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11. 发明专利

JPH01138132A MELTABLE SUPERCONDUCTOR AND ITS PRODUCTION 失效
公开(公告)号：JPH01138132A
公开(公告)日：1989-05-31
申请号：JP19594288
申请日：1988-08-05
申请人： UNIV ARKANSAS
发明人： AREN EMU HAAMAN , ZENGUJI SUENGU
IPC分类号： C04B35/00 , C01G1/00 , C01G3/00 , C04B35/45 , C04B35/653 , H01B12/00 , H01B13/00 , H01L39/12 , H01L39/24
摘要： A meltable high temperature superconductor has a preferred composition of Tb-R-Ba-Cu-O wherein R is chosen from the group or rare earth metals excluding: Praseudyium; Cerium; and Terbium.

12. 发明专利

JP2000508475A 失效
公开(公告)号：JP2000508475A
公开(公告)日：2000-07-04
申请号：JP53621397
申请日：1997-03-18
申请人： UNIV ARKANSAS
IPC分类号： H01G4/33 , H01G4/00 , H01G4/005 , H01G4/008 , H01G4/012 , H01G4/06 , H01G4/20 , H01G4/228 , H01G4/35 , H01G4/38 , H01G7/00 , H05K3/20

13. 发明专利

JPH02239520A MANUFACTURE OF SUPERCONDUCTIVE WIRE 失效
公开(公告)号：JPH02239520A
公开(公告)日：1990-09-21
申请号：JP1278090
申请日：1990-01-24
申请人： UNIV ARKANSAS
发明人： AREN EMU HAAMAN , ZENGUJI SHIENGU , KIYUU EI SHIYAMUZU
IPC分类号： C01G3/00 , C01G1/00 , H01B12/06 , H01B13/00 , H01L39/14 , H01L39/24
摘要： PURPOSE: To provide a high temperature superconducting wire of high quality, by coating a metal wire, oxidized to be selected from a group consisting of Y; Sm; Eu; Gd; Dy; Ho; Er; Tm; Yb; and Lu;, with a barium, copper-oxide. CONSTITUTION: A superconducting wire, using a wire of Sm; Eu; Gd; Dy; Ho; Er; Tm; Yb; and Lu; oxidized, can be also manufactured by coating with a barium, copper-oxide. A superconductor is formed in an interface between a barium, copper-oxide layer and an yttrium oxide layer. Accordingly, a superconducting wire capable of including a barium, copper-oxide protecting layer is given. The barium, copper-oxide has a composition represented by a formula: Bax Cuy Oz (where, 0

14. 发明专利

JPH02107520A PRODUCTION OF T1-BA-CA-CU-O SUPERCONDUCTOR 失效
公开(公告)号：JPH02107520A
公开(公告)日：1990-04-19
申请号：JP21844089
申请日：1989-08-24
申请人： UNIV ARKANSAS
发明人： AREN EMU HAAMAN , ZENGUJI SHIENGU
IPC分类号： C01G15/00 , C01G1/00 , C04B35/45 , H01B12/00 , H01B13/00 , H01L39/24

15. 发明公开

KR20090017577A EXTENDED RELEASE PERFORATED TABLET 审中-公开
标题翻译：扩展执行片
公开(公告)号：KR20090017577A
公开(公告)日：2009-02-18
申请号：KR20087029870
申请日：2008-12-05
申请人： UNIV ARKANSAS
发明人： KIM CHERNG JU
IPC分类号： A61K9/24 , A61K9/28 , A61K9/44
摘要： A tablet (30, 40, 50, 60, 70, 80) for the controlled release of a pharmaceutically active ingredient. The tablet is in the form of coated DSTs (30, 50, 70, 80) and MLDST's (40, 60) so that immediate release or time-delayed release can be achieved. Further, such extended release DST's and MLDST's may provide zero order or first order extended release kinetics depending on the excipients and types of pharmaceutically active ingredients in the tablet formulation. The time delay coating (31, 49, 57, 68, 76, 83) is made of high molecular weight water soluble polymers so that dose dumping can be minimized even when the hydrated surface of the DST and MLDST peels off. A second coating (58, 92, 84) of low molecular weight water soluble polymer with a pharmaceutically active ingredient dispersed therein provides for pulsatile release.
摘要翻译：用于控制释放药物活性成分的片剂（30,40,50,60,70,80）。片剂为涂层DST（30,50,70,80）和MLDST（40,60）的形式，因此可以实现立即释放或延时释放。此外，这种延长释放DST和MLDST可以根据片剂制剂中的药物活性成分的赋形剂和类型提供零级或一级延长释放动力学。延时涂层（31,49,57,68,76,83）由高分子量水溶性聚合物制成，因此即使当DST和MLDST的水合表面脱落时，剂量倾倒也可以最小化。具有分散在其中的药物活性成分的低分子量水溶性聚合物的第二涂层（58,92,84）提供脉动释放。

