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11. 发明申请

WO2006047242A2 DUFFY ANTIGEN RECEPTOR FOR CHEMOKINES AND USE THEREOF 审中-公开
标题翻译： DUFFY抗原接受者及其用途
公开(公告)号：WO2006047242A2
公开(公告)日：2006-05-04
申请号：PCT/US2005/037803
申请日：2005-10-20
申请人： THE NEW YORK BLOOD CENTER, INC. , CHAUNDHURI, Asok
发明人： CHAUNDHURI, Asok
IPC分类号： A61K38/19 , G01N33/567 , A61K39/395
CPC分类号： G01N33/6863 , A61K2039/505 , C07K16/2866 , C07K16/30 , C07K2317/73 , G01N2500/00
摘要： The invention relates to Duffy antigen receptor for chemokines and uses thereof. In on embodiment, the invention provides a method for screening for drug candidates that inhibit angiogenesis. The method comprises contacting a molecule with a Duffy antigen receptor for chemokines and determining whether the molecule binds to the Duffy antigen receptor for chemokines. In another embodiment, the invention provides a method for inhibiting tumor growth. In yet another embodiment, the invention provides a method for inhibiting angiogenesis. In a further embodiment, the invention provides a method for promoting tumor necrosis.
摘要翻译：本发明涉及趋化因子的Duffy抗原受体及其用途。在实施方案中，本发明提供了用于筛选抑制血管发生的候选药物的方法。该方法包括使分子与趋化因子的Duffy抗原受体接触并确定该分子是否与达菲抗原受体结合趋化因子。在另一个实施方案中，本发明提供了抑制肿瘤生长的方法。在另一个实施方案中，本发明提供了抑制血管生成的方法。在另一个实施方案中，本发明提供了促进肿瘤坏死的方法。

12. 发明申请

WO1996041170A1 MONOSPECIFIC ANTIBODIES AGAINST A SUBUNIT OF FIBRINOGEN 审中-公开
标题翻译：针对纤维蛋白亚纲的单一抗体
公开(公告)号：WO1996041170A1
公开(公告)日：1996-12-19
申请号：PCT/US1996009399
申请日：1996-06-07
申请人： THE NEW YORK BLOOD CENTER, INC.
发明人： THE NEW YORK BLOOD CENTER, INC. , GRIENINGER, Gerd , FU, Yiping , CAO, Yan , AHADI, Mohamad, Zaher , KUDRYK, Bohdan, J.
IPC分类号： G01N33/53
CPC分类号： C07K16/18 , G01N2333/75
摘要： The invention provides monospecific antibodies which are specifically reactive with the alpha E subunit of fibrinogen or a fragment thereof, but not with other portions of the fibrinogen molecule. The invention also provides anti- alpha E probes, including monospecific anti- alpha E antibodies which have been detectably labeled. In addition, the invention provides methods for using the monospecific antibodies for detection of the alpha E subunit and fragments thereof, as well as reagents and kits performing the methods. Diagnostic methods for determining information associated with atherogenesis and/or thrombogenesis, as well as for determining information associated with pregnancy status or outcome. The invention further provides continuous cell lines which produce monospecific anti- alpha E antibodies.
摘要翻译：本发明提供了与纤维蛋白原的αE亚单位或其片段特异性反应但与纤维蛋白原分子的其它部分不特异性反应的单特异性抗体。本发明还提供了抗αE探针，包括可检测标记的单特异性抗αE抗体。此外，本发明提供了使用单特异性抗体检测αE亚基及其片段以及进行该方法的试剂和试剂盒的方法。用于确定与动脉粥样化形成和/或血栓形成相关的信息的诊断方法，以及用于确定与怀孕状态或结果相关的信息。本发明还提供产生单特异性抗αE抗体的连续细胞系。

