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131. 发明申请

WO1995009920A1 VIRUS RESISTANT OR TOLERANT CELLS 审中-公开
标题翻译：抗病毒或耐药细胞
公开(公告)号：WO1995009920A1
公开(公告)日：1995-04-13
申请号：PCT/EP1994003295
申请日：1994-10-05
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH , DE HAAN, Petrus, Theodorus
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH
IPC分类号： C12N15/33
CPC分类号： C07K14/005 , C12N15/8283 , C12N2770/00022
摘要： A nucleotide sequence comprising a transcriptional regulatory sequence and a sequence contiguous therewith and under the transcriptional control thereof, which contiguous sequence encodes an RNA which consists of a plurality of sub-sequences, characterized in that at least two of the sub-sequences have the sequences of viral RNAs and the RNA contains at least one translational stop codon located upstream of the 3' terminal sub-sequence. It is preferred that at least one of the sub-sequences is in an anti-sense configuration with respect to virus RNA, and that the contiguous sequence encodes mRNA. The invention also includes, inter alia, the use of such a sequence in the generation of virus resistant or tolerant plants, and such plants comprising the sequence.
摘要翻译：一种核苷酸序列，其包含转录调节序列和与其连接并在其转录控制下的序列，所述连续序列编码由多个亚序列组成的RNA，其特征在于至少两个亚序列具有序列的病毒RNA，并且RNA含有位于3'末端亚序列上游的至少一个翻译终止密码子。优选地，至少一个亚序列对于病毒RNA是反义构型，并且连续序列编码mRNA。本发明还包括这样的序列在产生抗病毒或耐受性植物中的用途，以及包含该序列的这种植物。

132. 发明申请

WO1994025611A1 INTEGRATIVE DNA SEGMENT COMPRISING GENE ENCODING INSECTICIDAL PROTEIN 审中-公开
标题翻译：包含基因编码杀虫蛋白的整合DNA片段
公开(公告)号：WO1994025611A1
公开(公告)日：1994-11-10
申请号：PCT/EP1994001249
申请日：1994-04-21
申请人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH , SANDOZ-PATENT-GMBH , SANDOZ LTD. , KALMAN, Susan, Stephanie
发明人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH , SANDOZ-PATENT-GMBH , SANDOZ LTD.
IPC分类号： C12N15/75
CPC分类号： C07K14/325 , C12N15/75
摘要： This invention relates to a method of increasing the insecticidal spectrum and/or toxicity of Bacillus thuringiensis strains whereby an exogenous crystal toxin encoding DNA sequence is stably integrated into the chromosomal DNA of a host B.t. wherein the exogenous DNA sequence is expressed and further wherein crystal toxin encoding DNA sequences on resident plasmids may be expressed. The invention further relates to the B.t. host including said exogenous DNA sequences, methods of preparing said host, insecticidal compositions containing said host and methods of use.
摘要翻译：本发明涉及增加苏云金芽孢杆菌菌株的杀虫谱和/或毒性的方法，其中编码DNA序列的外源结晶毒素稳定整合到宿主B.t.的染色体DNA中。其中表达外源DNA序列，进一步其中可以表达编码驻留质粒上的DNA序列的结晶毒素。本发明还涉及B.t. 宿主，包括所述外源DNA序列，制备所述宿主的方法，含有所述宿主的杀虫组合物和使用方法。

133. 发明申请

WO1994024304A1 RAPAMYCIN ASSAY 审中-公开
标题翻译： RAPAMYCIN测定
公开(公告)号：WO1994024304A1
公开(公告)日：1994-10-27
申请号：PCT/EP1994001006
申请日：1994-03-30
申请人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH , SANDOZ-PATENT-GMBH , SANDOZ LTD. , QUESNIAUX, Valérie , SEDRANI, Richard
发明人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH , SANDOZ-PATENT-GMBH , SANDOZ LTD.
IPC分类号： C12P21/08
CPC分类号： C07K16/1292
摘要： Monoclonal antibodies to rapamycin and to 40-O-alkylated derivatives of rapamycin are provided, together with nobel haptens, immunogenic conjugates, and processes for making them and assay kits for using them.
摘要翻译：提供雷帕霉素的单克隆抗体和雷帕霉素的40-O-烷基化衍生物，以及诺贝尔半抗原，免疫原性缀合物及其制备方法和使用它们的试剂盒。

