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11. 发明申请

WO0214858A3 METHOD FOR PRODUCING AND IDENTIFYING APPROPRIATE EFFECTORS OF TARGET MOLECULES USING SUBSTANCE LIBRARIES 审中-公开
标题翻译：方法用于生产和使用此物质图书馆靶分子合适的效应物测定
公开(公告)号：WO0214858A3
公开(公告)日：2003-10-30
申请号：PCT/EP0109103
申请日：2001-08-07
申请人： NANOGEN RECOGNOMICS GMBH , KIENLE STEFAN , WINDHAB NORBERT , BRUECHER CHRISTOPH , KUHN KARSTEN
发明人： KIENLE STEFAN , WINDHAB NORBERT , BRUECHER CHRISTOPH , KUHN KARSTEN
IPC分类号： G01N27/62 , C12N15/09 , C12Q1/68 , C40B30/04 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/68 , G06F17/30 , C07K1/04 , C07B61/00
CPC分类号： C40B30/04 , G01N33/6845
摘要： The invention relates to a method for the phenomenological description of target substances using described substance libraries. The invention also relates to a method for selecting the components of a combinatorial substance library for the purpose of active ingredient screening and to the described and combinatorially produced substance libraries as such.
摘要翻译：本发明涉及一种方法，用于使用未表征物质库和用于药物筛选以及其特征和组合地产生的库本身一个组合化合物文库的部件的选择的方法的目标物质的现象学的描述。

12. 发明申请

WO2003008638A3 SORTING AND IMMOBILIZATION SYSTEM FOR NUCLEIC ACIDS USING SYNTHETIC BIDNING SYSTEMS 审中-公开
公开(公告)号：WO2003008638A3
公开(公告)日：2003-01-30
申请号：PCT/EP2002/001532
申请日：2002-02-14
申请人： NANOGEN RECOGNOMICS GMBH , SCHWEITZER, Markus , ANDERSON, Richard , FIECHTNER, Michael , MÜLLER-IBELER, Jochen , RADDATZ, Stefan , BRÜCHER, Christoph , WINDHAB, Norbert , ORWICK, Jill , SCHNEIDER, Eberhard , PIGNOT, Marc , KIENLE, Stefan
发明人： SCHWEITZER, Markus , ANDERSON, Richard , FIECHTNER, Michael , MÜLLER-IBELER, Jochen , RADDATZ, Stefan , BRÜCHER, Christoph , WINDHAB, Norbert , ORWICK, Jill , SCHNEIDER, Eberhard , PIGNOT, Marc , KIENLE, Stefan
IPC分类号： C12Q1/68
摘要： The present invention relates to conjugates of synthetic binding units and nucleic acids. The present invention also relates to methods for sorting and immobilizing nucleic acids on support materials using such conjugates by specific molecular addressing of the nucleic acids mediated by the snythetic binding systems. Particularly, the present invention also relates to novel methods of utilizing conjugates of synthetic binding units and nucleic acids to in active electronic array systems to produce novel array constructs from the conjugates, and the use of such constructs in various nucleic acid assay formats. In addition, the present invention relates to various novel forms of such conjugates, improved methods of making solid phase synthesized conjugates, and improved methods of conjugating pre-synthesized synthetic binding units and nucleic acids. The present invention also relates to the use of conjugates of synthetic binding units and nucleic acids as substrates for various enzymatic reactions, including nucleic acid amplification reactions.

