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11. 发明申请

WO2007103447A2 A METHOD FOR THE PREPARATION OF RECOMBINANT HUMAN THROMBIN AND FIBRINOGEN 审中-公开
标题翻译：一种重组人类血红蛋白和纤维蛋白原的制备方法
公开(公告)号：WO2007103447A2
公开(公告)日：2007-09-13
申请号：PCT/US2007/005845
申请日：2007-03-06
申请人： HUMAGENE, INC. , OSHTER, Kurt
发明人： OSHTER, Kurt
IPC分类号： A61K31/405
CPC分类号： C07K14/745
摘要： The present invention discloses a novel method for the preparation of recombinant human proteins expressed in human cells. Specifically, the present invention relates to novel methods for the preparation of human recombinant thrombin and human recombinant fibrinogen. Moreover, the method employs serum-free culturing conditions and therefore provides recombinant human proteins expressed in human cells of increased safety to the patient when used in human medical treatments. In addition, the immunogenic response to the recombinant human proteins expressed in human cells may be lower. Human recombinant thrombin is expressed in the human embryonic kidney 293 cell line and the protein can be prepared using two different routes, one starting from a point mutated prothrombin with gla and Kringle 1 and 2 domains, and maintaining these domains during the process; the other one starting with prothrombin (non-mutated), via a prethrombin with a HPC4-Kringle 2 domain and subjecting this prethrombin to a point mutation. Human recombinant fibrinogen is expressed in the human embryonic kidney 293 cell line.
摘要翻译：本发明公开了一种在人细胞中表达的重组人蛋白质的制备方法。具体地说，本发明涉及制备人重组凝血酶和人重组纤维蛋白原的新方法。此外，该方法使用无血清培养条件，因此当在人类医学治疗中使用时，向患者提供在人细胞中表达增强安全性的重组人蛋白质。此外，对在人细胞中表达的重组人蛋白的免疫原性应答可能较低。人重组凝血酶在人胚胎肾293细胞系中表达，蛋白质可以使用两种不同的途径制备，一种是从具有gla和Kringle 1和2结构域的突变型凝血酶原点开始，并在该过程中维持这些结构域; 另一个从凝血酶原（非突变）开始，通过具有HPC4-Kringle2结构域的凝血酶原并使该凝血酶原发生点突变。人重组纤维蛋白原在人胚肾293细胞系中表达。

12. 发明申请

WO2006060619A3 PRESSURE CONTROL VALVE HAVING INTRINSIC MECHANICAL FEEDBACK SYSTEM 审中-公开
公开(公告)号：WO2006060619A3
公开(公告)日：2006-06-08
申请号：PCT/US2005/043546
申请日：2005-12-02
申请人： SARCOS INVESTMENTS LC , JACOBSEN, Stephen C. , OLSEN, Shane , MORRISON, Michael
发明人： JACOBSEN, Stephen C. , OLSEN, Shane , MORRISON, Michael
IPC分类号： F15B15/02 , F15B15/08 , F15B13/04
摘要： The present invention describes, generally, a method and system for controlling the dynamics of an actuatable load functioning or operable within a servo or servo-type system, wherein the dynamics of the load are controlled by way of a unique pressure control valve configured to provide intrinsic pressure regulation. The pressure control valve, which may be referred to as a dynamic pressure regulator because of its capabilities, utilizes dual spools that are physically independent of one another and freely supported in the valve body to regulate the pressures acting within the overall system between the control or pilot pressure and the load or load pressure. The dual spools of the pressure control valve, although physically independent of one another, function in cooperation with one another in an attempt to maintain a state of equilibrium in the system, namely to keep pressure acting on or within the actuator (the load pressure), or the feedback force corresponding to the load pressure, the same as the control or pilot pressure.