134. 发明申请

WO1994012493A1 2,2-DIALKYL- AND 2,2-DIALKYL-3,4-DIHYDRO-3-HYDROXY-2H-1-BENZOPYR ANS, THEIR USE AS PHARMACEUTICALS 审中-公开
标题翻译： 2,2-二烷基和2,2-二烷基-3,4-二氢-3-羟基-2H- 1-BENZOPYR ANS，它们作为药物使用
公开(公告)号：WO1994012493A1
公开(公告)日：1994-06-09
申请号：PCT/EP1992002719
申请日：1992-11-25
申请人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH , SANDOZ-PATENT-GMBH , SANDOZ, LTD. , MANLEY, Paul, W.
发明人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH , SANDOZ-PATENT-GMBH , SANDOZ, LTD.
IPC分类号： C07D405/14
CPC分类号： C07D405/14
摘要： 2,2-Di(C1-5alkyl)- and trans-2,2-di(C1-5alkyl)-3,4-dihydro-3-hydroxy- -6-(pyridin-4-yl)-2H-1-benzopyrans, e.g. of formula (I) in which R1 and R2 = H, alkyl, hydroxyalkyl or alkoxyalkyl, at least one being other than H, R3 = typically a 2-piperidinone group, R4 = H and R5 = -OH or R4 + R5 = an additional bond, and R6, R7 are alkyl and R8 is H or alkyl, and N-oxides, esters and salts thereof, processes for their production and their uses as pharmaceuticals e.g. as K -channel openers, bronchodilators and asthma prophylactic agents.
摘要翻译： 2,2-二（C 1-5烷基） - 和反式-2,2-二（C 1-5烷基）-3,4-二氢-3-羟基-6-（吡啶-4-基）苯并吡喃，例如其中R 1和R 2 = H，烷基，羟基烷基或烷氧基烷基，至少一个不同于H，R 3 =通常为2-哌啶酮基，R 4 = H且R 5 = -OH或R 4 + R 5 = R 6，R 7为烷基，R 8为H或烷基，并且其N-氧化物，酯和盐的制备及其用作药物例如作为K +通道开放剂，支气管扩张剂和哮喘预防剂。

135. 发明申请

WO1994005778A1 NEW PRODUCTS OF DEPOLYMERIZING PARTIALLY ACETYLATED CHITOSAN, NEW ENZYMES AND NEW THERMOACTINOMYCES STRAIN FOR THE PRODUCTION THEREOF 审中-公开
标题翻译：部分乙酰化壳聚糖新产品，新产品及其生产新型热灭菌素菌株
公开(公告)号：WO1994005778A1
公开(公告)日：1994-03-17
申请号：PCT/EP1993002352
申请日：1993-08-31
申请人： SANDOZ-PATENT-GMBH , SANDOZ LTD. , BRODEL, Bruno, Maurice, Léon , DEBEIRE, Philippe, Victor, Jean , MONSAN, Pierre, Frédéric, Emmanuel , PAUL, François, Marie, Bernard , TOUZEL, Jean-Pierre, Marie
发明人： SANDOZ-PATENT-GMBH , SANDOZ LTD.
IPC分类号： C12N09/24
CPC分类号： D21H17/005 , A61K8/736 , A61L15/28 , A61L17/10 , A61Q5/00 , A61Q11/00 , C12N9/2402 , C12N9/2442 , C12P19/26 , C12Y302/01014 , C12Y302/01132 , C08L5/08
摘要： It has been found that various strains of the genus Thermoactinomyces produce substantial quantities of chitosanase when cultivated under appropriate conditions and that a new strain of Thermoactinomyces with the identification I-1052, Institut Pasteur, Paris, is of special interest. A new thermostable enzyme has been isolated from the culture broth of this new strain. This new enzyme hydrolyzes chitosans with varying acetylation degrees. New depolymerized partially acetylated chitosan products are obtained by the use of these new enzymes and are characterized by their viscosity, molecular weight distribution and degree of acetylation. Such new products can be used in pharmaceuticals and cosmetic compositions and as auxiliaries in paper making.
摘要翻译：已经发现，在适当条件下培育时，热乳杆菌属的各种菌株产生大量的壳聚糖酶，并且具有鉴定I-1052（巴斯研究所巴斯德研究所）的新型热激活素菌株是特别感兴趣的。已经从这种新菌株的培养液中分离出一种新的热稳定酶。这种新的酶水解具有不同乙酰化度的壳聚糖。通过使用这些新的酶获得新的解聚的部分乙酰化的壳聚糖产物，其特征在于它们的粘度，分子量分布和乙酰化度。这些新产品可用于制药和化妆品组合物以及造纸助剂。

