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141. 发明专利

AU5329073A ISOINDOLINE DERIVATIVES 未知
公开(公告)号：AU5329073A
公开(公告)日：1974-09-19
申请号：AU5329073
申请日：1973-03-14
申请人： RHONE POULENC SA
发明人： MESSER MAYER NAOUM , JEANMART CALUDE , COTREL CLAUDE
IPC分类号： C07D209/44 , A61K31/40 , A61K31/403 , A61K31/4035 , A61P9/06 , C07D209/48 , C07D215/48 , C07D303/36 , C07D401/04 , C07D403/04 , C07D405/12 , C07D405/14 , C07D27/50 , A61K27/00
摘要： Isoindolin-1-one derivatives substituted on the nitrogen atom in the 2-position by an unsubstituted or substituted phenyl radical or a heterocyclic radical having aromatic characteristics, substituted in the 3-position by a 3-amino(or substituted amino)-2-hydroxypropoxy group, and optionally substituted in the 5- and/or 6-positions by one or two alkoxy radicals or optionally substituted in the 5- and 6-positions by a methylenedioxy radical, possess pharmacodynamic properties, and are especially useful as antiarrhythmic agents.

142. 发明专利

AU5183273A ISOINDOLE DERIVATIVES 未知
公开(公告)号：AU5183273A
公开(公告)日：1974-08-08
申请号：AU5183273
申请日：1973-02-05
申请人： SANDOZ AG
发明人： EBERLE MARCEL K
IPC分类号： C07D209/44 , C07D27/50 , A61K27/00

143. 发明专利

GB1359178A 2-SUBSTITUTED-3-METHYLENE-6-NITROISOINDOL-1-ONES 未知
公开(公告)号：GB1359178A
公开(公告)日：1974-07-10
申请号：GB5257471
申请日：1971-11-12
申请人： BASF AG
IPC分类号： C07D209/46 , C07D27/50
摘要： 1359178 2 Substituted - 3 - methylene - 6- nitro - isoindol -1 - ones BADISCHE ANILIN- & SODA-FABRIK AG 12 Nov 1971 [13 Nov 1970] 52574/71 Heading C2C The invention comprises a 2-substituted-3- methylene-6-nitro - isoindol - 1 - one of the formula in which n is one of the integers 1 and 2; and R is unsubstituted or substituted alkyl or cycloalkyl when n is 1 and alkylene of two to six carbon atoms or cyclohexylene when n is 2. These compounds may be prepared by reacting a compound of the formula with formaldehyde or with an agent yielding formaldehyde, in aqueous or aqueous-organic solution, preferably in the presence of a basic condensing agent.

144. 发明专利

CH548386A 5-substd-5-hydroxy-2,3-dihydro-5h-imidazo (2 未知
公开(公告)号：CH548386A
公开(公告)日：1974-04-30
申请号：CH28374
申请日：1971-04-16
申请人： SANDOZ AG
IPC分类号： C07D209/46 , C07D27/50
摘要： 5-Substd-5-hydroxy-2,3-dihydro-5H-imidazo 2,1-a isoindoles prepn. Title cpds. of formula (I) are prepared by reacting novel cpds. (II) with 85-100% H2SO4 or H3PO4 at 15-75 degrees C (pref. 50-65 degrees C). (I) are known anorexics and CNS stimulants. (where R, R1 = H, Cl, F; R2 = 1-5C alkyl or R3,R4 = H, Cl,Br, 1-3C straight chain alkyl. At least one of R3 and R4 is in a position other than ortho when neither are H).

145. 发明专利

DE2242007A1 Phthalimidine and polyphthalimidine prepn - from diphthalides or mono-phthalide carboxylic acids and mono- or polyisocyanates reacted esp. in polar solvents 未知
公开(公告)号：DE2242007A1
公开(公告)日：1974-03-14
申请号：DE2242007
申请日：1972-08-26
申请人： BASF AG
发明人： SPOOR HERBERT DR , KOVACS JENOE DR , SCHEFCZIK ERNST DR
IPC分类号： C07D209/46 , C07D487/04 , C08G69/00 , C08G73/00 , C08G73/06 , C07D27/50
摘要： Phthalimidines are prepd. by reacting diphthalides or monophthalide carboxylic acids having the general formula R1R2Ar-CO-O-CH2 (I) (where R1 and R2 as well as -CO-O-CH2 are each linked to vicinal C atoms of a benzene ring; Ar denotes 1 or 2 linked benzene rings which may be linked by a gp. X, where X is -O-, -S-, -CO-, alkylene or -p-NH-CO-C6H4-CO-NH-; R1 and R2 together form a -CO-O-CH2- gp. or R1 is COOH and R2 is H) with isocyanates in anhydrous polar solvents. Reaction with polyisocyanates may take place in the presence of aromatic dicarboxylic acids, to form amide-contg. copolymers or polyphthalimidine amides. Lower phthalimides can be converted to aromatic tri- and tetracarboxylic acids. Higher phthalimidines or phthalimidine amides are interesting polymers for prepn. of coatings, esp. wire lacquers, laminates and fibres.

