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131. 发明授权

US5763586A Extraction of proteins from naturally occuring membranes 失效
标题翻译：从天然膜中提取蛋白质
公开(公告)号：US5763586A
公开(公告)日：1998-06-09
申请号：US747670
申请日：1996-11-12
申请人： Don N. Gray
发明人： Don N. Gray
IPC分类号： C07H15/20 , C07H15/207 , C11D3/22 , C07H1/00 , C07K1/14
CPC分类号： C07H15/20 , C07H15/207 , C11D3/221
摘要： The extraction of proteins from selected naturally occurring membranes without any harmful, adverse, or other deleterious effect(s). In one preferred embodiment the detergent is prepared from the reaction of a cycloalkyl aliphatic alcohol and a saccharide.
摘要翻译：从选定的天然存在的膜中提取蛋白质而没有任何有害的，不利的或其他有害的作用。在一个优选的实施方案中，洗涤剂由环烷基脂族醇和糖的反应制备。

132. 发明授权

US4946950A Inositol glycoside 2-O-Beta-L-arabinopyranosyl-myo-inositol 失效
标题翻译：肌醇糖苷2-O-β-L-阿拉伯吡喃糖肌醇肌醇
公开(公告)号：US4946950A
公开(公告)日：1990-08-07
申请号：US153850
申请日：1988-02-08
申请人： Yukihiko Hara , Kazuo Okushio , Kanzo Sakata
发明人： Yukihiko Hara , Kazuo Okushio , Kanzo Sakata
IPC分类号： A61K36/18 , C07H15/207 , C07H15/20 , A61K31/70
CPC分类号： C07H15/207
摘要： A glycoside of inositol which has been isolated from a hot-water extract of tea leaves. The glycoside is identified from the analytical results to be 2-O-beta-L-arabinopyranosyl-myo-inositol.

133. 发明授权

US4728643A Method of treating psoriasis 失效
标题翻译：治疗牛皮癣的方法
公开(公告)号：US4728643A
公开(公告)日：1988-03-01
申请号：US667813
申请日：1984-11-02
申请人： Michael F. Holick , Julia McLaughlin
发明人： Michael F. Holick , Julia McLaughlin
IPC分类号： A61K31/59 , A61P3/02 , A61P17/00 , A61P35/00 , A61P43/00 , C07C67/00 , C07C401/00 , C07H15/207
CPC分类号： A61K31/59 , C07H15/207 , Y10S514/863
摘要： A method of treating psoriasis in a patient which comprises administering to said patient an effective amount of a vitamin D compound which is capable of stimulating the differentiation of cultured tumor cells or normal rodent or human fibroblasts or keratinocytes in vitro.
摘要翻译：一种治疗患者牛皮癣的方法，其包括向所述患者施用有效量的体外能够刺激培养的肿瘤细胞或正常啮齿动物或人成纤维细胞或角化细胞分化的维生素D化合物。

134. 发明授权

US4460767A Process for production of sugar ketals 失效
标题翻译：糖缩酮生产工艺
公开(公告)号：US4460767A
公开(公告)日：1984-07-17
申请号：US418266
申请日：1982-09-15
申请人： Koichi Matsumura , Tetsuya Aono
发明人： Koichi Matsumura , Tetsuya Aono
IPC分类号： C07H9/04 , B01J23/00 , B01J23/72 , C07B61/00 , C07D317/12 , C07H15/207 , C07H1/00 , C07C47/18
CPC分类号： C07H9/04 , C07D317/12 , C07H15/207
摘要： A process is disclosed for production of a sugar ketal, which comprises reacting a sugar with a ketone in the presence of (A) (1) copper, or an oxide, hydroxide or salt thereof and (2) hydrogen chloride or hydrogen bromide, or (B) cupric chloride or cupric bromide, said catalyst system being very effective in a small amount. The formation of unfavorable by-products can be reduced to a trace amount. The process offers the objective ketal in improved yields, and an industrially advantageous process.
摘要翻译：公开了一种生产糖缩酮的方法，其包括在（A）（1）铜或其氧化物，氢氧化物或盐存在下使糖与酮反应，和（2）氯化氢或溴化氢，或（B）氯化铜或溴化铜，所述催化剂体系在少量中非常有效。不利副产物的形成可以减少到微量。该方法提供了目标缩酮在提高产率和工业上有利的过程。

135. 发明授权

US3968100A Guanidio derivatives of kasugamycin and their production 失效
标题翻译：春日霉素的胍基衍生物及其生产
公开(公告)号：US3968100A
公开(公告)日：1976-07-06
申请号：US220374
申请日：1972-01-24
申请人： Hamao Umezawa , Yasuji Suhara
发明人： Hamao Umezawa , Yasuji Suhara
IPC分类号： C07H15/207 , C07H15/22
CPC分类号： C07H15/207
摘要： New guanidino derivatives of kasugamycin in which the oxalamidino group at the 4-position of kasugamycin molecule has been replaced by different guanidino groups are produced and found to show an improved antibacterial activity against Gram negative bacteria and a decreased toxicity to man and animals, as compared to kasugamycin itself. The new guanidino derivatives of kasugamycin may readily be produced by reacting an amine with an isourea derivative of kasugamycin which has been prepared by reacting sodium hypobromite with kasugamycin and then treating the resulting cyanamide derivative with hydrogen chloride in methanol.
摘要翻译：产生春日霉素的新胍基衍生物，其中在春日霉素分子的4位上的草酰脒基被不同的胍基取代，发现其显示出对革兰氏阴性细菌的抗菌活性改善和对人和动物的毒性降低，到春日霉素本身。春日霉素的新的胍基衍生物可以容易地通过使胺与异硫氰酸钠与春日霉素反应制备的春日霉素的异脲衍生物反应，然后用氯化氢在甲醇中处理所得的氰胺衍生物来制备。

