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11. 发明申请

US20210280088A1 NON-LETHAL WEAPONS MODULAR HUMAN SURROGATE TESTING DEVICE AND METHOD 有权
公开(公告)号：US20210280088A1
公开(公告)日：2021-09-09
申请号：US16696997
申请日：2019-11-26
申请人： CFD Research Corporation
发明人： David Keith Sedberry , Vincent J. Harrand , Phillip E. Whitley , Andrzej Przekwas
IPC分类号： G09B23/34 , G01N33/00
摘要： A modular surrogate can include: a body having an external body surface with an anatomical shape, wherein the body includes an internal chamber with at least one port formed in the body extending inwardly; at least one anatomical module having an external module portion and a module stem coupled thereto, the module stem being received into a corresponding module port of the at least one port, the external module portion having an external module surface with an anatomical shape, the external body surface matches with the external module surface to provide a continuous anatomical shape; at least one sensor located in the at least one anatomical module; and at least one controller, wherein when the at least one anatomical module is coupled with the body, the at least one sensor is capable of being operably coupled with the at least one controller.

12. 发明申请

US20210269868A1 PCR INCORPORATION OF EXOGENOUS NUCLEIC ACID SEQUENCES ENABLING MELT-BASED DETECTION 有权
公开(公告)号：US20210269868A1
公开(公告)日：2021-09-02
申请号：US17187267
申请日：2021-02-26
申请人： CFD Research Corporation
发明人： David Edwin Gaddes, III , Ketan Harendrakumar Bhatt , Balabhaskar Prabhakarpandian
IPC分类号： C12Q1/6853 , C12Q1/6832 , C12Q1/6816
摘要： A primer composition for amplifying a target nucleic acid of a plurality of target organisms can include: a first primer having in order: 3′-a first target specific sequence; a melt key region; and a first super primer region, wherein the first target specific sequence includes a nucleic acid sequence that specifically hybridizes with a first unique nucleic acid sequence of a first target organism over nucleic acid sequences of other organisms, the melt key region includes a nucleic acid sequence that has less than full identity with a melt key probe and a complement of the melt key region hybridizes with the melt key probe with at least one nucleotide mismatch with the melt key probe, and the first super primer region includes a nucleic acid sequence that is common to the plurality of target organisms.

13. 发明申请

US20210187332A1 DEVICE AND METHOD FOR BREACHING OUTWARD OPENING AND REINFORCED DOORS 有权
公开(公告)号：US20210187332A1
公开(公告)日：2021-06-24
申请号：US17119621
申请日：2020-12-11
申请人： CFD Research Corporation
发明人： Zachary William Wright , William Christopher Krolick , Wyatt Gilbert Ramos
IPC分类号： A62B3/00
摘要： A door breach device can include: an elongate shaft having a first end and an opposite second end; a pivot mechanism at the first end of the shaft; a spearhead rotatably coupled with the pivot mechanism and having a tip on a tip-side of the pivot mechanism and having a shaft cavity on a shaft-side, where the shaft cavity is adapted to receive the shaft therein; a restraint slidably received on the shaft-side of the spearhead and on the shaft; a handle protruding from the shaft; and a hitch at the second end of the shaft. A method of breaching a door can include: forcing the spearhead through a door until the restraint releases the spearhead and the spearhead rotates by the pivot mechanism so as to form an angle with the shaft; and pulling the spearhead against the door until the door is breached.

14. 发明申请

US20210116338A1 FLUIDIC BEAD TRAP AND METHODS OF USE 有权
公开(公告)号：US20210116338A1
公开(公告)日：2021-04-22
申请号：US17074007
申请日：2020-10-19
申请人： CFD RESEARCH CORPORATION
发明人： David Edwin Gaddes, III , Balabhaskar Prabhakarpandian , Ketan Harendrakumar Bhatt
IPC分类号： G01N1/40 , B01L3/00
摘要： A fluidic device can include: a plurality of fluid conduits, each fluid conduit including a first conduit portion separated from a second conduit portion; and at least one transport body that is movably positioned between the first conduit portion and the second conduit portion of each fluid conduit. The at least one transport body can include: at least one port adapted to be aligned with a first conduit portion and a second conduit portion of at least one first conduit so as to fluidly couple the first conduit portion with the second conduit portion; and at least one blocking body portion adapted to be aligned with a first conduit portion and a second conduit portion of at least one second conduit so as to fluidly isolate the first conduit portion from the second conduit portion of the at least one second conduit.