16. 发明授权

US6140074A SH3 protein, gene, chimeric cells, vectors and expression method for producing the novel protein, and uses 失效
标题翻译： SH3蛋白，基因，嵌合细胞，载体和用于产生新蛋白的表达方法及用途
公开(公告)号：US6140074A
公开(公告)日：2000-10-31
申请号：US871732
申请日：1997-06-09
申请人： Timothy J. O'Brien , Yinxiang Wang
发明人： Timothy J. O'Brien , Yinxiang Wang
IPC分类号： C12N9/64 , C12P21/02 , C07H21/04 , C12N9/12 , C12N15/63
CPC分类号： C12N9/6424
摘要： The invention is a protein having the amino acid sequence of Seq. I.D. No. 1 or an allelic variation retaining the biological activity of the protein having the amino acid sequence of Seq. I.D. No. 1, a DNA segment coding for a protein according to claim 1, preferably DNA segment according to claim 2 having the sequence of Seq. I.D. No. 2, or a substitution analog or allelic variation of Seq. I.D. No. 2, a chimeric cell comprising the DNA segment coding for a protein of Seq. I.D. No. 1, preferably a chimeric cell comprising the DNA segment of Seq. I.D. No. 2, a vector comprising a DNA segment coding for a protein having Seq. I.D. No. 1 operably linked to a promoter. The invention provides a preferred vector comprising the following components operably linked from 5' to 3': (a) a promoter; (b) a signal sequence; (c) 5' portion of a highly expressed gene endogenous to a selected host cell, (d) a linker sequence; all preceding the nucleotide sequence coding for TADG5 protein. The invention provides a protein production method which comprises expressing a DNA segment coding for a protein with the amino acid sequence of Seq. I.D. No. 1 in a chimeric host cell, preferably one which comprises expressing the DNA segment having the sequence of Seq. I.D. No. 2 or a substitution analog. The invention also provides peptides derived from TADG5 protein and further characterized by binding to an oligonucleotide having the sequence selected from the group consisting of Seq. I.D. Nos. 3, 4, 5, 6 7, 8, 9, 10, 11, 12, 13 or a strand complementary to one of the preceding sequences.
摘要翻译：本发明是具有Seq的氨基酸序列的蛋白质。 ID。 1或保留具有Seq的氨基酸序列的蛋白质的生物活性的等位基因变异。 ID。权利要求1所述的编码蛋白质的DNA片段，优选具有Seq序列的权利要求2所述的DNA片段。 ID。第2号，或Seq的取代类似物或等位基因变异。 ID。 No.2，包含编码Seq蛋白的DNA区段的嵌合细胞。 ID。 No.1，优选包含Seq的DNA片段的嵌合细胞。 ID。 No.2，包含编码具有Seq的蛋白质的DNA区段的载体。 ID。与启动子可操作地连接。本发明提供了一种优选的载体，其包含与5'至3'可操作地连接的以下组分：（a）启动子; （b）信号序列; （c）所选宿主细胞内源的高表达基因的5'部分，（d）接头序列; 在编码TADG5蛋白的核苷酸序列之前。本发明提供一种蛋白质生产方法，其包括用Seq的氨基酸序列表达编码蛋白质的DNA区段。 ID。 1，在嵌合宿主细胞中，优选包括表达具有Seq序列的DNA区段。 ID。 2或替代类似物。本发明还提供衍生自TADG5蛋白的肽，并进一步表征为与具有选自Seq。 ID。 3,4,5,6,7,8,9,10,11,12,13或与上述序列之一互补的链。

17. 发明授权

US5981705A Natural killer lytic associated protein 失效
标题翻译：自然杀伤细胞溶解相关蛋白
公开(公告)号：US5981705A
公开(公告)日：1999-11-09
申请号：US893333
申请日：1997-07-16
申请人： Jackie Kornbluth
发明人： Jackie Kornbluth
IPC分类号： A61K38/00 , C07K14/47
CPC分类号： C07K14/47 , A61K38/00
摘要： A unique gene sequence encoding a natural killer lytic associated molecule (natural killerlytic associated protein) has been isolated. Using recombinant DNA techniques, the natural killerlytic associated protein may be produced in useful quantities. Methods for preparing the gene sequence and the gene product are disclosed, as well as methods of using the product to enhance anti-tumor, anti-viral and anti-microbial activity of natural killer cells. A method of inhibiting expression of the gene product is also disclosed, which may be used to turn off immune responses in situations of graft rejection and autoimmune disorders. Furthermore, methods of treating tumors and viruses in humans have been developed.
摘要翻译：已经分离了编码天然杀伤裂解相关分子（天然杀戮蛋白相关蛋白）的唯一基因序列。使用重组DNA技术，可以以有用的量生产天然的杀戮相关蛋白。公开了制备基因序列和基因产物的方法，以及使用该产物增强天然杀伤细胞的抗肿瘤，抗病毒和抗微生物活性的方法。还公开了抑制基因产物表达的方法，其可以用于在移植排斥和自身免疫疾病的情况下关闭免疫应答。此外，已经开发了治疗人类肿瘤和病毒的方法。

