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11. 发明申请

WO2011157995A1 METHOD FOR PRODUCING A STRESS TOLERANT PLANT OR PRECURSOR THEREOF 审中-公开
标题翻译：用于生产耐应变材料或其前体的方法
公开(公告)号：WO2011157995A1
公开(公告)日：2011-12-22
申请号：PCT/GB2011/000904
申请日：2011-06-14
申请人： ABERYSTWYTH UNIVERSITY , WILKINSON, Michael James , LOPEZ, Carlos Marcelino Rodriguez , TRICKER, Penelope , HADLEY, Paul
发明人： WILKINSON, Michael James , LOPEZ, Carlos Marcelino Rodriguez , TRICKER, Penelope , HADLEY, Paul
IPC分类号： A01H1/04
CPC分类号： A01H3/00 , A01H1/04
摘要： Provided are methods for the production of a stress tolerant plant or precursor thereof. The methods comprise (i) subjecting one or more parental plants to one or more stress conditions selected from unfavourable conditions relating to relative humidity, water availability, periodic drought, nutrients, sunlight, wind, temperature, pH, exogenous chemicals, chemical toxins such as salt, herbivory, prophylactic chemicals, fertilizers, pathogen attack such as bacterial, fungal, or virus infection and pest infestation; and (ii) generating offspring from said one or more parental plants. The offspring show enhanced tolerance relative to the one or more parental plants to one or more stress conditions selected from unfavourable conditions relating to relative humidity, water availability, periodic drought, nutrients, sunlight, wind, temperature, pH, exogenous chemicals, chemical toxins such as salt, herbivory, prophylactic chemicals, fertilizers, pathogen attack such as bacterial, fungal, or virus infection and pest infestation. Also provided are plants, or precursor thereof, produced by the methods and assays for identifying a plant, or precursor thereof, produced by the methods.
摘要翻译：提供了用于生产胁迫耐受植物或其前体的方法。所述方法包括（i）使一种或多种亲本植物经受一种或多种胁迫条件，所述胁迫条件选自与相对湿度，水可利用性，周期性干旱，营养物，阳光，风，温度，pH，外源化学物质，化学毒素如盐，食草，预防化学品，化肥，细菌，真菌或病毒感染和虫害等病原体攻击; 和（ii）从所述一个或多个亲本植物产生后代。后代显示相对于一个或多个亲本植物对一种或多种胁迫条件的增强的耐受性，所述胁迫条件选自与相对湿度，水可用性，周期性干旱，营养物，阳光，风，温度，pH，外源性化学物质，化学毒素等有关的不利条件作为盐，食草，预防化学物质，肥料，病原体攻击如细菌，真菌或病毒感染和害虫侵袭。还提供了通过用于鉴定通过该方法产生的植物或其前体的方法和测定法产生的植物或其前体。

