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131. 发明授权

US08799625B2 Fast remote communication and computation between processors using store and load operations on direct core-to-core memory 有权
标题翻译：在直接核心到内核存储器之间使用存储和加载操作的处理器之间的快速远程通信和计算
公开(公告)号：US08799625B2
公开(公告)日：2014-08-05
申请号：US13413787
申请日：2012-03-07
申请人： John Bruce Carter , Elmootazbellah Nabil Elnozahy , Ahmed Gheith , Eric Van Hansbergen , Karthick Rajamani , William Evan Speight , Lixin Zhang
发明人： John Bruce Carter , Elmootazbellah Nabil Elnozahy , Ahmed Gheith , Eric Van Hansbergen , Karthick Rajamani , William Evan Speight , Lixin Zhang
IPC分类号： G06F9/30
CPC分类号： G06F9/544
摘要： A method for fast remote communication and computation between processors is provided in the illustrative embodiments. A direct core to core communication unit (DCC) is configured to operate with a first processor, the first processor being a remote processor. A memory associated with the DCC receives a set of bytes, the set of bytes being sent from a second processor. An operation specified in the set of bytes is executed at the remote processor such that the operation is invoked without causing a software thread to execute.
摘要翻译：在说明性实施例中提供了用于处理器之间的快速远程通信和计算的方法。核心通信单元（DCC）的直接核心被配置为与第一处理器一起操作，第一处理器是远程处理器。与DCC相关联的存储器接收一组字节，该字节集合是从第二处理器发送的。在远程处理器中执行在该组字节中指定的操作，使得调用操作而不使软件线程执行。

132. 发明申请

US20140080208A1 ADENOVIRAL VECTOR VACCINE 有权
公开(公告)号：US20140080208A1
公开(公告)日：2014-03-20
申请号：US13974353
申请日：2013-08-23
申请人： Albert B. Deisseroth , Lixin Zhang
发明人： Albert B. Deisseroth , Lixin Zhang
IPC分类号： C07K14/705 , C07K14/005
CPC分类号： A61K39/12 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , A61K2039/575 , C07K14/005 , C07K14/70575 , C07K14/70578 , C07K2319/02 , C07K2319/40 , C07K2319/74 , C12N15/86 , C12N2710/10343 , C12N2710/10371 , C12N2710/20022 , C12N2710/20034 , C12N2710/20071
摘要： Provided are adenoviral vectors for generating an immune response to antigen. The vectors comprise a transcription unit encoding a secretable polypeptide, the polypeptide comprising a secretory signal sequence upstream of a tumor antigen upstream of CD40 ligand, which is missing all or substantially all of the transmembrane domain rendering CD40L secretable. Also provided are methods of generating an immune response against cells expressing a tumor antigen by administering an effective amount of the invention vector. Further provided are methods of generating an immune response against cancer expressing a tumor antigen in an individual by administering an effective amount of the invention vector. Still further provided are methods of generating immunity to infection by human papilloma virus (HPV) by administering an effective amount of the invention vector which encodes the E6 or E7 protein of HPV. The immunity generated is long term.
摘要翻译：提供用于产生对抗原的免疫应答的腺病毒载体。载体包含编码可分泌多肽的转录单元，该多肽包含在CD40配体上游的肿瘤抗原上游的分泌信号序列，其缺失所有或基本上所有的跨膜结构域再现CD40L可分泌。还提供了通过施用有效量的本发明载体产生针对表达肿瘤抗原的细胞的免疫应答的方法。还提供了通过施用有效量的本发明载体产生针对表达个体肿瘤抗原的癌症的免疫应答的方法。还提供了通过施用有效量的编码HPV的E6或E7蛋白的本发明载体来产生人乳头瘤病毒（HPV）感染免疫的方法。产生的免疫力是长期的。

