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151. 发明申请

US20120208234A1 PROTEIN HAVING AFFINITY FOR IMMUNOGLOBULIN, AND IMMUNOGLOBULIN-BINDING AFFINITY LIGAND 有权
标题翻译：具有免疫球蛋白的免疫原性蛋白质和免疫球蛋白结合亲和力配体
公开(公告)号：US20120208234A1
公开(公告)日：2012-08-16
申请号：US13258655
申请日：2010-03-24
申请人： Shinichi Yoshida , Dai Murata , Masayuki Takano , Junya Akagi , Keita Iguchi , Yoshiyuki Nakano
发明人： Shinichi Yoshida , Dai Murata , Masayuki Takano , Junya Akagi , Keita Iguchi , Yoshiyuki Nakano
IPC分类号： C12P21/02 , C07K19/00 , C12N15/31 , C12N15/62 , C12N1/21 , C07K16/12 , C07K1/14 , C07K14/31 , C12N15/74
CPC分类号： C07K14/47 , B01D15/3809 , B01J20/286 , B01J20/3244 , B01J20/3274 , C07K14/31
摘要： An object of the present invention is to create a novel engineered Protein A ligand having better antibody dissociation properties in the presence of an acid than conventional engineered Protein A ligands and a further object of the present invention is to create a novel engineered Protein A ligand having higher alkali resistance. The present invention is to provide a protein having an affinity for an immunoglobulin, including an amino acid sequence derived from any of E, D, A, B and C domains of Protein A, wherein at least one Gly residue in the amino acid sequence is replaced with an amino acid other than Ala, and the protein has a lower affinity for an Fab region of an immunoglobulin than a protein including an amino acid sequence in which the Gly residue is replaced with Ala. Also, the present invention is to provide the protein having an affinity for an immunoglobulin, which has improved chemical stability in an alkaline condition compared to the corresponding domain.
摘要翻译：本发明的一个目的是在酸存在下产生具有比常规工程改造的蛋白A配体更好的抗体解离性能的新型工程改造的蛋白A配体，本发明的另一个目的是产生一种新的工程改造的蛋白A配体，其具有耐碱性较高。本发明提供一种对免疫球蛋白具有亲和性的蛋白质，其包括衍生自蛋白A的E，D，A，B和C结构域中的任一个的氨基酸序列，其中氨基酸序列中至少一个Gly残基为被除Ala以外的氨基酸所取代，并且该蛋白质对包含氨基酸序列的蛋白质的免疫球蛋白Fab区域的亲和力低于其中Gly残基被Ala置换的蛋白质，本发明还提供对于免疫球蛋白具有亲和力的蛋白质，与相应的结构域相比，其在碱性条件下具有改善的化学稳定性。

152. 发明申请

US20120030490A1 COMMUNICATION SYSTEM 有权
标题翻译：通讯系统
公开(公告)号：US20120030490A1
公开(公告)日：2012-02-02
申请号：US13187032
申请日：2011-07-20
申请人： Masahiro Makino , Shinichi Yoshida , Osamu Inagaki
发明人： Masahiro Makino , Shinichi Yoshida , Osamu Inagaki
IPC分类号： G06F1/26 , G06F1/32
CPC分类号： G06F1/3203 , G06F1/3287 , H04L12/12 , H04L12/40039 , H04L2012/40273 , Y02D50/40
摘要： A communication system includes a network formed by a plurality of control units, each operated in a high power consumption mode and a low power consumption mode. A selected one or more of the control units act solely or in cooperation with each other to implement a specific function. Each of the selected one or more of the control units related to the specific function is set in the high power consumption mode. Each of the non-selected control units unrelated to the specific function is set in the low power consumption mode.
摘要翻译：通信系统包括由多个控制单元形成的网络，每个控制单元以高功耗模式和低功耗模式运行。所选择的一个或多个控制单元相互作用或彼此协作以实现特定功能。与特定功能相关的所选择的一个或多个控制单元中的每一个被设置在高功耗模式中。与特定功能无关的每个未选择的控制单元被设置在低功耗模式中。