12. 发明申请

WO2011033290A2 DUAL-FLUORESCENCE ASSAY 审中-公开
标题翻译：双色荧光测定
公开(公告)号：WO2011033290A2
公开(公告)日：2011-03-24
申请号：PCT/GB2010/051527
申请日：2010-09-13
申请人： ABERYSTWYTH UNIVERSITY , PEAK, Emily , HOFFMANN, Karl Francis
发明人： PEAK, Emily , HOFFMANN, Karl Francis
IPC分类号： G01N33/569
CPC分类号： G01N33/5308 , G01N33/5085 , G01N2021/6441 , G01N2333/43526
摘要： A two colour fluorescent assay and a kit are described that permit the determination of live and dead parasitic or non-parasitic worms, for example helminths. The assay permits screening for the effect of one or more agents or an event on the viability of a parasitic or non-parasitic worm, In one example, the assay comprises (a) providing a sample comprising one or more parasitic or non-parasitic worms; (b) contacting the parasitic or non-parasitic worms with a concentration of fluorescein diacetate sufficient to yield detectable green fluorescence in any live parasitic or non-parasitic worms present in the sample and a concentration of propidium iodide sufficient to yield detectable red fluorescence in any dead parasitic or non-parasitic worms present in the sample; and (c) detecting the red and green fluorescence of the parasitic or non-parasitic worms. The assay further comprises contacting the parasitic or non-parasitic worms with one or more test agents, or subjecting the parasitic or non-parasitic worms to an event. The assay allows for a rapid and objective score of parasitic or non-parasitic worm death and survival and enables the performance of high- throughput screens for the identification of potential agents against diseases such as schistosomiasis. Also described are methods and kits for discriminatory analysis of parasitic or non-parasitic worm phenotype and/or metabolics using FTIR analysis.
摘要翻译：描述了双色荧光测定和试剂盒，其允许测定活的和死的寄生虫或非寄生虫，例如蠕虫。该测定允许筛选一种或多种试剂或事件对寄生虫或非寄生虫的活力的影响。在一个实例中，测定包括（a）提供包含一种或多种寄生虫或非寄生虫的样品 ; （b）将寄生虫或非寄生虫与一种浓度的荧光素二乙酸酯接触，足以在样品中存在的任何活的寄生虫或非寄生虫中产生可检测的绿色荧光，以及足以产生任何可检测的红色荧光的碘化丙啶浓度存在于样品中的死寄生虫或非寄生虫; 和（c）检测寄生虫或非寄生虫的红色和绿色荧光。该测定还包括将寄生虫或非寄生虫与一种或多种测试试剂接触，或将寄生虫或非寄生虫蠕虫接触事件。该测定允许寄生虫或非寄生虫蠕虫死亡和存活的快速客观评分，并且能够实现高通量筛选用于鉴定针对诸如血吸虫病的疾病的潜在药剂。还描述了使用FTIR分析对寄生虫或非寄生虫表型和/或代谢物进行鉴别分析的方法和试剂盒。

13. 发明申请

WO2010103261A2 FAECAL MARKERS 审中-公开
公开(公告)号：WO2010103261A2
公开(公告)日：2010-09-16
申请号：PCT/GB2010/000412
申请日：2010-03-09
申请人： ABERYSTWYTH UNIVERSITY , LEE, Michael , THEODOROU, Michael , OUGHAM, Helen , THOMAS, Howard
发明人： LEE, Michael , THEODOROU, Michael , OUGHAM, Helen , THOMAS, Howard
IPC分类号： C09B61/00
CPC分类号： C09B61/00 , G01N33/12
摘要： Described are methods for analysing an animal carcass, meat obtained therefrom, or product produced by or obtained from an animal for the presence or absence of faecal matter. The methods comprise analysing an animal carcass, meat obtained therefrom, or product produced by or obtained from the animal for the presence or absence of a detectable marker, the presence of the detectable marker being indicative of the presence of faecal matter and the absence of the detectable marker being indicative of the absence of faecal matter, wherein the animal carcass, meat obtained therefrom, or product produced by or obtained from the animal has been obtained from an animal fed a composition comprising a supplement of the detectable marker and/or a precursor thereof. Also described are compositions for feeding to an animal and for use in the methods.
摘要翻译：描述了用于分析动物尸体，由其获得的肉或由动物产生或从动物获得的产品的方法，用于存在或不存在粪便物质。所述方法包括分析动物尸体，由其获得的肉或由动物产生或从动物获得的产品是否存在可检测标志物，所述可检测标志物的存在表明存在粪便物质且不存在其中动物尸体，由其获得的肉或由动物产生或从动物获得的产品已经从饲喂包含可检测标记和/或前体的补充物的组合物的动物获得，它们。还描述了用于喂养动物和用于该方法的组合物。

