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11. 发明申请

WO2013006503A1 MULTIGENE PROGNOSTIC ASSAY FOR LUNG CANCER 审中-公开
标题翻译：多发肺癌预后测定
公开(公告)号：WO2013006503A1
公开(公告)日：2013-01-10
申请号：PCT/US2012/045139
申请日：2012-06-29
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , PINPOINT GENOMICS, INC. , MANN, Michael, J. , JABLONS, David, M. , KRATZ, Johannes , BERRYMAN, David
发明人： MANN, Michael, J. , JABLONS, David, M. , KRATZ, Johannes , BERRYMAN, David
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , G01N33/57423 , G01N2800/52
摘要： The present invention provides methods for providing a prognosis for lung cancer using a panel of eleven molecular markers that includes BAG1, BRCA1, CDC6, CDK2AP1, ERBB3, FUT3, IL11, LCK, RND3, SH3BGR, and WNT3A, which are differentially expressed in lung cancer. The eleven markers are related to patient prognosis to 5 -year overall survival outcomes, and are particularly useful in providing a prognosis for non-squamous NSCLC.
摘要翻译：本发明提供使用包括在肺中差异表达的BAG1，BRCA1，CDC6，CDK2AP1，ERBB3，FUT3，IL11，LCK，RND3，SH3BGR和WNT3A的11个分子标志物组来提供肺癌预后的方法癌症。 11项标志物与患者预后相关，为5年整体生存结局，并且对于提供非鳞状NSCLC的预后特别有用。

12. 发明申请

WO2012061833A1 COMPOSITIONS AND METHODS FOR TREATING MYELOFIBROSIS 审中-公开
标题翻译：用于治疗脑血管病的组合物和方法
公开(公告)号：WO2012061833A1
公开(公告)日：2012-05-10
申请号：PCT/US2011/059643
申请日：2011-11-07
申请人： TARGEGEN, INC. , JAYAN, Arvind , CACACE, Janice , TEFFERI, Ayalew
发明人： JAYAN, Arvind , CACACE, Janice , TEFFERI, Ayalew
IPC分类号： A61K31/497 , A61K9/48 , A61P7/00
CPC分类号： A61K31/506 , A61K9/48 , A61K9/4866
摘要： Provided herein are compositions and methods for treating myelofibrosis in a subject. The methods comprise administering to the subject an effective amount of compound which is which is N- tert -butyl-3-[(5-methyl-2-{ [4-(2-pyrrolidin-1-ylethoxy)phenyl]amino}pyrimidin-4- yl)amino]benzenesulfonamide or a pharmaceutical salt thereof or a hydrate thereof.
摘要翻译：本文提供了用于治疗受试者骨髓纤维化的组合物和方法。所述方法包括向受试者施用有效量的化合物，其为N-叔丁基-3 - [（5-甲基-2 - {[4-（2-吡咯烷-1-基乙氧基）苯基]氨基}嘧啶 -4-基）氨基]苯磺酰胺或其药用盐或其水合物。

13. 发明申请

WO2011109784A1 FORMULATION OF INSULINOTROPIC PEPTIDE CONJUGATES 审中-公开
标题翻译：胰岛素诱导剂配方
公开(公告)号：WO2011109784A1
公开(公告)日：2011-09-09
申请号：PCT/US2011/027311
申请日：2011-03-04
申请人： CONJUCHEM, LLC , CARRIER, Mariéve , THIBAUDEAU, Karen , ROBITAILLE, Martin
发明人： CARRIER, Mariéve , THIBAUDEAU, Karen , ROBITAILLE, Martin
IPC分类号： A61K47/48 , A61K47/06 , A61P3/10
CPC分类号： C07K14/65 , A61K9/0019 , A61K47/643
摘要： The present invention provides pharmaceutical formulations comprising insulinotropic peptide conjugates, particularly a conjugate of albumin to exendin-4, or a derivative thereof, and methods of administration thereof. The present invention also provides methods for treating diabetes and insulinotropic peptides related diseases or conditions by administering the pharmaceutical formulations described herein.
摘要翻译：本发明提供包含促胰岛素肽缀合物，特别是白蛋白与毒蜥外泌肽-4的缀合物或其衍生物的药物制剂及其施用方法。本发明还提供了通过施用本文所述的药物制剂治疗糖尿病和促胰岛素肽相关疾病或病症的方法。

