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151. 发明授权

US08252064B2 Fiber-reinforced composite absorbable endoureteral stent 有权
标题翻译：纤维增强复合材料吸收性输尿管支架
公开(公告)号：US08252064B2
公开(公告)日：2012-08-28
申请号：US11346117
申请日：2006-02-02
申请人： Shalaby W. Shalaby , Kenneth W. Clinkscales
发明人： Shalaby W. Shalaby , Kenneth W. Clinkscales
IPC分类号： A61F2/06 , A61F2/04 , A61M5/00
CPC分类号： A61F2/90 , A61F2002/821 , A61L31/06 , A61L31/128 , A61M25/0041 , A61M27/008 , C08L71/02
摘要： Absorbable/disintegratable endourological stents, specifically endoureteral stents, and applicators for their introduction into the biological site, are formed from fiber-reinforced elastomeric films configured to prevent their migration from the application site.
摘要翻译：可吸收/可分解的内科支架，特别是输尿管内支架，以及用于引入生物部位的敷料器，由纤维增强的弹性膜形成，以防止其从应用部位迁移。

152. 发明申请

US20120077823A1 Controlled release systems of pluribioactive antifungal drugs and applications thereof 有权
标题翻译： pluribioactive抗真菌药物的控制释放系统及其应用
公开(公告)号：US20120077823A1
公开(公告)日：2012-03-29
申请号：US12931327
申请日：2011-01-29
申请人： Shalaby W. Shalaby , Georgios T. Hilas , Sheila Nagatomi
发明人： Shalaby W. Shalaby , Georgios T. Hilas , Sheila Nagatomi
IPC分类号： A61K31/496 , A61P35/00 , A61P7/00 , A61P31/12 , A61P15/00 , A61K31/4164 , A61P31/04
CPC分类号： A61K31/7048 , A61K31/4174 , A61K31/496 , A61K31/506
摘要： Controlled release systems release at least one pluribioactive antifungal drug exhibiting at least one additional bioactivity from the group consisting of spermiostatic, antineoplastic, antibacterial, antirestenotic and antiviral activities. The drug release system is designed for use as a spermiostatic contraceptive, intravaginal ringed-mesh which may also exhibit antiviral activity, an in situ-forming implant for treating different forms of cancer and topical film for treating or preventing bacterial and fungal infections.
摘要翻译：控制释放系统释放至少一种展现至少一种额外生物活性的多药抗真菌药物，其由精子，抗肿瘤，抗菌，抗再狭窄和抗病毒活性组成。药物释放系统被设计用作精子避孕药，也可能表现出抗病毒活性的阴道内环网，用于治疗不同形式癌症的原位形成植入物和用于治疗或预防细菌和真菌感染的局部膜。

153. 发明授权

US08083805B2 Absorbable endo-urological devices and applications therefor 有权
标题翻译：可吸收的泌尿外科装置及其应用
公开(公告)号：US08083805B2
公开(公告)日：2011-12-27
申请号：US11204822
申请日：2005-08-16
申请人： Shalaby W. Shalaby
发明人： Shalaby W. Shalaby
IPC分类号： A61F2/04 , A61M5/00 , A61F2/06
CPC分类号： A61F2/04 , A61F2/90 , A61F2002/047 , A61F2002/048 , A61F2002/821 , A61F2210/0004 , A61L31/06 , A61L31/128 , A61M25/0041 , A61M27/008 , C08L71/02
摘要： This invention deals with an absorbable/disintegratable endo-urological stent and applicators for introduction into biological conduits, including such as urethras and ureters, with said stent comprising a fiber-reinforced, multicomponent tube made of polyesters having a range of physicochemical properties.
摘要翻译：本发明涉及用于引入生物管道（包括例如尿道和输尿管）的可吸收/分解的内泌支架和施用器，所述支架包括由具有一定理论物理性质的聚酯制成的纤维增强的多组分管。