13. 发明申请

WO2002064825A3 MICROELECTRONIC ARRAY DEVICES TO PERFORM MULTIPLEX IMMUNOASSAY ANALYSIS 审中-公开
公开(公告)号：WO2002064825A3
公开(公告)日：2002-08-22
申请号：PCT/EP2002/001521
申请日：2002-02-14
申请人： NANOGEN RECOGNOMICS GMBH , WINDHAB, Norbert , HELLER, Michael , ANDERSON, Richard , FIETCHNER, Michael , HOPPE, Hans-Ulrich , NOVA, Tina , SUNDQUIST, Alfred , ORWICK, Jill , MÜLLER-IBELER, Jochen , ACKLEY, Donald , SCHWEITZER, Markus , BRÜCHER, Christoph , RADDATZ, Stefan , HAMON, Christian
发明人： WINDHAB, Norbert , HELLER, Michael , ANDERSON, Richard , FIETCHNER, Michael , HOPPE, Hans-Ulrich , NOVA, Tina , SUNDQUIST, Alfred , ORWICK, Jill , MÜLLER-IBELER, Jochen , ACKLEY, Donald , SCHWEITZER, Markus , BRÜCHER, Christoph , RADDATZ, Stefan , HAMON, Christian
IPC分类号： C12Q1/68
摘要： This invention relates to devices and methods for carrying out multi-step and multiplex immunoaffinity binding reactions in microscopic formats. In particular, these devices and methods allow the user to rapidly carry out multiple immunoassays in the same sample volume, and to rapidly resolve the results of those immunoassays in an electronically assisted format. The assays may be further multiplexed in that several samples may be analyzed and visualized on the same microelectronic array. In addition, the methods and procedures of the invention allow the use of electronic stringency to further improve the specificity and accuracy of the immunoassays on the microelectronic array devices.

14. 发明申请

WO2003016561A3 VERFAHREN ZUR HERSTELLUNG VON CNA 审中-公开
公开(公告)号：WO2003016561A3
公开(公告)日：2003-02-27
申请号：PCT/EP2002/009044
申请日：2002-08-13
申请人： NANOGEN RECOGNOMICS GMBH , REUSCHLING, Dieter , MÜLLER-IBELER, Jochen , WAGNER, Thomas , KRUMM, Thomas , WERMUTH, Jochen , PIGNOT, Marc
发明人： REUSCHLING, Dieter , MÜLLER-IBELER, Jochen , WAGNER, Thomas , KRUMM, Thomas , WERMUTH, Jochen , PIGNOT, Marc
IPC分类号： C07D239/54
摘要： Die Erfindung betrifft ein neues Verfahren zur Herstellung von CNA-Oligomeren sowie künstliche supramolekulare CNA-p-RNA-Paarungssysteme und deren Verwendung, insbesondere in biotechnologischen Assays.

15. 发明申请

WO0212553A3 METHOD FOR DETECTING MUTATIONS IN NUCLEOTIDE SEQUENCES 审中-公开
标题翻译：法突变的核苷酸序列检测
公开(公告)号：WO0212553A3
公开(公告)日：2003-01-30
申请号：PCT/EP0108127
申请日：2001-07-13
申请人： NANOGEN RECOGNOMICS GMBH , KAPPEL ANDREAS , POLAKOWSKI THOMAS , PIGNOT MARC , WINDHAB NORBERT , BEHRENSDORF HEIKE , MUTH JOCHEN
发明人： KAPPEL ANDREAS , POLAKOWSKI THOMAS , PIGNOT MARC , WINDHAB NORBERT , BEHRENSDORF HEIKE , MUTH JOCHEN
IPC分类号： G01N33/53 , B01J19/00 , C07H21/00 , C07K14/195 , C07K14/245 , C12N9/00 , C12N15/09 , C12N15/52 , C12Q20060101 , C12Q1/25 , C12Q1/34 , C12Q1/68 , G01N33/566
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The invention relates to a method for simultaneously detecting mutations in different nucleotide sequences and for determining the transcription rate of mutated and non-mutated nucleotide sequences. The inventive method comprises the following steps: hybridizing single-stranded sample nucleotide sequences to single-stranded reference nucleotide sequences, fixating, before or during hybridization, single-stranded reference nucleotide sequences or single-stranded sample nucleotide sequences, or fixating, after or during hybridization, heteroduplices from reference and sample nucleotide sequences on an electronically addressable surface, incubating them with a substrate that recognizes heteroduplex mismatches, and detecting the substrate bonds.
摘要翻译：本发明涉及一种方法，突变可以在与各种核苷酸序列并行地检测到，毗邻允许突变和未突变的核苷酸序列的转录速率的测定方法。该方法包括用固定的单参考核苷酸序列或单样本的核苷酸序列的单链参考核苷酸序列的单样品核苷酸序列的杂交的步骤之前或之后或在杂交到一个过程中的杂交或异源双链从参考和样品的核苷酸序列中电子可寻址表面，孵育异源双链体不匹配识别衬底键的底物和检测。

