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131. 发明申请

WO2004000380A1 IMPLATABLE OR INSERTABLE MEDICAL DEVICES FOR CONTROLLED DELIVERY OF A THERAPEUTIC AGENT 审中-公开
标题翻译：用于控制输送治疗药物的可控或绝对医疗器械
公开(公告)号：WO2004000380A1
公开(公告)日：2003-12-31
申请号：PCT/US2003/019286
申请日：2003-06-19
申请人： SCIMED LIFE SYSTEMS, INC.
发明人： SCHWARZ, Marlene, C.
IPC分类号： A61L27/34
CPC分类号： A61L31/10 , A61L27/34 , A61L27/56 , A61L29/085 , A61L29/16 , A61L2300/416 , A61L2300/602
摘要： The present invention is directed to novel implantable or insertable medical devices that provide controlled release of a therapeutic agent. According to an embodiment of the present invention, a therapeutic-agent-releasing medical device is provided, which comprises : (a) an implantable or insertable medical device; (b) a release layer disposed over at least a portion of the implantable or insertable medical device; and (c) a therapeutic agent. The release layer comprises a styrene copolymer and at least one additional polymer. The release layer regulates the rate of release of the therapeutic agent from the medical device upon implantation or insertion of the device into a patient. The present invention is also directed to methods of forming the above implantable or insertable medical devices, methods of administering a therapeutic agent to a patient using such devices, and methods of modulating the release of therapeutic agent from such devices.
摘要翻译：本发明涉及提供治疗剂受控释放的新型可植入或可插入的医疗装置。根据本发明的一个实施方案，提供了一种治疗剂释放医疗装置，其包括：（a）可植入或可插入的医疗装置; （b）设置在所述可植入或可插入医疗装置的至少一部分上的释放层; 和（c）治疗剂。脱模层包含苯乙烯共聚物和至少一种另外的聚合物。释放层调节在将装置植入或插入患者体内治疗剂从医疗装置释放的速率。本发明还涉及形成上述可植入或可插入医疗装置的方法，使用这种装置向患者施用治疗剂的方法，以及调节治疗剂从这些装置释放的方法。

132. 发明申请

WO2003103738A1 SUSTAINED RELEASE OF SUPEROXIDE DISMUTASE MIMICS FROM IMPLANTABLE OR INSERTABLE MEDICAL DEVICES 审中-公开
标题翻译：从可植入或插入式医疗器械中继续释放超氧化物歧化酶
公开(公告)号：WO2003103738A1
公开(公告)日：2003-12-18
申请号：PCT/US2003/018323
申请日：2003-06-10
申请人： SCIMED LIFE SYSTEMS, INC.
发明人： HERRMANN, Robert, A.
IPC分类号： A61L27/26
CPC分类号： A61L31/16 , A61L29/16 , A61L2300/114 , A61L2300/416 , A61L2300/602
摘要： An implantable or insertable medical device is provided which comprises (a) a superoxide dismutase mimic and (b) a polymeric release region. Upon administration to a patient, the polymeric release region controls the release of the superoxide dismutase mimic, which is beneficially selected from a metal-chelate superoxide dismutase mimic and a nitroxide superoxide dismutase mimic. Also provided is a method of making an implantable or insertable medical device.
摘要翻译：提供了可植入或可插入的医疗装置，其包括（a）超氧化物歧化酶模拟物和（b）聚合物释放区域。在给予患者时，聚合物释放区域控制超氧化物歧化酶模拟物的释放，其有利地选自金属螯合物超氧化物歧化酶模拟物和氮氧化物超氧化物歧化酶模拟物。还提供了制造可植入或可插入的医疗装置的方法。

