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141. 发明授权

US08017118B2 Anti-hDlk-1 antibody having an antitumor activity in vivo 有权
标题翻译：具有体内抗肿瘤活性的抗hDlk-1抗体
公开(公告)号：US08017118B2
公开(公告)日：2011-09-13
申请号：US12404419
申请日：2009-03-16
申请人： Koji Nakamura , Rie Tajima , Shankar Kumar , J. Yun Tso , Naoya Tsurushita
发明人： Koji Nakamura , Rie Tajima , Shankar Kumar , J. Yun Tso , Naoya Tsurushita
IPC分类号： C07K16/18
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/28 , C07K2317/24 , C07K2317/56 , C07K2317/73 , C07K2317/732 , C07K2317/77 , C07K2317/92 , G01N2800/00
摘要： The present invention provides antibodies specifically against hDlk-1 and having anti-tumor activity in vivo (anti-hDlk-1 antibodies), a fragments of the antibodies, hybridomas that produce the antibodies, a complex of the antibody or antibody fragment and an agent, a pharmaceutical composition comprising the antibody and the like, a tumor therapeutic agent, a tumor angiogenesis inhibitor, a tumor diagnostic agent, a method for detecting tumor, a kit for detecting and/or diagnosing tumor, etc.
摘要翻译：本发明提供抗体特异性抗体，并具有体内抗肿瘤活性（抗hDlk-1抗体），抗体片段，产生抗体的杂交瘤，抗体或抗体片段的复合物和药剂，包含抗体等的药物组合物，肿瘤治疗剂，肿瘤血管生成抑制剂，肿瘤诊断剂，肿瘤检测方法，肿瘤检测和/或诊断用试剂盒等。

142. 发明授权

US07976420B2 Eccentric oscillating type speed reducer 有权
标题翻译：偏心摆动式减速机
公开(公告)号：US07976420B2
公开(公告)日：2011-07-12
申请号：US12160820
申请日：2007-01-12
申请人： Koji Nakamura
发明人： Koji Nakamura
IPC分类号： F16H57/04 , F16H1/32
CPC分类号： B25J19/0054 , B25J9/102 , F16H1/32 , F16H57/0412
摘要： The present invention provides an eccentric oscillating type speed reducer that can more effectively be cooled with an extremely simple structure.An eccentric oscillating type speed reducer 1 includes a camshaft 11 having crank portions 11a and 11b, a plurality of externally toothed gear members 12 that respectively have holes, each of which accommodates an associated one of the crank portions, and that are eccentrically moved by rotation of the camshaft, an internally toothed gear member 13 having an inner peripheral surface in which internal teeth to be meshed with external teeth formed on external peripheral surfaces of the externally toothed gear members are formed so as to set the number of the internal teeth to be slightly larger than that of external teeth, and support members 14 respectively positioned at both ends of the externally toothed gear members so as to rotatably support both ends of the camshaft. Further, support members 18 and 19 are integrally coupled to each other via a pillar portion 17. In the eccentric oscillating type speed reducer 1, a coolant passage 30 passing through the integrally coupled support members 18 and 10, and the pillar portion 17 is provided. A coolant, such as cooling water or cooling air, is passed through the coolant passage. Consequently, the eccentric oscillating type speed reducer can efficiently be cooled.
摘要翻译：本发明提供一种能够以非常简单的结构更有效地冷却的偏心摆动式减速机。偏心摆动式减速机1包括具有曲柄部分11a和11b的凸轮轴11，分别具有孔的多个外齿轮构件12，每个外齿轮构件12容纳相关联的一个曲柄部分，并且通过旋转偏心地移动凸轮轴的内齿面构成，内周面形成有与形成在外齿轮构件的外周面上的外齿啮合的内齿，从而将内齿的数量设定为稍微大于外齿的位置，以及分别位于外齿轮构件的两端的支撑构件14，以便可旋转地支撑凸轮轴的两端。此外，支撑构件18和19经由柱部17彼此一体地联接。在偏心摆动式减速器1中，设置有穿过整体连接的支撑构件18和10的冷却剂通道30和柱部17 。诸如冷却水或冷却空气的冷却剂通过冷却剂通道。因此，可以有效地冷却偏心摆动式减速机。