16. 发明申请

WO2002072595A2 VERBESSERTES VERFAHREN ZUR HERSTELLUNG VON PENTOPYRANOSYL-NUCLEOSIDEN 审中-公开
标题翻译：改进的方法PRODUCING pentopyranosylnucleosides
公开(公告)号：WO2002072595A2
公开(公告)日：2002-09-19
申请号：PCT/EP2002/002536
申请日：2002-03-07
申请人： NANOGEN RECOGNOMICS GMBH , KRETZSCHMAR, Gerhard
发明人： KRETZSCHMAR, Gerhard
IPC分类号： C07H19/06
CPC分类号： C07H19/06 , C07H19/16 , Y02P20/55
摘要： Die vorliegende Erfindung betrifft ein verbessertes Verfahren zur Herstellung von Pentopyranosyl-Nucleosiden, bei dem eine signifikante Verbesserung und Vereinfachung des in der DE-A-19741715 beschriebenen Verfahrensschrittes erreicht werden kann. Mit dem erfindungsgemäßen Verfahren wird eine Wanderung der 2'-Acyl-Schutzgruppe von der 2'-Position zur 3'-Position des Pentopyranosids bewirkt, wobei ein Katalysator der Formel (IVa) bzw. (IVb) zum Einsatz kommt. Darin bedeuten A-CH 2 - oder -NR 20 -,R 20 Wasserstoff, Alkyl, Cycloalkyl, Aryl oder Aralkyl, die gegebenenfalls substituiert sind, D eine Gruppe der Formel -C m H 2m -, und m eine ganze Zahl von 1 bis 6, R 18 , R 19 und R 24 unabhängig voneinander, gleich oder verschieden, Wasserstoff, Alkyl, Cycloalkyl, Aryl oder Aralkyl, die gegebenenfalls substituiert sind, oder R 18 und R 19 stellen zusammen eine Gruppe -C o H 2o - dar, wobei o eine ganze Zahl von 2 bis 4 ist, und R 21 bedeutet eine Gruppe -NR 22 R 23 , worin R 22 und R 23 unabhängig voneinander, gleich oder verschieden, Wasserstoff, Alkyl, Cycloalkyl, Aryl oder Aralkyl bedeuten, die gegebenenfalls substituiert sind.
摘要翻译：本发明涉及一种用于制备在其中所描述的方法步骤的改进显著和简化DE-A-19741715，可以实现pentopyranosylnucleosides的改进方法。利用本发明的方法中，所述2'-酰基保护基的迁移是由2'-位置到pentopyranoside的3'-位置，实现其中在式（IVa）或（IVb）中使用的催化剂。在该式中A-CH 2 - 或-NR <20> - ，R <20>为氢，烷基，环烷基，芳基或芳烷基，其任选地被取代的，D是下式基团的-CmH2m-和m是从1到的整数 6，R <18>，R <19>和R <24>彼此独立地，相同或不同的，是氢，烷基，环烷基，芳基或芳烷基，其任选被取代，或者R <18>和R <19>一起代表代表一组-CoH2o-，其中o为2至4的整数，并且R <21>表示基团-NR <22> - [R <23>，其中R <22>和R <23>彼此独立地，等于或不同，是氢，烷基，环烷基，芳基或芳烷基，其任选被取代。