133. 发明申请

WO2003090806A1 MODULATION OF THERAPEUTIC AGENT RELEASE FROM A POLYMERIC CARRIER USING SOLVENT-BASED TECHNIQUES 审中-公开
标题翻译：使用基于溶剂的技术从聚合物载体调节治疗药物释放
公开(公告)号：WO2003090806A1
公开(公告)日：2003-11-06
申请号：PCT/US2003/012562
申请日：2003-04-22
申请人： SCIMED LIFE SYSTEMS, INC.
发明人： SCHWARZ, Marlene, C. , SHEPARD, Douglas, C.
IPC分类号： A61L31/10
CPC分类号： A61L31/16 , A61K9/1635 , A61L2300/416 , A61L2300/602 , A61L2300/606
摘要： A method of modulating a rate of release of a therapeutic agent from a medical device is provided. The method comprises: (a) providing a solution comprising a therapeutic agent, a polymer and a solvent system; and (b) forming a therapeutic-agent-loaded polymeric carrier for the medical device by evaporating the solvent system, such that the rate of release is modulated by changing the composition of the solvent system. The composition of the solvent system can be changed in a number of ways, including adding solvent species to the solvent system, removing solvent species from the solvent system, both adding and removing solvent species from the solvent system. The solvent system can also be changed by varying the ratio of solvent species within the solvent system.
摘要翻译：提供了一种从医疗装置调节治疗剂的释放速率的方法。该方法包括：（a）提供包含治疗剂，聚合物和溶剂体系的溶液; 和（b）通过蒸发溶剂系统形成用于医疗装置的治疗剂载体的聚合物载体，使得通过改变溶剂体系的组成来调节释放速率。可以多种方式改变溶剂体系的组成，包括向溶剂体系中加入溶剂种类，从溶剂体系中除去溶剂物质，从溶剂体系中加入和除去溶剂物质。溶剂系统也可以通过改变溶剂体系中溶剂种类的比例来改变。

134. 发明申请

WO2003068288A1 BIODEGRADABLE STENTS WITH CONTROLLED CHANGE OF PHYSICAL PROPERTIES LEADING TO BIOMECHANICAL COMPATIBILITY 审中-公开
标题翻译：具有控制的物理性质变化的生物可降硬体引导生物相容性
公开(公告)号：WO2003068288A1
公开(公告)日：2003-08-21
申请号：PCT/US2003/004443
申请日：2003-02-13
申请人： SCIMED LIFE SYSTEMS, INC.
发明人： HELMUS, Michael
IPC分类号： A61L31/00
CPC分类号： A61L31/10
摘要： The present invention provides an implantable or insertable medical device comprising a biodegradable or non-biodegradable inner material and a biodegradable coating or covering material at least partially covering the inner material; wherein after insertion or implantation into a patient, the medical device becomes decreasingly rigid and increasingly biomechanically compatible with body tissue in contact with the device over time.
摘要翻译：本发明提供了一种可植入或可插入的医疗装置，其包括至少部分地覆盖内部材料的可生物降解或不可生物降解的内部材料和可生物降解的涂层或覆盖材料; 其中在插入或植入患者体内之后，随着时间的过去，医疗装置变得越来越刚性并且越来越多地与机体接触的身体组织生物力学兼容。

135. 发明申请

WO2003061718A2 MEDICAL ARTICLES HAVING ENZYMATIC SURFACES FOR LOCALIZED THERAPY 审中-公开
标题翻译：具有用于局部治疗的酶学表面的医学文章
公开(公告)号：WO2003061718A2
公开(公告)日：2003-07-31
申请号：PCT/US2003/002020
申请日：2003-01-23
申请人： SCIMED LIFE SYSTEMS, INC.
发明人： SHEPARD, Douglas, C.
IPC分类号： A61L15/38
CPC分类号： A61L27/227 , A61L15/38 , C12N11/00
摘要： An enzymatically active medical article is provided, which comprises a medical article and an enzyme disposed at or near a surface of the medical article such that the medical article is provided with an enzymatically active surface. The enzyme is selected, for example, from the group consisting of protease enzymes, glycosidase enzymes, enzymes that degrade cholesterol esters, enzymes that convert hydrocortisone to cortisone, enzymes that degrade oxalate, and enzymes that generate NO from arginine.
摘要翻译：提供酶促活动的医疗用品，其包括医疗用品和设置在医疗用品的表面处或附近的酶，使得医疗用品具有酶活性表面。该酶选自例如蛋白酶，糖苷酶，降解胆固醇酯的酶，将氢化可的松转化为可的松的酶，降解草酸的酶，以及从精氨酸产生NO的酶。