143. 发明授权

US07811193B2 Speed reduction device 有权
标题翻译：减速装置
公开(公告)号：US07811193B2
公开(公告)日：2010-10-12
申请号：US12063267
申请日：2006-08-07
申请人： Koji Nakamura
发明人： Koji Nakamura
IPC分类号： F16H1/32
CPC分类号： F16H1/46 , F16H1/32
摘要： A low-noise speed reduction device that is simple in structure, small-sized, and little in energy loss is provided. Two-stage gears, i.e., a large-diameter gear 65 and a small-diameter gear 66 of a third external gear 63 are supported by a supporting shaft 59, and one-stage second external gear 58 that meshes with the small-diameter gear 66 is only attached to an axial one end of a crankshaft 40. Therefore, the axial length of the whole speed reduction device becomes short, and consequently, miniaturization becomes possible. Further, since gears mesh with each other only in two places until a driving force is transmitted to the crankshaft 40 from the first external gear 54, noises can be reduced, and energy loss can also be lowered.
摘要翻译：提供了一种结构简单，体积小，能量损失少的低噪音减速装置。两级齿轮，即第三外齿轮63的大直径齿轮65和小直径齿轮66由支撑轴59支撑，一级第二外齿轮58与小直径齿轮啮合 66仅附接到曲轴40的轴向一端。因此，整个减速装置的轴向长度变短，因此能够实现小型化。此外，由于齿轮仅在两个位置彼此啮合，直到驱动力从第一外齿轮54传递到曲轴40，所以可以降低噪声，并且能量损失也可以降低。

144. 发明申请

US20100199796A1 GEAR DEVICE AND TURNING PORTION STRUCTURE OF INDUSTRIAL ROBOT USING THE GEAR DEVICE 有权
标题翻译：使用齿轮装置的工业机器人的齿轮装置和转向部分结构
公开(公告)号：US20100199796A1
公开(公告)日：2010-08-12
申请号：US12671319
申请日：2008-07-30
申请人： Koji Nakamura
发明人： Koji Nakamura
IPC分类号： B25J17/00 , F16H37/06
CPC分类号： B25J9/102 , F16H1/32 , F16H2001/323 , Y10T74/20317
摘要： A gear device includes: an input gear fixed to an output shaft of a motor; an internal gear; an external gear which rotates while revolving around a central axis of the internal gear while meshing with the internal gear; a carrier supported rotatably within the internal gear and adapted to rotate about the central axis of the internal gear in conjunction with the rotation of the external gear; a plurality of crankshafts which are rotatably supported by the carrier and are adapted to cause the external gear to revolve around the central axis of the internal gear; transmission gears each provided on a central portion of each of the crankshafts; and a cylindrical gear which meshes with the transmission gears of the crankshafts and to which rotation is transmitted from the input gear, wherein the cylindrical gear is located on a radially inner side of an imaginary line passing through a center of rotation of each crankshaft and is rotatably supported by the carrier, and wherein the input gear and the cylindrical gear mesh with each other in an axially central portion of the carrier.
摘要翻译：齿轮装置包括：固定到马达的输出轴的输入齿轮; 内齿轮外齿轮，在与内齿轮啮合的同时围绕内齿轮的中心轴线旋转; 载体，其可旋转地支撑在所述内齿轮内并且适于与所述外齿轮的旋转一起围绕所述内齿轮的中心轴线旋转; 多个曲轴，其由所述托架可旋转地支撑并且适于使所述外齿轮围绕所述内齿轮的中心轴线旋转; 传动齿轮分别设置在每个曲轴的中心部分上; 以及与曲轴的传动齿轮啮合并且从输入齿轮传递旋转的圆柱齿轮，其中圆柱齿轮位于通过每个曲轴的旋转中心的假想线的径向内侧，并且是由所述载体可旋转地支撑，并且其中所述输入齿轮和所述圆柱齿轮在所述载体的轴向中心部分彼此啮合。

145. 发明授权

US07756697B2 Emulator and emulating method for adjusting the execution timing of instructions included in an application to be emulated 有权
标题翻译：用于调整包含在要仿真的应用程序中的指令的执行定时的仿真器和仿真方法
公开(公告)号：US07756697B2
公开(公告)日：2010-07-13
申请号：US11475044
申请日：2006-06-27
申请人： Koji Nakamura
发明人： Koji Nakamura
IPC分类号： G06F9/455 , G06F9/44
CPC分类号： G06F9/3836 , G06F9/3869 , G06F9/3879
摘要： An emulation technique adjusts the execution timing of instructions included in an application to be emulated. An emulator executes an instruction stream consisting of a plurality of instructions included in the application for an apparatus to be emulated to perform the object AP. This emulator performs successively the instructions included in the instruction stream at a predetermined period, and includes a speed controller for adjusting the emulation speed by intermittently inserting a wait into the instruction stream to emulate execution of the instruction stream. Preferably, this emulator includes a clock generator (145), in which the speed controller counts the clock input from the clock generator (145).
摘要翻译：仿真技术调整包含在要仿真的应用中的指令的执行定时。仿真器执行包括在应用程序中的多个指令的指令流，以供被仿真的设备执行对象AP。该仿真器以预定周期连续执行包括在指令流中的指令，并且包括速度控制器，用于通过间歇地将等待插入指令流来模拟指令流的执行来调整仿真速度。优选地，该仿真器包括时钟发生器（145），其中速度控制器对来自时钟发生器（145）的时钟输入进行计数。