14. 发明申请

WO2011056606A1 ASSAYS FOR DETECTING ANTIBODIES SPECIFIC TO THERAPEUTIC ANTI-IGE ANTIBODIES AND THEIR USE IN ANAPHYLAXIS 审中-公开
标题翻译：用于检测特异性抗精神病抗体的抗体及其在阿片样物质中的用途
公开(公告)号：WO2011056606A1
公开(公告)日：2011-05-12
申请号：PCT/US2010/054160
申请日：2010-10-26
申请人： GENENTECH, INC. , FISCHER, Saloumeh , BAKER, Dana, L. , LOWMAN, Henry, B. , NAKAMURA, Gerald, R.
发明人： FISCHER, Saloumeh , BAKER, Dana, L. , LOWMAN, Henry, B. , NAKAMURA, Gerald, R.
IPC分类号： G01N33/53 , C07K16/42
CPC分类号： C07K16/4291 , C07K16/4208 , C07K16/4241 , C07K16/4283 , C07K2317/24 , C07K2317/565 , C07K2317/76 , G01N33/543 , G01N33/564 , G01N33/6854 , G01N33/686 , G01N2800/24
摘要： The invention provides methods and reagents useful for detecting anti-drug antibodies of IgE isotype to therapeutic anti-IgE antibodies, and methods for assessing risk of anaphylaxis to administration of a therapeutic anti-IgE antibody.
摘要翻译：本发明提供了用于检测针对治疗性抗IgE抗体的IgE同种型的抗药物抗体的方法和试剂，以及评估治疗性抗IgE抗体施用过敏反应风险的方法。

15. 发明申请

WO2010087813A1 ANTI-HERPES SIMPLEX VIRUS ANTIBODIES 审中-公开
标题翻译：抗病毒简单病毒抗体
公开(公告)号：WO2010087813A1
公开(公告)日：2010-08-05
申请号：PCT/US2009/030203
申请日：2009-01-06
申请人： DCB-USA LLC , LAI, Jiann-Shiun , LIN, Young-Sun , CHAN, Woan-Eng
发明人： LAI, Jiann-Shiun , LIN, Young-Sun , CHAN, Woan-Eng
IPC分类号： C07K14/035 , A61K39/245 , G01N33/569
CPC分类号： C07K16/087 , A61K39/395 , C07K2317/34 , C07K2317/56 , G01N33/56994 , G01N2333/035
摘要： Antibodies specifically binding to herpes simplex virus (HSV) and use thereof for treating or diagnosing HSV infection.
摘要翻译：特异性结合单纯疱疹病毒（HSV）的抗体及其用于治疗或诊断HSV感染的抗体。

16. 发明申请

WO2010078518A1 ANTI-HERPES SIMPLEX VIRUS ANTIBODIES AND METHODS OF USE THEREOF 审中-公开
标题翻译：抗病毒复制病毒抗体及其使用方法
公开(公告)号：WO2010078518A1
公开(公告)日：2010-07-08
申请号：PCT/US2009/069952
申请日：2009-12-31
申请人： DCB-USA LLC , LAI, Jiann-Shiun , CHAN, Woan-Eng
发明人： LAI, Jiann-Shiun , CHAN, Woan-Eng
IPC分类号： C07K16/08 , A61K39/42 , A61P31/22 , G01N33/563
CPC分类号： C07K16/087 , A61K39/395 , C07K2317/34 , C07K2317/56 , G01N33/56994 , G01N2333/035
摘要： The invention provides antibodies and polypeptides that specifically bind to the glycoprotein D of herpes simplex virus (HSV) and use of the antibodies and polypeptides for treating or diagnosing HSV infections.
摘要翻译：本发明提供了特异性结合单纯疱疹病毒（HSV）的糖蛋白D的抗体和多肽以及抗体和多肽用于治疗或诊断HSV感染的用途。

17. 发明申请

WO2009062125A1 METHODS AND COMPOSITIONS FOR ASSESSING RESPONSIVENESS OF B-CELL LYMPHOMA TO TREATMENT WITH ANTI-CD40 ANTIBODIES 审中-公开
标题翻译：用于评估B细胞淋巴瘤对抗CD40抗体治疗反应的方法和组合物
公开(公告)号：WO2009062125A1
公开(公告)日：2009-05-14
申请号：PCT/US2008/082920
申请日：2008-11-07
申请人： GENENTECH, INC. , DORNAN, David , BURINGTON, Bruce
发明人： DORNAN, David , BURINGTON, Bruce
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158
摘要： The invention provides methods and kits useful for predicting or assessing responsiveness of B-cell lymphoma to treatment with anti-CD40 antibodies.
摘要翻译：本发明提供了可用于预测或评估B细胞淋巴瘤对抗CD40抗体治疗的反应性的方法和试剂盒。

18. 发明申请

WO2008054592A2 METHODS FOR PRODUCTION OF RECOMBINANT PLASMINOGEN AND PLASMIN POLYPEPTIDES 审中-公开
标题翻译：生产重组质粒和质粒多肽的方法
公开(公告)号：WO2008054592A2
公开(公告)日：2008-05-08
申请号：PCT/US2007/021061
申请日：2007-09-28
申请人： PROTEOMTECH, INC. , LIN, Xinli , MEDYNSKI, Daniel
发明人： LIN, Xinli , MEDYNSKI, Daniel
IPC分类号： C07K14/435
CPC分类号： C12N9/6435 , C12Y304/21007
摘要： Methods of producing properly refolded recombinant plasminogen and plasmin polypeptide are provided. Denatured recombinant plasminogen polypeptide is refolded by first solubilizing the polypeptide with a chaotroph and reducing and oxidizing agents at high pH, followed by refolding in the presence of reduced concentration of chaotroph and reducing and oxidizing agents and in the presence of arginine.
摘要翻译：提供了产生适当重折叠的重组纤溶酶原和纤溶酶多肽的方法。变性的重组纤溶酶原多肽通过首先在高pH下用离液剂和还原剂和氧化剂溶解多肽，然后在降低浓度的离液剂和还原剂和氧化剂以及存在精氨酸的情况下重折叠而重折叠。