18. 发明授权

US5665588A DNA encoding natural killer lytic associated protein 失效
标题翻译：编码天然杀伤细胞裂解相关蛋白的DNA
公开(公告)号：US5665588A
公开(公告)日：1997-09-09
申请号：US398008
申请日：1995-03-02
申请人： Jackie Kornbluth
发明人： Jackie Kornbluth
IPC分类号： A61K38/00 , C07K14/47 , C12N15/00 , C12N5/00 , C07H21/04
CPC分类号： C07K14/47 , A61K38/00
摘要： A unique gene sequence encoding a natural killer lytic associated molecule (natural killerlytic associated protein) has been isolated. Using recombinant DNA techniques, the natural killerlyric associated protein may be produced in useful quantities. Methods for preparing the gene sequence and the gene product are disclosed, as well as methods of using the product to enhance anti-tumor, anti-viral and anti-microbial activity of natural killer cells. A method of inhibiting expression of the gene product is also disclosed, which may be used to turn off immune responses in situations of graft rejection and autoimmune disorders. Furthermore, methods of treating tumors and viruses in humans have been developed.
摘要翻译：已经分离了编码天然杀伤裂解相关分子（天然杀戮蛋白相关蛋白）的唯一基因序列。使用重组DNA技术，可以以有用的量生产天然杀戮蛋白相关蛋白。公开了制备基因序列和基因产物的方法，以及使用该产物增强天然杀伤细胞的抗肿瘤，抗病毒和抗微生物活性的方法。还公开了抑制基因产物表达的方法，其可以用于在移植排斥和自身免疫疾病的情况下关闭免疫应答。此外，已经开发了治疗人类肿瘤和病毒的方法。

19. 发明申请

WO2016090163A3 ANTI-ACETAMINOPHEN ANTIBODIES AND ACETAMINOPHEN PROTEIN ADDUCTS 审中-公开
标题翻译：抗 - ACETAMINOPHEN抗体和ACETAMINOPHEN蛋白加成物
公开(公告)号：WO2016090163A3
公开(公告)日：2016-08-25
申请号：PCT/US2015063786
申请日：2015-12-03
申请人： UNIV ARKANSAS , ARKANSAS CHILDREN'S HOSPITAL RES INST INC
发明人： ROBERTS DEAN W , JAMES LAURA , HINSON JACK
IPC分类号： G01N33/53
CPC分类号： C07K16/44 , C07K19/00 , G01N33/53 , G01N33/9486
摘要： The present disclosure provides isolated antibodies that bind to acetaminophen-protein adducts that are useful in the detection and diagnosis of acetaminophen-induced toxicity.
摘要翻译：本公开提供了结合对乙酰氨基酚 - 蛋白质加合物的分离的抗体，其可用于检测和诊断对乙酰氨基酚诱导的毒性。

20. 发明申请

WO2015196114A2 COMPOSITIONS AND METHODS FOR MODULATING NEURONAL DEGENERATION 审中-公开
标题翻译：用于调节神经元变性的组合物和方法
公开(公告)号：WO2015196114A2
公开(公告)日：2015-12-23
申请号：PCT/US2015036755
申请日：2015-06-19
申请人： UNIV ARKANSAS
发明人： KIAEI MAHMOUD
IPC分类号： A01K67/027 , C12N15/85
CPC分类号： C07K14/4716 , A01K67/0275 , A01K67/0278 , A01K2207/15 , A01K2217/052 , A01K2217/072 , A01K2217/206 , A01K2227/105 , A01K2267/0318 , A61K49/0008 , C12N15/8509
摘要： The present disclosure provides genetically modified animals and cells comprising a polynucleotide encoding human profilin1. Also provided are methods of assessing the effects of agents in genetically modified animals and cells comprising a polynucleotide encoding human profilin1.
摘要翻译：本公开提供了转基因动物和细胞，其包含编码人类雌激素1的多核苷酸。还提供了评价试剂在转基因动物和细胞中的作用的方法，所述细胞包含编码人类profilin1的多核苷酸。

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