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11. 发明申请

WO2009077608A1 2 -AMINOPYRIMIDINE DERIVATIVES AS HISTAMINE H4 ANTAGONISTS 审中-公开
标题翻译： 2-氨基嘧啶衍生物作为组胺H4拮抗剂
公开(公告)号：WO2009077608A1
公开(公告)日：2009-06-25
申请号：PCT/EP2008/067949
申请日：2008-12-18
申请人： PALAU PHARMA, S. A. , CARCELLER GONZÁLEZ, Elena , VIRGILI BERNADÓ, Marina , MARTÍ VIA, Josep , MEDINA FUENTES, Eva María
发明人： CARCELLER GONZÁLEZ, Elena , VIRGILI BERNADÓ, Marina , MARTÍ VIA, Josep , MEDINA FUENTES, Eva María
IPC分类号： C07D403/04 , C07D407/14 , A61K31/506 , A61P37/00 , A61P29/00
CPC分类号： C07D403/04 , C07D407/14
摘要： 2-Amino-pyrimidine derivatives of formula I, wherein the meaning of the different substituents are those indicated in the description. These compounds are useful as histamine receptor H 4 antagonists.
摘要翻译：式I的2-氨基 - 嘧啶衍生物，其中不同取代基的含义是说明书中指出的那些。这些化合物可用作组胺受体H4拮抗剂。

12. 发明申请

WO2009052860A1 METHOD AND SYSTEM FOR STORING MULTIMEDIA FILES 审中-公开
标题翻译：用于存储多媒体文件的方法和系统
公开(公告)号：WO2009052860A1
公开(公告)日：2009-04-30
申请号：PCT/EP2007/061440
申请日：2007-10-24
申请人： SOFT-R RESEARCH LLC , PINSON, Jean Marc
发明人： PINSON, Jean Marc
IPC分类号： G11B20/12 , G11B27/034 , G06F9/445 , H04N1/00 , H04N5/232
CPC分类号： G11B27/034 , G11B20/1217 , H04N1/00236 , H04N1/00241 , H04N1/00408 , H04N5/76 , H04N5/85 , H04N2201/0084
摘要： The invention relates to a method for storing multimedia files which comprises the steps of (A) detecting a connection of a first multimedia files storing device to a computing system; (B) displaying multimedia files comprised in said first storing device; (C) obtaining at least one of the multimedia files from the first storing device; and (D) storing the obtained multimedia files in a second storing device.
摘要翻译：本发明涉及一种存储多媒体文件的方法，包括以下步骤：（A）检测第一多媒体文件存储装置与计算系统的连接; （B）显示包含在所述第一存储装置中的多媒体文件; （C）从所述第一存储装置获得所述多媒体文件中的至少一个; 和（D）将所获得的多媒体文件存储在第二存储装置中。

13. 发明申请

WO2009019297A1 METHOD FOR CONTROLLED DISPOSAL OF REFUSE 审中-公开
标题翻译：用于控制排污的方法
公开(公告)号：WO2009019297A1
公开(公告)日：2009-02-12
申请号：PCT/EP2008/060370
申请日：2008-08-07
申请人： ROS ROCA, S. A. , CULLERÉ VIDAL, David
发明人： CULLERÉ VIDAL, David
IPC分类号： B65F5/00
CPC分类号： B65F5/005
摘要： Refuse is collected from n refuse chutes (RC) through waste pipes (100) leading to transport pipes (110). The transport pipes (110) comprise several branches (b) and at least one refuse chute (RC) is connected to each branch (b) through a corresponding waste pipe (100) for driving refuse to at least one collection station (200). The method consists in emptying a first refuse chute (RC 1 ); establishing the refuse chute being emptied as a reference refuse chute (RC R ); selecting a new refuse chute to be analyzed (RC x ); determining whether at least a first condition is met, said condition depending on said reference refuse chute (RC R ) and said refuse chute to be analyzed (RC x ); if said condition is met, emptying the selected refuse chute (RC x ), establishing said refuse chute (RC x ) as a new reference refuse chute, and selecting again a new refuse chute to be analyzed (RC x ); and if said condition is not met, selecting another new refuse chute to be analyzed (RC x ) and then determining again whether said first condition is met.
摘要翻译：垃圾通过废物管道（100）从垃圾槽（RC）收集，导致运输管道（110）。运输管道（110）包括多个分支（b），并且至少一个垃圾槽（RC）通过相应的废物管道（100）连接到每个分支（b），用于驱动至少一个收集站（200）的垃圾。该方法包括排空第一个垃圾槽（RC1）; 建立垃圾槽作为参考垃圾槽清空; 选择要分析的新垃圾槽（RCx）; 确定是否满足至少第一条件，所述条件取决于所述参考垃圾槽（RCR）和要分析的所述垃圾槽（RCx）; 如果满足所述条件，排空所选择的垃圾槽（RCx），将所述垃圾槽（RCx）建立为新的参考垃圾槽，并再次选择要分析的新垃圾槽（RCx）; 并且如果不满足所述条件，则选择待分析的另一个新的垃圾槽（RCx），然后再次确定是否满足所述第一条件。

