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141. 发明授权

EP0611315B1 METHOD AND APPARATUS FOR HEART TRANSPLANT MONITORING AND ANALOG TELEMETRY CALIBRATION 失效
标题翻译：方法和仪器监测心脏移植和校准模拟遥测
公开(公告)号：EP0611315B1
公开(公告)日：1997-11-05
申请号：EP93912212.3
申请日：1993-04-12
申请人： MEDTRONIC, INC.
发明人： WAHLSTRAND, John, D. , MULIER, Peter, M., J. , THOMPSON, David, L.
IPC分类号： A61N1/372
CPC分类号： A61N1/37211 , A61B5/0002 , A61B5/0006 , A61B5/413 , A61N1/37252
摘要： A cardiac pacemaker with an analog telemetry system. A calibration circuit within the pacemaker is adapted to provide a reference signal of known character to the pacemaker's telemetry system. The reference signal is transmitted across the telemetry link as if it were an actual cardiac signal, and received by an external programmer. Since the reference signal has known, predetermined qualities, the programmer can automatically calibrate and scale the telemetry signal from the pacemaker, thereby increasing the accuracy of the telemetry channel. The increased accuracy is particularly useful in assessing rejection of a transplanted heart, which is known to be associated with a 15 % decline in the peak R-wave amplitude of the cardiac signal.

142. 发明授权

EP0407647B1 Einrichtung zur Bewertung ausgewählter Signalanteile in physiologischen Messsignalen, insbesondere von Spätpotentialen in Elektrokardiogrammen 失效
标题翻译：用于评估生理信号中特定信号部分的设备，特别是电磁场中的潜在信号
公开(公告)号：EP0407647B1
公开(公告)日：1993-10-06
申请号：EP89112971.0
申请日：1989-07-14
申请人： Haberl, Ralph, Dr.med. , Steinbeck, Gerhard, Prof.Dr.med.
发明人： Haberl, Ralph, Dr. med. , Schels, Hans F., Dipl.-Phys.
IPC分类号： G06F15/20
CPC分类号： A61B5/0452 , A61B5/413 , A61B5/7257

143. 发明公开

EP0545242A1 Vorrichtung zur Bestimmung medizinischer, organ- oder stoffwechselfunktionsrelevanter, elektrochemischer Messgrössen 失效
标题翻译：装置用于确定医疗，器官或代谢功能相关，电化学测量参数。
公开(公告)号：EP0545242A1
公开(公告)日：1993-06-09
申请号：EP92120049.9
申请日：1992-11-25
申请人： Fenzlein, Paul-Gerhard
发明人： Fenzlein, Paul-Gerhard , Anderer, Wolfgang, Dr.
IPC分类号： A61B5/00 , G01N27/416
CPC分类号： A61B5/1495 , A61B5/413 , A61B2562/085
摘要： Eine Meßvorrichtung zur Bestimmung medizinischer, Organ- oder Stoftwechsel-funktionsrelevanter, elektrochemischer Meßgrößen umfasst einen Sensorkopf (1), ein Kopplungsteil (2) an dem der Sensorkopf (1) auswechselbar befestigt ist und ein mikroprozessor-gesteuertes Basisgerät (5), das versehen ist mit einer zentralen Steuereinheit (Mikroprozessor 6), mit einer Meßwerterfassungs- und -auswerteeinrichtung (7) zur Erfassung und Umrechnung der vom Kopplungsteil (2) herangeführten Meßsignale entsprechend einer jeweils zugeordneten Kalibriervorschrift, mit einer Anzeigeeinheit (8) zur Anzeige von Meßwerten und mit einer Tastatur (11) zur Eingabe meßrelevanter Informationen. Der Sensorkopf (1) ist mit seinen Meßelektroden herstellungsseitig standardisiert vorkalibriert, wobei die jeweils einer bestimmten Meßelektrode zugeordneten Kalibriervorschriften im Basisgerät (5) abgespeichert sind und beim Meßeinsatz eines Sensorkopfes (1) die Meßwerterfassungs- und -auswerteeinrichtung (7) durch eine entsprechende externe Eingabe am Basisgerät gesteuert auf die der jeweils im Sensorkopf (1) vorhandenen Meßelektrode zugeordnete Kalibriervorschrift zugreift.
摘要翻译：用于确定医疗，器官或Stoftwechsel-功能相关的，电化学的测量值的测量装置包括一个传感器头（1），（2），以将传感器头（1），其安装可更换的连接部和一个微处理器控制的基本单元（5），其被提供与中央控制单元（微处理器6），与数据采集和分析装置（7），用于检测和所述联接部件的转化率（2）提出了对应于相应的相关联的Kalibriervorschrift测量信号，与显示单元（8），用于显示测量的值，并用键盘（11）进入meßrelevanter信息。传感器头（1）是预校准的标准化生产侧与它的测量电极，其中每个特定测量电极相关联的校准要求被存储在基本单元（5），并且在传感器头的测量嵌件（1）所述数据采集和分析装置（7）通过一个相应的外部输入基本单元上控制为每个现有的传感器头（1）测量电极相关Kalibriervorschrift访问的顶部。