153. 发明申请

US20110053790A1 METHOD AND KIT FOR DETECTION OF MICROORGANISM 有权
标题翻译：用于检测微生物的方法和工具包
公开(公告)号：US20110053790A1
公开(公告)日：2011-03-03
申请号：US12445506
申请日：2008-08-01
申请人： Shinichi Yoshida , Takashi Soejima
发明人： Shinichi Yoshida , Takashi Soejima
IPC分类号： C40B30/04 , C12Q1/68 , C40B99/00
CPC分类号： C12Q1/68 , C12Q1/689 , C12Q2523/101
摘要： A live cell of microorganism in a test sample is detected by the following steps of: a) adding a cross-linker capable of cross-linking a DNA by irradiation with light having a wavelength of 350 nm to 700 nm to the test sample; b) irradiating the test sample to which the cross-linker is added with light having a wavelength of 350 nm to 700 nm; c) removing the cross-linker contained in the test sample irradiated with light; d) adding a medium to the test sample from which the cross-linker is removed and incubating the test sample; e) adding again the cross-linker capable of cross-linking a DNA by irradiation with light having a wavelength of 350 nm to 700 nm to the incubated test sample; f) irradiating the test sample to which the cross-linker is added with light having a wavelength of 350 nm to 700 nm; g) extracting a DNA from the test sample and amplifying a target region of the extracted DNA by a nucleic acid amplification method; and h) analyzing the amplified product.
摘要翻译：通过以下步骤检测测试样品中微生物的活细胞：a）通过用波长为350nm至700nm的光照射能够将DNA交联的交联剂加入到测试样品中; b）用波长为350nm至700nm的光照射加入交联剂的测试样品; c）除去用光照射的测试样品中所含的交联剂; d）向测试样品中加入培养基，从中除去交联剂并培养测试样品; e）再次加入能够通过用波长为350nm至700nm的光照射到孵育的测试样品的DNA来交联DNA的交联剂; f）用波长为350nm至700nm的光照射加入交联剂的测试样品; g）从测试样品中提取DNA并通过核酸扩增方法扩增提取的DNA的靶区域; 和h）分析扩增产物。

154. 发明申请

US20100078745A1 SOLID-STATE IMAGING DEVICE, METHOD FOR MANUFACTURING SOLID-STATE IMAGING DEVICE, AND ELECTRONIC APPARATUS 失效
标题翻译：固态成像装置，制造固态成像装置的方法和电子装置
公开(公告)号：US20100078745A1
公开(公告)日：2010-04-01
申请号：US12567345
申请日：2009-09-25
申请人： Hiromi Wano , Takamasa Tanikuni , Shinichi Yoshida
发明人： Hiromi Wano , Takamasa Tanikuni , Shinichi Yoshida
IPC分类号： H01L31/0232
CPC分类号： H01L27/14685 , H01L27/14603 , H01L27/14629
摘要： A solid-state imaging device includes a light-receiving portion, which serves as a pixel, and a waveguide, which is disposed at a location in accordance with the light-receiving portion and which includes a clad layer and a core layer embedded having a refractive index distribution in the wave-guiding direction.
摘要翻译：固态成像装置包括：作为像素的受光部和配置在与受光部相对的位置的波导，该波导包括包覆层和芯层，波导方向的折射率分布。

155. 发明授权

US07598254B2 Substituted 1,3-thiazolo[5,4-d]pyrimidines as xanthine oxidase inhibitors 有权
标题翻译：取代的1,3-噻唑并[5,4-d]嘧啶黄嘌呤氧化酶抑制剂
公开(公告)号：US07598254B2
公开(公告)日：2009-10-06
申请号：US11629277
申请日：2005-06-13
申请人： Shinichi Yoshida , Kunio Kobayashi , Nobutaka Mochiduki , Tomio Yamakawa , Tadashi Kobayashi , Yoriko Shinohara
发明人： Shinichi Yoshida , Kunio Kobayashi , Nobutaka Mochiduki , Tomio Yamakawa , Tadashi Kobayashi , Yoriko Shinohara
IPC分类号： C07D513/04 , A61K31/519 , A61P19/06 , C07D515/04
CPC分类号： C07D513/04 , C07D498/04
摘要： The invention relates to compounds of the following formula (I) or their salts: in which R1 is a group of phenyl, naphthyl, pyridyl or the like which may have a substituent such as an alkyl group having 1-8 carbon atoms, an alkoxy group having 1-8 carbon atoms, an alkoxycarbonyl group having 2-8 carbon atoms, carboxyl, halogen, hydroxyl, nitro, or cyano; R2 is cyano, nitro, or the like; R3 is hydroxyl or the like; X is oxygen, sulfur, or the like; and Y is oxygen or sulfur, and a xanthine oxidase inhibitor containing the compound.
摘要翻译：本发明涉及下式（I）的化合物或其盐：其中R 1为可具有取代基的苯基，萘基，吡啶基等基团，例如具有1-8个碳原子的烷基，烷氧基具有1-8个碳原子的基团，具有2-8个碳原子的烷氧基羰基，羧基，卤素，羟基，硝基或氰基; R2是氰基，硝基等; R3是羟基等; X是氧，硫等; Y为氧或硫，含有该化合物的黄嘌呤氧化酶抑制剂。