136. 发明申请

WO2003061028A3 OLEDS HAVING INCREASED EXTERNAL ELECTROLUMINESCENCE QUANTUM EFFICIENCIES 审中-公开
公开(公告)号：WO2003061028A3
公开(公告)日：2003-07-24
申请号：PCT/US2003/000400
申请日：2003-01-08
申请人： UNIVERSAL DISPLAY CORPORATION
发明人： WEAVER, Michael, S. , BULOVIC, Vladimir , LU, Min-Hao, Michael
IPC分类号： H01L51/20
摘要： OLED devices are disclosed having increased external electroluminescence quantum efficiencies, i.e., increased "out-coupling" efficiencies. OLED devices that have increased out-coupling efficiencies and that are also protected from environmental elements such as moisture and oxygen are also disclosed. The OLED device of the present invention comprises a substrate (110); an active region (180) positioned on the substrate, wherein the active region comprises an anode layer (130), a cathode layer (150) and a light-emitting layer (140) disposed between the anode layer and the cathode layer; and a polymeric layer (120) disposed (a) over the active region, (b) under the active region or (c) both over and under the active region. The polymeric layer (120) has microparticles (170) incorporated therein, and the microparticles are effective to increase the out-coupling efficiency of the OLED. In one embodiment, the OLED device comprises a composite barrier layer and the microparticles are incorporated in a polymeric planarizing sublayer of the composite barrier layer. The composite barrier layer in this embodiment also protects the OLED from damage caused by environmental elements such as moisture and/or oxygen.

137. 发明申请

WO2003061028A2 OLEDS HAVING INCREASED EXTERNAL ELECTROLUMINESCENCE QUANTUM EFFICIENCIES 审中-公开
标题翻译：具有增加的外部电致发光效率的OLEDs
公开(公告)号：WO2003061028A2
公开(公告)日：2003-07-24
申请号：PCT/US2003/000400
申请日：2003-01-08
申请人： UNIVERSAL DISPLAY CORPORATION
发明人： WEAVER, Michael, S. , BULOVIC, Vladimir , LU, Min-Hao, Michael
IPC分类号： H01L51/20
CPC分类号： H01L51/5268 , H01L51/5253 , H01L51/5256 , H01L2251/5323
摘要： OLED devices are disclosed having increased external electroluminescence quantum efficiencies, i.e., increased "out-coupling" efficiencies. OLED devices that have increased out-coupling efficiencies and that are also protected from environmental elements such as moisture and oxygen are also disclosed. The OLED device of the present invention comprises a substrate; an active region positioned on the substrate, wherein the active region comprises an anode layer, a cathode layer and a light-emitting layer disposed between the anode layer and the cathode layer; and a polymeric layer disposed (a) over the active region, (b) under the active region or (c) both over and under the active region. The polymeric layer has microparticles incorporated therein, and the microparticles are effective to increase the out-coupling efficiency of the OLED. In one embodiment, the OLED device comprises a composite barrier layer and the microparticles are incorporated in a polymeric planarizing sublayer of the composite barrier layer. The composite barrier layer in this embodiment also protects the OLED from damage caused by environmental elements such as moisture and/or oxygen.
摘要翻译：公开了具有增加的外部电致发光量子效率的OLED器件，即增加的“输出耦合”效率。还公开了具有增加的外耦合效率并且也被保护免受环境因素如水分和氧气的OLED器件。本发明的OLED器件包括位于衬底上的有源区的衬底，其中有源区包括阳极层，阴极层和布置在阳极层和阴极层之间的发光层和设置在阳极层和阴极层之间的聚合物层 a在有源区域之上，b在有源区域下方，c处于有源区域之上和之下。聚合物层具有并入其中的微粒，并且微粒有效地增加OLED的外耦合效率。在一个实施例中，OLED器件包括复合阻挡层，并且微粒被并入复合阻挡层的聚合物平坦化子层中。该实施例中的复合阻挡层还保护OLED免受诸如水分和/或氧气等环境因素的损害。