144. 发明授权

EP0268708B1 Apparatus for recognising rejection of transplanted hearts 失效转让
标题翻译：用于识别移动听力的拒绝的装置
公开(公告)号：EP0268708B1
公开(公告)日：1992-10-07
申请号：EP86309102.1
申请日：1986-11-20
申请人： Davies, David Wyn , SIEMENS AKTIENGESELLSCHAFT
发明人： Davies, David Wyn Department of Cardiology , Lekholm, Bengt Anders
IPC分类号： A61B5/04
CPC分类号： A61B5/413 , A61B5/0006 , A61B5/0452 , A61B5/7239

145. 发明公开

EP0489010A1 CARDIAC BIOPOTENTIAL ANALYSIS SYSTEM AND METHOD 失效
标题翻译：心脏生物分析系统与方法
公开(公告)号：EP0489010A1
公开(公告)日：1992-06-10
申请号：EP90905061.0
申请日：1990-03-13
申请人： ASPECT SYSTEMS CORPORATION
发明人： CHAMOUN, Nassib, G.
IPC分类号： A61B5 , A61B10 , G06F17
CPC分类号： A61B5/044 , A61B5/0452 , A61B5/04525 , A61B5/0464 , A61B5/413 , A61B5/7257 , A61B5/7275 , G06F19/00
摘要： Disclosed is a cardiac biopotential analysis system and method for detecting and quantifying in a noninvasive manner nonlinear dynamic patterns of depolarization and repolarization on a beat to beat basis in real time using bispectral analysis. A suitable body surface electrode acquires the signal from a region of interest. The signal is then amplified, digitized, and transmitted to a host microcomputer where an arrhythmia-free QRST complex is chosen interactively. Using standard cross-correlation methods a suitable number of complexes are extracted from the record. The extracted complexes are used to compute bispectral parameters using a frequency domain or a parametric based approach. A reference clinical database is used to identify frequency pairs most sensitive to particular interventions or diagnostic states of interest. The values at these frequency pairs are then extracted from the patient's bispectral arrays. The ensemble of values for the particular diagnostic determination under consideration is used to compute a single value index which serves as the diagnostic criterion by which the patient's state is judged. In this way the quantification of nonlinear dynamic properties of the frequency structure of the QRST yields information about the presence and extent of coronary artery disease (CAD), myocardial ischemia, cardiac electrical stability, risk of malignant ventricular arrhydthmia, site(s) of origin of malignant arrhythmias, extent of malignancy of arrhythmias, degree of antiarrhythmic drug efficacy, neural and humoral inputs to the heart, pump function/ejection fraction, and ongoing organ rejection in cardiac transplant patients.
摘要翻译：连接到患者（100）的导线（101）通过电缆（102）将具有串行接口的ECG信号收集到16信道ECG数据收集系统（104）。系统（104）对ECG的波形进行滤波，放大和数字转换，并使用高速同步串行线路（106）将数据发送到微型计算机（110）。微型计算机处理这个数据流以产生数据表。这些与预定参考表结合使用以产生诊断指数。这些索引显示在屏幕上（108）。在连接到微型计算机（110）的打印机（116）上有纸张输出。操作员和系统之间的交互通过键盘（112）和在屏幕（108）上具有反馈的“鼠标”（114）来实现。