14. 发明授权

US08913795B2 Identification of texture connectivity 有权
标题翻译：识别纹理连接
公开(公告)号：US08913795B2
公开(公告)日：2014-12-16
申请号：US13512525
申请日：2010-11-25
申请人： Reyer Zwiggelaar , Harry Strange
发明人： Reyer Zwiggelaar , Harry Strange
IPC分类号： G06K9/00 , G06T7/40
CPC分类号： G06T7/40 , G06T2207/30004
摘要： A method for identifying the connectivity of texture types represented in a digital image comprising pixels, each pixel having a texture value which is representative of texture at a respective position, the method comprising: partitioning the texture values into local neighborhoods of texture values; determining a directionality for each neighborhood; using the directionality of the neighborhoods to determine their nearest neighborhood or neighborhoods; connecting the neighborhoods with their nearest neighborhood or neighborhoods; and determining the connectivity of the texture types of the digital image based on the connections formed between neighborhoods.
摘要翻译：一种用于识别在包括像素的数字图像中表示的纹理类型的连接性的方法，每个像素具有代表各个位置处的纹理的纹理值，所述方法包括：将纹理值分割成纹理值的本地邻域; 确定每个邻域的方向性; 使用社区的方向性来确定他们最近的邻里或邻域; 将邻里与邻近邻里连接起来; 并且基于在邻域之间形成的连接来确定数字图像的纹理类型的连接性。

15. 发明授权

US08431354B1 Bacterial pheromones and uses therefor 失效
标题翻译：细菌信息素及其用途
公开(公告)号：US08431354B1
公开(公告)日：2013-04-30
申请号：US09445289
申请日：1998-06-03
申请人： Galina V Mukamolova , Arseny S Kaprelyants , Danielle I Young , Douglas B Kell , Michael Young
发明人： Galina V Mukamolova , Arseny S Kaprelyants , Danielle I Young , Douglas B Kell , Michael Young
IPC分类号： G01N33/554 , G01N33/53 , C12Q1/70 , C12N5/00
CPC分类号： C07K14/33 , A61K38/00 , A61K39/00 , C07K14/195 , C07K14/305 , C07K14/31 , C07K14/315 , C07K14/32 , C07K14/335 , C07K14/34 , C07K14/35 , C07K14/36
摘要： RP-factors, their cognate receptors, convertases, respective genes and inhibitors or mimetics thereof are described. In particular, antibodies, pharmaceutical compositions and (therapeutic, diagnostic) methods based on the RP-factors and their receptors/convertases are described.
摘要翻译：描述了RP因子，它们的同源受体，转化酶，各自的基因和抑制剂或其模拟物。特别地，描述了基于RP因子及其受体/转化酶的抗体，药物组合物和（治疗，诊断）方法。

16. 发明申请

US20120061588A1 FAECAL MARKERS 有权
公开(公告)号：US20120061588A1
公开(公告)日：2012-03-15
申请号：US13255288
申请日：2010-03-09
申请人： Michael Lee , Michael Theodorou , Helen Ougham , Howard Thomas
发明人： Michael Lee , Michael Theodorou , Helen Ougham , Howard Thomas
IPC分类号： G01N21/64 , A23K1/00
CPC分类号： C09B61/00 , G01N33/12
摘要： Described are methods for analysing an animal carcass, meat obtained therefrom, or product produced by or obtained from an animal for the presence or absence of faecal matter. The methods comprise analysing an animal carcass, meat obtained therefrom, or product produced by or obtained from the animal for the presence or absence of a detectable marker, the presence of the detectable marker being indicative of the presence of faecal matter and the absence of the detectable marker being indicative of the absence of faecal matter, wherein the animal carcass, meat obtained therefrom, or product produced by or obtained from the animal has been obtained from an animal fed a composition comprising a supplement of the detectable marker and/or a precursor thereof. Also described are compositions for feeding to an animal and for use in the methods.
摘要翻译：描述了用于分析动物屠体，从其获得的肉，或由动物产生或获得的用于粪便物质的存在或不存在的产品的方法。所述方法包括分析动物屠体，从其获得的肉，或由动物产生或获自动物的产物，以检测标记的存在或不存在，可检测标记物是否存在指示粪便物质的存在和不存在可检测标记指示不存在粪便物质，其中动物尸体，由其获得的肉或由动物产生或从动物获得的产品已经从喂食包含可检测标记物和/或前体的补充物的组合物的动物获得其中。还描述了用于喂养动物并用于该方法的组合物。