13. 发明申请

WO2005070131A3 RAIL-CAR UNLOADING APPARATUS AND METHOD 审中-公开
公开(公告)号：WO2005070131A3
公开(公告)日：2005-08-04
申请号：PCT/US2005/000758
申请日：2005-01-10
申请人： ASHROSS L.L.C. , ASH, Lloyd
发明人： ASH, Lloyd
IPC分类号： B65F9/00 , A01D90/00
摘要： A rail-car unloading apparatus and method for the same configured to be positioned over fixed rails of a railroad track. The rail-car unloading apparatus includes a frame structure (110) and two parallel rails (140). The frame structure includes two outer main beams (120) extending substantially parallel with two inner main beams (130). The two outer main beams are coupled to the two inner main beams with lateral supports (112). The two inner main beams include tapered end portions at opposite ends thereof and the two inner main beams are configured to extend over and to be positioned against the fixed rails along substantially an entire length of the two inner main beams. The two parallel rails each include a rail length respectively coupled to the two inner main beams of the frame structure. The rail length of each of the two parallel rails is configured to be positioned over the fixed rails with substantially an entire portion of the rail length configured to be positioned over and against the two inner main beams.

14. 发明申请

WO2005003678A3 BLAST HOLE LINER SYSTEM AND METHOD FOR THE SAME 审中-公开
公开(公告)号：WO2005003678A3
公开(公告)日：2005-01-13
申请号：PCT/US2004/021446
申请日：2004-07-02
申请人： DYNO NOBEL, INC. , OSBORNE, Alfred, M. , HURLEY, Eldon, K.
发明人： OSBORNE, Alfred, M. , HURLEY, Eldon, K.
IPC分类号： F42D5/00 , F42B3/00 , E21B36/00
摘要： The present invention relates to a method and apparatus providing a blast hole sealing system (100) configured to substantially seal explosive material in a blast hole (10) from moisture. The blast hole sealing system includes a securing structure (110), a cap member (120), a tubular liner and an air compressor (130). The securing structure is operable to be disposed over an upper portion of the blast hole. The cap member defines a nozzle opening (124) and a liner passage (126) therein and is operable to attach to a top portion of the securing structure. The tubular liner includes an unexpanded configuration (154) having a length with an openable-expandable end (156) and a sealed tail end (158). The openable-expandable end is operable to be disposed through the liner passage in the cap member so that an end portion disposed therethrough is invertedly opened in an expanded configuration and operatively secured to the securing structure

15. 发明申请

WO2007114846A2 MULTI-ELEMENT PROBE ARRAY 审中-公开
标题翻译：多元素探索阵列
公开(公告)号：WO2007114846A2
公开(公告)日：2007-10-11
申请号：PCT/US2006/047433
申请日：2006-12-12
申请人： SARCOS INVESTMENTS LC , JACOBSEN, Stephen, C. , MARCEAU, David, P. , ZURN, Shayne
发明人： JACOBSEN, Stephen, C. , MARCEAU, David, P. , ZURN, Shayne
IPC分类号： F41A23/00 , B64D7/00
CPC分类号： H01R11/18 , A61B5/04001 , A61B5/6868 , A61B5/6877 , A61N1/0529 , A61N1/0551 , H01R2201/12 , Y10T29/49117
摘要： A multi-element probe array suitable for sensing or stimulating is disclosed. On one embodiment, the multi-element probe array (10) includes a plurality of microfibers (12) extending longitudinally and oriented substantially parallel to form a bundle. Prob elements (14) are defined by a first subset of the microfibers displaced in a forward direction along the longitudinal axis relative to spacer elements defined by a second subset of the microfibers. Interface elements (20) and communication elements (22) are disposed on the probe elements.
摘要翻译：公开了一种适用于感测或刺激的多元件探针阵列。在一个实施例中，多元件探针阵列（10）包括多个微纤维（12），所述多个微纤维纵向延伸并且基本平行取向以形成束。探针元件（14）由相对于由微纤维的第二子集限定的间隔元件沿着纵向轴向前移位的微纤维的第一子集限定。接口元件（20）和通信元件（22）设置在探针元件上。