14. 发明申请

WO2009007397A1 NEW POLYMERS AND THEIR USE AS FLUORESCENT LABELS 审中-公开
标题翻译：新型聚合物及其作为荧光标签使用
公开(公告)号：WO2009007397A1
公开(公告)日：2009-01-15
申请号：PCT/EP2008/058922
申请日：2008-07-09
申请人： CRYSTAX PHARMACEUTICALS, S.L. , AYMAMÍ BOFARULL, Juan , ALBERICIO PALOMERA, Fernando , AVIÑÓ ANDRÉS, Anna Maria , FARRERA SINFREU, Josep , ROYO EXPÓSITO, Míriam , NAVARRO MUÑOZ, Isabel , ERITJA CASADELLÀ, Ramón
发明人： AYMAMÍ BOFARULL, Juan , ALBERICIO PALOMERA, Fernando , AVIÑÓ ANDRÉS, Anna Maria , FARRERA SINFREU, Josep , ROYO EXPÓSITO, Míriam , NAVARRO MUÑOZ, Isabel , ERITJA CASADELLÀ, Ramón
IPC分类号： C08G73/02 , C08G79/02 , C09K11/06
CPC分类号： C08G73/0273 , C08G73/028 , C08G79/04
摘要： The present invention relates to a polymer composed by two to ten monomers of formula (I) as well as to a process for its preparation and its use as fluorophore. wherein: X is a radical of formula (II) wherein -R 5 is an electron pair or a (C 1 -C 3 )-alkyl radical; -R a and -R b are radicals independently selected from the group consisting of H, (C 1 -C 4 )-alKyI, (C 1 -C 4 )-alkoxy, (C 1 -C 4 )-alkylamιno, phenyl, F, Cl, Br, amino, hydroxy, and nitro or -R a and -R b are fused forming with the carbon atoms to which they are attached a ring of formula (III) with the condition that (I) when -R 5 is an electron pair, a is a N=C double bond, and R a and R b are fused forming the ring (III), said ring being a biradical selected from (IIIa) and (IIIb). thus, radical (II) is (IIa) or (IIb) respectively (II) when -R 5 is a (C 1 -C 3 )-alkyl radical, ais a N-C single bond and R a and R b are fused forming the ring (III), said ring being a biradical (a), thus, the radical (II) is (IIc) R 1 -R 4 and R 7 -R 18 represent radicals, same or different, selected fro the group consisting of H 1 (C 1 -C 4 )-alkyl,, (C 1 -C 4 )-alkylamiπo, phenyl, F, Cl, Br, amino, hydroxy, and nitro; p is an integer from 0 to 1; R 6 is a biradical selected from the group consisting of -CO-; -CONH(CH 2 ) m CO-; and -CO[NHCHR''CO] m -, wherein -R" are side chains radicals, same or different, corresponding to natural aminoacids; and m is an integer from 1 to 3; Z is a triradical of formula (IV) wherein r is an integer from O to 1; v is an integer from O to 1; Z' is a triradical selected from -CH 2 - and nitrogen; Z" is H, with the proviso that: (a) when Z' is nitrogen, forming an amide bound with R 6 , then is hydrogen and v is an integer from O to 1, and (b) when Z" is -NH-, forming an amide group with R 6 , then Z1 is -CH 2 - and v= O or of formula (V) wherein Z" is selected from -CH 3 and -CH 2 NH-, Z lv is selected from H and NH, Z v is selected from S and O atom, W is an integer from 0 to 1, with the proviso that (c) when R 6 is bound to Z"' then Z"' is -CH 2 NH-, Z ιv is hydrogen and w is 0; and (d) when Z ιv is -NH- forming an amide bound with R 6 , Z'" is - CH 3 and w is 1; and and wherein the monomers of formula (I) are linked through the triradical Z, forming an amide or phosphate bound.
摘要翻译：本发明涉及由2至10个式（I）单体组成的聚合物，以及其制备方法及其作为荧光团的用途。其中：X是式（II）的基团，其中-R5是电子对或（C1-C3） - 烷基; -R a和-R b是独立地选自H，（C 1 -C 4） - 烷基，（C 1 -C 4） - 烷氧基，（C 1 -C 4） - 烷基氨基，苯基，F，Cl，Br，氨基，羟基和硝基或-Ra和-Rb与其连接的式（III）的环与碳原子稠合形成，条件是当-R5是电子对时，（I），a是N = C双键，并且R a和R b熔合形成环（III），所述环为选自（IIIa）和（IIIb）的双原子。因此，当-R5是（C1-C3） - 烷基时，基团（II）分别为（IIa）或（IIb），即NC单键，Ra和Rb稠合形成环（III），所述环是双原子（a），因此，基团（II）是（IIc）R 1 -R 4和R 7 -R 18表示相同或不同的选自H1（C1-C4） - 烷基，（C 1 -C 4） - 烷基氨基，苯基，F，Cl，Br，氨基，羟基和硝基; p是从0到1的整数; R6是选自-CO-的一个双原子; -CONH（CH 2）mCO-; 和-CO [NHCHR'CO] m - ，其中-R“是对应于天然氨基酸的侧链基团，相同或不同; m是1至3的整数; Z是式（IV）的三元组，其中 r为0至1的整数; v为0至1的整数; Z'为选自-CH 2 - 和氮的三元组; Z“为H，条件是：（a）当Z'为氮时，形成与R6结合的酰胺，然后是氢，v是从0到1的整数，和（b）当Z“是-NH-时，与R6形成酰胺基，则Z1是-CH2-，v = 0或其中Z“选自-CH 3和-CH 2 NH-，Z 1v选自H和NH，Zv选自S和O原子，W是0至1的整数，条件是（c ）当R 6与Z“'结合时，Z”'是-CH 2 NH-，Z 2 v是氢，w是0; 和（d）当Z？v是-NH-形成与R6结合的酰胺时，Z'“是-CH 3，w是1;并且其中式（I）的单体通过三元Z连接，形成酰胺或磷酸盐结合。