136. 发明授权

US3652535A Kasugamycin derivatives 失效
标题翻译： KASUGAMYCIN衍生物
公开(公告)号：US3652535A
公开(公告)日：1972-03-28
申请号：US3652535D
申请日：1970-05-01
申请人： BRISTOL MYERS CO
发明人： KEIL JOHN G , SCHREIBER RICHARD H
IPC分类号： C07H15/207 , C07C47/18
CPC分类号： C07H15/207
摘要： SEMI-SYNTHETIC KASUGAMYCIN DERIVATIVES HAVE BEEN FOUND USEFUL IN THE TREATMENT OF DISEASES CAUSED BY BACTERIAL INFECTION. THESE DERIVATIVES CAN BE PREPARED BY THE USE OF THE INTERMEDIATE COMPOUND, BIOS C (5-(2-CARBOBENZOXAMIDO-2,3,4,6-TETRADEOXY - 4 - AMINO-A-D-ARABINOHEXOPYRANOSYL)-(IR:2S:3S:4R:5R:6R)-INOSITOL).

137. 发明授权

US3607657A Process for the production of kasugamycin 失效
标题翻译：生产KASUGAMYCIN的方法
公开(公告)号：US3607657A
公开(公告)日：1971-09-21
申请号：US3607657D
申请日：1968-03-20
申请人： HAMAO UMEZAWA , YOSHIRO OKAMI , TOMIO TAKEUCHI , MASA HAMADA
发明人： UMEZAWA HAMAO , OKAMI YOSHIRO , TAKEUCHI TOMIO , HAMADA MASA
IPC分类号： C07H15/207 , C12D9/00
CPC分类号： C07H15/207 , Y10S435/886 , Y10S435/911
摘要： Kasugamycin is produced by fermentation of a new species of streptomyces which has been named Streptomyces kasugaspinus.

138. 发明授权

US11987598B2 E-selectin antagonist compounds, compositions, and methods of use 有权
公开(公告)号：US11987598B2
公开(公告)日：2024-05-21
申请号：US17724585
申请日：2022-04-20
申请人： GLYCOMIMETICS, INC.
发明人： John L. Magnani , Arun K. Sarkar , Myung-Gi Baek , Frank E. Anderson, III , Yanhong Li
IPC分类号： A61K31/7034 , A61K45/06 , C07H15/207 , C07H15/26 , C09C1/62
CPC分类号： C07H15/207 , A61K31/7034 , A61K45/06 , C07H15/26 , C09C1/62
摘要： Methods and compositions using E-selectin antagonists are provided for the treatment and prevention of diseases and disorders treatable by inhibiting binding of E-selectin to an E-selectin ligand. Described herein are E-selectin antagonists including, for example, glycomimetic compounds, antibodies, aptamers and peptides that are useful in methods for treatment of cancers, and treatment and prevention of metastasis, inhibiting infiltration of the cancer cells into bone marrow, reducing or inhibiting adhesion of the cancer cells to endothelial cells including cells in bone marrow, and inhibiting thrombus formation.

139. 发明授权

US11919921B2 Galactoside inhibitor of galectins 有权
公开(公告)号：US11919921B2
公开(公告)日：2024-03-05
申请号：US17748338
申请日：2022-05-19
申请人： Galecto Biotech AB
发明人： Thomas Brimert , Richard Johnsson , Hakon Leffler , Ulf Nilsson , Fredrik Zetterberg
IPC分类号： A61K31/7056 , A61K31/706 , C07H15/203 , C07H13/10 , C07H19/056 , C07H13/08 , C07H15/26 , C07H15/207 , C07H17/02
CPC分类号： C07H15/203 , A61K31/706 , A61K31/7056 , C07H13/08 , C07H13/10 , C07H15/207 , C07H15/26 , C07H17/02 , C07H19/056
摘要： An embodiment of the present invention relates to a compound of the general formula. The compound of formula is suitable for use in a method for treating a disorder relating to the binding of a galectin, such as galectin-3 to a ligand in a mammal, such as a human. Furthermore an embodiment of the present invention concerns a method for treatment of a disorder relating to the binding of a galectin, such as galectin-3 to a ligand in a mammal, such as a human.

140. 发明授权

US11773128B2 Electrocatalytic synthesis of dihydrochalcones 有权
公开(公告)号：US11773128B2
公开(公告)日：2023-10-03
申请号：US17598590
申请日：2020-03-27
申请人： BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY
发明人： Mikhail Redko , Christopher M. Saffron , James E. Jackson
IPC分类号： C25B3/05 , C25B3/25 , C07H15/207 , C25B9/19
CPC分类号： C07H15/207 , C25B3/25 , C25B9/19
摘要： The disclosure relates to methods of forming a dihydrochalcone using electrocatalytic dehydrogenation. In particular, the disclosure relates to methods of forming a dihydrochalcone electrocatalytically hydrogenating (ECH) a reactant compound over a catalytic cathode in a reaction medium having a non-alkaline pH value, thereby forming a dihydrochalcone product; wherein the reactant compound has a structure according to Formula (I). The method can be used to prepare dihydrochalcone sweeteners, such as, for example, naringin dihydrochalcone and neohesperidin dihydrochalcone.

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