16. 发明申请

WO2007070533A2 ELECTRICAL MICROFILAMENT TO CIRCUIT INTERFACE 审中-公开
标题翻译：电路微电路到电路接口
公开(公告)号：WO2007070533A2
公开(公告)日：2007-06-21
申请号：PCT/US2006/047432
申请日：2006-12-12
申请人： SARCOS INVESTMENTS LC , JACOBSEN, Stephen, C. , MARCEAU, David, P. , ZURN, Shayne
发明人： JACOBSEN, Stephen, C. , MARCEAU, David, P. , ZURN, Shayne
IPC分类号： H01L23/52
CPC分类号： H01L23/4952 , H01L24/43 , H01L24/45 , H01L24/46 , H01L24/48 , H01L24/49 , H01L24/85 , H01L2224/43 , H01L2224/45012 , H01L2224/45013 , H01L2224/45014 , H01L2224/45015 , H01L2224/451 , H01L2224/45188 , H01L2224/4554 , H01L2224/45578 , H01L2224/48091 , H01L2224/4824 , H01L2224/48247 , H01L2224/49113 , H01L2224/4912 , H01L2224/49171 , H01L2224/85205 , H01L2224/85801 , H01L2224/8582 , H01L2224/8585 , H01L2924/00014 , H01L2924/01005 , H01L2924/01006 , H01L2924/01013 , H01L2924/01014 , H01L2924/01027 , H01L2924/01033 , H01L2924/01082 , H01L2924/014 , H01L2924/10253 , H01L2924/10329 , H01L2924/14 , H05K3/321 , H05K3/328 , H05K3/3421 , H05K2201/10287 , H05K2201/10356 , Y02P70/613 , H01L2924/20751 , H01L2924/00 , H01L2224/05599
摘要： Devices and methods for electrical interconnection for microelectronic circuits are disclosed. One method of electrical interconnection (90) includes forming (92) a bundle of microfilaments, wherein at least two of the microfilaments include electrically conductive portions extending along their lengths. The method can also include bonding (94) the microfilaments to corresponding bond pads of a microelectronic circuit substrate to form electrical connections between the electrically conductive portions and the corresponding bond pads. One microelectronic circuit (10) can include a bundle (16) of microfilaments (18) bonded to corresponding bond pads (14) to make electrical connection between corresponding bonds pads and electrically-conductive portions of the microfilaments.
摘要翻译：公开了用于微电子电路的电互连的装置和方法。电互连（90）的一种方法包括形成（92）一束微丝，其中至少两个微丝包括沿其长度延伸的导电部分。该方法还可以包括将微丝结合（94）到微电子电路基板的相应接合焊盘，以在导电部分和相应的接合焊盘之间形成电连接。一个微电子电路（10）可以包括结合到对应的接合焊盘（14）的微丝束（16），以在对应的接合焊盘和微丝的导电部分之间进行电连接。

17. 发明申请

WO2006089157A2 METHOD AND APPARATUS FOR REDUCING FREE FLOW RISK 审中-公开
标题翻译：减少自由流动风险的方法和装置
公开(公告)号：WO2006089157A2
公开(公告)日：2006-08-24
申请号：PCT/US2006/005730
申请日：2006-02-16
申请人： SARCOS INVESTMENTS LC , JACOBSEN, Stephen , BECK, Jon , BRYDON, Christopher
发明人： JACOBSEN, Stephen , BECK, Jon , BRYDON, Christopher
IPC分类号： F04B49/00
CPC分类号： F04B49/10 , A61M5/14212 , A61M5/16813 , A61M2205/3351 , A61M2205/3355 , Y10T137/2605
摘要： A technique for reducing the risk of free flow through a pump 102 is disclosed. The technique includes sensing a pressure difference between the pump inlet 110 and outlet 112. The pressure difference is mechanically communicated to a flow restricting element 106. The flow restricting element 106 increases resistance to flow exiting the pump outlet 112 in relation to the pressure difference present between the pump inlet 110 and pump outlet 112.
摘要翻译：公开了一种降低通过泵102的自由流动风险的技术。该技术包括感测泵入口110和出口112之间的压力差。压力差机械地连通到流量限制元件106.流量限制元件106增加了抵抗泵出口112相对于存在的压力差的流动阻力在泵入口110和泵出口112之间。

18. 发明申请

WO2006020084A2 PARAMETRIC AUDIO SYSTEM FOR OPERATION IN A SATURATED AIR MEDIUM 审中-公开
标题翻译：用于在饱和空气介质中操作的参数音频系统
公开(公告)号：WO2006020084A2
公开(公告)日：2006-02-23
申请号：PCT/US2005/025237
申请日：2005-07-14
申请人： AMERICAN TECHNOLOGY CORPORATION , CROFT, James, J., III
发明人： CROFT, James, J., III
IPC分类号： H04B3/00 , H04B5/00
CPC分类号： H04B5/0006 , H04R3/00 , H04R2217/03
摘要： A parametric loudspeaker system (200) and method for reducing distortion in a decoupled audio wave by creating a double sideband parametric ultrasonic signal that substantially approximates a non-square-rooted modulation envelope and emitting a parametric ultrasonic wave (210) that corresponds to the double sideband parametric ultrasonic signal from a parametric loudspeaker (202) at a sufficient amplitude to drive the surrounding air into saturation.
摘要翻译：一种参数化扬声器系统（200）和方法，用于通过产生基本上近似于非平方根的调制包络并发射对应于双重频率的参数超声波（210）的双边带参数超声信号来减少解耦音频波中的失真来自参数化扬声器（202）的边带参数超声信号以足够的幅度驱动周围空气进入饱和。