17. 发明授权

US07700761B2 3-deoxypentopyranosyl nucleic acid, its production and its use 失效
标题翻译： 3-脱氧吡喃糖基核酸，其生产及其应用
公开(公告)号：US07700761B2
公开(公告)日：2010-04-20
申请号：US11445037
申请日：2006-05-31
申请人： Christian Miculka , Thomas Wagner , Norbert Windhab
发明人： Christian Miculka , Thomas Wagner , Norbert Windhab
IPC分类号： C07H21/00 , C07H19/04
CPC分类号： C07H21/02 , C07H19/04 , C07H21/00 , F16H15/42 , Y02P20/55
摘要： Provided are processes for preparing a 3′-deoxypentopyranosyl oligomers with linkers for linking biomolecules. The processes can the steps of: bonding a 4′-protected-3′-deoxypentopyranosyl nucleoside to a solid support by coupling the 2′-OH group with a CPG support or other similar support with an amide linkage; deprotecting the 4′-protected-3′-deoxypentopyranosyl nucleoside at the 4′ position; deprotecting the 4′-protected-3′-deoxypentopyranosyl nucleoside at the 4′ position; and conjugating a linker to the free 4′ position. The resulting product can be conjugated via the linker to a biomolecule. The method can include, prior to addition of the linker, reacting the 4′-OH group of the 4′-protected-3′-deoxypentopyranosyl nucleoside that is linked to the solid support with a 4′-protected-3′-deoxypentopyranosyl nucleoside phosphoramidite in the presence of a coupling reagent, and oxidizing the reaction product. This step can be repeated one or more times to produce an oligomer of desired length.
摘要翻译：提供制备具有用于连接生物分子的接头的3'-脱氧吡喃糖基寡聚物的方法。该方法可以通过以下步骤：通过将2'-OH基团与CPG载体或其它类似载体与酰胺键偶联，将4'-保护的-3'-脱氧吡喃糖基核苷键合到固体支持物上; 在4'位保护4'-保护的3'-脱氧吡喃糖基核苷; 在4'位保护4'-保护的3'-脱氧吡喃糖基核苷; 并将接头缀合到游离的4'位置。所得产物可通过接头与生物分子结合。该方法可以包括在加入连接体之前，将与固体支持物连接的4'-保护的3'-脱氧吡喃糖基核苷的4'-OH基团与4'-保护的-3'-脱氧吡喃糖基核苷亚磷酰胺在偶联剂存在下反应，氧化反应产物。该步骤可以重复一次或多次以制备所需长度的低聚物。

18. 发明授权

US06893822B2 Enzymatic modification of a nucleic acid-synthetic binding unit conjugate 失效
标题翻译：核酸 - 合成结合单位缀合物的酶修饰
公开(公告)号：US06893822B2
公开(公告)日：2005-05-17
申请号：US09910469
申请日：2001-07-19
申请人： Markus Schweitzer , Richard R. Anderson , Michael D. Fiechtner , Jochen Müller , Stefan Raddatz , Christoph Brücher , Norbert Windhab , Jill M. Orwick , Eberhard Schneider , Marc Pignot , Stefan Kienle
发明人： Markus Schweitzer , Richard R. Anderson , Michael D. Fiechtner , Jochen Müller , Stefan Raddatz , Christoph Brücher , Norbert Windhab , Jill M. Orwick , Eberhard Schneider , Marc Pignot , Stefan Kienle
IPC分类号： G01N33/53 , B01J19/00 , B05D3/00 , C07H21/00 , C07H21/04 , C12M1/00 , C12M1/34 , C12N15/09 , C12P19/34 , C12Q1/68 , G01N33/543 , G01N33/566 , G01N37/00
CPC分类号： C07H21/00 , B01J19/0046 , B01J2219/00608 , B01J2219/00617 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00653 , B01J2219/00659 , B01J2219/00722 , C12Q1/6837 , G01N33/54353 , C12Q2565/518 , C12Q2525/117 , C12Q2525/113
摘要： The present invention relates to conjugates of synthetic binding units and nucleic acids. The present invention also relates to methods for sorting and immobilizing nucleic acids on support materials using such conjugates by specific molecular addressing of the nucleic acids mediated by the synthetic binding systems. Particularly, the present invention also relates to novel methods of utilizing conjugates of synthetic binding units and nucleic acids to in active electronic array systems to produce novel array constructs from the conjugates, and the use of such constructs in various nucleic acid assay formats. In addition, the present invention relates to various novel forms of such conjugates, improved methods of making solid phase synthesized conjugates, and improved methods of conjugating pre-synthesized synthetic binding units and nucleic acids. The present invention also relates to the use of conjugates of synthetic binding units and nucleic acids as substrates for various enzymatic reactions, including nucleic acid amplification reactions.
摘要翻译：本发明涉及合成结合单元和核酸的缀合物。本发明还涉及使用这种共轭物通过由合成结合系统介导的核酸的特异性分子寻址来分选和固定核酸的载体材料的方法。特别地，本发明还涉及利用合成结合单元和核酸的缀合物在活性电子阵列体系中从缀合物产生新型阵列构建体的新方法，以及以各种核酸测定形式使用这种构建体。此外，本发明涉及这种缀合物的各种新型形式，制备固相合成的缀合物的改进方法，以及与预合成的合成结合单元和核酸缀合的改进方法。本发明还涉及合成结合单元和核酸的缀合物作为各种酶反应的底物的用途，包括核酸扩增反应。