138. 发明申请

WO2003052842A2 ENCAPSULATION STRUCTURE THAT ACTS AS A MULTILAYER MIRROR 审中-公开
标题翻译：作为多层镜子的包层结构
公开(公告)号：WO2003052842A2
公开(公告)日：2003-06-26
申请号：PCT/US2002/035671
申请日：2002-11-06
申请人： UNIVERSAL DISPLAY CORPORATION
发明人： WEAVER, Michael, Stuart
IPC分类号： H01L51/20
CPC分类号： H01L51/5271 , H01L51/5256 , H01L51/5262 , H01L51/5265
摘要： The present invention is directed to novel structures for use in connection with OLED devices that simultaneously act as a multilayer mirror and as a barrier to harmful species in the exterior environment. According to one embodiment of the invention, an OLED structure is provided that comprises: (a) a substrate; (b) an OLED over the substrate that comprises (i) a first electrode, (ii) an emission region above the first electrode and (iii) a second electrode above the emission region, wherein the OLED emits light having a range of wavelengths upon being turned on; and (c) a multilayer mirror over the substrate, the multilayer mirror comprising an alternating series of (i) planarizing layers having a first refractive index and (ii) high-density layers having a second refractive index that differs from the first refractive index. The thicknesses of the planarizing layers and of the high-density layers in this embodiment are selected such that the multilayer mirror is tuned to transmit light at a peak wavelength within the range of wavelengths emitted by the OLED. Moreover, the planarizing layers and the high-density layers cooperate to restrict transmission of water and oxygen.
摘要翻译：本发明涉及用于与同时作为多层反射镜和作为外部环境中的有害物质的屏障的OLED装置相结合的新型结构。根据本发明的一个实施例，提供了一种OLED结构，其包括：（a）衬底; （b）衬底上的OLED，其包括（i）第一电极，（ii）第一电极上方的发射区域和（iii）在发射区域上方的第二电极，其中OLED发射具有波长范围的光被打开和（c）在所述衬底上的多层反射镜，所述多层反射镜包括交替的（i）具有第一折射率的平坦化层和（ii）具有不同于所述第一折射率的第二折射率的高密度层的交替系列。选择本实施例中的平坦化层和高密度层的厚度，使得多层反射镜被调谐以透射由OLED发射的波长范围内的峰值波长的光。此外，平坦化层和高密度层协调以限制水和氧的传输。