156. 发明授权

US07493469B2 Performance evaluation apparatus, performance evaluation method, program and computer readable recording medium 失效
标题翻译：性能评估装置，性能评估方法，程序和计算机可读记录介质
公开(公告)号：US07493469B2
公开(公告)日：2009-02-17
申请号：US11078422
申请日：2005-03-14
申请人： Ricardo T. Shichiku , Shinichi Yoshida
发明人： Ricardo T. Shichiku , Shinichi Yoshida
IPC分类号： G06F15/00 , G06F9/30 , G06F12/00 , G06F9/26
CPC分类号： G06F11/3404 , G06F11/3409
摘要： From an application program described in the form of a flow graph, input and output arcs are extracted. Packet rates on the input and output arcs are extracted, and it is determined whether the packet rates of the input arc and the output arc are lower than an upper-limit value of a pipeline transfer rate of a processor element. Based on the determination result, it is determined whether it is possible to execute the described flow graph program in the processor element. Performance evaluation of a program to be executed by a data driven processor based on an asynchronous pipeline transfer control can be carried out with ease and in a short time.
摘要翻译：从流程图形式描述的应用程序中，提取输入和输出弧。提取输入和输出弧上的分组速率，确定输入弧和输出弧的分组速率是否低于处理器元件的流水线传送速率的上限值。基于确定结果，确定是否可以在处理器元件中执行所描述的流程图程序。由数据驱动处理器基于异步流水线传送控制执行的程序的性能评估可以在短时间内轻松进行。

157. 发明授权

US07483427B2 Data driven type information processing apparatus and method of increasing transfer speed of data packet 失效
标题翻译：数据驱动型信息处理装置和数据包传送速度提高的方法
公开(公告)号：US07483427B2
公开(公告)日：2009-01-27
申请号：US11052901
申请日：2005-02-09
申请人： Shinichi Yoshida , Tsuyoshi Muramatsu
发明人： Shinichi Yoshida , Tsuyoshi Muramatsu
IPC分类号： H04L12/28
CPC分类号： H04L47/10 , G06F9/4494
摘要： A branching control unit includes a logic gate and a NAND circuit that can receive transfer permission for each branching designation. The branching control unit further includes a transfer request unit receiving respective outputs of the logic gate and NAND circuit. The transfer request unit sends a data transfer request to a branching designation when the logic gate or NAND circuit is rendered active. Since transfer permission can be received for each branching designation to send a transfer request, a data waiting state depending upon the data holding state of another branching destination will no longer occur. Thus, a data driven type information processing apparatus and method of transferring a data packet at higher speed in a data transmission path can be provided.
摘要翻译：分支控制单元包括可以接收每个分支指定的传送许可的逻辑门和NAND电路。分支控制单元还包括接收逻辑门和NAND电路的各个输出的传送请求单元。当逻辑门或NAND电路被激活时，传送请求单元将数据传送请求发送到分支指定。由于可以为每个分支指定接收到传送许可以发送传送请求，所以将不再发生根据另一分支目的地的数据保持状态的数据等待状态。因此，可以提供数据驱动型信息处理装置和在数据传输路径中以较高速度传输数据包的方法。

158. 发明申请

US20090018629A1 Heat exchanger, method for manufacturing the same, and heart-lung machine 有权
标题翻译：换热器，制造方法及心肺机
公开(公告)号：US20090018629A1
公开(公告)日：2009-01-15
申请号：US10584478
申请日：2005-02-07
申请人： Shinichi Yoshida , Minoru Tanaka , Tomokazu Niitsuma
发明人： Shinichi Yoshida , Minoru Tanaka , Tomokazu Niitsuma
IPC分类号： A61F7/12 , F28D7/00 , B23P15/26 , F28F9/02
CPC分类号： F28F9/0229 , A61M1/1698 , A61M1/369 , A61M2205/366 , F28D7/1653 , F28F2265/16 , Y10T29/49391
摘要： In a heat exchanger including a plurality of tubes 1 through which a first fluid passes, a housing 2 in which the tubes 1 are installed, and sealing members for sealing a second fluid that flows over surfaces of the tubes 1, the housing 2 includes an inlet 4 for introducing the second fluid therein and a first outlet 5 and second outlets 6 for discharging the second fluid, and the sealing members include a first sealing member 3a positioned on one of end sides of the tubes 1, a second sealing member 3b positioned on the other end side of the tubes 1, and a third sealing member 3c positioned between the first and second sealing members 3a and 3b. The third sealing member 3c is provided so that a gap 7 is provided between the first sealing member 3a and the third sealing member 3c while another gap 7 is provided between the second sealing member 3b and the third sealing member 3c, and that a flow path for the second fluid is formed therein. The second outlets 6 are provided so as to be connected to the gaps 7.
摘要翻译：在包括第一流体通过的多个管1的热交换器中，安装管1的壳体2和用于密封在管1的表面上流动的第二流体的密封构件，壳体2包括用于在其中引入第二流体的入口4和用于排出第二流体的第一出口5和第二出口6，并且密封构件包括位于管1的一端的第一密封构件3a，第二密封构件3b定位在管1的另一端侧和位于第一密封件3a和第二密封件3b之间的第三密封件3c。第三密封构件3c设置成在第一密封构件3a和第三密封构件3c之间设置有间隙7，而在第二密封构件3b和第三密封构件3c之间设置有间隙7，因为在其中形成第二流体。第二出口6设置成与间隙7连接。

