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11. 发明专利

ES240041Y 未知
公开(公告)号：ES240041Y
公开(公告)日：1979-06-16
申请号：ES240041
申请日：1978-12-07
申请人： AMERICAN HOME PRODUCTS CORPORATION
IPC分类号： A61B20060101 , A61B

12. 发明专利

ES241036U APARATO PARA MEDIR LA PRESION EN EL INTERIOR DE UNA CAVIDAD CORPORAL. 未知
公开(公告)号：ES241036U
公开(公告)日：1979-04-01
申请号：ES241036
申请日：1979-01-30
申请人： AMERICAN HOME PRODUCTS CORPORATION
IPC分类号： A61B5/00 , A61B5/03 , A61B10/00 , A61M25/00 , A61M25/02 , A61M25/06 , A61M39/00
摘要： Aparato para medir la presión en el interior de una cavidad corporalcaracterizado porque comprende un catéter flexible alargado lleno de líquido y provisto de un extremo de medición apto para conectarse a un transductor y un extremo corporal perforado apto para insertarse en dicha cavidad del cuerpo; un diafragma transmisor de presión que sella el extremo de medición de dicho catéter; y un tubo de guía apto para definir una trayectoria en el interior del cuerpo a tarvés de la cual ha de avanzar dicho catétersiendo dicho tubo de guía menos flexible y sustancialmente más corto que dicho catétersituándose la porción anterior de dicho catéter en el interior de dicho tubo de guía siendo apto dicho tubo de guía para tener una porción de su paredque discurre por toda la longitud de dicho tuboabierta para permitir el paso de dicho catéter a través de dicha pared de tubo guía para separar dicho catéter y tubo guía y medios que conectan de forma separable dicho catéter y tubo de guía.

13. 发明专利

ES205240Y 未知
公开(公告)号：ES205240Y
公开(公告)日：1976-06-16
申请号：ES205240
申请日：1974-08-12
申请人： AMERICAN HOME PRODUCTS CORPORATION
IPC分类号： E04C20060101 , E04C

14. 发明专利

ES202032Y 未知
公开(公告)号：ES202032Y
公开(公告)日：1976-02-16
申请号：ES202032
申请日：1974-04-04
申请人： AMERICAN HOME PRODUCTS CORPORATION
IPC分类号： B65D20060101 , E03D20060101 , B65D

15. 发明专利

ES159624Y 未知
公开(公告)号：ES159624Y
公开(公告)日：1971-03-16
申请号：ES159624
申请日：1970-06-20
申请人： AMERICAN HOME PRODUCTS CORPORATION
IPC分类号： F16N20060101 , F16N

16. 发明专利

AU640429B2 2-ANILINO PHENYLACETIC ACID DERIVATIVES AS INHIBITORS OF PLA2 AND LIPOXYGENASE 未知
公开(公告)号：AU640429B2
公开(公告)日：1993-08-26
申请号：AU6724790
申请日：1990-10-27
申请人： AMERICAN HOME PRODUCTS CORPORATION
发明人： AMEDEO ARTURO FAILLI , ANTHONY FRANK KREFT III , JOHN HENRY MUSSER
IPC分类号： A61K31/165 , A61K31/19 , A61K31/215 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/415 , A61K31/4184 , A61K31/47 , A61P29/00 , A61P37/08 , A61P43/00 , C07C229/40 , C07C229/42 , C07D209/34 , C07D215/14 , C07D215/18 , C07D235/12 , C07D235/16 , C07D401/04 , C07D401/12 , C07D521/00
摘要： There are disclosed compounds of the formula wherein R is hydroxy, lower alkoxy or lower alkoxyamino; R1 is hydrogen or A(CH2)nO-; R2 is hydrogen or A(CH2)nO-, with the proviso that one of R1 and R2 is A(CH2)nO- and the other is hydrogen; n is 1-2; A is phenoxyethyl, phenoxyphenyl or a group having the formula X is -N- or Z is R3 is hydrogen, lower alkyl or phenyl; R4 is hydrogen or lower alkyl; or R3 and R4 taken together form a benzene ring; R5 is hydrogen or lower alkyl; R6 is hydrogen, halo or lower alkyl; and the pharmacologically acceptable salts thereof, and their use in the treatment of inflammatory conditions, such as rheumatoid arthritis, ulcerative colitis, psoriasis and other immediate hypersensitivity reactions; in the treatment of leukotriene-mediated naso-bronchial obstructive air-passageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like; and as gastric cytoprotective agents.