133. 发明授权

US08612687B2 Latency-tolerant 3D on-chip memory organization 失效
标题翻译：延迟容忍的3D片上存储器组织
公开(公告)号：US08612687B2
公开(公告)日：2013-12-17
申请号：US12787895
申请日：2010-05-26
申请人： Jian Li , William E. Speight , Lixin Zhang
发明人： Jian Li , William E. Speight , Lixin Zhang
IPC分类号： H01L29/00 , H01L21/00 , G06F12/00
CPC分类号： G06F12/0895 , G11C8/18
摘要： A mechanism is provided within a 3D stacked memory organization to spread or stripe cache lines across multiple layers. In an example organization, a 128B cache line takes eight cycles on a 16B-wide bus. Each layer may provide 32B. The first layer uses the first two of the eight transfer cycles to send the first 32B. The next layer sends the next 32B using the next two cycles of the eight transfer cycles, and so forth. The mechanism provides a uniform memory access.
摘要翻译：在3D堆叠存储器组织内提供了一种机制，用于跨多层传播或条带化高速缓存行。在一个示例组织中，128B高速缓存行在16B宽的总线上需要八个周期。每层可提供32B。第一层使用八个传输周期中的前两个发送第一个32B。下一层使用八个传输周期的接下来的两个周期发送下一个32B，等等。该机制提供了一个统一的内存访问。

134. 发明授权

US08595443B2 Varying a data prefetch size based upon data usage 有权
标题翻译：基于数据使用改变数据预取大小
公开(公告)号：US08595443B2
公开(公告)日：2013-11-26
申请号：US12024163
申请日：2008-02-01
申请人： Ravi K. Arimilli , Gheorghe C. Cascaval , Balaram Sinharoy , William E. Speight , Lixin Zhang
发明人： Ravi K. Arimilli , Gheorghe C. Cascaval , Balaram Sinharoy , William E. Speight , Lixin Zhang
IPC分类号： G06F12/08
CPC分类号： G06F12/0862 , G06F2212/6024
摘要： A method of data processing in a processor includes maintaining a usage history indicating demand usage of prefetched data retrieved into cache memory. An amount of data to prefetch by a data prefetch request is selected based upon the usage history. The data prefetch request is transmitted to a memory hierarchy to prefetch the selected amount of data into cache memory.
摘要翻译：一种处理器中的数据处理方法，包括维护指示对高速缓存存储器检索的预取数据的需求使用的使用历史。基于使用历史来选择由数据预取请求预取的数据量。将数据预取请求发送到存储器层次结构，以将所选择的数据量预取到高速缓冲存储器中。

135. 发明授权

US08546376B2 Pharmaceutical compounds 失效
标题翻译：药物化合物
公开(公告)号：US08546376B2
公开(公告)日：2013-10-01
申请号：US13496287
申请日：2010-09-17
申请人： Mark Peter Bell , Timothy Harrison , Sumita Bhattacharyya , James Samuel Shane Rountree , Frank Burkamp , Stephen Price , Calum MacLeod , Richard Leonard Elliott , Phillip Smith , Toby Jonathan Blench , Colin Roderick O'Dowd , Lixin Zhang , Graham Peter Trevitt , Hazel Joan Dyke
发明人： Mark Peter Bell , Timothy Harrison , Sumita Bhattacharyya , James Samuel Shane Rountree , Frank Burkamp , Stephen Price , Calum MacLeod , Richard Leonard Elliott , Phillip Smith , Toby Jonathan Blench , Colin Roderick O'Dowd , Lixin Zhang , Graham Peter Trevitt , Hazel Joan Dyke
IPC分类号： A61K31/4188 , A61K31/352 , A61K31/357 , A61K31/397 , A61K31/4155 , A61K31/4162 , A61K31/4178 , A61K31/4192 , A61K31/422 , A61K31/436 , A61K31/437 , A61K31/496 , A61K31/5377 , A61K31/5383 , A61P35/00 , C07C225/20 , C07D311/26 , C07D405/10 , C07D413/10 , C07D491/052 , C07D491/147 , C07D493/04 , C07D498/04
CPC分类号： C07D311/26 , C07D407/04 , C07D491/04
摘要： The invention relates to a series of compounds with particular activity as inhibitors of the serine-threonine kinase AKT. Also provided are pharmaceutical compositions comprising same as well as methods for treating cancer.
摘要翻译：本发明涉及作为丝氨酸 - 苏氨酸激酶AKT抑制剂的特定活性的一系列化合物。还提供了包含其的药物组合物以及用于治疗癌症的方法。

