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151. 发明申请

US20170370878A1 UV-ABSORBANCE MULTICHANNEL CAPILLARY ELECTROPHORESIS SYSTEM 审中-公开
公开(公告)号：US20170370878A1
公开(公告)日：2017-12-28
申请号：US15677535
申请日：2017-08-15
申请人： ADVANCED ANALYTICAL TECHNOLOGIES, INC.
发明人： Michael Stebniski , Bruce R. Boeke , Martin Chris Foster , Scott Stueckradt , Thomas J. Kurt
IPC分类号： G01N27/447
CPC分类号： G01N27/44791 , G01N27/44721 , G01N27/44743 , G01N27/44782
摘要： The invention is an improved ultraviolet absorption-based multiplex capillary electrophoresis instrument with at least four and preferably six user-accessible vertically stacked drawers. An x-z stage moves samples from the user accessible drawers to the capillary array for analysis. A computer program allows users to add capillary electrophoresis jobs to a queue corresponding to the analysis of rows or plates of samples without stopping or interrupting runs in progress. A double-set of enclosures surrounding the light source enables collection of high-quality data. The invention also may include a capillary reservoir with separate flow channels for the capillary tips and electrode.

152. 发明授权

US09752181B2 System and method for capturing and analyzing cells 有权
公开(公告)号：US09752181B2
公开(公告)日：2017-09-05
申请号：US14163185
申请日：2014-01-24
申请人： DeNovo Sciences, Inc.
发明人： Kalyan Handique , Priyadarshini Gogoi , Saedeh Sepehri Javdani , Yi Zhou
IPC分类号： C12Q1/68 , G01N33/574 , G01N33/487 , G01N27/447
CPC分类号： C12Q1/6841 , C12Q1/6844 , C12Q1/686 , G01N27/44782 , G01N33/48721 , G01N33/574 , G01N33/57492 , G01N2333/70585 , G01N2333/70596
摘要： A system and method for capturing and analyzing a set of cells, comprising: an array including a set of parallel pores, each pore including a chamber including a chamber inlet and a chamber outlet, and configured to hold a single cell, and a pore channel fluidly connected to the chamber outlet; an inlet channel fluidly connected to each chamber inlet of the set of parallel pores; an outlet channel fluidly connected to each pore channel of the set of parallel pores; a set of electrophoresis channels fluidly coupled to the outlet channel, configured to receive a sieving matrix for electrophoretic separation; and a set of electrodes including a first electrode and a second electrode, wherein the set of electrodes is configured to provide an electric field that facilitates electrophoretic analysis of the set of cells.

153. 发明申请

US20170003250A1 Method of Charge State Selection 有权
标题翻译：充电状态选择方法
公开(公告)号：US20170003250A1
公开(公告)日：2017-01-05
申请号：US15100034
申请日：2014-12-01
申请人： MICROMASS UK LIMITED
发明人： Martin Raymond Green , Keith Richardson , Jason Lee Wildgoose
IPC分类号： G01N27/447 , H01J49/04 , G01N27/62 , H01J49/00
CPC分类号： G01N27/44717 , G01N27/4473 , G01N27/44782 , G01N27/44791 , G01N27/624 , H01J49/0027 , H01J49/0031 , H01J49/004 , H01J49/0404
摘要： A method of mass spectrometry or ion mobility spectrometry is disclosed in which analyte ions of a desired charge state are isolated. The method comprises: separating analytes according to their electrophoretic mobility; ionising the analytes; and mass filtering the resulting analyte ions, wherein the mass to charge ratios of the ions transmitted by a mass filter are varied as a function of the electrophoretic mobility and according to a predetermined relationship such that substantially only ions having said desired charge state are transmitted by the mass filter.
摘要翻译：公开了一种质谱法或离子迁移光谱法，其中分离出所需电荷状态的分析物离子。该方法包括：根据其电泳迁移率分离分析物; 电离分析物; 并且对所得到的分析离子进行质量过滤，其中质量过滤器传输的离子的质荷比随着电泳迁移率的变化而变化，并且根据预定关系使得基本上仅具有所需电荷状态的离子通过质量过滤器。