146. 发明专利

GB1344663A ISOINDOLINE COMPOUNDS 未知
公开(公告)号：GB1344663A
公开(公告)日：1974-01-23
申请号：GB4991871
申请日：1971-10-27
申请人： ERBA CARLO SPA
IPC分类号： C07D209/44 , C07D209/46 , C07D27/50 , A61K27/00
摘要： 1344663 Isoindolinone derivatives CARLO ERBA SpA 27 Oct 1971 [5 Nov 1970 10 Nov 1970] 49918/71 Heading C2C The invention comprises compounds of formula wherein R is H or C 1-4 alkyl, R 1 is H, alkyl or (CH 2 ) n NR 2 R 3 , n is 1 or 2 and R 2 , R 3 are each H or C 1-4 alkyl, and their physiologically acceptable addition salts (where R 1 is H or aminoalkyl). In examples, these compounds are prepared (1) when R 1 is H, by hydrolysing (a) the corresponding esters or nitriles (II), or (b) the analogous iminoisoindolinecarboxylic acids or alkyl esters; (2) when R 1 is alkyl, by (a) esterifying the acids, (b) reducing the analogous phthalimide compounds, (c) reacting the corresponding alkyl p-aminophenylacetates with phthalide, thiophthalide or phthalaldehyde; (3) when R 1 is aminoalkyl, by reacting the corresponding acid chlorides with R 2 R 3 N(CH 2 ) n OH. Also prepared are the iminoisoindoline and phthalimide analogues of II. Therapeutic compositions having analgesic and anti-inflammatory activity comprise compounds of the above formula, and may be administered orally, parenterally, rectally or topically.

147. 发明专利

HU164127B 未知
公开(公告)号：HU164127B
公开(公告)日：1973-12-28
申请号：HUSA002330
申请日：1972-03-17
IPC分类号： C07D209/46 , C07D209/48 , C07D209/50 , C07D307/89 , C07D27/50

148. 发明专利

HU163610B 未知
公开(公告)号：HU163610B
公开(公告)日：1973-09-27
申请号：HURO000657
申请日：1972-05-02
IPC分类号： C07D209/02 , C07D209/46 , C07D209/48 , C07D237/20 , C07D237/22 , C07D295/10 , C07D57/00 , C07D27/50 , C07D51/04 , C07D51/70

149. 发明专利

NL7303291A 未知
公开(公告)号：NL7303291A
公开(公告)日：1973-09-18
申请号：NL7303291
申请日：1973-03-08
IPC分类号： C07D209/44 , A61K31/40 , A61K31/403 , A61K31/4035 , A61P9/06 , C07D209/48 , C07D215/48 , C07D303/36 , C07D401/04 , C07D403/04 , C07D405/12 , C07D405/14 , C07D27/50 , C07D57/00 , C07D99/02 , A61K27/00
摘要： Isoindolin-1-one derivatives substituted on the nitrogen atom in the 2-position by an unsubstituted or substituted phenyl radical or a heterocyclic radical having aromatic characteristics, substituted in the 3-position by a 3-amino(or substituted amino)-2-hydroxypropoxy group, and optionally substituted in the 5- and/or 6-positions by one or two alkoxy radicals or optionally substituted in the 5- and 6-positions by a methylenedioxy radical, possess pharmacodynamic properties, and are especially useful as antiarrhythmic agents.

150. 发明专利

GB1324936A ISOINDOLINE DERIVATIVES 未知
公开(公告)号：GB1324936A
公开(公告)日：1973-07-25
申请号：GB5781371
申请日：1971-12-13
申请人： RHONE POULENC SA
IPC分类号： C07D209/48 , C07D27/50 , A61K27/00 , C07D99/02
摘要： 1324936 Derivatives of 3-hydroxy-2-phenylisoindolinone RHONE-POULENC SA 13 Dec 1971 [14 Dec 1970] 57813/71 Heading C2C The invention comprises compounds of formula and their acid addition salts wherein X is halogen, C 1-4 alkyl or NO 2 , m is 0-4, Y is halogen, CN or NO 2 , or C 1-4 alkyl or alkoxy, and n is 0-5; R 1 is H or C 1-4 alkyl, and R 2 is C 1-4 alkyl or di-(C 1-4 alkyl)-amino-C 1-4 -alkyl, or NR 1 R 2 is a 5- or 6-membered monocyclic heterocyclic radical, possibly substituted by C 1-4 alkyl or hydroxyalkyl. These compounds may be prepared by reacting (a) a corresponding 3-hydroxy isoindolinone, in the form of its alkali metal salt, with ClCONR 1 R 2 , or (b) a corresponding phenyl/ 3-hydroxyindolinonyl carbonate with HNR 1 R 2 , the phenyl being optionally C 1-4 -alkyl-substituted. N-(3-cyanophenyl)phthalimide is also prepared. Therapeutic compositions having anticonvulsant and tranquillizing activity comprise compounds of the above formula, which may be administered orally, parenterally, rectally or topically.

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