154. 发明申请

US20100330138A1 BIOSTABLE, MULTIPURPOSE, MICROBICIDAL INTRAVAGINAL DEVICES 有权
标题翻译： BIOSTABLE，MULTIPURPOSE，MICROBICIDAL INTRAVAGINAL DEVICES
公开(公告)号：US20100330138A1
公开(公告)日：2010-12-30
申请号：US12448022
申请日：2009-05-11
申请人： Shalaby W. Shalaby , Georgios T. Hilas
发明人： Shalaby W. Shalaby , Georgios T. Hilas
IPC分类号： A61F6/08 , C07D233/60 , A61K31/4174 , A61K31/42 , A61P35/00 , A61P31/14 , A61P31/12 , A61P31/10 , A61P31/18 , A61P31/00 , A61P31/04 , A61P37/06
CPC分类号： A61K31/4174 , A61F6/08 , A61K9/0036 , A61K31/42 , A61L31/02 , A61L31/16 , A61L2300/404 , A61L2300/606 , A61L2420/06
摘要： Biostable, multipurpose, microbicidal intravaginal devices in the form of rings, ringed-meshes, sponges, or diaphragms for use by women and condoms for use by male partners are provided, wherein each of the devices contains a drug effective in treating a particular vaginal infection, while further exhibiting at least one additional function selected from the group dealing with non-hormonal contraception, management of sexually transmitted diseases, viral infections, and retroviral infections as well as the treatment of cervical cancer.
摘要翻译：提供了由男性和女性使用的妇女和避孕套使用的戒指，环形网，海绵或隔膜形式的生物稳定，多用途，杀微生物的阴道内装置，其中每个装置含有有效治疗特定阴道感染的药物同时进一步显示出选自治疗非激素避孕，性传播疾病，病毒感染和逆转录病毒感染的治疗组以及子宫颈癌治疗的组中的至少一种附加功能。

155. 发明申请

US20100256081A1 Absorbable crystalline copolyester-based bioactive hydroforming luminal liner compositions 有权
标题翻译：可吸收的基于结晶共聚酯的生物活性液压成型内衬衬垫组合物
公开(公告)号：US20100256081A1
公开(公告)日：2010-10-07
申请号：US12798457
申请日：2010-04-05
申请人： Shalaby W. Shalaby , Kenneth David Gray , Georgios T. Hilas
发明人： Shalaby W. Shalaby , Kenneth David Gray , Georgios T. Hilas
IPC分类号： A61K31/7036 , A61K31/497 , A61K31/4174 , A61K31/506 , A61K31/427 , A61K31/4164 , A61K31/4025 , A61K31/65 , A61K31/192 , A61K31/337 , A61K31/12 , A61K31/436 , A61P31/00 , A61P29/00 , A61P35/00 , A61P37/00 , A61M31/00 , B65B55/14
CPC分类号： A61K31/7036 , A01N25/34 , A61K9/0034 , A61K9/0053 , A61K31/12 , A61K31/192 , A61K31/337 , A61K31/4025 , A61K31/4164 , A61K31/4174 , A61K31/4196 , A61K31/427 , A61K31/436 , A61K31/496 , A61K31/497 , A61K31/505 , A61K31/506 , A61K31/65 , A61K47/34 , A61M25/002 , A61M25/04 , A61M25/10 , A61M31/00 , A61M31/007 , A61M2025/0024 , A61M2025/105 , B65B3/04 , B65B51/10 , B65B55/04 , B65B55/14 , B65D65/38
摘要： Bioactive, hydroforming luminal liner compositions are formed of high molecular weight crystalline, absorbable copolyesters dissolved in a liquid derivative of a polyether glycol that undergoes transformation into a tissue-adhering, resilient interior cover or liner for the controlled release of its bioactive payload at clinically compromised conduits in humans as in the case of bacteria- and yeast-infected vaginal canals, esophagi, and arteries following angioplasty.
摘要翻译：生物活性的液压成型管腔内衬组合物由溶解在聚醚二醇的液体衍生物中的高分子量结晶的可吸收的共聚酯形成，所述聚醚二醇经历转变成组织粘附的弹性内盖或衬垫，用于在临床受损的情况下控制释放其生物活性有效载荷如在细胞和酵母感染的阴道运河，食管和血管成形术后的动脉的情况下，人的管道。