13. 发明申请

WO1998021224A1 THE CLONING OF DUFFY BLOOD GROUP ANTIGEN 审中-公开
标题翻译： DUFFY血液组抗原克隆
公开(公告)号：WO1998021224A1
公开(公告)日：1998-05-22
申请号：PCT/US1997021067
申请日：1997-11-14
申请人： THE NEW YORK BLOOD CENTER, INC.
发明人： THE NEW YORK BLOOD CENTER, INC. , POGO, Oscar, A. , CHAUDHURI, Asok
IPC分类号： C07H21/00
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0337 , A01K2267/0381 , C07K14/715 , C12N15/8509
摘要： The major subunit of the Duffy blood group antigenic system, gp-Fy protein, has been isolated, as have two variants, gp-Fy alpha and/or gp-Fy beta , which are produced from the Duffy FY gene by a differential splicing mechanism. gp-Fy protein contains the receptor by which P. vivax enters red cells and causes malaria. gp-Fy protein has therapeutic value in the prevention of malaria and in the regulation of erythrocyte, neural and renal functions and can be combined with physiologically acceptable diluents to yield a therapeutic agent suitable for these purposes. Peptides corresponding to a portion of gp-Fy protein that contains the receptor also have been synthesized. gp-Fy protein and derived peptides have utility in the production of therapeutics, e.g., antibodies, complementary peptides, etc., which are also useful to treat malaria and regulate essential erythrocyte, neural and renal functions. Also provided are nucleic acid primers and probes which specifically bind to or hybridize with portions of the FY gene or DNA or RNA derived therefrom for detecting the presence of gp-Fy alpha and/or gp-Fy beta nucleic acids in tissues samples. Methods for detecting Duffy protein expression, i.e., differential expression of gp-Fy alpha and/or gp-Fy beta proteins are provided.
摘要翻译：已经分离了Duffy血型抗原系统gp-Fy蛋白的主要亚单位，其具有通过差异剪接机制从Duffy FY基因产生的两种变体gp-Fyα和/或gp-Fyβ 。 gp-Fy蛋白含有间日疟原虫进入红细胞并引起疟疾的受体。 gp-Fy蛋白在预防疟疾和调节红细胞，神经和肾功能方面具有治疗价值，并且可以与生理上可接受的稀释剂组合以产生适合于这些目的的治疗剂。对应于含有受体的gp-Fy蛋白的一部分的肽也已经合成。 gp-Fy蛋白质和衍生肽可用于生产治疗剂，例如抗体，互补肽等，其也可用于治疗疟疾和调节重要的红细胞，神经和肾功能。还提供了与FY基因的部分或其衍生的DNA或RNA特异性结合或杂交的核酸引物和探针，用于检测组织样品中gp-Fyα和/或gp-Fyβ核酸的存在。提供了检测Duffy蛋白表达的方法，即gp-Fyα和/或gp-Fyβ蛋白的差异表达。

14. 发明申请

WO1996036227A1 FIBRIN(OGEN) DEGRADATION AND CLOT LYSIS BY FIBRINOLYTIC MATRIX METALLOPROTEINASE 审中-公开
标题翻译：纤维素（OGEN）降解和纤维素基质金属蛋白酶的衣物
公开(公告)号：WO1996036227A1
公开(公告)日：1996-11-21
申请号：PCT/US1996007188
申请日：1996-05-17
申请人： THE NEW YORK BLOOD CENTER, INC. , BINI, Alessandra
发明人： THE NEW YORK BLOOD CENTER, INC.
IPC分类号： A01N37/18
CPC分类号： A61K38/4886
摘要： The invention provides a method of causing the degradation of fibrin(ogen) (i.e., fibrin, fibrinogen, and related substances) by means of a fibrinolytic metalloproteinase, preferably an endogenous metalloproteinase such as MMP-3. The method of the invention can be performed in vitro to provide diagnostic information characterizing fibrin(ogen) and fibrinolytic physiology. The method can also be performed in vivo as a method of thrombolytic therapy in which a fibrinolytic metalloproteinase is administered to a subject to degrade thrombus in situ. The endogenous fibrinolytic metalloproteinase can be administered in conjunction with other active agents, preferably with agents having thrombolytic activity to improve thrombolytic and fibrinolytic therapy. The invention further provides compositions containing a fibrinolytic metalloproteinase for the performance of fibrinolytic or thrombolytic procedures. Also provided are kits which include a fibrinolytic metalloproteinase for performing fibrinolytic or thrombolytic procedures.
摘要翻译：本发明提供了通过纤维蛋白溶解性金属蛋白酶（优选内源性金属蛋白酶如MMP-3）引起纤维蛋白（原子）（即纤维蛋白，纤维蛋白原和相关物质）降解的方法。本发明的方法可以在体外进行以提供表征纤维蛋白（ogen）和纤维蛋白溶解生理学的诊断信息。该方法也可以作为血栓溶解治疗方法在体内进行，其中向受试者施用纤维蛋白溶解性金属蛋白酶以原位降解血栓。内源性纤维蛋白溶解性金属蛋白酶可以与其他活性剂联合施用，优选与具有溶栓活性的试剂一起施用以改善溶栓和纤维蛋白溶解治疗。本发明还提供含有纤维蛋白溶解性金属蛋白酶用于纤维蛋白溶解或血栓溶解过程的组合物。还提供了包括用于进行纤维蛋白溶解或血栓溶解过程的纤维蛋白溶解性金属蛋白酶的试剂盒。