136. 发明授权

US08543769B2 Fine grained cache allocation 有权
标题翻译：细粒度缓存分配
公开(公告)号：US08543769B2
公开(公告)日：2013-09-24
申请号：US12509752
申请日：2009-07-27
申请人： Ramakrishnan Rajamony , William E. Speight , Lixin Zhang
发明人： Ramakrishnan Rajamony , William E. Speight , Lixin Zhang
IPC分类号： G06F12/00
CPC分类号： G06F12/084 , G06F12/0864 , G06F12/126 , Y02D10/13
摘要： A mechanism is provided in a virtual machine monitor for fine grained cache allocation in a shared cache. The mechanism partitions a cache tag into a most significant bit (MSB) portion and a least significant bit (LSB) portion. The MSB portion of the tags is shared among the cache lines in a set. The LSB portion of the tags is private, one per cache line. The mechanism allows software to set the MSB portion of tags in a cache to allocate sets of cache lines. The cache controller determines whether a cache line is locked based on the MSB portion of the tag.
摘要翻译：在虚拟机监视器中提供了用于共享高速缓存中的细粒度高速缓存分配的机制。该机制将高速缓存标签分成最高有效位（MSB）部分和最低有效位（LSB）部分。标签的MSB部分在一组中的高速缓存行之间共享。标签的LSB部分是私有的，每个缓存行一个。该机制允许软件将缓存中的标签的MSB部分设置为分配高速缓存行集合。高速缓存控制器基于标签的MSB部分来确定高速缓存行是否被锁定。

137. 发明授权

US08540979B2 Methods of generating immune responses with compositions comprising an adenoviral expression vector comprising a CD40L fusion protein 有权
标题翻译：用包含CD40L融合蛋白的腺病毒表达载体的组合物产生免疫应答的方法
公开(公告)号：US08540979B2
公开(公告)日：2013-09-24
申请号：US13549581
申请日：2012-07-16
申请人： Albert B. Deisseroth , Lixin Zhang
发明人： Albert B. Deisseroth , Lixin Zhang
IPC分类号： A61K48/00 , C12N15/00
CPC分类号： A61K39/12 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , A61K2039/575 , C07K14/005 , C07K14/70575 , C07K14/70578 , C07K2319/02 , C07K2319/40 , C07K2319/74 , C12N15/86 , C12N2710/10343 , C12N2710/10371 , C12N2710/20022 , C12N2710/20034 , C12N2710/20071
摘要： Provided are adenoviral vectors for generating an immune response to antigen. The vectors comprise a transcription unit encoding a secretable polypeptide, the polypeptide comprising a secretory signal sequence upstream of a tumor antigen upstream of CD40 ligand, which is missing all or substantially all of the transmembrane domain rendering CD40L secretable. Also provided are methods of generating an immune response against cells expressing a tumor antigen by administering an effective amount of the invention vector. Further provided are methods of generating an immune response against cancer expressing a tumor antigen in an individual by administering an effective amount of the invention vector. Still further provided are methods of generating immunity to infection by human papilloma virus (HPV) by administering an effective amount of the invention vector which enocodes the E6 or E7 protein of HPV. The immunity generated is long term.
摘要翻译：提供用于产生对抗原的免疫应答的腺病毒载体。载体包含编码可分泌多肽的转录单元，该多肽包含在CD40配体上游的肿瘤抗原上游的分泌信号序列，其缺失所有或基本上所有的跨膜结构域再现CD40L可分泌。还提供了通过施用有效量的本发明载体产生针对表达肿瘤抗原的细胞的免疫应答的方法。还提供了通过施用有效量的本发明载体产生针对表达个体肿瘤抗原的癌症的免疫应答的方法。还提供了通过施用有效量的本发明的针对HPV的E6或E7蛋白的本发明载体来产生人乳头瘤病毒（HPV）感染免疫的方法。产生的免疫力是长期的。