154. 发明申请

US20160266066A1 Screening Methods for Antiperspirants 审中-公开
标题翻译：防汗剂的筛选方法
公开(公告)号：US20160266066A1
公开(公告)日：2016-09-15
申请号：US15036261
申请日：2013-11-12
申请人： COLGATE-PALMOLIVE COMPANY
发明人： Long Pan , Shaotang Yuan , Iraklis Pappas , John Vaughn , James G. Masters
IPC分类号： G01N27/447 , A61K8/28 , A61Q15/00 , A61K8/19 , A61K8/44 , A61K8/26 , A61K8/27
CPC分类号： G01N27/44782 , A61K8/19 , A61K8/26 , A61K8/27 , A61K8/28 , A61K8/44 , A61K2800/58 , A61K2800/74 , A61K2800/805 , A61Q15/00 , D06M13/005
摘要： Methods of estimating the suitability of a candidate antiperspirant material by measuring the zeta potential of the material.
摘要翻译：通过测量材料的ζ电位来估计候选止汗材料的适用性的方法。

155. 发明授权

US09377436B2 Electrophoresis gel cassette and a method of filling an electrophoresis gel cassette 有权
标题翻译：电泳凝胶盒和填充电泳凝胶盒的方法
公开(公告)号：US09377436B2
公开(公告)日：2016-06-28
申请号：US14403604
申请日：2013-05-31
申请人： GE HEALTHCARE BIO-SCIENCES AB
发明人： Owe Salven , Camilla Larsson , Stefan Ogeus , Henrik Ostlin , Stefan Sjolander , Malin Eriksson
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： G01N27/447 , G01N27/44704 , G01N27/44747 , G01N27/44782
摘要： Electrophoresis gel cassette comprising a cassette housing defining a gel compartment for molding a gel member wherein the gel compartment comprises a fill port at an inlet end of the gel compartment and one or more over-fill ports at a distal end of the gel compartment with respect to a filling direction, and wherein the over-fill port(s) is arranged in fluidic communication with an overfill chamber.
摘要翻译：电泳凝胶盒，其包括限定用于模制凝胶构件的凝胶室的盒壳体，其中所述凝胶隔室包括在所述凝胶室的入口端处的填充口和在所述凝胶隔室的远端处的一个或多个过充填口，到填充方向，并且其中所述过填充端口被布置成与溢流室流体连通。

156. 发明申请

US20160109474A1 HIGHLY AUTOMATED CAPILLARY ELECTROPHORESIS SYSTEM 审中-公开
标题翻译：高自动毛细管电泳系统
公开(公告)号：US20160109474A1
公开(公告)日：2016-04-21
申请号：US14983985
申请日：2015-12-30
申请人： Advanced Analytical Technologies, LLC
发明人： Bruce R. Boeke , Martin Chris Foster , Thomas J. Kurt , Scott Stueckradt , Steven J. Lasky
IPC分类号： G01N35/02 , G01N27/447
CPC分类号： G01N27/44704 , G01N27/44743 , G01N27/44782 , G01N2035/0498
摘要： The invention is an improved multiplex capillary electrophoresis instrument or module with at least four and preferably six user-accessible vertically stacked drawers. An x-z stage moves samples from the user accessible drawers to the capillary array for analysis. An additional mechanical stage moves the array from side-to-side. The x-z stage, coupled with the additional array stage allows the system to sample all wells of a 384 well plate with a 96-capillary array. A computer program allows users to add capillary electrophoresis jobs to a queue corresponding to the analysis of rows or plates of samples without stopping or interrupting runs in progress.
摘要翻译：本发明是一种改进的多重毛细管电泳仪器或模块，其具有至少四个并且优选六个用户易于垂直堆叠的抽屉。 x-z平台将样品从用户可访问的抽屉移动到毛细管阵列进行分析。一个额外的机械台将阵列从一侧移动到另一侧。 x-z平台与附加的阵列舞台相结合，可以让系统用96-毛细管阵列对384孔板的所有孔进行采样。计算机程序允许用户将毛细管电泳作业添加到对应于样品行或板的分析的队列中，而不停止或中断正在进行的运行。