146. 发明申请

US20090234033A1 Separating Agent for IgG Purification and Method for Purifying an IgG Monomer by Using It 有权
标题翻译：用于IgG纯化的分离剂和使用它来纯化IgG单体的方法
公开(公告)号：US20090234033A1
公开(公告)日：2009-09-17
申请号：US12226597
申请日：2007-04-24
申请人： Koji Nakamura
发明人： Koji Nakamura
IPC分类号： C07K16/00 , B01J39/20 , C08J5/20
CPC分类号： C07K16/065 , B01J20/261 , B01J20/28019 , B01J20/28033 , B01J20/28042 , B01J20/286 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/3248 , B01J20/3255 , B01J20/327 , B01J2220/54 , B01J2220/58
摘要： To provide a separating agent for IgG purification, whereby IgG can be separated and purified efficiently at a high purity, and a method for purifying an IgG using it.A separating agent for IgG purification, characterized in that a polyacrylic acid and/or a polymethacrylic acid is immobilized on a carrier, and a method for purifying an IgG monomer, characterized in that a mixture containing an IgG monomer and an impurity containing polymeric IgG is contacted to the separating agent and eluted.
摘要翻译：提供用于IgG纯化的分离剂，其中可以以高纯度有效地分离和纯化IgG，以及使用其纯化IgG的方法。一种用于IgG纯化的分离剂，其特征在于将聚丙烯酸和/或聚甲基丙烯酸固定在载体上，以及纯化IgG单体的方法，其特征在于，含有IgG单体和含有聚合IgG的杂质的混合物为与分离剂接触并洗脱。

147. 发明申请

US20080112956A1 Method of Detecting Liver Cancer, Diagnostic for Liver Cancer and Remedy for Cancer 审中-公开
标题翻译：检测肝癌，肝癌诊断和癌症治疗方法
公开(公告)号：US20080112956A1
公开(公告)日：2008-05-15
申请号：US10580567
申请日：2004-11-25
申请人： Koji Nakamura , Hiroko Anzai , Hiroyuki Yanai , Atsushi Miyajima
发明人： Koji Nakamura , Hiroko Anzai , Hiroyuki Yanai , Atsushi Miyajima
IPC分类号： A61K39/395 , C12Q1/68 , A61P1/16 , G01N33/574
CPC分类号： C07K16/28 , C07K16/303 , C07K2317/734 , C12Q1/6886 , C12Q2600/158 , G01N33/57438 , G01N2333/9121
摘要： Disclosed are a method for detecting liver cancer capable of detecting liver cancer with high specificity and a diagnostic therefor, as well as a novel therapeutic drug for cancer having an excellent anticancer effect. The method for detecting liver cancer cells in a sample utilizes as an index the expression of dlk gene. The expression of dlk gene may be measured by immunoassay using an anti-dlk antibody or by measuring mRNA of dlk gene. The therapeutic drug for cancer comprises as an effective ingredient an antibody which undergoes antigen-antibody reaction with Dlk expressing on surfaces of cancer cells and which exerts anticancer action against the cancer cells.
摘要翻译：公开了一种能够高特异性检测肝癌的肝癌检测方法及其诊断方法，以及具有优异抗癌作用的新型癌症治疗药物。检测样品中肝癌细胞的方法用作dlk基因的表达指标。 dlk基因的表达可以通过使用抗dlk抗体的免疫测定或通过测定dlk基因的mRNA来测量。用于癌症的治疗药物包含作为有效成分的抗体，其与在癌细胞表面上表达的D1K进行抗原抗体反应并对癌细胞发挥抗癌作用。