17. 发明公开

US20240019436A1 BIOMARKERS FOR MYCOBACTERIUM AVIUM PARATUBERCULOSIS 审中-公开
公开(公告)号：US20240019436A1
公开(公告)日：2024-01-18
申请号：US18038901
申请日：2021-11-24
申请人： ABERYSTWYTH UNIVERSITY
发明人： Luis Alejando Jose Mur , Emma Nicole Taylor , David John Rooke , Adriaan Peter Koets
IPC分类号： G01N33/569
CPC分类号： G01N33/5695 , G01N2800/065 , G01N2570/00
摘要： The present invention relates to a method for determining the presence of Mycobacterium avium paratuberculosis in a subject. The method comprises: (i) determining the level of one or more metabolites in a sample from the subject; and (ii) comparing the level of said one or more metabolites with the level of said one or more metabolites in a control sample to determine whether Mycobacterium aviumparatuberculosis is present in the subject. The metabolites are selected from: 2-hydroxyglutaric acid; leukotriene B4; itaconic acid; bicyclo-prostaglandin E2; N6-acetyl-L-lysine; guanidinobutanoic acid; creatine; docosahexaenoic acid; cis-10-non-adecenoic acid; creatinine; 5-hydroxyeicosapentaenoic acid, 17-hydroxy docosahexaenoic acid, palmitoleic acid; R-3-hydroxy-octade-canoic acid; 8, 11, 14-eicosatrienoic acid; nonadecanoic acid; stearic acid; eicosapentaenoic acid; 16-methylheptadecanoic acid; phytanic acid; arachidonic acid; 9,10-dihydroxy-12-octadecenoic acid, 8,11,14, 17-eicosatetraenoic acid; palmitic acid; pyruvic acid; and p-cresol.

18. 发明授权

US11535872B2 Microbial strains and uses thereof 有权
公开(公告)号：US11535872B2
公开(公告)日：2022-12-27
申请号：US16641318
申请日：2018-08-24
申请人： Aberystwyth University
发明人： Abhishek Somani , David Neil Bryant , Sreenivas Rao Ravella , Joseph Anthony Gallagher , Narcis Fernandez-Fuentes
IPC分类号： C12N1/18 , C12N1/22 , C12P7/18 , C12N1/16 , C12R1/72 , C12R1/74
摘要： The present invention relates to Candida strains comprising a mutation or deletion in the first and/or second XYL2 allele which can be used for producing one or more sugar alcohols from a lignocellulosic feedstock. The preferred sugar alcohol is xylitol.

19. 发明申请

WO2022167822A2 A CANNABINOID MIXTURE 审中-公开
公开(公告)号：WO2022167822A2
公开(公告)日：2022-08-11
申请号：PCT/GB2022/050334
申请日：2022-02-08
申请人： TTS PHARMA LTD , ABERYSTWYTH UNIVERSITY
发明人： WALTON, Robert , TUCKER, Mark , NASH, Debbie , ALLEN, Nathan , WONFOR, Ruth , SHAH, Ifat
IPC分类号： A61K31/015 , A61K31/05 , A61K31/192 , A61K45/06 , A61P29/00 , A23L33/00 , A23L33/105
摘要： There is disclosed a composition comprising cannabidiol (CBD) and one or more cannabinoids selected from cannabidiolic acid (CBDA), cannabigerol (CBG) and cannabigerolic acid (CBGA) for use in the treatment or prevention of inflammation and disorders associated with inflammation or an IL-6 related disorder.

20. 发明申请

WO2019038565A1 MICROBIAL STRAINS AND USES THEREOF 审中-公开
公开(公告)号：WO2019038565A1
公开(公告)日：2019-02-28
申请号：PCT/GB2018/052416
申请日：2018-08-24
申请人： ABERYSTWYTH UNIVERSITY
发明人： SOMANI, Abhishek , BRYANT, David Neil , RAVELLA, Sreenivas Rao , GALLAGHER, Joseph Anthony , FERNANDEZ-FUENTES, Narcis
IPC分类号： C12P7/18
摘要： The present invention relates to Candida strains comprising a mutation or deletion in the first and/or second XYL2 allele which can be used for producing one or more sugar alcohols from a lignocellulosic feedstock. The preferred sugar alcohol is xylitol.

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