15. 发明申请

WO2005122739A2 ADJUVANCY AND IMMUNE POTENTIATING PROPERTIES OF NATURAL PRODUCTS OF ONCHOCERCA VOLVULUS 审中-公开
标题翻译：黄疸病毒自然产物的免疫和免疫潜能
公开(公告)号：WO2005122739A2
公开(公告)日：2005-12-29
申请号：PCT/US2005/021004
申请日：2005-06-15
申请人： THE NEW YORK BLOOD CENTER, INC. , MACDONALD, Angus, J. , LUSTIGMAN, Sara
发明人： MACDONALD, Angus, J. , LUSTIGMAN, Sara
IPC分类号： A61K31/739 , A61K39/21 , A61K39/215 , A61K39/39 , C07K14/435
CPC分类号： C07K16/18 , A61K31/739 , A61K39/002 , A61K39/02 , A61K39/12 , A61K39/21 , A61K39/215 , A61K39/39 , A61K2039/545 , A61K2039/55516 , A61K2039/55572 , A61K2039/575 , C07K14/4354 , C12N2740/16034 , C12N2770/20034 , Y02A50/422 , Y10S530/82 , Y10S530/822
摘要： The present invention relates to a method for potentiating a specific immune response to an antigen in a mammal in need thereof. The method comprises administering to the mammal an effective amount of Ov -ASP, or at least one subunit of Ov -ASP, and an antigenic moiety.
摘要翻译：本发明涉及在有需要的哺乳动物中增强对抗原的特异性免疫应答的方法。该方法包括向哺乳动物施用有效量的Ov-ASP或至少一个Ov-ASP亚单位和抗原部分。

16. 发明申请

WO1994009123A1 RECYCLING OF ENZYMES USED TO CONVERT SUB-TYPE A, B AND AB ERYTHROCYTES 审中-公开
标题翻译：用于转化亚型A，B和AB亚型的酶的回收
公开(公告)号：WO1994009123A1
公开(公告)日：1994-04-28
申请号：PCT/US1993010066
申请日：1993-10-21
申请人： THE NEW YORK BLOOD CENTER, INC.
发明人： THE NEW YORK BLOOD CENTER, INC. , GOLDSTEIN, Jack , HURST, Rosa, S.
IPC分类号： C12N09/40
CPC分类号： C12N9/2465 , A61K35/18
摘要： This invention is directed to a method of recycling enzymes, including the enzyme alpha -galactosidase, used to remove antigens from the surface of cells in blood products. The enzymes are recycled from enzyme-treated blood products. This invention is also directed to recycled enzymes.
摘要翻译：本发明涉及一种再循环酶的方法，包括用于从血液制品中的细胞表面除去抗原的α-半乳糖苷酶。酶从酶处理的血液制品中回收。本发明还涉及再循环的酶。

17. 发明授权

EP1768696B1 ADJUVANCY AND IMMUNE POTENTIATING PROPERTIES OF NATURAL PRODUCTS OF ONCHOCERCA VOLVULUS 有权
标题翻译：天然产物盘尾丝虫的ADJUVANZ-和免疫增强性质
公开(公告)号：EP1768696B1
公开(公告)日：2015-08-12
申请号：EP05790464.1
申请日：2005-06-15
申请人： THE NEW YORK BLOOD CENTER, INC.
发明人： MACDONALD, Angus, J. , LUSTIGMAN, Sara
IPC分类号： A61K39/00 , A61K39/385 , A61K39/002 , A61K39/12 , A61K38/00
CPC分类号： C07K16/18 , A61K31/739 , A61K39/002 , A61K39/02 , A61K39/12 , A61K39/21 , A61K39/215 , A61K39/39 , A61K2039/545 , A61K2039/55516 , A61K2039/55572 , A61K2039/575 , C07K14/4354 , C12N2740/16034 , C12N2770/20034 , Y02A50/422 , Y10S530/82 , Y10S530/822
摘要： The present invention relates to a method for potentiating a specific immune response to an antigen in a mammal in need thereof. The method comprises administering to the mammal an effective amount of Ov-ASP, or at least one subunit of Ov-ASP, and an antigenic moiety.