15. 发明申请

US20200083543A1 FLUORINE-BASED CATHODE MATERIALS FOR THERMAL BATTERIES 审中-公开
公开(公告)号：US20200083543A1
公开(公告)日：2020-03-12
申请号：US16503261
申请日：2019-07-03
申请人： CFD Research Corporation
发明人： Pyoungho CHOI , Sameer Singhal , Joe Don Edington
IPC分类号： H01M6/36 , H01M4/06
摘要： A thermal battery can include: an anode of lithium alloy; a metal-fluoride cathode having Ni; and an electrolyte composition in contact with the anode and cathode. The electrolyte composition can be a tertiary electrolyte composition of LiF—LiCl—Li2SO4. A thermal battery can also include: an anode of lithium alloy; a metal-fluoride cathode having an oxide selected from V2O5 or LiVO3; and an electrolyte composition in contact with the anode and cathode. In one aspect, a metal of the metal fluoride cathode includes Ni, Fe, V, Cr, Mn, Co, or mixture thereof. In one aspect, the metal-fluoride cathode includes NiF2, FeF3, VF3, CrF3, MnF3, CoF3, or a mixture thereof. A method of providing electricity can include: providing an electronic device having a thermal battery with a metal-fluoride cathode having Ni and/or having an oxide selected from V2O5 or LiVO3; and discharging the thermal battery to provide electricity.

16. 发明授权

US10012640B2 Cell culture device with an array of microfluidic networks 有权
公开(公告)号：US10012640B2
公开(公告)日：2018-07-03
申请号：US14768154
申请日：2014-02-14
申请人： CFD Research Corporation
发明人： Kapil Pant , Balabhaskar Prabhakarpandian
IPC分类号： C12M1/00 , C12M3/00 , B01L3/00 , G01N33/50 , C12M3/06 , C12M1/12 , C12M1/34 , C12M1/36 , C12M1/42
CPC分类号： G01N33/5008 , B01L3/5025 , B01L3/502715 , B01L2300/0829 , B01L2300/0861 , B01L2300/0874 , B01L2400/0487 , C12M23/16 , C12M23/34 , C12M25/14 , C12M29/00 , C12M29/04 , C12M35/08 , C12M41/00 , C12M41/48
摘要： A cell culture assay device can include: a substrate having a plurality of discrete microfluidic networks and a plurality of wells over the discrete microfluidic networks, each discrete microfluidic network having one or more wells fluidly coupled thereto, the wells extending upward from the discrete microfluidic networks; and a manifold body coupled with the substrate and having at least one fluid conduit pair for each microfluidic network and/or each well, each fluid conduit pair including a fluid inlet conduit and a fluid outlet conduit fluidly coupled to a corresponding microfluidic network and/or well. The substrate can be formed from a substrate base having the microfluidic networks coupled to a well plate having the wells associated with the microfluidic networks.

17. 发明申请

US20140255970A1 SYNTHETIC MICROFLUIDIC SYSTEMS FOR HYPOXIA 审中-公开
标题翻译： HYPOXIA合成微流控系统
公开(公告)号：US20140255970A1
公开(公告)日：2014-09-11
申请号：US14202491
申请日：2014-03-10
申请人： CFD Research Corporation
发明人： Balabhaskar Prabhakarpandian , Kapil Pant
IPC分类号： G01N33/50
CPC分类号： G01N33/5029 , B01L3/5027 , G01N33/5005 , G01N33/5011 , G01N33/5061 , G01N33/5088 , G01N33/86 , G01N2333/4703 , G01N2333/70525
摘要： A cell culture device can include: an internal chamber configured for an internal cell culture that has at least one port coupled to a perfusion modulating device capable of modulating perfusion in the internal chamber; at least one fluid channel bordering the internal chamber that is configured for a channel cell culture that has at least one port coupled to a perfusion modulating device capable of modulating perfusion in the fluid channel; and a wall separating the internal chamber and at least one fluid channel having gaps that fluidly couple the internal chamber with the at least one fluid channel, wherein the perfusion modulating device causes reduced fluid flow. The internal chamber can include a first cell type and the at least one fluid channel includes a second cell type. The first cell type has an ischemic zone in the middle, a non-ischemic zone adjacent with the at least one fluid channel, and a border zone between the ischemic zone and non-ischemic zone. In one aspect, the internal chamber and at least one fluid channel are modeled from physiological features. In one aspect, the internal chamber and at least one fluid channel are modeled from idealized features.
摘要翻译：细胞培养装置可以包括：配置用于内部细胞培养物的内部室，其具有耦合到能够调节内部腔室灌注的灌注调节装置的至少一个端口; 至少一个与所述内室邻接的流体通道，其构造成用于通道细胞培养，所述通道细胞培养物具有至少一个端口，所述至少一个端口耦合到能够调节所述流体通道中的灌注的灌注调节装置; 以及分隔内室和至少一个流体通道的壁，所述至少一个流体通道具有使内室与至少一个流体通道流体连接的间隙，其中灌注调节装置引起减少的流体流动。内部腔室可以包括第一细胞类型，并且所述至少一个流体通道包括第二细胞类型。第一细胞类型在中间具有缺血区，与至少一个流体通道相邻的非缺血区，以及缺血区与非缺血区之间的边界区。在一个方面，内部室和至少一个流体通道由生理特征建模。在一个方面，内部室和至少一个流体通道由理想特征建模。