138. 发明授权

US08495307B2 Target memory hierarchy specification in a multi-core computer processing system 失效
标题翻译：多核计算机处理系统中的目标存储器层次结构规范
公开(公告)号：US08495307B2
公开(公告)日：2013-07-23
申请号：US12777603
申请日：2010-05-11
申请人： Tong Chen , Yaoqing Gao , Kevin K. O'Brien , Zehra N. Sura , Lixin Zhang
发明人： Tong Chen , Yaoqing Gao , Kevin K. O'Brien , Zehra N. Sura , Lixin Zhang
IPC分类号： G06F12/00
CPC分类号： G06F12/0811 , G06F12/0862 , G06F2212/6028
摘要： Target memory hierarchy specification in a multi-core computer processing system is provided including a system for implementing prefetch instructions. The system includes a first core processor, a dedicated cache corresponding to the first core processor, and a second core processor. The second core processor includes instructions for executing a prefetch instruction that specifies a memory location and the dedicated local cache corresponding to the first core processor. Executing the prefetch instruction includes retrieving data from the memory location and storing the retrieved data on the dedicated local cache corresponding to the first core processor.
摘要翻译：提供了多核计算机处理系统中的目标存储器层级规范，包括用于实现预取指令的系统。该系统包括第一核心处理器，对应于第一核心处理器的专用缓存器和第二核心处理器。第二核心处理器包括用于执行指定存储器位置的预取指令和对应于第一核心处理器的专用本地高速缓存的指令。执行预取指令包括从存储器位置检索数据并将检索的数据存储在与第一核心处理器对应的专用本地高速缓存上。

139. 发明授权

US08458408B2 Cache directed sequential prefetch 失效
标题翻译：缓存定向顺序预取
公开(公告)号：US08458408B2
公开(公告)日：2013-06-04
申请号：US13023615
申请日：2011-02-09
申请人： William E. Speight , Lixin Zhang
发明人： William E. Speight , Lixin Zhang
IPC分类号： G06F12/00
CPC分类号： G06F12/0862 , G06F2212/6026
摘要： A technique for performing stream detection and prefetching within a cache memory simplifies stream detection and prefetching. A bit in a cache directory or cache entry indicates that a cache line has not been accessed since being prefetched and another bit indicates the direction of a stream associated with the cache line. A next cache line is prefetched when a previously prefetched cache line is accessed, so that the cache always attempts to prefetch one cache line ahead of accesses, in the direction of a detected stream. Stream detection is performed in response to load misses tracked in the load miss queue (LMQ). The LMQ stores an offset indicating a first miss at the offset within a cache line. A next miss to the line sets a direction bit based on the difference between the first and second offsets and causes prefetch of the next line for the stream.
摘要翻译：用于在高速缓冲存储器内执行流检测和预取的技术简化了流检测和预取。高速缓存目录或高速缓存条目中的一点表示高速缓存行未被访问，并且另一位指示与高速缓存行相关联的流的方向。当先前预取的高速缓存行被访问时，预取下一个高速缓存行，使得高速缓存总是尝试在检测到的流的方向上预取访问之前的一个高速缓存行。响应于在负载未命中队列（LMQ）中跟踪的加载未命中，执行流检测。 LMQ存储指示高速缓存行内的偏移处的第一个未命中的偏移。下一个未命中的线路将基于第一和第二个偏移量之间的差异设置方向位，并导致流的下一行的预取。

140. 发明申请

US20130116243A1 INHIBITORS OF AKT ACTIVITY 有权
标题翻译： AKT活动的抑制剂
公开(公告)号：US20130116243A1
公开(公告)日：2013-05-09
申请号：US13517219
申请日：2010-12-23
申请人： Lixin Zhang , Graham Peter Trevitt , Hugues Miel , Frank Burkamp , Timothy Harrison , Andrew John Wilkinson , Charles-Henry Fabritius
发明人： Lixin Zhang , Graham Peter Trevitt , Hugues Miel , Frank Burkamp , Timothy Harrison , Andrew John Wilkinson , Charles-Henry Fabritius
IPC分类号： A61K31/47 , C07D215/38 , C07D471/04 , A61K31/4745 , A61K31/5377 , A61P35/00 , A61K31/5383 , C07D498/14 , C07D515/04 , A61K31/542 , A61K31/551 , C07D215/20 , C07D498/04
CPC分类号： C07D498/04 , C07D471/04 , C07D498/14
摘要： The invention relates to a series of compounds with particular activity as inhibitors of the serine-threonine kinase AKT. Also provided are pharmaceutical compositions comprising same as well as methods for treating cancer.
摘要翻译：本发明涉及作为丝氨酸 - 苏氨酸激酶AKT抑制剂的特定活性的一系列化合物。还提供了包含其的药物组合物以及用于治疗癌症的方法。

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