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    • 11. 发明专利
    • System and method for targeting magnetic resonance imaging of vascular system
    • 用于瞄准血管系统磁共振成像的系统和方法
    • JP2006006962A
    • 2006-01-12
    • JP2005218095
    • 2005-07-27
    • Epix Pharmaceuticals Incエピックス ファーマシューティカルズ,インコーポレイテッド
    • WEISSKOFF ROBERT MCARAVAN PETER DWITTE SONIALAUFFER RANDALL BCARPENTER ALAN P JR
    • A61B5/055G01R33/28A61K49/00
    • A61B5/416A61B5/055
    • PROBLEM TO BE SOLVED: To provide a system and a method for a targeting magnetic resonance imaging of vascular system which are cost-effective and safe and identify the presence, position, and size of a CVD (celebrovascular disease) target in a vascular system correctly by using a simple method. SOLUTION: A method to decide presence or absence of a static target in the vascular system of a mammal comprises (a) a process to administer a targeting MRI (magnetic resonance imaging) contrast agent to this mammal, (b) a process to acquire a first MRI data set including an image of this vascular system, and (c) a process to acquire a second MRI data set. This targeting MRI contrast agent has a specific affinity for this static target, and furthermore, this targeting MRI contrast agent can provide contrast enhancement of the vascular system of this static target and this mammal. This second MRI data set comprises a process to be acquired in suitable hours in order to provide contrast enhancement of this static target at an observable level for the reinforcement of blood and tissue of a background when this static target is present. COPYRIGHT: (C)2006,JPO&NCIPI
    • 要解决的问题:提供一种用于血管系统的靶向磁共振成像的系统和方法,所述系统和方法是成本有效和安全的,并且识别CVD(血管性脑血管疾病)靶的存在,位置和大小 血管系统正确使用简单的方法。 决定哺乳动物血管系统中静止靶的存在或不存在的方法包括(a)向该哺乳动物施用靶向MRI(磁共振成像)造影剂的方法,(b) 以获取包括该血管系统的图像的第一MRI数据集,以及(c)获取第二MRI数据集的处理。 该靶向MRI造影剂对该静态靶具有特异性亲和性,此外,该靶向MRI造影剂可以提供该静态靶和该哺乳动物的血管系统的对比度增强。 该第二MRI数据集包括在合适的时间内获取的过程,以便当存在该静态目标时,以可观察的水平提供该静态目标的对比度增强以加强背景的血液和组织。 版权所有(C)2006,JPO&NCIPI