal comprising administering to the mammal an effective amount of a carrier having coupled thereto a plurality of dipeptides selected from the group consisting of tryptophan-tyrosine, tyrosine-tryptophan and tryptophan-tryptophan. The invention further provides a method of prolonging the survival of tissue transplanted into a mammal comprising administering to the mammal an effective amount of a carrier having coupled thereto a plurality of dipeptides selected from the group consisting of tryptophan-tyrosine, tyrosine-tryptophan and tryptophan-tryptophan. The invention also provides a method of treating an inflammatory response in a mammal comprising administering to the mammal an effective amount of a carrier having coupled thereto a plurality of dipeptides selected from the group consisting of tryptophan-tyrosine, tyrosine-tryptophan and tryptophan-tryptophan. Finally, the invention provides a pharmaceutical composition comprising a carrier having coupled thereto a plurality of dipeptides selected from the group consisting of tryptophan-tyrosine, tyrosine-tryptophan and tryptophan-tryptophan in a pharmaceutically-acceptable vehicle.

17. 发明专利

DE68925899T2 未知
公开(公告)号：DE68925899T2
公开(公告)日：1996-10-02
申请号：DE68925899
申请日：1989-03-31
申请人： POTEMPA LAWRENCE A , ANDERSON BYRON E
发明人： POTEMPA LAWRENCE A , ANDERSON BYRON E
IPC分类号： A61M1/36 , A61M1/14 , A61K35/12 , A61K38/00 , A61K39/385 , A61K39/395 , C07K1/00 , C07K16/06 , C07K16/18 , G01N33/564 , G01N33/566

18. 发明专利

DE68925899D1 未知
公开(公告)号：DE68925899D1
公开(公告)日：1996-04-11
申请号：DE68925899
申请日：1989-03-31
申请人： POTEMPA LAWRENCE A , ANDERSON BYRON E
发明人： POTEMPA LAWRENCE A , ANDERSON BYRON E
IPC分类号： A61M1/36 , A61M1/14 , A61K35/12 , A61K38/00 , A61K39/385 , A61K39/395 , C07K1/00 , C07K16/06 , C07K16/18 , G01N33/564 , G01N33/566

19. 发明专利

DE69229230D1 未知
公开(公告)号：DE69229230D1
公开(公告)日：1999-06-24
申请号：DE69229230
申请日：1992-09-25
申请人： MAKHLOUF SAMAR , PANKOW MARK LEE , ANDERSON BYRON E , BEAN PAMELA
发明人： MAKHLOUF SAMAR , PANKOW MARK LEE , ANDERSON BYRON E , BEAN PAMELA
IPC分类号： C07K7/08 , C07K14/79 , C07K16/00 , C07K16/18 , C12N5/10 , C12N5/20 , C12N15/02 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/68 , G01N33/577
摘要： The invention provides an antibody which reacts selectively with a transferrin homolog found in alcoholics but not in non-alcoholics. The invention also provides methods of making the antibody and hybridomas producing the antibody. Finally, the invention provides an immunoassay which utilizes the antibody to detect or quantitate the alcoholic transferrin homolog and a kit for an immunoassay which comprises a container of the antibody.

20. 发明专利

CA1339290C BINDING OF IMMUNE COMPLEXES BY MODIFIED FORMS OF C-REACTIVE PROTEIN 未知
公开(公告)号：CA1339290C
公开(公告)日：1997-08-12
申请号：CA595543
申请日：1989-04-03
申请人： POTEMPA LAWRENCE A , ANDERSON BYRON E
发明人： POTEMPA LAWRENCE A , ANDERSON BYRON E
IPC分类号： A61M1/36 , C07K16/18 , C07K1/22 , C07K16/06 , G01N33/543 , G01N33/564 , G01N33/566
摘要： A method of binding aggregated immunoglobulin or immune complexes comprising contacting them with modified forms of C-reactive protein. The method may be employed for diagnostic and therapeutic purposes and to deplete fluids of aggregated immunoglobulin or immune complexes. Further, a method of reducing the levels of immune complexes in a mammal comprising administering modified-CRP to the mammal, and a method of binding immunoglobulins comprising contacting them with modified C-reactive protein. Also, a method of binding aggregated immunoglobulin or immune complexes comprising contacting them with antibody to neo-CRP, and a method of modifying C-reactive protein. Finally, a test kit for detecting or quantitating immune complexes and a device for removing aggregated immunoglobulin or immune complexes from fluids are disclosed.

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