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131. 发明专利

CA2627358C HETEROCYCLIC MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS 未知
公开(公告)号：CA2627358C
公开(公告)日：2015-10-06
申请号：CA2627358
申请日：2006-11-08
申请人： VERTEX PHARMA
发明人： HADIDA RUAH SARA , HAMILTON MATTHEW , MILLER MARK , GROOTENHUIS PETER D J , BEAR BRIAN , MCCARTNEY JASON , ZHOU JINGLAN
IPC分类号： C07D405/12 , A61K31/4418 , A61K31/5585 , A61P11/00 , C07D213/75 , C07D405/14
摘要： Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). In one broad aspect, there is disclosed a compound of the general formula (I): (see formula I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R'3, R4, and n are described herein. In a more specific embodiment, the invention relates to a compound having the following formula: (see formula II).

132. 发明专利

DK2615085T3 Pyridylderivater som CFTR-modulatorer 未知
公开(公告)号：DK2615085T3
公开(公告)日：2015-10-05
申请号：DK12188920
申请日：2009-03-25
申请人： VERTEX PHARMA
发明人： HADIDA-RUAH SARA , MILLER MARK , ZHOU JINGLAN , BEAR BRIAN , GROOTENHUIS PETER
IPC分类号： C07D213/75 , A61K31/44 , A61K31/4427 , A61P43/00 , C07D405/12 , C07D405/14 , C07D413/14

133. 发明专利

DK2007756T3 MODULATORER AF ATP-BINDINGS-KASSETTE-TRANSPORTERE 未知
公开(公告)号：DK2007756T3
公开(公告)日：2015-10-05
申请号：DK07755298
申请日：2007-04-09
申请人： VERTEX PHARMA
发明人： RUAH SARA S HADIDA , GROOTENHUIS PETER D J , ZHOU JINGLAN , BEAR BRIAN , MILLER MARK T , MCCARTNEY JASON , NUMA MEHDI MICHEL JAMEL , VAN GOOR FREDRICK , YANG XIAOQING
IPC分类号： C07D405/12 , A61K31/404 , A61P31/00 , C07D405/14

134. 发明专利

AU2015203461A1 Isoquinoline modulators of ATP-Binding Cassette transporters 未知
公开(公告)号：AU2015203461A1
公开(公告)日：2015-08-06
申请号：AU2015203461
申请日：2015-06-23
申请人： VERTEX PHARMA
发明人： HADIDA RUAH SARA , MILLER MARK , ZHOU JINGLAN , BEAR BRIAN , GROOTENHUIS PETER D J
IPC分类号： C07D217/22 , A61K31/472 , A61K31/4725 , A61P11/00 , C07D401/04 , C07D405/12 , C07D405/14
摘要： Compounds of the present invention, of formula (I) and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention. I R3' y, -N O (R1 )n (I)

135. 发明专利

AU2013231151B2 Isoquinoline modulators of ATP-Binding Cassette transporters 未知
公开(公告)号：AU2013231151B2
公开(公告)日：2015-06-25
申请号：AU2013231151
申请日：2013-09-23
申请人： VERTEX PHARMA
发明人： HADIDA RUAH SARA , MILLER MARK , ZHOU JINGLAN , BEAR BRIAN , GROOTENHUIS PETER
IPC分类号： C07D217/22 , A61K31/472 , A61K31/4725 , A61P11/00 , C07D401/04 , C07D405/12 , C07D405/14
摘要： Compounds of the present invention, of formula (I) and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention. I R3' y, -N O (R1 )n (I)

136. 发明专利

PL2365972T3 Modulatory transporterów posiadających kasetę wiążącą ATP 未知
公开(公告)号：PL2365972T3
公开(公告)日：2015-05-29
申请号：PL08876364
申请日：2008-11-12
申请人： VERTEX PHARMA
发明人： RUAH SARA S HADIDA , GROOTENHUIS PETER D J , VAN GOOR FREDRICK , MILLER MARK T , MCCARTNEY JASON , ZHOU JINGLAN , BEAR BRIAN , NUMA MEHDI MICHEL DJAMEL
IPC分类号： C07D405/12 , A61K31/404 , A61P3/00 , A61P25/00