19. 发明申请

WO2007146172A3 ANTIBODIES RECOGNIZING A CARBOHYDRATE CONTAINING EPITOPE ON CD-43 AND CEA EXPRESSED ON CANCER CELLS AND METHODS USING SAME 审中-公开
公开(公告)号：WO2007146172A3
公开(公告)日：2007-12-21
申请号：PCT/US2007/013587
申请日：2007-06-08
申请人： ABGENOMICS CORPORATION , LIN, Rong-Hwa , LIN, Leewen , LIN, Shih-Yao , LEE, Shu-Hua
发明人： LIN, Rong-Hwa , LIN, Leewen , LIN, Shih-Yao , LEE, Shu-Hua
IPC分类号： C07K16/28 , C07K16/30 , A61K39/395
摘要： The present invention provides novel antibodies specifically bind to an epitope on CD43 and CEA expressed on nonhematopoietic cancer cells, but do not specifically bind to a CD43 expressed by a leukocyte or by a Jurkat cell, and is capable of inducing apoptosis of the nonhematopoietic cancer cell after binding to the epitope on cell surface of the nonhematopoietic cancer cell in the absence of cytotoxin conjugation and immune effector function, wherein the epitope comprises a carbohydrate structure and the binding of the antibody to the epitope is inhibited by a carbohydrate comprising a Le a structure, a Le a -lactose structure, a LNDFH II structure, or a LNT structure. In addition, the present invention also provides use of the antibodies described herein for diagnostic and therapeutic purposes.

20. 发明申请

WO2007008933A2 COMPOSITIONS AND METHODS COMPRISING COMPLEX ALTERNATIVE SPLICE VARIANTS OF MYELIN/OLIGODENDROCYTE GENES (MOGS) AND ANTIBODIES DIRECTED THERETO 审中-公开
标题翻译：包含MYELIN / OLIGODENDROCYTE基因（MOGS）及其抗体的复杂替代性裂解物变体的组合物和方法
公开(公告)号：WO2007008933A2
公开(公告)日：2007-01-18
申请号：PCT/US2006/026962
申请日：2006-07-11
申请人： CARANTECH BIOSCIENCES, INC. , GENAIN, Claude, P.
发明人： GENAIN, Claude, P.
IPC分类号： C07K16/28 , C07K14/705
CPC分类号： C07K14/70503
摘要： Provided are isolated MOG isoforms generated in vivo by exon splicing and that contribute to phenotypic diversity in the peripheral and central nervous systems. Presented herein are transcriptomic analyses for a gene expressed only in mammalian nervous system, myelin oligodendrocyte glycoprotein (MOG). Complex splicing patterns were exclusively found in primates and not in mice. Primate-specific transcripts predicted the existence of multiple MOG isoforms including truncated intra-membranous and/or alternate cytoplasmic domains, and soluble secreted proteins with AIu motifs. The multitude of MOG isoforms is predictive of functions unique to primates, including humans, with regards to maintenance of myelin structure, intracellular signaling, and/or expression of CNS autoimmunity via exposure of specific epitope determinants. Differential expression of MOG isoforms along the neuroaxis is correlative of the broad variability of phenotypes that characteristic of the CNS demyelinating disorder multiple sclerosis. MOG splice variants, isoforms, antibodies, and methods presented herein may be suitably employed for the identification, characterization, and treatment of diseases including, but not limited to, demyelinating and other neurodegenerative, infectious, inflammatory, inherited, and metabolic disorders such as multiple sclerosis (MS) and Alexander's disease.
摘要翻译：提供的是通过外显子剪接在体内产生的分离的MOG同种型，并且促成外周和中枢神经系统中的表型多样性。本文提供了仅在哺乳动物神经系统髓鞘少突胶质细胞糖蛋白（MOG）中表达的基因的转录组分析。复杂的拼接模式只在灵长类动物中发现，而不是在小鼠中发现。灵长类特异性转录物预测存在多种MOG同种型，包括截短的膜内和/或替代胞质结构域，以及具有AIu基序的可溶性分泌蛋白。众多的MOG同种型对于灵长类动物（包括人类）来说独特的功能是关于维持髓磷脂结构，细胞内信号传导和/或通过暴露特定的表位决定簇而表达的CNS自身免疫性的预测。沿着神经轴的MOG同种型的差异表达与CNS脱髓鞘疾病多发性硬化症的特征的表型广泛变异性相关。本文提供的MOG剪接变体，同种型，抗体和方法可适用于鉴定，表征和治疗疾病，包括但不限于脱髓鞘和其它神经退行性疾病，传染性疾病，炎症性疾病，遗传性疾病和代谢疾病，例如多发性硬化症（MS）和亚历山大病。

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