139. 发明申请

WO2003045457A2 IMPLANTABLE OR INSERTABLE MEDICAL DEVICES VISIBLE UNDER MAGNETIC RESONANCE IMAGING 审中-公开
标题翻译：可视或不可剥离的医疗设备可见于磁共振成像
公开(公告)号：WO2003045457A2
公开(公告)日：2003-06-05
申请号：PCT/US2002/037706
申请日：2002-11-26
申请人： SCIMED LIFE SYSTEMS, INC.
发明人： ZHONG, Sheng-Ping , SAHATJIAN, Ronald, A. , MA, Enxin
IPC分类号： A61L27/00
CPC分类号： G01R33/286 , A61L29/145 , A61L29/18 , A61L31/145 , A61L31/18 , A61M25/0045 , A61M25/0108
摘要： Disclosed is an implantable or insertable medical device comprising (a) a substrate and (b) a hydrogel polymer coating at a least a portion of the surface of the substrate, wherein the hydrogel polymer is adapted to render the medical device visible under magnetic resonance imaging (MRI) upon insertion or implantation of the medical device into a patient. Also disclosed is the use of such a hydrogel coated implantable or insertable medical device in a medical procedure, wherein during or after insertion or implantation of the medical device in a patient, the position of the medical device is viewed under MRI. The use of a hydrogel polymer for coating a medical device wherein the hydrogel polymer is adapted to render a medical device coated with the hydrogel polymer visible under MRI and a hydrogel polymer adapted to render a medical device coated therewith visible under MRI are also disclosed.
摘要翻译：公开了一种可植入或可插入的医疗装置，其包括（a）基底和（b）在所述基底表面的至少一部分表面上的水凝胶聚合物涂层，其中所述水凝胶聚合物适于使所述医疗装置在磁共振成像（MRI）在将医疗装置插入或植入患者体内时。还公开了在医疗过程中使用这种水凝胶涂覆的可植入或可插入的医疗装置，其中在将医疗装置插入或植入患者体内或之后，在MRI下观察医疗装置的位置。还公开了使用水凝胶聚合物涂覆医疗装置，其中水凝胶聚合物适于使涂覆有水凝胶聚合物的医疗装置在MRI下可见，并且还公开了适于使其涂覆的医疗装置在MRI下可见的水凝胶聚合物。

140. 发明申请

WO2002087623A1 MICROPARTICLE PROTECTION OF THERAPEUTIC AGENTS 审中-公开
标题翻译：微生物保护治疗药物
公开(公告)号：WO2002087623A1
公开(公告)日：2002-11-07
申请号：PCT/US2002/013418
申请日：2002-04-26
申请人： SCIMED LIFE SYSTEMS, INC.
发明人： NAIMARK, Wendy , PALASIS, Maria
IPC分类号： A61K47/32
CPC分类号： A61K47/32 , A61K9/0019 , A61K9/10 , A61L2/0088
摘要： The present invention is directed to the use of microparticles to protect the pharmaceutically active agent. According to one embodiment, a pharmaceutically acceptable suspension is provided that comprises microparticles and a pharmaceutically active agent. This pharmaceutically acceptable suspension is then exposed to a component or condition that is incompatible with the pahrmaceutically active agent, such that the microparticles provide a pharmaceutical effectiveness that is greater than it would have been in the absence of the microparrticles. Preferably, the microparticles result in a pharmaceutical effectiveness of the pharmaceutically active agent that is at least 10% greater than the pharmaceutical effectiveness of the pharmaceutically active agent would have been in the absence of the microparticles. Polymer microparticles such as polystyrene microparticles, are one preferred class of microparticles. The microparticles preferably range from 0.01 to 100 microns in largest dimension, more preferably 0.1 to 10 microns in largest dimension. The microparticles are preferably provided in an amount of 0.1 to 1 wt% within the suspension. Agnets comprising polynucleotides, including cells, plasmids and viral vectors, are preferred class of pharmaceutically active agent. Other embodiments on the invention are directed to pharmaceutically acceptable suspensions, medical devices for parenteral injection, and methods of treatment.
摘要翻译：本发明涉及微粒用于保护药物活性剂的用途。根据一个实施方案，提供了包含微粒和药物活性剂的药学上可接受的悬浮液。然后将这种药学上可接受的悬浮液暴露于与药物活性剂不相容的组分或病症，使得微粒提供的药物效力大于在不存在微细颗粒的情况下的药效。优选地，微粒导致药物活性剂的药学有效性比药物活性剂在不存在微粒时所具有的药物有效性高至少10％。聚合物微粒如聚苯乙烯微粒是一类优选的微粒。微粒的最大尺寸优选为0.01〜100微米，更优选为0.1〜10微米。在悬浮液中，微粒优选以0.1〜1重量％的量提供。包含多核苷酸，包括细胞，质粒和病毒载体的Agnets是优选的药物活性剂类。本发明的其它实施方案涉及药学上可接受的悬浮液，用于肠胃外注射的医疗装置和治疗方法。

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