137. 发明专利

SI2365972T1 MODULATORJI PRENAĹ ALCEV Z ATP-VEZAVNO KASETO 未知
公开(公告)号：SI2365972T1
公开(公告)日：2015-04-30
申请号：SI200831394
申请日：2008-11-12
申请人： VERTEX PHARMA
发明人： RUAH SARA S HADIDA , GROOTENHUIS PETER D J , VAN GOOR FREDRICK , MILLER MARK T , MCCARTNEY JASON , ZHOU JINGLAN , BEAR BRIAN , NUMA MEHDI MICHEL DJAMEL
IPC分类号： C07D405/00 , A61K31/00 , A61P3/00 , A61P25/00

138. 发明专利

SI1773816T1 MODULATORJI PRENAĹ ALCEV Z ATP-VEZAVNO KASETO 未知
公开(公告)号：SI1773816T1
公开(公告)日：2015-04-30
申请号：SI200531953
申请日：2005-06-24
申请人： VERTEX PHARMA
发明人： HADIDA RUAH SARAH S , HAZLEWOOD ANNA R , GROOTENHUIS PETER D J , VAN GOOR FREDRICK F , SINGH ASHVANI K , ZHOU JINGLAN , MCCARTNEY JASON
IPC分类号： C07D215/00 , A61K31/00 , A61P1/00 , A61P3/00 , A61P5/00 , A61P11/00 , A61P25/00 , A61P31/00

139. 发明专利

NZ620944A Heteroaryl derivatives as cftr modulators 未知
公开(公告)号：NZ620944A
公开(公告)日：2015-02-27
申请号：NZ62094409
申请日：2009-02-25
申请人： VERTEX PHARMA
发明人： HADIDA-RUAH SARA , MILLER MARK , ZHOU JINGLAN , BEAR BRIAN
IPC分类号： C07D239/42 , A61K31/435 , A61K31/4965 , A61K31/505 , A61P3/00 , A61P25/00 , C07D213/75 , C07D241/20
摘要： Disclosed herein are 1-(benzo[d][1,3]dioxol-5-yl)-carboxamide compounds of formula (I), wherein the substituents are as defined in the specification, processes for its preparation, compositions comprising said compound and uses thereof. These compounds are useful as modulators of ATP-Binding Cassette (ABC) transporter or fragments thereof and is therefore useful in the treatment of condition, disease or disorders selected from cystic fibrosis, hereditary emphysema, hereditary hemochromatosis, protein C deficiency, Type 1 hereditary angioedema, familial hypercholesterolemia, Type 1 chylomicronemia, abetalipoproteinemia, I-cell disease/pseudo-Hurler, mucopolysaccharidoses, Sandhof/Tay-Sachs, Crigler-Najjar type II, polyendocrinopathy/hyperinsulemia, diabetes mellitus, laron dwarfism, myeloperoxidase deficiency, primary hypoparathyroidism, melanoma, glycanosis CDG type 1, hereditary emphysema, congenital hyperthyroidism, osteogenesis imperfecta, hereditary hypofibrinogenemia, ACT deficiency, diabetes insipidus (di), neurophyseal di, neprogenic DI, Charcot-Marie Tooth syndrome, Perlizaeus-Merzbacher disease, Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, progressive supranuclear plasy, Pick’s disease, Huntington, spinocerebullar ataxia type I, spinal and bulbar muscular atrophy, dentatorubal pallidoluysian, myotonic dystrophy, hereditary Creutzfeldt-Jakob disease, Fabry disease, Straussler-Scheinker syndrome, COPD, dry-eye disease, and Sjögren’s disease.

140. 发明专利

CA2917198A1 FUSED PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS 未知
公开(公告)号：CA2917198A1
公开(公告)日：2015-01-15
申请号：CA2917198
申请日：2014-07-08
申请人： VERTEX PHARMA
发明人： DENINNO MICHAEL PAUL , ANDERSON COREY , CONROY ERICA LYNN , FRIEMAN BRYAN A , GROOTHENHUIS PETER DIEDERIK JAN , HADIDA-RUAH SARA SABINA , HURLEY DENNIS JAMES , PIERRE FABRICE JEAN DENIS , SILINA ALINA , UY JOHNNY , ZHOU JINGLAN
IPC分类号： C07D221/04 , A61K31/435 , A61K31/4355 , A61K31/436 , A61K31/472 , A61P25/04 , C07D401/04 , C07D401/06 , C07D403/06 , C07D405/06 , C07D487/04 , C07D491/044 , C07D491/048 , C07D491/056
摘要： The invention relates to fused piperidine amides useful as inhibitors of ion channels for the treatment of pain. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

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