136. 发明申请

WO1993020126A1 BIODEGRADABLE POLYCARBONATES AND THEIR USE AS DRUG CARRIERS 审中-公开
标题翻译：生物可降解的聚碳酸酯及其作为药物载体的用途
公开(公告)号：WO1993020126A1
公开(公告)日：1993-10-14
申请号：PCT/EP1993000699
申请日：1993-03-23
申请人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELSCHAFT M.B.H. , SANDOZ-PATENT-GMBH , SANDOZ LTD. , ACEMOGLU, Murat
发明人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELSCHAFT M.B.H. , SANDOZ-PATENT-GMBH , SANDOZ LTD.
IPC分类号： C08G64/02
CPC分类号： C08G64/42 , A61K9/1647 , C08G64/0208
摘要： A biodegradable and biocompatible polycarbonate comprising (C3-10) alkylene carbonic acid ester units, each alkylene group being a C3-alkylene group having 1 oxy substituent or a (C4-10) alkylene group having 2-8 oxy substituents, each of the oxy substituents occurring individually as a hydroxyl group or as a derivatized hydroxyl group comprising an ester or an ortho ester or an acetal residue. The polycarbonates may be used as matrices for the sustained release of pharmacologically active compounds, e.g. peptides or proteins, in the form of microparticles or implants.
摘要翻译：包含（C3-10）亚烷基碳酸酯单元的生物可降解和生物相容的聚碳酸酯，每个亚烷基是具有1个氧取代基的C3-亚烷基或具有2-8个氧取代基的（C4-10）亚烷基，作为羟基单独发生的取代基或作为包含酯或原酸酯或缩醛残基的衍生化羟基。聚碳酸酯可以用作药物活性化合物的持续释放的基质，例如，肽或蛋白质，以微粒或植入物的形式。

137. 发明申请

WO1992016624A1 MONOCLONAL ANTIBODY AGAINST LPS CORE 审中-公开
标题翻译：针对LPS核心的单克隆抗体
公开(公告)号：WO1992016624A1
公开(公告)日：1992-10-01
申请号：PCT/EP1992000380
申请日：1992-02-22
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , GRAM, Hermann , DI PADOVA, Franco , BARCLAY, George, Robin , POXTON, Ian, Raymond
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH
IPC分类号： C12N15/13
CPC分类号： C07K16/1203 , A61K38/00 , C07K2319/00 , C07K2319/02 , G01N2400/50
摘要： By use of the Köhler/Milstein procedure involving immunization of mice with a number of different rough strains of heat-killed Gram-negative bacteria followed by fusion and suitable screening of the resulting hybridomas, murine monoclonal antibodies are obtained which are cross-protective against endotoxemia caused by at least two different Gram-negative bacterial strains having different core structures. The murine MAbs may be chimerized or humanized by known methods. The preferred product is a chimeric MAb of IgG isotype in which the hypervariable regions of the heavy chain have the amino acid sequences: Asp Tyr Tyr Met Thr; Leu Ile Arg Asn Lys Arg Asn Gly Asp Thr Ala Glu Tyr Ser Ala Ser Val Lys; and Gln Gly Arg Gly Tyr Thr Leu Asp Tyr; the hypervariable regions of the light chain have the amino acid sequences: Arg Ala Ser Gln Asn Ile Asn Ile Trp Leu Ser; Lys Ala Ser Asn Leu His Thr; and Leu Gln Gly Gln Ser Tyr Pro Arg Thr; the framework regions in the variable domains are murine and the constant domains are human.
摘要翻译：通过使用Köhler/ Milstein程序，其涉及用许多不同的热杀死的革兰氏阴性菌的粗糙株免疫小鼠，随后融合并适当筛选得到的杂交瘤，获得了鼠抗单克隆抗体，其是针对内毒素血症的交叉保护由具有不同核心结构的至少两种不同的革兰氏阴性细菌菌株引起。鼠MAb可以通过已知方法嵌合或人源化。优选的产物是IgG同种型的嵌合MAb，其中重链的高变区具有氨基酸序列：Asp Tyr Tyr Met Thr; Leu Ile Arg Asn Lys Arg Asn Gly Asp Thr Ala Glu Tyr Ser Ala Ser Val Lys; 和Gln Gly Arg Gly Tyr Thr Leu Asp Tyr; 轻链的高变区具有氨基酸序列：Arg Ala Ser Gln Asn Ile Asn Ile Trp Leu Ser; Lys Ala Ser Asn Leu His Thr; 和Leu Gln Gly Gln Ser Tyr Pro Arg Thr; 可变结构域中的框架区是鼠，恒定结构域是人。