148. 发明授权

US07304754B1 Image inputting and outputting apparatus which judges quality of an image 有权
标题翻译：判断图像品质的图像输入输出装置
公开(公告)号：US07304754B1
公开(公告)日：2007-12-04
申请号：US09624916
申请日：2000-07-24
申请人： Koji Nakamura , Atsushi Ito , Hitoshi Ueno , Toshiyuki Takao , Shigeharu Hara
发明人： Koji Nakamura , Atsushi Ito , Hitoshi Ueno , Toshiyuki Takao , Shigeharu Hara
IPC分类号： G06F3/12 , G06K1/00
CPC分类号： H04N5/907 , G11B27/105 , G11B27/34 , H04N1/00132 , H04N1/00135 , H04N1/00161 , H04N1/00175 , H04N1/00188 , H04N1/00193 , H04N1/00411 , H04N1/00413 , H04N1/00416 , H04N1/00424 , H04N1/00442 , H04N1/00453 , H04N1/00461 , H04N1/00466 , H04N1/00474 , H04N1/0048 , H04N1/00482 , H04N5/84
摘要： The number of pixels of image data recorded in a recording medium is determined, and it is determined whether or not an image to be looked at will be of good quality according to the determined number of the pixels and the number of pixels required for an apparatus that will print or display the image. An image list on a print image selecting picture has frames of colors according to the determination result. The user can easily select image files with resolutions suitable for the print size even if the user does not have a special knowledge of a quality, pixels and a resolution of photo image data.
摘要翻译：确定记录在记录介质中的图像数据的像素数，并且根据所确定的像素数和装置所需的像素数来确定要观察的图像是否将具有良好的质量这将打印或显示图像。打印图像选择图像上的图像列表根据确定结果具有颜色的帧。即使用户对照片图像数据的质量，像素和分辨率没有特别的了解，用户也可以容易地选择具有适合于打印尺寸的分辨率的图像文件。

149. 发明授权

US07298507B2 Product production system, apparatus for managing productions, and method for producing designated products 有权
标题翻译：产品生产系统，生产管理设备，以及生产指定产品的方法
公开(公告)号：US07298507B2
公开(公告)日：2007-11-20
申请号：US09769382
申请日：2001-01-26
申请人： Toshiyuki Takao , Koji Nakamura , Shigeharu Hara , Shinsuke Kato
发明人： Toshiyuki Takao , Koji Nakamura , Shigeharu Hara , Shinsuke Kato
IPC分类号： G06F15/00 , G06K1/00 , G06Q99/00
CPC分类号： G06Q30/06 , G06Q10/087 , G06Q20/3674
摘要： A product production system for producing a product ordered by a customer, wherein the product includes an output image for outputting image data received from the customer to another medium. The system includes a first terminal having an image data input unit for inputting the image data; an order information input unit for inputting order information to designate order contents of the product; and an identification information input unit for inputting identification information to identify the order contents; an image data storing unit for storing the image data by associating with said identification information; an order information storing unit for storing order information by associating with the identification information; a second terminal for inputting the identification information as information to be used for authenticating the order information; and a production unit for producing the product designated in the order information after receiving the authenticated order information and the image data.
摘要翻译：一种用于生产由客户订购的产品的产品生产系统，其中所述产品包括用于将从客户接收的图像数据输出到另一介质的输出图像。该系统包括具有用于输入图像数据的图像数据输入单元的第一终端; 订单信息输入单元，用于输入用于指定商品的订单内容的订单信息; 以及识别信息输入单元，用于输入识别信息以识别订单内容; 图像数据存储单元，用于通过与所述识别信息相关联来存储图像数据; 订单信息存储单元，用于通过与所述识别信息相关联来存储订单信息; 用于输入识别信息作为用于认证订单信息的信息的第二终端; 以及生产单元，用于在接收到认证的订单信息和图像数据之后，在订单信息中指定的产品。

150. 发明授权

US07289711B2 Waveguide type optical element 有权
标题翻译：波导型光学元件
公开(公告)号：US07289711B2
公开(公告)日：2007-10-30
申请号：US11063832
申请日：2005-02-23
申请人： Koji Nakamura
发明人： Koji Nakamura
IPC分类号： G02B6/10
CPC分类号： B82Y20/00 , G02B2006/12078 , G02B2006/12097 , G02B2006/12126 , G02B2006/12142 , G02B2006/12173 , G02B2006/12176 , G02B2006/1218 , G02F1/01708 , G02F1/025 , G02F2201/063 , G02F2202/06 , G02F2202/102 , H01S5/0265 , H01S5/22 , H01S5/2226 , H01S5/3054
摘要： A waveguide type optical element wherein Zn is selectively diffused on a light absorption layer using an undoped InP layer. Since an impurity diffusion area is made on the light absorption layer under a ridge part, a depletion layer becomes thin in a thickness direction and an electric field can strongly be applied. Thereby, an extinction ratio characteristic of a device can be improved.
摘要翻译：一种波导型光学元件，其中Zn使用未掺杂的InP层选择性地扩散在光吸收层上。由于在脊部下方的光吸收层上形成杂质扩散区域，因此耗尽层在厚度方向上变薄，能够强烈施加电场。由此，能够提高装置的消光比特性。

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