156. 发明申请

US20100255016A1 Absorbable crystalline polyether-ester-urethane-based bioactive luminal liner compositions 有权
标题翻译：可吸收的结晶聚醚 - 酯 - 氨基甲酸酯基生物活性腔内衬组合物
公开(公告)号：US20100255016A1
公开(公告)日：2010-10-07
申请号：US12798458
申请日：2010-04-05
申请人： Shalaby W. Shalaby , David Ingram , Georgios T. Hilas , Sheila Nagatomi
发明人： Shalaby W. Shalaby , David Ingram , Georgios T. Hilas , Sheila Nagatomi
IPC分类号： A61K39/00 , A61K31/496 , A61K31/4164 , A61K31/506 , A61K31/4196 , A61P31/04 , A61P31/00 , A61K31/4025 , A61K31/65 , A61K31/70
CPC分类号： A61K47/34 , A61K9/0034 , A61K9/0053 , A61K9/7015 , A61K31/4025 , A61K31/4164 , A61K31/4196 , A61K31/496 , A61K31/506 , A61K31/65 , A61K31/70 , A61M25/10 , A61M31/00 , A61M2025/105 , A61M2210/1475 , B65B51/10 , B65B55/14
摘要： Bioactive hydroforming luminal liner compositions are formed of an absorbable crystalline amphiphilic polyether-ester-urethane dissolved in a liquid derivative of a polyether glycol that undergoes transformation into a tissue-adhering, resilient interior cover or liner for the controlled release of its bioactive payload at clinically compromised conduits in humans as in the case of bacteria- and yeast-infected vaginal canals, esophagi, and arteries following angioplasty.
摘要翻译：生物活性液压成型腔内衬组合物由溶解在聚醚二醇的液体衍生物中的可吸收的结晶两亲性聚醚 - 酯 - 聚氨酯形成，其经历转变成组织粘附的弹性内盖或衬垫，用于临床控制释放其生物活性有效载荷如在细菌和酵母感染的阴道运河，食管和血管成形术后的动脉的情况下，人的受损管道。

157. 发明申请

US20100196196A1 METHOD FOR RADIOCHEMICAL STERILIZATION 有权
标题翻译：放射化学灭菌方法
公开(公告)号：US20100196196A1
公开(公告)日：2010-08-05
申请号：US12658956
申请日：2010-02-18
申请人： Shalaby W. Shalaby
发明人： Shalaby W. Shalaby
IPC分类号： A61L2/20 , A61L2/08 , A61L2/26
CPC分类号： A61L2/204 , A61L2/08 , B65D75/14 , B65D2205/025
摘要： This invention deals with package components for radiochemical sterilization of medical or pharmaceutical products consisting of a hermetically sealed foil pack containing (1) a solid device, as in absorbable sutures and meshes, in a perforated holder or a liquid formulation in a sealed, flexible dispenser, as in absorbable cyanoacrylate-based tissue adhesive; (2) a microparticulate, unstabilized polyformaldehyde as a source of radiolytically generated formaldehyde encased in a sealed pouch comprising a porous, non-woven or woven fabric; and (3) a nitrogenous compound capable of reacting with residual formaldehyde, such as melamine or urea, that is encased in a sealed pouch comprising a porous, non-woven or woven fabric.
摘要翻译：本发明涉及医疗或药物产品的放射化学灭菌的包装组件，其由密封的箔包组成，其包含（1）在可吸收的缝合线和网眼中的固体装置，在穿孔保持器或密封的柔性分配器中的液体制剂中，如可吸收的氰基丙烯酸酯基组织粘合剂; （2）微囊化，未稳定的聚甲醛，作为包含在密封袋中的放射性产生的甲醛的源，其包含多孔，无纺布或机织织物; 和（3）能够与残留的甲醛反应的含氮化合物，例如三聚氰胺或尿素，其被封装在包含多孔，无纺布或机织织物的密封袋中。