17. 发明专利

AU639129B2 N',N'N',-TRISUBSTITUTED-5-METHYLENE-1,3-DIOXANE-4,6-DIONE INHIBITORS OF ACYL-COA: CHOLESTEROL-ACYL TRANSFERASE 未知
公开(公告)号：AU639129B2
公开(公告)日：1993-07-15
申请号：AU8243091
申请日：1991-08-14
申请人： AMERICAN HOME PRODUCTS CORPORATION
发明人： WILLIAM FLOYD FOBARE , DONALD PETER STRIKE
IPC分类号： A61K31/335 , A61K31/357 , A61P3/06 , A61P9/10 , C07D319/06 , C07D405/12 , C07F7/18
摘要： The compounds of the formula: in which X, and Y are, independently, hydrogen, halogen, hydroxy, nitro, cyano, carboxyl, trifluoromethyl, phenyl, amino, alkylamino, dialkylamino, alkyl, alkoxy or phenylalkyloxy; R1 is hydrogen, alkyl, hydroxyalkyl, alkenyl, cycloalkyl, phenylcycloalkyl, 1-hydroxymethylphenethyl, 1-(t-butyl)dimethylsilyloxymethylphenethyl, 1-(t-butyl)dimenthylsilyloxy methylisopentyl, 1-hydroxymethylisopentyl, phenyl, benzyl or substituted phenyl or benzyl, where the substituents are alkyl, alkoxy, halogen, cyano, trifluoromethyl, amino, alkylamino, dialkylamino, nitro or phenyl, benzyl, phenethyl or R1 is thienyl, imidazolyl, thiazolyl, pyridinyl, pyrimidinyl, pyrazinyl, benzamidazolyl, phenylalkylpiperidinyl or morpholino; R2 is alkyl, cycloalkyl, phenyl, benzyl or substituted phenyl or benzyl in which said substituent is alkyl, alkoxy, halogen, cyano, trifluoromethyl amino, nitro, alkylamino or dialkylamino; and a pharmaceutically acceptable salt thereof; are ACAT inhibitors, some of which possess antioxidant properties.

18. 发明专利

ES2033850T3 未知
公开(公告)号：ES2033850T3
公开(公告)日：1993-04-01
申请号：ES87306174
申请日：1987-07-13
申请人： AMERICAN HOME PRODUCTS CORPORATION
发明人： UPTON, GERTRUDE VIRGINIA
IPC分类号： A61K31/565 , A61P13/02 , A61P15/00 , A61P43/00 , C07J1/00
摘要： Disclosed herein is a method of providing hormonal replacement therapy and contraception for a pre-menopausal woman, which comprises administering to a pre-menopausal woman in need thereof a combination dosage form of an estrogen selected from 0.5-2.0 mg. of 17 beta -estradiol, 0.008-0.030 mg. of ethinyl estradiol, and 0.015-0.060 mg. of mestranol; and a progestogen selected from 0.025-0.100 mg. of levonorgestrel, 0.010-0.070 mg. of gestodene, 0.025-0.100 mg. of desogestrel, 0.025-0.100 mg. of 3-ketodesogestrel, and 0.085-0.35 mg. of norethindrone, said combination dosage form being administered for 23-25 days beginning at day one of the menstrual cycle, followed by 2-5 pill-free or blank pill days, for a total of 28 days in the administration cycle. The preferred dosage form of the invention is a combination of 1 mg. of 17 beta -estradiol and 0.050 or 0.075 mg. of levonorgestrel. The preferred administration cycle of the invention is administration of the combination dosage form for the first 24 days of the menstrual cycle and no dosage form for the last 4 days of the menstrual cycle.

19. 发明专利

ES2032295T3 未知
公开(公告)号：ES2032295T3
公开(公告)日：1993-02-01
申请号：ES87309253
申请日：1987-10-20
申请人： AMERICAN HOME PRODUCTS CORPORATION
发明人： BLANK, ROBERT GEORGE , REUTER, GERALD LOUIS
IPC分类号： A61K9/00 , A61K9/14 , A61K9/16 , A61K9/20 , A61K9/68 , A61K31/165 , A61K47/00 , A61K47/02 , A61K47/04 , A61K47/38 , A61P25/04 , A61P29/00 , B01J2/04 , C08J3/12
摘要： A therapeutic taste-neutral powder form of acetaminophen is obtained by spray-drying a suspension of colloidal silica in a lower alkanol solution of acetaminophen and ethyl cellulose. The powder can be formulated into fast dissolving dosage forms, chewable tablets and the like.

20. 发明专利

ES2032018T3 未知
公开(公告)号：ES2032018T3
公开(公告)日：1993-01-01
申请号：ES88306888
申请日：1988-07-26
申请人： AMERICAN HOME PRODUCTS CORPORATION
发明人： KREFT, ANTHONY FRANK , MUSSER, JOHN HENRY , BICKSLER, JAMES JACOB , GIBERSON, JOHN WILLIAM , KUBRAK, DENNIS MARTIN
IPC分类号： C12N9/99 , A61K31/34 , A61K31/341 , A61K31/38 , A61K31/381 , A61K31/415 , A61K31/4184 , A61K31/425 , A61K31/426 , A61K31/428 , A61K31/44 , A61K31/4402 , A61K31/4418 , A61K31/47 , A61P1/16 , A61P29/00 , A61P37/08 , A61P39/02 , A61P43/00 , C07C59/64 , C07C59/68 , C07D213/30 , C07D215/14 , C07D233/64 , C07D235/12 , C07D277/24 , C07D277/64 , C07D307/40 , C07D333/56 , A61K31/19 , A61K31/33
摘要： There are disclosed compounds of the formula wherein A is alkyl of 3-19 carbon atoms, diloweralkylvinyl, dihalovinyl, diphenylvinyl, lower alkynyl X is N or CR; Z is - @=@-, - @=N-, -N= @-, -@-, S or O; R is hydrogen or lower alkyl; R is hydrogen, lower alkyl or phenyl; R is hydrogen or lower alkyl; or R and R taken together with the carbon atoms to which they are attached form a benzene ring; and the pharmaceutically acceptable salts thereof, and their use in the treatment of leukotriene-mediated naso-bronchial obstructive airpassageway conditions, such as allergic rhinitis, allergic bronchial asthma and the like, in psoriasis, ulcerative colitis, rheumatoid arthritis as well as in other immediate hypersensitivity reactions and as cyloprotective agents. Intermediates for these compounds are also disclosed.

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