157. 发明申请

US20150160155A1 ELECTROPHORESIS GEL CASSETTE AND A MTHOD OF FILLING AN ELECTROPHORESIS GEL CASSETTE 有权
标题翻译：电泳胶凝胶和填充电泳凝胶盒
公开(公告)号：US20150160155A1
公开(公告)日：2015-06-11
申请号：US14403604
申请日：2013-05-31
申请人： GE HEALTHCARE BIO-SCIENCES AB
发明人： Owe Salven , Camilla Larsson , Stefan Ogeus , Henrik Ostlin , Stefan Sjolander , Malin Eriksson
IPC分类号： G01N27/447
CPC分类号： G01N27/447 , G01N27/44704 , G01N27/44747 , G01N27/44782
摘要： Electrophoresis gel cassette comprising a cassette housing defining a gel compartment for molding a gel member wherein the gel compartment comprises a fill port at an inlet end of the gel compartment and one or more over-fill ports at a distal end of the gel compartment with respect to a filling direction, and wherein the over-fill port(s) is arranged in fluidic communication with an overfill chamber.
摘要翻译：电泳凝胶盒，其包括限定用于模制凝胶构件的凝胶室的盒壳体，其中所述凝胶隔室包括在所述凝胶室的入口端处的填充口和在所述凝胶隔室的远端处的一个或多个过充填口，到填充方向，并且其中所述过填充端口被布置成与溢流室流体连通。

158. 发明申请

US20150151859A1 FRAGMENTATION AND DISPENSING APPARATUS OF GEL PLATE AND FRAGMENTATION AND DISPENSING METHOD OF THE SAME 审中-公开
标题翻译：凝胶板的分离和分配装置及其分离方法及其分配方法
公开(公告)号：US20150151859A1
公开(公告)日：2015-06-04
申请号：US14409537
申请日：2014-02-27
申请人： SYORYUKENSETSU CORPORATION
发明人： Tetsuo Nagano , Toru Komatsu , Satoru Konno , Masahiro Simoda
IPC分类号： B65B3/04 , B26D5/02 , B65B35/00
CPC分类号： B65B3/04 , B01J19/00 , B01L3/5085 , B01L3/50853 , B01L2300/046 , B01L2300/0672 , B01L2300/069 , B01L2300/0829 , B26D5/02 , B26F1/40 , B26F1/44 , B26F2001/4472 , B65B35/00 , C12M1/00 , G01N1/04 , G01N1/28 , G01N27/447 , G01N27/44782
摘要： Provided is a simple apparatus and a simple method for readily dispensing a gel after electrophoresis used for analysis of protein or DNA into respective wells of a microtiter plate.Using a microtiter plate 10 and a pressing tool 20, a gel plate 30 is divided into gel fragments 31 and the gel fragments 31 are then dispensed into respective wells 11 of the microtiter plate 10. In the microtiter plate 10, end portions 13 of a lattice-shaped partition wall 12 constituting the wells 11 of a square shape are formed to be sharp. The pressing tool 20 includes a frame portion 21 configured to be fit onto the microtiter plate 10, and a lattice-shaped partition wall 23 formed thereon. The lattice-shaped partition wall 23 includes end surfaces 26 each having a predetermined width configured to be opposed to and abut against the end portions 13 of the lattice-shaped partition wall 12 of the microtiter plate 10 when the pressing tool 20 is fit onto the microtiter plate. By placing the gel plate 30 on the partition wall 12 of the microtiter plate 10 and by pressing the gel plate 30 by fitting the pressing tool 20 onto the microtiter plate 10, the gel plate 30 is divided into the gel fragments 31, and the gel fragments 31 are then dispensed into the respective wells 11 of the microtiter plate 10.
摘要翻译：提供了一种简单的装置和用于在将蛋白质或DNA分析用于分析微量滴定板的各个孔中的电泳后容易地分配凝胶的简单方法。使用微量滴定板10和压制工具20，将凝胶板30分成凝胶片段31，然后将凝胶片段31分配到微量滴定板10的各孔11中。在微量滴定板10中，构成方形形状的孔11的格子状分隔壁12形成为锋利的。按压工具20包括构造成配合到微量滴定板10上的框架部分21和形成在其上的格子状分隔壁23。格子状分隔壁23包括端面26，每个端面26具有预定的宽度，该宽度构成为当按压工具20安装在微孔板10上时与微孔板10的格子状分隔壁12的端部13相对并邻接。微量滴定板。通过将凝胶板30放置在微量滴定板10的分隔壁12上，并通过将加压工具20装配到微量滴定板10上来压制凝胶板30，将凝胶板30分成凝胶片段31，凝胶然后将片段31分配到微量滴定板10的相应孔11中。

