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    • 143. 发明申请
    • Novel antidiabetic agents
    • US20050203031A1
    • 2005-09-15
    • US11106594
    • 2005-04-15
    • David Evans
    • David Evans
    • C12N9/99A61K31/401A61K31/4439A61K38/00A61P3/10A61P43/00C07D207/16C07D207/22C07D401/12C07K5/062A61K38/04
    • C07D401/12C07D207/16
    • Compounds which are 1-(2′-aminoacyl)-2-cyanopyrrolidine derivatives according to general formula (1) are DP-IV inhibitors for treatment of impaired glucose tolerance or type 2 diabetes; wherein A is selected from groups (2, 3 and 4); X is selected from aminoacyl groups corresponding to the natural amino acids, acyl groups R3CO, groups R4COOC(R5)(R6)OCO, methoxycarbonyl, ethoxycarbonyl and benzyloxycarbonyl; R1 is selected from H, C1-C6alkyl residues, (CH2)aNHW1, (CH2)bCOW2, (CH2)cOW3, CH(Me)OW4, (CH2)d—C6H4—W5 and (CH2)eSW6, where a is 2-5, b is 1-4, c is 1-2, d is 1-2, e is 1-3, W1 is COW6, CO2W6 or SO2W6, W2 is OH, NH2, OW6 or NHW6, W3 is H or W6, W4 is H or W6, W5 is H, OH or OMe, and W6 is C1-C6 alkyl, optionally substituted phenyl, optionally substituted heteroaryl or benzyl and R2 is selected from H and (CH2)n—C5H3N—Y, where n is 2-4 and Y is H, F, Cl, NO2 or CN, or R1 and R2 together are —(CH2)p— where p is 3 or 4; R3 is selected from H, C1-C6 alkyl and phenyl; R4 is selected from H, C1-C6 alkyl, benzyl and optionally substitued phenyl; R5 and R6 are each independently selected from H and C1-C6 alkyl or together are —(CH2)m—, where m is 4-6; R7 is selected from pyridyl and optionally substituted phenyl; R8 is selected from H and C1-C3 alkyl; and R9 is selected from H, C1-C6 alkyl, C1-C6 alkoxy and phenyl.
    • 145. 发明申请
    • Heat exchanger, method of manufacture and tube plate therefor
    • 换热器,制造方法及管板
    • US20050178525A1
    • 2005-08-18
    • US10515947
    • 2004-08-19
    • David PierceDavid Evans
    • David PierceDavid Evans
    • F28D1/053F28F9/02F28F9/16F28F9/04
    • F28F9/162F28D1/05333F28D2021/0094F28F9/02F28F9/0229
    • This invention relates to a heat exchanger, to a method of manufacturing the heat exchanger, and to a tube plate for use in the heat exchanger. The heat exchanger is particularly suited for radiators for motor vehicles. The heat exchanger comprises an array of tubes, at least one end of each tube being sealingly connected to a tube plate, the tube plate having a first tube plate wall and a second tube plate wall with a gap between the tube plate walls, each of the first tube plate wall and the second tube plate wall having an opening to receive the end of a tube, the gap between the tube plate walls providing a chamber for containing a sealing material. There is also provided a method of making a heat exchanger including the step is injecting a settable sealing material into the chamber defined by the tube plate walls.
    • 本发明涉及热交换器,热交换器的制造方法和热交换器中使用的管板。 热交换器特别适用于机动车辆的散热器。 热交换器包括一组管子,每个管的至少一端密封地连接到管板,管板具有第一管板壁和第二管板壁,在管板壁之间具有间隙,每个管板 第一管板壁和第二管板壁具有用于容纳管的端部的开口,管板壁之间的间隙提供用于容纳密封材料的室。 还提供了一种制造热交换器的方法,该方法包括将可固化的密封材料注入由管板壁限定的室中。
    • 147. 发明授权
    • Face mask with gas sampling port
    • 带气体采样口的面罩
    • US5474060A
    • 1995-12-12
    • US110515
    • 1993-08-23
    • David Evans
    • David Evans
    • A61M16/06A61M16/08A61M16/00A62B7/10A62B18/02F16K31/02
    • A61B5/097A61B5/4821A61M16/06A61M16/085A61M16/0666A61M2230/202A61M2230/205
    • This invention relates to face masks, and particularly respiratory face masks for administering a gas, such as oxygen or a mixture thereof, to a patient, and specifically when an operation is performed involving a local anaesthetic or when a patient is recuperating in an intensive care unit or post-anaesthetic care unit. The face mask includes a body adapted to cover at least the nose of a wearer, and having a peripheral edge for substantially sealing at least a portion of the body of the mask to the face of a wearer. Moreover, the peripheral edge is contoured to extend over the bridge of the nose and well below the level of the eyes of the patient or wearer. The face mask includes an inlet for directing a flow of gas to the interior of the mask, and a port for allowing the exhaled air stream by the patient to flow therethrough, and particularly to a tube for directing such flow to suitable monitoring apparatus for measuring the components thereof, such as a mass spectrometer or capnograph. The port includes a connector having a configuration for releasably engaging one end of the tube presented thereto, with such connector including a conduit, and, in the preferred embodiment, in the term of a tubular portion or element, for directing the flow of gas from the interior of the mask to such tube.
    • 本发明涉及面罩,特别是呼吸面罩,用于向患者施用诸如氧气或其混合物的气体,特别是当进行包括局部麻醉剂的操作或当患者在重症监护中恢复时 单位或麻醉后护理单位。 所述面罩包括适于至少覆盖穿戴者的鼻子的主体,并且具有用于将所述面罩的至少一部分基本上密封到穿戴者的脸部的周缘。 此外,外围边缘被轮廓化以在鼻子的桥上延伸并且远低于患者或佩戴者的眼睛的水平面。 面罩包括用于将气体流引导到面罩内部的入口,以及用于允许患者呼出的气流流过其中的端口,特别是用于将这种流引导到合适的测量装置的管 其组分,例如质谱仪或capnograph。 该端口包括具有用于可释放地接合呈现在其上的管的一端的构造的连接器,其中这种连接器包括导管,并且在优选实施例中,在管状部分或元件中用于引导来自 面罩的内部到这样的管子。