15. 发明申请

WO2009000899A1 A NOVEL STRAIN OF BIFIDOBACTERIUM AND ACTIVE PEPTIDES AGAINST ROTAVIRUS INFECTIONS 审中-公开
标题翻译：双歧杆菌和有效磷酸酶的新型菌株对抗风疹感染
公开(公告)号：WO2009000899A1
公开(公告)日：2008-12-31
申请号：PCT/EP2008/058206
申请日：2008-06-26
申请人： LABORATORIOS ORDESA, S.L. , RIVERO URGELL, Montserrat , FÀBREGA SÁNCHEZ, Joan , MORENO MUÑOZ, José Antonio , BATALLER LEIVA, Esther , BUESA GÓMEZ, Javier , GENOVÉS MARTÍNEZ, Salvador , RAMÓN VIDAL, Daniel , VILLANUEVA ROIG, Adela , CASINOS RAMO, Beatriz
发明人： RIVERO URGELL, Montserrat , FÀBREGA SÁNCHEZ, Joan , MORENO MUÑOZ, José Antonio , BATALLER LEIVA, Esther , BUESA GÓMEZ, Javier , GENOVÉS MARTÍNEZ, Salvador , RAMÓN VIDAL, Daniel , VILLANUEVA ROIG, Adela , CASINOS RAMO, Beatriz
IPC分类号： C12N1/20 , C12P21/06 , A23L1/30 , A23L1/305 , A61K35/74 , A61K38/04 , C12R1/01
CPC分类号： C12R1/01 , A23L33/135 , A23L33/18 , A61K35/745 , A61K38/08 , A61K38/10 , C12N1/20
摘要： A strain of Bifidobacterium longum biovar infantis deposited in the Colección Española de Cultivos Tipo (CECT) under the accession number CECT 7210, or a mutant or variant thereof having an activity of inhibiting rotavirus and having the ability to produce a peptide from the fermentation of a substrate, said peptide having a length from 11 to 17 amino acids and an amino acid sequence which comprises SEQ ID NO: 1 or a derivative of said peptide. The invention relates to the use of these bacteria as probiotics.
摘要翻译：保藏在保藏号CECT 7210的ColecciónEspañolade Cultivos Tipo（CECT）中的双歧杆菌长生物婴幼儿的菌株或其具有抑制轮状病毒活性并具有从发酵中产生肽的能力的突变体或变体底物，所述肽具有11至17个氨基酸的长度和包含SEQ ID NO：1或所述肽的衍生物的氨基酸序列。本发明涉及这些细菌作为益生菌的用途。

16. 发明申请

WO2008138871A1 PROCESS FOR THE PREPARATION OF VALSARTAN 审中-公开
标题翻译：制备VALSARTAN的方法
公开(公告)号：WO2008138871A1
公开(公告)日：2008-11-20
申请号：PCT/EP2008/055719
申请日：2008-05-08
申请人： QUÍMICA SINTÉTICA, S.A. , COSME GOMEZ, Antonio , PALOMO NICOLAU, Francisco Eugenio
发明人： COSME GOMEZ, Antonio , PALOMO NICOLAU, Francisco Eugenio
IPC分类号： C07D257/04 , C07D413/10
CPC分类号： C07D257/04 , C07D413/10 , Y02P20/55