146. 发明公开

EP3094245A1 HEALTH MONITORING SYSTEM 审中-公开
标题翻译：健康监测系统
公开(公告)号：EP3094245A1
公开(公告)日：2016-11-23
申请号：EP15700235.3
申请日：2015-01-13
申请人： Dermal Devices INC.
发明人： RUSU, Ana , DUENAS, Saul Alejandro Rodriguez , OLLMAR, Stig
IPC分类号： A61B5/053 , A61B5/07 , A61B5/145 , A61B5/01 , A61B5/1455
CPC分类号： A61B5/0538 , A61B5/0022 , A61B5/0031 , A61B5/01 , A61B5/053 , A61B5/0537 , A61B5/076 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/14551 , A61B5/1473 , A61B5/18 , A61B5/413 , A61B5/4318 , A61B5/4833 , A61B5/4878 , A61B5/7278 , A61B5/742 , A61B5/747 , A61B10/0012 , A61B2010/0019 , A61B2503/22 , A61B2560/0219
摘要： The present invention relates to a health monitoring system comprising an implantable sensor configured to measure impedance within a body tissue of the subject resulting from an electrical current flowing through said body tissue, wherein the body tissue is sub-dermal or subcutaneous tissue of said subject, the sensor including a powering and communication circuit having a coil configured to be powered by an electromagnetic field and to communicate with external devices. Further, the system comprises a reader module including a coil configured to produce the electromagnetic field for powering the powering and communication circuit and for communicating with the powering and communication circuit, a computing device comprising a display device, a processing device and at least one storage device, the computing device being configured to communicate with other devices via at least one wireless network and a monitoring engine for determining or monitoring at least one physiological parameter based on measured impedance, wherein the reader module and the computing device and the monitoring engine are configured to communicate with each other.

147. 发明授权

EP1750501B1 APPARATUS AND METHOD FOR PERFUSION AND DETERMINING THE VIABILITY OF AN ORGAN 有权
标题翻译：方法和设备灌注与测定机构的生存能力
公开(公告)号：EP1750501B1
公开(公告)日：2016-03-23
申请号：EP05817022.6
申请日：2005-05-09
申请人： Organ Recovery Systems, Inc.
发明人： BRASSIL, John , BAICU, Simona
IPC分类号： A01N1/02 , A61B5/02 , A61B5/04
CPC分类号： A61B5/14525 , A01N1/02 , A01N1/0247 , A61B5/413