158. 发明授权

US07722914B2 Micromantled drug-eluting stent 有权
标题翻译：微胶囊药物洗脱支架
公开(公告)号：US07722914B2
公开(公告)日：2010-05-25
申请号：US12152390
申请日：2008-05-14
申请人： Shalaby W. Shalaby
发明人： Shalaby W. Shalaby
IPC分类号： B05D3/14 , A61F2/06 , B05C5/04
CPC分类号： A61L17/12 , A61F2/82 , A61F2250/0067 , A61L31/06 , A61L31/10 , A61L31/146 , A61L31/16 , A61L2300/00 , C08G63/08 , C08G63/64 , C08L67/04
摘要： Pharmacologically active, easy-to-deploy, biomechanically compatible, inflatable endovascular, drug-eluting stent are formed of a primary expandable polymeric or metallic construct, intimately mantled with a biomechanically compatible, polymeric microporous, microfibrous, compliant, stretchable fabric formed by direct electrospinning onto the outside surface of the primary construct using at least one polymer solution containing at least one active compound, selected from those expected to control key biological events leading to in-stent restenosis.
摘要翻译：药物活性，易于部署，生物力学兼容，可充气的血管内药物洗脱支架由主要的可扩张聚合物或金属构造体形成，与生物力学相容的聚合物微孔，微纤维，柔顺的可伸缩织物紧密结合，通过直接静电纺丝形成使用至少一种含有至少一种活性化合物的聚合物溶液在主要构建体的外表面上，所述活性化合物选自预期控制导致支架内再狭窄的关键生物学事件的活性化合物。

159. 发明授权

US07709556B2 Radiation and radiochemically sterilized absorbable devices with dose-controlled functional strength retention 失效
标题翻译：具有剂量控制功能强度保持的辐射和放射化学灭菌吸收性设备
公开(公告)号：US07709556B2
公开(公告)日：2010-05-04
申请号：US10683060
申请日：2003-10-09
申请人： Shalaby W. Shalaby
发明人： Shalaby W. Shalaby
IPC分类号： C08J3/28 , C08F2/48 , C08F2/42 , A61K47/00
CPC分类号： A61L24/0042 , A61L2/08 , A61L2/204 , A61L17/12 , A61L17/14 , A61L24/001
摘要： Absorbable radiation or radiochemically sterilized medical devices, including sutures, whose breaking strength and absorption profile can be modulated by controlling the total dose received during sterilization are disclosed.
摘要翻译：公开了可吸收辐射或放射化学消毒的医疗装置，包括缝合线，其断裂强度和吸收曲线可通过控制灭菌期间接收的总剂量来调节。

160. 发明授权

US07694813B2 Package components for radiochemical sterilization 失效
标题翻译：用于放射化学灭菌的包装组件
公开(公告)号：US07694813B2
公开(公告)日：2010-04-13
申请号：US11228719
申请日：2005-09-16
申请人： Shalaby W. Shalaby
发明人： Shalaby W. Shalaby
IPC分类号： A61L2/08
CPC分类号： A61L2/204 , A61L2/08 , B65D75/14 , B65D2205/025
摘要： This invention deals with package components for radiochemical sterilization of medical or pharmaceutical products consisting of a hermetically sealed foil pack containing (1) a solid device, as in absorbable sutures and meshes, in a perforated holder or a liquid formulation in a sealed, flexible dispenser, as in absorbable cyanoacrylate-based tissue adhesive; (2) a microparticulate, unstabilized polyformaldehyde as a source of radiolytically generated formaldehyde encased in a sealed pouch comprising a porous, non-woven or woven fabric; and (3) a nitrogenous compound capable of reacting with residual formaldehyde, such as melamine or urea, that is encased in a sealed pouch comprising a porous, non-woven or woven fabric.
摘要翻译：本发明涉及医疗或药物产品的放射化学灭菌的包装组件，其由密封的箔包组成，其包含（1）在可吸收的缝合线和网眼中的固体装置，在穿孔保持器或密封的柔性分配器中的液体制剂中，如可吸收的氰基丙烯酸酯基组织粘合剂; （2）微囊化，未稳定的聚甲醛，作为包含在密封袋中的放射性产生的甲醛的源，其包含多孔，无纺布或机织织物; 和（3）能够与残留的甲醛反应的含氮化合物，例如三聚氰胺或尿素，其被封装在包含多孔，无纺布或机织织物的密封袋中。

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