138. 发明申请

WO1997002315A1 REGENERATED CELLULOSE INCORPORATING PHOSPHOROUS COMPOUNDS SO AS TO BE FLAME-RETARDANT 审中-公开
标题翻译：磷化合物的阻燃再生沥青
公开(公告)号：WO1997002315A1
公开(公告)日：1997-01-23
申请号：PCT/EP1996002945
申请日：1996-07-04
申请人： CLARIANT FINANCE (BVI) LIMITED , LENZING AKTIENGESELLSCHAFT , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH , WOLF, Rainer , RÜF, Hartmut
发明人： CLARIANT FINANCE (BVI) LIMITED , LENZING AKTIENGESELLSCHAFT , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH
IPC分类号： C08K05/5398
CPC分类号： C08K5/5397 , C07F9/65685 , C08K5/5398 , D01F1/07 , D01F2/00 , D01F2/10 , C08L1/06
摘要： The invention concerns regenerated celluloses which are made flame-retardant and contain at least one compound of formula (I). The invention also pertains to the use of compounds of formula I as flame retardants specifically for regenerated cellulose and a process for modifying regenerated cellulose characterised by the addition of compounds of formula (I) or a dispersion containing these compounds.
摘要翻译：本发明涉及含有式（I）的至少一种化合物的阻燃再生纤维素。本发明还提供了含有式（I）分散的化合物的特征在于特定的再生纤维素和由式（I）或这些化合物的化合物的掺入得到的再生纤维素的阻燃整理的方法的阻燃剂。

139. 发明申请

WO1989010917A2 RENIN INHIBITORS, PROCESS FOR PRODUCING THEM AND USE THEREOF 审中-公开
标题翻译：雷宁抑制剂，生产和使用它们的方法
公开(公告)号：WO1989010917A2
公开(公告)日：1989-11-16
申请号：PCT/EP1989000509
申请日：1989-05-09
申请人： SANDOZ-PATENT-GMBH , SANDOZ AG , WEIDMANN, Beat
发明人： SANDOZ-PATENT-GMBH , SANDOZ AG
IPC分类号： C07C125/65
CPC分类号： C07D295/088 , C07C237/22 , C07C271/22 , C07C327/42 , C07C327/44 , C07C333/04 , C07D213/30 , C07D213/82 , C07F7/081 , C07K5/0205 , C07K5/0207 , C07K5/021 , C07K5/0212 , C07K5/0227
摘要： Compound of formula (I), wherein R1, W, R2, Z, A and B have the meaning given in claim 1, process for producing it, and its use as a renin inhibitor in the treatment of hypertension and chronic cardiac insufficiency and in the treatment of diseases of retroviral origin.

140. 发明申请

WO1989006246A1 VINYL MONO- AND COPOLYMERS CONTAINING SIDE-CHAINS 审中-公开
标题翻译：包含侧链的乙烯基单体和共聚物
公开(公告)号：WO1989006246A1
公开(公告)日：1989-07-13
申请号：PCT/EP1989000007
申请日：1989-01-05
申请人： SANDOZ-PATENT-GMBH , SANDOZ AG
发明人： SANDOZ-PATENT-GMBH , SANDOZ AG , DANNER, Bernard
IPC分类号： C08F08/32
CPC分类号： C08F8/44 , C08F8/32 , Y10S526/923
摘要： Water-dilutable vinyl copolymers containing side chains contain groups (gamma) of formula -X-alk-Y-, where alk stands for alkyls with 2 to 6 carbon atoms, hydroxy-substituted alkyls with 3 to 6 carbon atoms, or alkyls with 4 to 6 carbon atoms interrupted by -O-, X stands for a basic amino group or an ammonium group, and Y stands for a basic -NH- group or an acid adduct thereof, one of X or Y also being bonded to a possibly substituted aliphatic or heteroaromatic residual hydrocarbon, the other being bonded to hydrogen or to a possibly substituted aliphatic residual hydrocarbon, in at least one part of the side chains. At least 1 mol % of the comonomer units in the copolymer carry such (gamma)-containing side chains. Said copolymers can be produced by copolymerization of suitable comonomers or by aminoalkylation of suitable starting polymers, and are useful as precipitating or flocculating agents, for example for purifying water or sewage, and in particular in the manufacture of paper.

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