159. 发明申请

US20080049373A1 High voltage output device and ion generator provided therewith 审中-公开
标题翻译：提供高电压输出装置和离子发生器
公开(公告)号：US20080049373A1
公开(公告)日：2008-02-28
申请号：US11826757
申请日：2007-07-18
申请人： Masakazu Ikeda , Masayuki Ehiro , Atsushi Yamashita , Shinichi Yoshida , Manabu Yumoto
发明人： Masakazu Ikeda , Masayuki Ehiro , Atsushi Yamashita , Shinichi Yoshida , Manabu Yumoto
IPC分类号： H01J3/04
CPC分类号： H01T23/00
摘要： A high voltage output device in accordance with the present invention, which comprises a transformer that amplifies a voltage being fed to a primary side coil thereof so as to be produced from a secondary side coil thereof, and in which an alternate current input voltage is fed from the primary side coil, and an output voltage is taken out from the secondary side coil, further comprises a feedback circuit that feeds back the output voltage, and a voltage amplifying circuit that amplifies the voltage being fed back so as to be fed to the primary side coil. As a result, it is possible to provide such a high voltage output device as can obtain an output voltage efficiently, although a load capacity on a secondary side of a transformer fluctuates.
摘要翻译：本发明的高电压输出装置，其特征在于，包括：变压器，其放大从其一次侧线圈供给的电压，从其二次侧线圈产生，并输入交流输入电压并且从次级侧线圈取出输出电压，还包括反馈输出电压的反馈电路和放大反馈电压的电压放大电路，以将其馈送到初级侧线圈结果，尽管变压器次级侧的负载容量波动，但是可以提供这样的高电压输出装置，可以有效地获得输出电压。

160. 发明申请

US20070229673A1 IMAGE CAPTURING APPARATUS 审中-公开
标题翻译：图像捕获设备
公开(公告)号：US20070229673A1
公开(公告)日：2007-10-04
申请号：US11533112
申请日：2006-09-19
申请人： Yoshitaka Araya , Masanori Sonoi , Shinichi Yoshida
发明人： Yoshitaka Araya , Masanori Sonoi , Shinichi Yoshida
IPC分类号： H04N5/225
CPC分类号： H04N5/772 , H04N5/23232 , H04N5/23245 , H04N9/7921 , H04N9/8042 , H04N9/8205
摘要： During capture of a motion picture, a still image of high resolution and frame images of a moving mage are formed from one image signal. Each of the frame images is synthesized with a tag image for identifying the frame image. A motion picture is formed from the frame image synthesized with the tag image. Concurrently, data pertaining to a difference between the frame image synthesized with the tag image and the still image are computed, and the difference data are stored in a storage device. The still image is deleted. At this time, an address of difference data and details of the tag image synthesized with the frame image are recorded in an associated manner as index information. When the still image is formed from an arbitrary frame image of the motion picture, the frame image is identified by reference to the tag image, and an identification result is utilized.
摘要翻译：在拍摄动态图像期间，从一个图像信号形成高分辨率的静止图像和移动的法师的帧图像。每个帧图像与用于识别帧图像的标签图像合成。从与标签图像合成的帧图像形成运动图像。同时，计算关于与标签图像合成的帧图像与静止图像之间的差异的数据，并将差异数据存储在存储装置中。静止图像被删除。此时，以相关联的方式记录与帧图像合成的差分数据和标签图像的细节的地址作为索引信息。当静止图像由运动图像的任意帧图像形成时，通过参照标签图像来识别帧图像，并且利用识别结果。

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