摘要： The present invention relates to a process for preparing valsartan from a compound of general formula (I), wherein R is cumyl, trityl or t-butyl. The process comprises a first step, wherein the protective group is eliminated and thereafter the oxazolidinone ring is opened by catalytic hydrogenationin the presence of an organic base. Finally, Valsartanor a pharmaceutically acceptable salt thereofis isolated.
摘要翻译：本发明涉及由通式（I）的化合物制备缬沙坦的方法，其中R是枯基，三苯甲基或叔丁基。该方法包括第一步骤，其中除去保护基，然后在有机碱的存在下通过催化加氢打开恶唑烷酮环。最后，分离其Valsartanor其药学上可接受的盐。

17. 发明申请

WO2008132115A2 PROCESS FOR PREPARING A GALACTOOLIGOSACCHARIDES POWDER 审中-公开
标题翻译：一种制备GALACTOOLIGOSACCHARIDES粉末的方法
公开(公告)号：WO2008132115A2
公开(公告)日：2008-11-06
申请号：PCT/EP2008/054934
申请日：2008-04-23
申请人： LABORATORIOS ORDESA, S.L. , SALVADÓ SOLERVICENS, Ramón , CHIFRÉ PETIT, Ricard , SANTPERE GIBERT, Josep , CUARTERO OLONA, Fernando , MARTÍN PALOMAS, Manel
发明人： SALVADÓ SOLERVICENS, Ramón , CHIFRÉ PETIT, Ricard , SANTPERE GIBERT, Josep , CUARTERO OLONA, Fernando , MARTÍN PALOMAS, Manel
IPC分类号： C07H3/06 , C08B37/00 , A23L1/29
CPC分类号： C08L3/02 , A23L5/00 , A23L7/00 , A23L7/198 , A23L29/30 , A23L33/10 , A23L33/40 , A23V2002/00 , A23V2200/3202 , A23V2250/28
摘要： The invention provides a process for the preparation of a galactooligosaccharides(GOS)product with a content of water equal or lower than 2% by weight, comprising the following steps: (i) mixing atleast water, GOS-containing syrup and a carrier, in continuous agitation; (ii) drum drying the mixture of step (i) in a drum dryer; and(iii) sieving the product resulting from step (ii). After this, the productcan be milled to obtain a GOSpowder. The invention also providesa GOS powdered product of high purity obtainable by saidprocess,food products and nutritional compositions comprising it, and its use as a prebiotic.
摘要翻译：本发明提供一种制备水含量等于或低于2重量％的低聚半乳糖（GOS）产品的方法，包括以下步骤：（i）将至少含有GOS的糖浆和载体混合在连续搅动（ii）将滚筒干燥器中的步骤（i）的混合物滚筒干燥; 和（iii）筛分由步骤（ii）得到的产品。之后，该产品可以被研磨以获得GOSpowder。本发明还提供了由所述方法获得的高纯度GOS粉末产品，包含它的食品和营养组合物，以及其作为益生元的用途。