18. 发明授权

US08685286B2 Electrically conductive ink and uses thereof 有权
标题翻译：导电油墨及其用途
公开(公告)号：US08685286B2
公开(公告)日：2014-04-01
申请号：US13155752
申请日：2011-06-08
申请人： Vojtech Svoboda , Jianjun Wei , Sameer Singhal
发明人： Vojtech Svoboda , Jianjun Wei , Sameer Singhal
IPC分类号： H01B1/00 , H01B1/04 , H01B1/06
CPC分类号： H01M4/60 , B82Y30/00 , H01M8/16 , Y02E60/527
摘要： The present disclosure provides an electrode including an electrically conductive ink deposited thereon comprising: a nano-scale conducting material; a binding agent; and an enzyme; wherein said ink is essentially solvent free. In one embodiment, the ink includes at least one of a mediator, a cross-linking agent and a substrate as well. In one further embodiment, the electrode provided herein is used in a battery, fuel cell or sensor.
摘要翻译：本公开提供了一种包括沉积在其上的导电油墨的电极，包括：纳米级导电材料; 粘合剂; 和酶; 其中所述油墨基本上不含溶剂。在一个实施方案中，油墨还包括介体，交联剂和底物中的至少一种。在另一实施例中，本文提供的电极用于电池，燃料电池或传感器。

19. 发明授权

US08417465B2 Synthetic microfluidic blood-brain barrier 有权
标题翻译：合成微流体血脑屏障
公开(公告)号：US08417465B2
公开(公告)日：2013-04-09
申请号：US12726140
申请日：2010-03-17
申请人： Balabhaskar Prabhakarpandian , Kapil Pant , Shivshankar Sundaram , Ketan Harendrakumar Bhatt
发明人： Balabhaskar Prabhakarpandian , Kapil Pant , Shivshankar Sundaram , Ketan Harendrakumar Bhatt
IPC分类号： G01N33/48
CPC分类号： G01N33/5082 , G01N33/5029 , G01N33/5032 , G01N33/54366 , G01N33/56972
摘要： An apparatus and method for assaying blood-brain barrier properties for drug and drug delivery vehicle screening comprising of a microfluidic apparatus with gaps separating lumen and tissue space enabling formation of tight junctions similar to in vivo conditions using endothelial cells and brain cells.
摘要翻译：用于测定用于药物和药物递送载体筛选的血脑屏障性质的装置和方法，包括具有分隔内腔和组织空间的间隙的微流体装置，从而能够形成类似于使用内皮细胞和脑细胞的体内条件的紧密连接。

20. 发明授权

US08158409B2 Nanoscale surface plasmonics sensor with nanofluidic control 有权
标题翻译：具有纳米流体控制的纳米级表面等离子体激元传感器
公开(公告)号：US08158409B2
公开(公告)日：2012-04-17
申请号：US12685487
申请日：2010-01-11
申请人： Jianjun Wei , Sameer Singhal , David Hennessey Waldeck , Matthew Joseph Kofke
发明人： Jianjun Wei , Sameer Singhal , David Hennessey Waldeck , Matthew Joseph Kofke
IPC分类号： C12M1/34
CPC分类号： G01N21/553 , B82Y35/00 , G01N2021/0346 , Y10S435/808 , Y10S436/805
摘要： A microfluidically-controlled transmission mode nanoscal surface plasmonics sensor device comprises one or more arrays of aligned nanochannels in fluid communication with inflowing and outflowing fluid handling manifolds that control the flow of fluid through the array(s). Fluid comprising a sample for analysis is moved from an inlet manifold, through the nanochannel array, and out through an exit manifold. The fluid may also contain a reagent used to modify the interior surfaces of the nanochannels, and/or a reagent required for the detection of an analyte.
摘要翻译：微流控制的透射模式纳米表面等离子体激元传感器装置包括一个或多个对准的纳米通道阵列，其与流入和流出的流体处理歧管流体连通，所述歧管控制流体通过所述阵列的流动。包括用于分析的样品的流体从入口歧管移动通过纳米通道阵列，并通过出口歧管流出。流体还可以含有用于改变纳米通道的内表面的试剂和/或检测分析物所需的试剂。

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