18. 发明公开

EP1954717A2 PEPTIDE INHIBITORS OF ABL KINASES 审中-公开
标题翻译：肽抑制剂ABL激酶
公开(公告)号：EP1954717A2
公开(公告)日：2008-08-13
申请号：EP06844600.4
申请日：2006-11-29
申请人： THE NEW YORK BLOOD CENTER, INC.
发明人： KOTULA, Leszek , XIONG, Xiaoling
IPC分类号： C07K16/00
CPC分类号： C07K14/475 , A61K38/00 , C07K14/4702 , C12Q1/485
摘要： Provided are purified compounds comprising SEQ ID NO:1, where the tyrosine at residue (10) is phosphorylated. Also provided are purified compounds comprising SEQ ID NO:1, where the amino acid sequence of the compound is less than 400 amino acids. Additionally provided are methods of determining whether an agent is a candidate inhibitor of an Abl kinase. Further provided are methods of inhibiting an Abl kinase. Also provided are methods of treating a patient having a condition characterized by a mutant AbI kinase. Additionally provided are methods of treating a patient at risk for a condition characterized by a mutant AbI kinase. Methods of labeling an AbI kinase are also provided. Additionally, methods of isolating an Abl kinase from a tissue are provided.

19. 发明公开

EP1846579A2 METHOD FOR EXTRACTION AND IDENTIFICATION OF NUCLEIC ACIDS 审中-公开
标题翻译：提取方法和核酸鉴定
公开(公告)号：EP1846579A2
公开(公告)日：2007-10-24
申请号：EP06748166.3
申请日：2006-01-20
申请人： THE NEW YORK BLOOD CENTER, INC.
发明人： PFAHLER, Wolfman H.E. , PRINCE, Alfred M. , LEE, Don-hun , ANDRUS, Linda
IPC分类号： C12Q1/68
CPC分类号： C07H21/02 , C07H21/04 , C12N15/1017 , C12Q1/6806 , Y02A50/58
摘要： The invention provides a method for extracting nucleic acids from a sample. The sample contains cells, viruses, or both cells and viruses. The method include adding a lysing solution containing a detergent to the sample to lyse the cells or viruses to form a lysate, adding alcohol to the lysate to aggregate or precipitate the nucleic acids, and purifying the nucleic acids from the lysate-alcohol mixture by filtering the mixture through a glass-fiber filter.

20. 发明公开

EP1793679A2 STARCH-POMEGRANATE JUICE COOMPLEX AS AN HIV ENTRY INHIBITOR AND TOPICAL MICROBICIDE 审中-公开
标题翻译：强度石榴汁复合HIV和局部杀菌剂抑制剂入侵
公开(公告)号：EP1793679A2
公开(公告)日：2007-06-13
申请号：EP05812513.9
申请日：2005-09-15
申请人： THE NEW YORK BLOOD CENTER, INC.
发明人： NEURATH, Alexander Robert , STRICK, Nathan , LI, Yun-Yao
IPC分类号： A01N65/00
CPC分类号： A61K36/185 , A61K9/0031 , A61K9/0034
摘要： A complex comprising a starch and an active antiHIV-1 or anti-HIV-2 ingredient of pomegranate juice that is adsorbed on the starch when the starch is in a water insoluble form. The complex inhibits HIV-1 or HIV-2 infection and blocks the binding of HIV-1 or HIV-2 to the CD4 receptor and the CCR5 and CXCR4 coreceptors. The complex is used in a method of preventing HIV-1 or HIV-2 infection comprising administering to a mucous membrane of a human a pharmaceutically effective anti-HIV-1 or anti-HIV-2 amount of the complex.

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