18. 发明申请

WO2008119792A1 PYRROLOPYRIMIDINE DERIVATIVES AS JAK3 INHIBITORS 审中-公开
标题翻译：作为JAK3抑制剂的吡咯烷酮衍生物
公开(公告)号：WO2008119792A1
公开(公告)日：2008-10-09
申请号：PCT/EP2008/053842
申请日：2008-03-31
申请人： PALAU PHARMA, S. A. , SALAS SOLANA, Jorge , ALMANSA ROSALES, Carmen , SOLIVA SOLIVA, Robert , FONTES USTRELL, Montserrat , VENDRELL ESCOBAR, Marc
发明人： SALAS SOLANA, Jorge , ALMANSA ROSALES, Carmen , SOLIVA SOLIVA, Robert , FONTES USTRELL, Montserrat , VENDRELL ESCOBAR, Marc
IPC分类号： C07D487/04 , A61K31/519 , A61P37/06
CPC分类号： C07D487/04
摘要： Pyrrolopyrimidine derivatives of formula (I), wherein the meanings for the various substituents are as disclosed in the description. These compounds are useful as JAK3 kinase inhibitors.
摘要翻译：式（I）的吡咯并嘧啶衍生物，其中各种取代基的含义如说明书中所公开的。这些化合物可用作JAK3激酶抑制剂。

19. 发明申请

WO2008095903A1 NEW ADDITION SALT OF N-AMINO-N'-PENTYLGUANIDINE, THE PROCESS FOR ITS PREPARATION AND USE THEREOF FOR OBTAINING TEGASEROD 审中-公开
标题翻译： N-氨基-N-戊基胍的新添加盐，其制备方法及其用于获得泰乐菌素的方法
公开(公告)号：WO2008095903A1
公开(公告)日：2008-08-14
申请号：PCT/EP2008/051357
申请日：2008-02-04
申请人： CHEMO IBÉRICA, S.A. , MARRAS, Giovanni
发明人： MARRAS, Giovanni
IPC分类号： C07C281/16 , C07D209/14
CPC分类号： C07C281/16 , C07D473/18
摘要： The present invention refers to a new addition salt of N-amino-N - pentylguanidine, particularly to the oxalate addition salt of N-amino-N - pentylguanidine.The process for preparing saidoxalate addition salt comprises the steps of:a) reacting the N-amino-N -pentylguanidine, as a free base or in a salt form, with oxalic acid in a polar medium; andb) recovering the product in a solid form. This addition salt is useful for obtaining the tegaserod free base with a better purity and yield.
摘要翻译：本发明涉及N-氨基-N-戊基胍的新加成盐，特别是N-氨基-N-戊基胍的草酸盐加成盐。制备过氧化物加成盐的方法包括以下步骤：a）使N - 氨基-N-戊基胍，作为游离碱或盐形式，与极性介质中的草酸反应; 和b）以固体形式回收产物。该加成盐可用于获得更好的纯度和产率的替加色罗游离碱。