19. 发明申请

WO2005069811A3 MOBILE SYSTEM FOR RAIL-CAR UNLOADING APPARATUS AND METHOD 审中-公开
公开(公告)号：WO2005069811A3
公开(公告)日：2005-08-04
申请号：PCT/US2005/001050
申请日：2005-01-10
申请人： ASHROSS L.L.C. , ASH, Lloyd
发明人： ASH, Lloyd
IPC分类号： B61K1/00 , B61B1/00 , B61D17/00 , B61D3/00 , B61D9/00 , B61D7/00 , B60P1/00 , B65G65/00
摘要： A rail-car unloading apparatus and method for the same configured to move over a surface. The rail-car unloading apparatus comprises a frame structure (110), having opposite first and second sides, hydraulic arms (222) and hydraulic legs (232). The hydraulic arms are coupled to the frame structure with at least two of the hydraulic arms extendable from the first side of the frame structure and at least two of the hydraulic arms extendable from the second side of the frame structure. The hydraulic legs are coupled to the hydraulic arms and configured to extend transverse from the arm portions. The hydraulic legs are operable to move the frame structure between a non-elevated position and an elevated position. With this arrangement, the hydraulic arms are configured to move the frame structure laterally toward the hydraulic legs disposed on one of the first side and second side of the frame structure while the frame structure is in the elevated position.

20. 发明申请

WO2010025409A1 A BIOMIMETIC MECHANICAL JOINT 审中-公开
标题翻译：生物力学机制
公开(公告)号：WO2010025409A1
公开(公告)日：2010-03-04
申请号：PCT/US2009/055429
申请日：2009-08-28
申请人： RAYTHEON SARCOS, LLC , JACOBSEN, Stephen, C. , OLIVIER, Marc , MACLEAN, Brian
发明人： JACOBSEN, Stephen, C. , OLIVIER, Marc , MACLEAN, Brian
IPC分类号： A61F2/68 , B25J13/00 , B25J9/16
CPC分类号： A61F2/68 , A61F5/0102 , A61F2002/5093 , A61F2002/701 , A61F2002/704 , A61F2002/745 , A61F2002/747 , A61H1/0262 , A61H1/0266 , A61H3/00 , A61H3/008 , A61H2201/1215 , A61H2201/123 , A61H2201/1238 , A61H2201/14 , A61H2201/1628 , A61H2201/164 , A61H2201/165 , A61H2201/1676 , B25J9/0006 , B25J9/104 , Y10T74/20305 , Y10T74/20323 , Y10T74/20329
摘要： A biomimetic mechanical joint for generating a variable torque between support members of a biomimetic robotic device, including a base support member, a rotary support member rotatably coupled to the base support member, and a variable-radius pulley operably coupled between the base support member and rotary support member. The variable-radius pulley comprises a sheave body having a variable radius and one or more tendon grooves formed in the circumferential outer surface. The mechanical joint further includes one or more flexible tendons and antagonistic actuator pairs, with each actuator pair being coupled to one or more tendons and configured to operate the tendon around the variable-radius pulley in either direction to create a variable torque between the base and rotary support members.
摘要翻译：一种用于在仿生机器人装置的支撑构件之间产生可变扭矩的仿生机械接头，包括基部支撑构件，可旋转地联接到所述基部支撑构件的旋转支撑构件和可操作地联接在所述基部支撑构件和旋转支撑构件。可变半径滑轮包括具有可变半径的滑轮主体和形成在周向外表面中的一个或多个腱槽。机械接头还包括一个或多个柔性腱和对抗性致动器对，其中每个致动器对联接到一个或多个腱并且构造成在任一方向上围绕可变匝角轮滑轮操作腱以在基部和旋转支撑构件。

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