159. 发明申请

US20150090591A1 APPARATUS, SYSTEMS, AND METHODS FOR CAPILLARY ELECTROPHORESIS 有权
标题翻译：用于毛细管电泳的装置，系统和方法
公开(公告)号：US20150090591A1
公开(公告)日：2015-04-02
申请号：US14039995
申请日：2013-09-27
申请人： ProteinSimple
发明人： Tom W. Yang , David John Roach
IPC分类号： G01N27/447
CPC分类号： G01N27/44782 , C07K1/26 , C07K1/285 , G01N27/44704 , G01N27/44726 , G01N27/44791
摘要： An apparatus includes a body portion that defines a reservoir and a set of substantially flexible capillaries. The set of substantially flexible capillaries are fixedly coupled to the body portion and in fluid communication with the reservoir. A connector is configured to be coupled to the body portion to be in fluid communication with the reservoir and the set of substantially flexible capillaries. The connector is further configured to be coupled to a vacuum source. The apparatus is arranged such that at least a part of the body portion is electrically conductive. Methods for separating and detecting an analyte from a biological sample with the apparatus are also provided. For example, methods for separating and detecting one or more proteins from a cellular lysate or a purified protein are also provided.
摘要翻译：一种装置包括限定储存器的主体部分和一组基本上柔性的毛细管。该组基本上柔性的毛细管固定地连接到主体部分并且与储存器流体连通。连接器被配置为联接到主体部分以与储存器和一组基本上柔性的毛细管流体连通。连接器还被配置为耦合到真空源。该装置被布置成使得主体部分的至少一部分是导电的。还提供了使用该装置从生物样品分离和检测分析物的方法。例如，还提供了用于从细胞裂解物或纯化的蛋白质分离和检测一种或多种蛋白质的方法。

160. 发明授权

US08858770B2 Plastic microfluidic separation and detection platforms 有权
标题翻译：塑料微流体分离检测平台
公开(公告)号：US08858770B2
公开(公告)日：2014-10-14
申请号：US12080745
申请日：2008-04-04
申请人： Eugene Tan , Cheuk Wai Kan , Heung Chuan Lam
发明人： Eugene Tan , Cheuk Wai Kan , Heung Chuan Lam
IPC分类号： G01N27/447 , B01L3/00 , G01N21/64 , B01L7/00
CPC分类号： B01L7/52 , B01L3/502715 , B01L3/50273 , B01L3/502753 , B01L2200/0684 , B01L2200/10 , B01L2200/147 , B01L2300/0627 , B01L2300/0654 , B01L2300/069 , B01L2300/0816 , B01L2300/0819 , B01L2300/0864 , B01L2300/0887 , B01L2300/16 , B01L2300/1822 , B01L2300/1844 , B01L2300/1894 , B01L2400/0421 , C12Q1/686 , C12Q1/6869 , G01N21/6402 , G01N21/6428 , G01N21/6452 , G01N21/6486 , G01N27/44726 , G01N27/44743 , G01N27/44782 , G01N27/44791 , G01N2021/6441 , G01N2201/06113 , Y10T436/2575
摘要： Plastic electrophoresis separation chips are provided comprising a plurality of microfluidic channels and a detection window, where the detection window comprises a thin plastic; and the detection window comprises a detection region of each microfluidic channel. Such chips can be bonded to a support provided an aperture is provided in the support to allow detection of samples in the electrophoresis chip at the thin plastic detection window. Further, methods for electrophoretically separating and detecting a plurality of samples on the plastic electrophoresis separation chip are described.
摘要翻译：提供了包括多个微流体通道和检测窗口的塑料电泳分离芯片，其中检测窗口包括薄塑料; 并且检测窗口包括每个微流体通道的检测区域。这样的芯片可以结合到支撑体上，只要在支撑体中设置一个孔，以便在薄塑料检测窗口检测电泳芯片中的样品。此外，描述了在塑料电泳分离芯片上电泳分离和检测多个样品的方法。

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