20. 发明申请

WO2008055875A1 COMPOUND HAVING INHIBITORY ACTIVITY ON A RHO-GTPASE CELL PROTEIN, A PROCESS FOR OBTAINING THE SAME, PHARMACEUTICAL COMPOSITIONS COMPRISION THEREOF AND A METHOD FOR THE TREATMENT OF A RHO-GTPASE CELL PROTEIN-MEDIATED CONDITION 审中-公开
标题翻译：在RHO-GTPASE细胞蛋白上具有抑制活性的化合物，其获得的方法，其药物组合物及其用于治疗RHO-GTPASE细胞蛋白质介导的条件的方法
公开(公告)号：WO2008055875A1
公开(公告)日：2008-05-15
申请号：PCT/EP2007/061887
申请日：2007-11-05
申请人： UNIVERSIDAD NACIONAL DE QUILMES , CONSEJO NACIONAL DE INVESTIGACIONES CIENTÍFICAS Y TÉCNICAS (CONICET) , ALONSO, Daniel Fernando , GÓMEZ, Daniel Eduardo , IGLESIAS, Luis Emilio , ZINNI, Maria Alejandra , IRIBARREN, Adolfo Marcelo , MENNA, Pablo Lorenzano
发明人： ALONSO, Daniel Fernando , GÓMEZ, Daniel Eduardo , IGLESIAS, Luis Emilio , ZINNI, Maria Alejandra , IRIBARREN, Adolfo Marcelo , MENNA, Pablo Lorenzano
IPC分类号： C07H19/167 , A61K31/7076 , A61K31/708 , A61P35/00 , A61P35/04 , C12P19/40
CPC分类号： C07H19/167 , C12P19/40
摘要： The present invention relates to a compound having inhibitory activity on a Rho-GTPase cell protein, the compound having the formula I (Formula I ) wherein A is selected from N and N-H, R 1 is selected from H and NHR 3 , R 2 is selected from NHR 4 , OR 4 , O and halogen, R 3 is selected from H and -COR 5 , R 4 is selected from H, a C 1 -C 6 alkyl and a substituted or unsubstituted phenyl, R 5 is selected from a C 1 -C 12 alkyl and a substituted or unsubstituted phenyl, R 6 is selected from H, -COR 5 , -CO 2 R 5 , -PR 7 R 8 and -PR 7 R 8 OPR 7 R 8 R 8 R 7, R 7 is selected from O and S, R 8 is selected from H, OR 4 and OSATE (-OCH 2 CH 2 SCOR 5 ), and wherein each represents a single bond or a double bond, provided that when one of them is a double bond the other one is a single bond, and pharmaceutically acceptable salts and derivatives thereof. In particular, the compounds of the invention may be used as antitumor agents the action of which interfere with the signaling pathways normally involved in tumor development processes. The invention also relates to processes for obtaining of compounds having inhibitory activity of a Rho- GTPase cell protein, to the pharmaceutical compositions thereof and to the therapeutic methods comprising the use of said compounds and compositions.
摘要翻译：本发明涉及对Rho-GTPase细胞蛋白具有抑制活性的化合物，其中A选自N和NH的式I（式I）化合物，R 1选自H 和NHR 3，R 2选自NHR 4，OR 4，O和卤素，R SUB > 3 选自H和-COR 5，R 4选自H，C 1 -C 3 > C 6烷基和取代或未取代的苯基，R 5选自C 1 -C 12烷基和取代的C 1 -C 12烷基，或未取代的苯基，R 6选自H，-COR 5，-CO 2 R 5， - 7＆lt; 7＆gt;＆lt; 8＆gt;和-PR 7＆lt; 7＆gt;＆lt; 8＆gt; OPR＆lt; 7＆lt; 8，R 8，R 7，R 7，R 7选自O和S，R 8，选自H，OR 4和OSATE（-OCH 2 CH 2 SCOR 5），并且其中每个代表单键或双键键，条件是当其中一个是双键时，另一个是单键，以及其药学上可接受的盐和衍生物。特别地，本发明的化合物可以用作其作用干扰通常参与肿瘤发展过程的信号通路的抗肿瘤剂。本发明还涉及获得具有Rho-GTPase细胞蛋白抑制活性的化合物的药物组合物和包括使用所述化合物和组合物的治疗方法的方法。

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