148. 发明公开

EP2982978A1 METHODS OF TREATING DISEASES 审中-公开
标题翻译： VERFAHREN ZUR BEHANDLUNG VON KRANKHEITEN
公开(公告)号：EP2982978A1
公开(公告)日：2016-02-10
申请号：EP15170346.9
申请日：2010-05-27
申请人： Immunaid Pty Ltd
发明人： ASHDOWN, Martin, Leonard , ROBINSON, Andrew
IPC分类号： G01N33/48 , G01N33/68 , G01N33/574 , G06N3/00 , G01N33/564 , G06F19/12 , A61B5/00 , G06F19/24 , G06F19/00
CPC分类号： G06F19/12 , A61B5/41 , A61B5/413 , A61B5/4836 , A61B5/7267 , A61K31/495 , G01N33/564 , G01N33/57407 , G01N33/68 , G01N2333/4737 , G01N2800/042 , G01N2800/102 , G01N2800/104 , G01N2800/24 , G01N2800/28 , G01N2800/2821 , G01N2800/2828 , G01N2800/52 , G01N2800/60 , G06F19/00 , G06F19/24 , G06F19/34 , G16H50/50
摘要： The present invention relates to computer-implemented methods and system for analysing a biomarker which cycles in a subject. In some other aspects, the present invention relates to analysing a biomarker which at least initially increases or decreases in amount in a subject following a treatment for a disease. In further aspects, the present invention relates to computer-implemented methods and systems for determining a preferred time to administer a therapy to treat a disease in a subject. The present invention also relates to computer program product to implement the methods. Further, the present invention relates to methods of determining the timing of treating a disease in a subject in which the immune system is cycling.
摘要翻译：本发明涉及用于分析在受试者中循环的生物标志物的计算机实现的方法和系统。在一些其它方面，本发明涉及分析生物标志物，其在治疗疾病之后至少最初增加或减少受试者的量。在另外的方面，本发明涉及用于确定施用治疗以治疗受试者的疾病的优选时间的计算机实现的方法和系统。本发明还涉及实现该方法的计算机程序产品。此外，本发明涉及确定在免疫系统循环的受试者中治疗疾病的时机的方法。

149. 发明授权

EP2435825B8 METHODS OF TREATING DISEASES 有权转让
标题翻译：治疗疾病的方法
公开(公告)号：EP2435825B8
公开(公告)日：2015-09-02
申请号：EP10779928.0
申请日：2010-05-27
申请人： Biotempus Limited
发明人： ASHDOWN, Martin, Leonard , ROBINSON, Andrew
IPC分类号： G06F19/12 , G06F19/24 , A61B5/00
CPC分类号： G06F19/12 , A61B5/41 , A61B5/413 , A61B5/4836 , A61B5/7267 , A61K31/495 , G01N33/564 , G01N33/57407 , G01N33/68 , G01N2333/4737 , G01N2800/042 , G01N2800/102 , G01N2800/104 , G01N2800/24 , G01N2800/28 , G01N2800/2821 , G01N2800/2828 , G01N2800/52 , G01N2800/60 , G06F19/00 , G06F19/24 , G06F19/34 , G16H50/50
摘要： The present invention relates to computer-implemented methods and system for analysing a biomarker which cycles in a subject. In some other aspects, the present invention relates to analysing a biomarker which at least initially increases or decreases in amount in a subject following a treatment for a disease. In further aspects, the present invention relates to computer-implemented methods and systems for determining a preferred time to administer a therapy to treat a disease in a subject. The present invention also relates to computer program product to implement the methods. Further, the present invention relates to methods of determining the timing of treating a disease in a subject in which the immune system is cycling.

150. 发明公开

EP2429389A4 SYSTEMS AND METHODS FOR HEART AND ACTIVITY MONITORING 审中-公开
标题翻译：系统和方法对心脏和活动监控
公开(公告)号：EP2429389A4
公开(公告)日：2015-01-28
申请号：EP10775305
申请日：2010-05-07
申请人： QRS HEART INC
发明人： SHOLDER JASON
IPC分类号： A61B5/0402 , A61B5/00 , A61B5/042 , A61B5/0452 , A61B5/11 , G06F19/00
CPC分类号： A61B5/042 , A61B5/0031 , A61B5/0452 , A61B5/1118 , A61B5/413 , A61B5/6882 , A61B5/7275 , A61B2562/0219 , G16H10/60 , G16H15/00 , G16H40/63 , G16H50/20
摘要： Methods and systems for monitoring a heart failure or transplant rejection status of a patient including use of a device or system to collect intramyocardial electrogram (IMEG) signals from the patient at different times automatically when a detected activity level of the patient is below a preset threshold level for a predetermined amount of time, and use of a device or system to generate a status indicator value proportional to a combination of parameters extracted from at least a portion of the collected IMEG signals. Methods and systems can also include measuring time delay values between IMEG signals collected from different locations in the patient. The IMEG signals can be collected from the right ventricular septum and the right ventricular apex of the patient or from the right and left ventricular myocardium of the patient.

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