19. 发明授权

US07186813B1 Biomolecules having multiple attachment moieties for binding to a substrate surface 有权
标题翻译：具有多个附着部分的生物分子用于结合底物表面
公开(公告)号：US07186813B1
公开(公告)日：2007-03-06
申请号：US10181207
申请日：2000-08-11
申请人： Markus Schweitzer , Norbert Windhab , John R. Havens , Thomas J. Onofrey , Charles Greef , Daguang Wang
发明人： Markus Schweitzer , Norbert Windhab , John R. Havens , Thomas J. Onofrey , Charles Greef , Daguang Wang
IPC分类号： C07H21/00 , C07H21/02 , C07H21/04 , C12Q1/68
CPC分类号： C07H21/00 , A61K47/61 , C07B2200/11 , C07F9/2408 , C07F9/2429 , C07F9/65616 , C40B40/00 , G01N33/54353
摘要： Biomolecules are provided having multiple binding sites for attachment to a substrate surface. The multiple attachment sites may be produced directly on the biomolecule or through use of branched phosphoramidite moieties that can be added in multiple to form dendritic structures which can in turn provide attachment sites for substrate binding moieties. Substrate binding moieties may include noncovalent binding moieties. For covalent binding moieties oligonucleotides containing hydrazides are provided. These hydrazides can be introduced via protected building blocks such as phosphoramidites or via building blocks containing precursor forms of such hydrazides.
摘要翻译：提供了生物分子，其具有用于附着到基底表面的多个结合位点。多个附着位点可以直接在生物分子上生产，或通过使用可以多次加入以形成树突状结构的支链亚磷酰胺部分，这又可以提供底物结合部分的附着位点。底物结合部分可以包括非共价结合部分。对于共价结合部分，提供了含有酰肼的寡核苷酸。这些酰肼可以通过保护的结构单元如亚磷酰胺或通过含有这种酰肼前体形式的构建块引入。

20. 发明申请

US20050004356A1 Linker nucleoside, its preparation and use 审中-公开
标题翻译：连接核苷，其制备和应用
公开(公告)号：US20050004356A1
公开(公告)日：2005-01-06
申请号：US10792289
申请日：2004-03-02
申请人： Christian Miculka , Norbert Windhab , Tilmann Brandstetter , Stefan Scherer
发明人： Christian Miculka , Norbert Windhab , Tilmann Brandstetter , Stefan Scherer
IPC分类号： A61K31/7042 , A61K31/7052 , A61K31/7064 , A61K31/7076 , A61K31/712 , A61K47/48 , C07F9/6558 , C07H19/04 , C07H19/06 , C07H19/16 , C07H21/00 , G01N33/532 , H01L51/30 , C07H19/048 , C07H19/22
CPC分类号： G01N33/532 , A61K47/54 , A61K47/549 , B82Y10/00 , C07H19/04 , C07H21/00 , H01L51/0093 , Y02P20/55
摘要： The present invention relates to a linker nucleoside, its preparation and use for the covalent bonding of biomolecules to oligonucleotides, in particular p-RNA oligonucleotides.
摘要翻译：本发明涉及连接体核苷，其制备和用于将生物分子共价键合到寡核苷酸，特别是p-RNA寡核苷酸的用途。

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